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  1. Article ; Online: Mastectomy skin flap thickness.

    Robertson, Stuart A / Cutress, Ramsey I

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2018  Volume 44, Issue 7, Page(s) 1118

    MeSH term(s) Breast Neoplasms/surgery ; Mammaplasty ; Mastectomy ; Skin Transplantation ; Surgical Flaps
    Language English
    Publishing date 2018-04-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2018.03.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mastectomy skin flap necrosis: challenges and solutions.

    Robertson, Stuart A / Jeevaratnam, Johann A / Agrawal, Avi / Cutress, Ramsey I

    Breast cancer (Dove Medical Press)

    2017  Volume 9, Page(s) 141–152

    Abstract: Introduction: Mastectomy skin flap necrosis (MSFN) has a reported incidence of 5%-30% in the literature. It is often a significant and underappreciated problem. The aim of this article was to review the associated challenges and possible solutions.: ... ...

    Abstract Introduction: Mastectomy skin flap necrosis (MSFN) has a reported incidence of 5%-30% in the literature. It is often a significant and underappreciated problem. The aim of this article was to review the associated challenges and possible solutions.
    Methods: A MEDLINE search was performed using the search term "mastectomy skin flap necrosis". Titles and abstracts from peer-reviewed publications were screened for relevance.
    Results: MSFN is a common complication and may present as partial- or full-thickness necrosis. Predictive patient risk factors include smoking, diabetes, obesity, radiotherapy, previous scars and severe medical comorbidity. MSFN leads to a number of challenges, including wound management problems, delays to adjuvant therapy, esthetic compromise, implant extrusion, patient distress and financial loss. Careful preoperative planning and meticulous surgical technique may reduce the incidence of MSFN. A number of intraoperative techniques are available to try and predict skin flaps at risk of MSFN. MSFN may be managed operatively or nonoperatively. Early intervention may reduce the morbidity of MSFN in selected cases. Topical nitroglycerin ointment may be beneficial in reducing MSFN following immediate reconstruction, but the evidence base is still limited.
    Conclusion: MSFN can result in considerable challenges for the patient and the health care service. This review discusses the management options for this problem.
    Language English
    Publishing date 2017-03-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520722-2
    ISSN 1179-1314
    ISSN 1179-1314
    DOI 10.2147/BCTT.S81712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Two-stage Fowler-Stephens orchidopexy preserving the gubernacular vessels and a purely laparoscopic second stage.

    Robertson, Stuart A / Munro, Fraser D / Mackinlay, Gordon A

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2007  Volume 17, Issue 1, Page(s) 101–107

    Abstract: Purpose: We describe a modification of the two-stage laparoscopic Fowler-Stephens technique in which the gubernacular vessels are preserved and the testis is brought down the canal via the internal ring. A purely laparoscopic second stage is performed. ... ...

    Abstract Purpose: We describe a modification of the two-stage laparoscopic Fowler-Stephens technique in which the gubernacular vessels are preserved and the testis is brought down the canal via the internal ring. A purely laparoscopic second stage is performed. We report our outcomes with this technique.
    Materials and methods: All laparoscopic Fowler-Stephens orchidopexies undertaken at our hospital from 1996 to July 2004 were identified from a prospectively collected database of all surgical procedures undertaken in the unit. A retrospective case-note review was undertaken.
    Results: We identified 21 patients, 4 bilateral and 17 unilateral, giving a total of 25 intra-abdominal testes. Mean age at presentation was 21 months (range, 0-56 months). Mean age at the first stage was 36 months (range, 11-68 months). The testis position at initial laparoscopy was high in 5, close to the internal inguinal ring in 9, peeping in 6, and pelvic in 5. The testis size at this stage was either normal, good sized, or reasonable sized in 15, small or dysplastic in 5, and in 5 the size was not commented upon. The testicular vessels were mainly divided by diathermy at the first stage, but in 6 the vessels were clipped. The second stage was undertaken 6 months after the first, in order to allow the collateral blood supply to adapt. Twelve testes had changed position category during this interval, 2 having ascended to a higher position and 10 descended to a lower position; 12 were in the same position at both stages; and in 1 case the position was not commented upon at the second stage. A purely laparoscopic second stage technique was used in 21 cases; an assisted-open second stage was undertaken in 1 case. In 3 cases the testis was palpable in the groin at examination under anesthesia and so an open second stage orchidopexy was performed. Follow-up was at 6 and 18 months after the second stage. Eighteen of the 21 testes that underwent a purely laparoscopic second stage survived at 6 months, giving a success rate with this technique of 86%. The overall testis survival rate in the entire group at 6 months was 88% (22/25). Findings in those patients reviewed at 18 months were unchanged.
    Conclusion: The two-stage laparoscopic Fowler-Stephens orchidopexy, with preservation of the gubernacular vessels and predominantly using a purely laparoscopic second stage, provided a very good testis survival rate, approaching 90%.
    MeSH term(s) Child ; Child, Preschool ; Cryptorchidism/surgery ; Humans ; Infant ; Infant, Newborn ; Laparoscopy ; Male ; Prospective Studies ; Testis/blood supply ; Testis/surgery ; Treatment Outcome
    Language English
    Publishing date 2007-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1092-6429
    ISSN 1092-6429
    DOI 10.1089/lap.2006.0565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The spleen--a potential source of new islets for transplantation?

