Article ; Online: A Spontaneous Melanoma Mouse Model Applicable for a Longitudinal Chemotherapy and Immunotherapy Study.
The Journal of investigative dermatology
2023 Volume 143, Issue 10, Page(s) 2007–2018.e6
Abstract: Mouse models that reflect human disorders provide invaluable tools for the translation of basic science discoveries to clinical therapies. However, many of these in vivo therapeutic studies are short term and do not accurately mimic patient conditions. ... ...
| Abstract | Mouse models that reflect human disorders provide invaluable tools for the translation of basic science discoveries to clinical therapies. However, many of these in vivo therapeutic studies are short term and do not accurately mimic patient conditions. In this study, we used a fully immunocompetent, transgenic mouse model, TGS, in which the spontaneous development of metastatic melanoma is driven by the ectopic expression of a normal neuronal receptor, mGluR1, as a model to assess longitudinal treatment response (up to 8 months) with an inhibitor of glutamatergic signaling, troriluzole, which is a prodrug of riluzole, plus an antibody against PD-1, an immune checkpoint inhibitor. Our results reveal a sex-biased treatment response that led to improved survival in troriluzole and/or anti-PD-1-treated male mice that correlated with differential CD8 |
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| MeSH term(s) | Male ; Humans ; Mice ; Animals ; CD8-Positive T-Lymphocytes ; Melanoma/pathology ; Immunotherapy/methods | |||||
| Language | English | |||||
| Publishing date | 2023-03-29 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80136-7 | |||||
| ISSN | 1523-1747 ; 0022-202X | |||||
| ISSN (online) | 1523-1747 | |||||
| ISSN | 0022-202X | |||||
| DOI | 10.1016/j.jid.2023.03.1664 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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