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  1. Book ; Online: The General's Goose

    Robertson, Robbie

    Fiji's Tale of Contemporary Misadventure

    (State, Society and Governance in Melanesia)

    2017  

    Series title State, Society and Governance in Melanesia
    Keywords Australasian & Pacific history ; Political structure & processes ; Political science & theory ; Political Science ; History
    Language English
    Size 1 Online-Ressource
    Publisher ANU Press
    Document type Book ; Online
    Note English
    HBZ-ID HT030612713
    ISBN 9781760461270 ; 176046127X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: DeGroot's endocrinoology / Volume two

    DeGroot, Leslie J. / Robertson, R. Paul

    basic science and clinical practice

    2023  

    Author's details R. Paul Robertson, editor
    Collection DeGroot's endocrinoology
    Language English
    Size xxiv Seiten, Seiten 1079 - 2322, I-75 Seiten, Illustationen
    Publishing country United States
    Document type Book
    HBZ-ID HT021607835
    ISBN 978-0-443-10781-8 ; 0-443-10781-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 1299 available for loan (reading room) Lesesaal EG

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  3. Book: DeGroot's endocrinoology / Volume one

    DeGroot, Leslie J. / Robertson, R. Paul

    basic science and clinical practice

    2023  

    Author's details R. Paul Robertson, editor
    Collection DeGroot's endocrinoology
    Language English
    Size xxiv, 1078, I-75 Seiten, Illustationen
    Publishing country United States
    Document type Book
    Accompanying material Zugang zu Enhanced Digital Version über Code
    HBZ-ID HT021607831
    ISBN 978-0-443-10780-1 ; 0-443-10780-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 1298 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Book ; Collection: DeGroot's endocrinoology

    DeGroot, Leslie J. / Robertson, R. Paul

    basic science and clinical practice

    2023  

    Title variant Endocrinology
    Author's details R. Paul Robertson, editor
    Keywords Endocrine System Diseases ; Metabolic Diseases
    Language English
    Dates of publication 2023-2023
    Size 2 Bände
    Edition Eighth editon
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Collection (display volumes)
    HBZ-ID HT021581522
    ISBN 978-0-323-69412-4 ; 0-323-69412-8
    Database Catalogue ZB MED Medicine, Health

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  5. Conference proceedings ; Online: La Soufriere Volcano eruption 2020-21 - testing the integration of Community Volcanic Emergency Plans and national EWS in St. Vincent

    Robertson, R.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: Caribbean Small Island Developing States are exposed to a multiplicity of natural hazards and St. Vincent and the Grenadines, home of La Soufriere Volcano, is one of the most disaster-prone. Overcoming the challenges associated with operating a ... ...

    Abstract Caribbean Small Island Developing States are exposed to a multiplicity of natural hazards and St. Vincent and the Grenadines, home of La Soufriere Volcano, is one of the most disaster-prone. Overcoming the challenges associated with operating a geophysical monitoring network aimed at providing early warning of an impending eruption has required the use of several strategies. A key component of these have been building partnership with local disaster management officials and community members in high-risk zones on the volcano. We have worked with disaster management officials and community members to help them develop Community Volcano Emergency Plans (CVEPs) that incorporated multi-hazard mapping, vulnerability and capacity assessments, training and equipping of Community Emergency Response teams and testing of plans through simulation exercises. Activities such as evacuation routing, identification of shelters and muster points and stocking of emergency supplies were all integral elements in these plans.CVEPs aim to effectively illustrate the role of and actively engage with monitoring scientists, disaster management agencies and citizens in dealing with volcanic emergencies. The 2020–2021 eruption of La Soufrière volcano served as an important test to the entire system. The eruption involved a series of explosions from 9–22 April 2021 that were preceded by three months of effusive activity, which commenced with a very low level of detected unrest. It occurred against the backdrop of the Covid pandemic which presented multiple challenges to effective response. In this presentation we share our experience of integrating community response with EWS and review its performance during the 2020-21 eruption.
    Subject code 710
    Language English
    Publishing date 2023-07-11
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Antioxidants for Early Treatment of Type 2 Diabetes in Rodents and Humans: Lost in Translation?

    Robertson, R Paul

    Diabetes

    2024  Volume 73, Issue 5, Page(s) 653–658

    MeSH term(s) Animals ; Humans ; Antioxidants/therapeutic use ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Rodentia/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Catalase/genetics ; Catalase/metabolism ; Superoxide Dismutase/genetics ; Hyperglycemia/drug therapy ; Glutathione Peroxidase/genetics ; Glutathione Peroxidase/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; NF-E2-Related Factor 2 ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Peroxidase (EC 1.11.1.9)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db23-0901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Nrf2 and Antioxidant Response in Animal Models of Type 2 Diabetes.

    Robertson, R Paul

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: This perspective examines the proposition that chronically elevated blood glucose levels caused by type 2 diabetes (T2D) harm body tissues by locally generating reactive oxygen species (ROS). A feed-forward scenario is described in which the initial ... ...