    Robertson, Stuart A / Rowan-Hull, Autumn M / Johnson, Paul R V

    Journal of pediatric surgery

    2008  Volume 43, Issue 2, Page(s) 274–278

    Abstract: Background/purpose: Islet transplantation offers the potential to reverse diabetes soon after diagnosis and has achieved considerable success in adults. Its use in children has been limited by long-term immunosuppression requirements and donor pancreas ... ...

    Abstract Background/purpose: Islet transplantation offers the potential to reverse diabetes soon after diagnosis and has achieved considerable success in adults. Its use in children has been limited by long-term immunosuppression requirements and donor pancreas shortages. An ideal alternative source of islets would be from autologous precursor cells. The aim of this study was to determine whether the spleen can produce insulin-producing cells (IPCs) in our established model of pancreatic development.
    Methods: Embryonic quail spleens (day 4.5) and chick pancreatic epithelium (day 4) were microdissected and recombined in a ratio of 1:1 (n = 12), 2:1 (n = 9) and 2:2 (n = 5). They were cultured for 7 days, sectioned, and analysed by fluorescent immunochemistry. Controls were performed to ensure clean separation.
    Results: Overall, 12 (46%) of 26 recombinants contained IPCs of splenic origin, occurring in 5 (42%) of 12 of the of 1 spleen-1 epithelium recombinants, 3 (33%) of 9 of the 2 spleen-1 epithelium recombinants, and 4 (80%) of 5 of the 2 spleen-2 epithelia recombinants. Controls were negative.
    Conclusions: Preliminary results suggest developing avian spleens can differentiate into IPCs. Increased tissue mass enhanced the likelihood of this occurring. Mesenchyme-to-epithelia ratio did not influence this. The spleen could be an ideal autologous islet source for transplantation in children.
    MeSH term(s) Animals ; Cell Transplantation ; Cells, Cultured ; Chick Embryo ; Chimera ; Embryo, Nonmammalian ; Epithelium/embryology ; In Situ Hybridization ; Insulin/metabolism ; Insulin Secretion ; Islets of Langerhans/embryology ; Islets of Langerhans/metabolism ; Islets of Langerhans Transplantation ; Models, Animal ; Pancreas/embryology ; Quail ; Reference Values ; Sensitivity and Specificity ; Spleen/cytology
    Chemical Substances Insulin
    Language English
    Publishing date 2008-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2007.10.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Audio / Video ; Thesis: An evaluation of the characteristics of successful students at the Brinkman-Froemming Umpire School

    Robertson, Stuart A.

    1993  

    Author's details by Stuart A. Robertson
    Size VIII, 70 Blatt: Illustrationen
    Edition [Mikrofiche-Ausg.]
    Document type Audio / Video ; Thesis
    Thesis / German Habilitation thesis Thesis (Master of Arts), University of North Carolina, Chapel Hill, 1993
    HBZ-ID HT016386578
    Database Central Library of Sport Science of the German Sport University Cologne

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  6. Article: Superior mediastinal teratoma containing well-differentiated bowel.

    Robertson, Stuart A / Nazir, Safraz / Bowker, Colene / Lakhoo, Kokila

    Fetal and pediatric pathology

    2007  Volume 26, Issue 2, Page(s) 69–73

    Abstract: A previously fit and well 14-month-old-girl presented with a 2-month history of worsening cough and wheeze. Chest radiograph revealed a widened mediastinum and thoracic CT showed a large mixed density mass in the superior mediastinum, consistent with a ... ...

    Abstract A previously fit and well 14-month-old-girl presented with a 2-month history of worsening cough and wheeze. Chest radiograph revealed a widened mediastinum and thoracic CT showed a large mixed density mass in the superior mediastinum, consistent with a mediastinal teratoma. Her tumor markers were within the normal range. The mass was resected and found to be a mature cystic teratoma. Surprisingly, well-formed bowel-like structures were present, containing all bowel wall layers and having a ganglionated myenteric plexus. The identification of complete sections of bowel in this context is a rare finding and to the best of our knowledge has not been published previously for the mediastinal teratoma. The possibility of secondary neoplasia developing in these areas is a complicating factor.
    MeSH term(s) Female ; Humans ; Infant ; Intestines/pathology ; Mediastinal Neoplasms/diagnosis ; Mediastinal Neoplasms/pathology ; Myenteric Plexus/pathology ; Radiography, Thoracic ; Teratoma/diagnosis ; Teratoma/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2165508-X
    ISSN 1551-3815 ; 1522-7952
    ISSN 1551-3815 ; 1522-7952
    DOI 10.1080/15513810701448326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: ISL-1 is induced in stomach mesenchyme in the presence of pancreatic epithelia.

    Rowan-Hull, Autumn M / Rao, Roheet / Robertson, Stuart A / Johnson, Paul R V

    Journal of pediatric surgery

    2009  Volume 44, Issue 2, Page(s) 348–352

    Abstract: Background/purpose: beta-Cell replacement offers a potential cure for type 1 diabetes mellitus in children. We have previously shown that stomach mesenchyme (SM) is competent to derive islet tissue by mesenchymal-to-epithelial transition (iMET). The aim ...

    Abstract Background/purpose: beta-Cell replacement offers a potential cure for type 1 diabetes mellitus in children. We have previously shown that stomach mesenchyme (SM) is competent to derive islet tissue by mesenchymal-to-epithelial transition (iMET). The aim of this study was to further characterize the developmental fate of this SM in the presence of pancreatic epithelia (PE) in SM/PE recombinants. The homeobox ISL-1 was examined in these recombinants because this gene is restricted to the dorsal pancreatic mesenchyme and endocrine cells in early pancreatic development.
    Methods: Chick-quail recombinants of SM + PE (n = 15) and whole stomach controls (n = 8) were cultured for 7 days. In addition, organ blocks were examined after normal development at days 4 to 10 (n = 4 for each stage). Tissues were analyzed using immunochemistry against quail-specific antigen and ISL-1.
    Results: Thirteen of 15 SM + PE recombinants expressed the ISL-1 protein in cells from SM origin. Nine of 15 of these recombinants showed iMET and coexpression of insulin, and ISL-1 was recorded.
    Conclusions: Pancreatic epithelium is able to reprogram SM to a more caudal pancreatic fate when cocultured. Islet tissue by mesenchymal-to-epithelial transition observed in recombinants showed coexpression of insulin and ISL-1. These experiments are important to identify the molecular mechanisms behind iMET for potential therapeutic use for treating children with diabetes.
    MeSH term(s) Animals ; Chick Embryo ; Epithelium/embryology ; Epithelium/physiology ; Homeodomain Proteins/biosynthesis ; Homeodomain Proteins/physiology ; LIM-Homeodomain Proteins ; Mesoderm/embryology ; Pancreas/embryology ; Pancreas/physiology ; Quail/embryology ; Stomach/embryology ; Transcription Factors ; Transplantation Chimera
    Chemical Substances Homeodomain Proteins ; LIM-Homeodomain Proteins ; Transcription Factors ; insulin gene enhancer binding protein Isl-1
    Language English
    Publishing date 2009-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2008.10.085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Flowering plants of Seychelles

    Robertson, Stuart A

    (an annotated check list, of angiosperms and gymnosperms with line drawings)

    1989  

    Author's details S. A. Robertson
    Language English
    Size XVI, 327 S, Ill
    Publisher Royal Botanic Gardens
    Publishing place Kew
    Document type Book
    ISBN 0947643141 ; 9780947643140
    Database Former special subject collection: coastal and deep sea fishing

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