    Abstract This perspective examines the proposition that chronically elevated blood glucose levels caused by type 2 diabetes (T2D) harm body tissues by locally generating reactive oxygen species (ROS). A feed-forward scenario is described in which the initial onset of defective beta cell function T2D becomes sustained and causes chronic elevations in blood glucose, which flood metabolic pathways throughout the body, giving rise to abnormally high local levels of ROS. Most cells can defend themselves via a full complement of antioxidant enzymes that are activated by ROS. However, the beta cell itself does not contain catalase or glutathione peroxidases and thereby runs a greater risk of ROS-induced damage. In this review, previously published experiments are revisited to examine the concept that chronic hyperglycemia can lead to oxidative stress in the beta cell, how this relates to the absence of beta cell glutathione peroxidase (GPx) activity, and whether this deficiency might be ameliorated by genetic enrichment of beta cell GPx and by oral antioxidants, including ebselen, a GPx mimetic.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Diabetes Mellitus, Type 2/metabolism ; Reactive Oxygen Species/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Blood Glucose ; Glutathione Peroxidase/metabolism ; Models, Animal
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; NF-E2-Related Factor 2 ; Blood Glucose ; Glutathione Peroxidase (EC 1.11.1.9)
    Language English
    Publishing date 2023-02-04
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Brief overview: glucagon history and physiology.

    Robertson, R Paul

    The Journal of endocrinology

    2023  Volume 258, Issue 2

    Abstract: Glucagon is a peptide hormone that is produced primarily by the alpha cells in the islet of Langerhans in the pancreas, but also in intestinal enteroendocrine cells and in some neurons. Approximately 100 years ago, several research groups discovered that ...

    Abstract Glucagon is a peptide hormone that is produced primarily by the alpha cells in the islet of Langerhans in the pancreas, but also in intestinal enteroendocrine cells and in some neurons. Approximately 100 years ago, several research groups discovered that pancreatic extracts would cause a brief rise in blood glucose before they observed the decrease in glucose attributed to insulin. An overall description of the regulation of glucagon secretion requires the inclusion of its sibling insulin because they both are made primarily by the islet and they both regulate each other in different ways. For example, glucagon stimulates insulin secretion, whereas insulin suppresses glucagon secretion. The mechanism of action of glucagon on insulin secretion has been identified as a trimeric guanine nucleotide-binding protein (G-protein)-mediated event. The manner in which insulin suppresses glucagon release from the alpha cell is thought to be highly dependent on the peri-portal circulation of the islet through which blood flows downstream from beta cells to alpha cells. In this scenario, it is via the circulation that insulin is thought to suppress the release of glucagon. However, high levels of glucose also have been shown to suppress glucagon secretion. Consequently, the glucose-lowering effect of insulin may be additive to the direct effects of insulin to suppress alpha cell function, so that in vivo both the discontinuation of the insulin signal and the condition of low glucose jointly are responsible for induction of glucagon secretion.
    MeSH term(s) Glucagon/metabolism ; Islets of Langerhans/metabolism ; Glucagon-Like Peptide 1/metabolism ; Insulin/metabolism ; Glucagon-Secreting Cells ; Glucose/metabolism
    Chemical Substances Glucagon (9007-92-5) ; Glucagon-Like Peptide 1 (89750-14-1) ; Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3028-4
    ISSN 1479-6805 ; 0022-0795
    ISSN (online) 1479-6805
    ISSN 0022-0795
    DOI 10.1530/JOE-22-0224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.133: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Case of Retropulsed Gonorrhœa, Succeeded by a Severe Affection of the Eyes, Terminating Favourably.

    Robertson, R

    Annals of medicine, for the year ... : exhibiting a concise view of the latest and most important discoveries in medicine and medical philosophy

    2018  Volume 4, Page(s) 455–458

    Language English
    Publishing date 2018-10-30
    Publishing country Scotland
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Silent Echoes: A Case Report of Wernicke Encephalopathy's Unheard Voice.

    Gafoor, Stefan / Robertson, Raheem

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52151

    Abstract: Wernicke encephalopathy (WE) is an acute neuropsychiatric emergency that is caused by a deficiency in vitamin B1 (thiamine). This condition is most commonly seen in patients with alcohol use disorder; however, patients with other disorders of severe ... ...

    Abstract Wernicke encephalopathy (WE) is an acute neuropsychiatric emergency that is caused by a deficiency in vitamin B1 (thiamine). This condition is most commonly seen in patients with alcohol use disorder; however, patients with other disorders of severe malnourishment are also at increased risk. In severe cases, this disease may be followed by Korsakoff's psychosis and even death.  We present a case of a 64-year-old African American female with a history of alcohol use disorder who presented to the emergency department on account of an acute confusional state. Neurological examination revealed right beating nystagmus on the left gaze and a wide-based gait. Initial laboratory work-up was unrevealing; however, magnetic resonance imaging (MRI) of the brain demonstrated an abnormal T2 fluid-attenuated inversion recovery (FLAIR) signal involving the bilateral mammillary bodies and surrounding lateral ventricles that extended into the periaqueductal parenchyma. The patient was admitted to the neurology unit, and high-dose intravenous thiamine was commenced. During hospitalization, the patient's confusion improved and they were subsequently discharged with oral thiamine. The spectrum of severity of WE is wide, ranging from fatal disease and can lead to permanent brain damage or even Korsakoff syndrome, characterized by severe memory loss and confabulation. The diagnosis is mainly clinical and based on the presence of symptoms in the classic triad of mental status change, oculomotor abnormality, and ataxia. This triad is only present in about 10% of cases, making the diagnosis very challenging. Laboratory testing can assist in making the diagnosis, but it is not always reliable or available. In situations of clinical uncertainty, imaging may also be used to support diagnosis or rule out other differentials. The mainstay of treatment is with high-dose parenteral thiamine.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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