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  1. Book ; Online ; E-Book: Frozen section pathology

    Borczuk, Alain C. / Yantiss, Rhonda K. / Robinson, Brian D. / Scognamiglio, Theresa / D'Alfonso, Timothy M.

    diagnostic challenges

    2021  

    Author's details Alain C. Borczuk, Rhonda K. Yantiss, Brian D. Robinson, Theresa Scognamiglio, Timothy M. D'Alfonso
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (x, 453 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020935385
    ISBN 978-3-030-71308-9 ; 9783030713072 ; 3-030-71308-3 ; 3030713075
    DOI 10.1007/978-3-030-71308-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Precision molecular pathology of prostate cancer

    Robinson, Brian D. / Mosquera, Juan Miguel / Ro, Jae Y. / Divatia, Mukul

    (Molecular pathology library)

    2018  

    Author's details Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia editors
    Series title Molecular pathology library
    Keywords Medicine ; Oncology ; Pathology ; Urology
    Subject code 616.07
    Language English
    Size 1 Online-Ressource (xiv, 570 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019634020
    ISBN 978-3-319-64096-9 ; 9783319640645 ; 3-319-64096-8 ; 331964064X
    DOI 10.1007/978-3-319-64096-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Evaluating the Learning Curve for In-office Freehand Cognitive Fusion Transperineal Prostate Biopsy.

    Gereta, Sofia / Hung, Michael / Alexanderani, Mohammad K / Robinson, Brian D / Hu, Jim C

    Urology

    2023  Volume 181, Page(s) 31–37

    Abstract: Objective: To define the learning curve of the in-office, freehand MRI-ultrasound cognitive fusion transperineal prostate biopsy (CTPB) by assessing cancer detection, biopsy core quantity and quality, procedure times, and complications over the initial ... ...

    Abstract Objective: To define the learning curve of the in-office, freehand MRI-ultrasound cognitive fusion transperineal prostate biopsy (CTPB) by assessing cancer detection, biopsy core quantity and quality, procedure times, and complications over the initial experience.
    Methods: We reviewed 110 consecutive CTPB performed March 2021-September 2022 by a urologist inexperienced with the PrecisionPoint platform. The study period was divided into quarters to assess for temporal variation in outcomes. Univariable and multivariable analysis modeled the learning curve.
    Results: Across quarters, there were no differences in the detection of clinically significant prostate cancer (Q1:50%, Q2:52%, Q3:50%, Q4:48%, P > .9) or Gleason grade group upgrading by targeted vs systematic biopsy (P = .6). Median procedure times improved with experience (Q1:17 minutes, Q2:14 minutes, Q3:12 minutes, Q4:13 minutes, P = .018). On multivariable analysis, procedure times decreased by 1minute per 20 cases (P < .001). On linear regression, CTPB procedure times approximated transrectal biopsy times after 90 cases (P < .001). The histopathologic core quality did not differ, as evidenced by consistent core length (P = .13) and presence of minimal fibromuscular tissue (P > .9). The most common complications, hematuria and hematospermia, were similar across quarters (P = .7, P = .3, respectively). There was a single episode of urinary retention and no reported infections.
    Conclusion: There is no evidence of a learning curve for CTPB as shown by consistent clinically significant prostate cancer detection, high-quality biopsy cores, and low complications. However, CTPB procedural times begin to approximate cognitive targeted transrectal biopsy times after 90 cases.
    MeSH term(s) Male ; Humans ; Prostate ; Learning Curve ; Prostatic Neoplasms/diagnosis ; Image-Guided Biopsy ; Cognition
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2023.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1142: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 275: Show issues

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  4. Article ; Online: HER2/ ERBB2 Immunohistochemical Expression and Copy Number Status in Ovarian Mucinous Tumors.

    Smithgall, Marie C / Yemelyanova, Anna / Mathew, Susan / Gogineni, Swarna / He, Bing / Zhang, Taotao / Robinson, Brian D / Tu, Jiangling J

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

    2023  Volume 43, Issue 2, Page(s) 134–139

    Abstract: Primary mucinous ovarian carcinoma (MOC) is a rare ovarian epithelial cancer, which is often refractory to chemotherapy. HER2-targeting therapy is being increasingly considered in gynecologic malignancies. Although there have been limited studies ... ...

    Abstract Primary mucinous ovarian carcinoma (MOC) is a rare ovarian epithelial cancer, which is often refractory to chemotherapy. HER2-targeting therapy is being increasingly considered in gynecologic malignancies. Although there have been limited studies examining the HER2 status of such tumors, the criteria for HER2 expression scoring have not been standardized for MOC as it has for other sites. This study aimed to survey immunohistochemical HER2 expression patterns in MOC and its precursor, mucinous borderline tumor in correlation with fluorescence in situ hybridization (FISH). Immunohistochemistry (IHC) for HER2 was performed on 12 cases of MOC and 15 mucinous borderline tumors, including 7 with intraepithelial carcinoma. HER2 expression was quantified using the gastric/gastroesophageal carcinoma protocol. Cases were considered 3+ if the tumor cells displayed strong complete or basolateral/lateral membranous staining in ≥10% of tumor cells. Cases (2+) had weak to moderate staining in ≥10% of tumor cells. Cases (1+) had faint staining in ≥10% of tumor cells. Cases considered 0 had no staining or faint staining in <10% of tumor cells. HER2 expression was also quantified with the endometrial serous carcinoma protocol, which uses a 30% tumor cell positivity cutoff. FISH for HER2 was performed on all 3+ and 2+ and a subset of 1+ cases. Of the MOC cases, 25% were 3+ and 1 mucinous borderline tumor with intraepithelial carcinoma had 3+ staining. All 3+ IHC MOC cases had >30% basolateral membranous staining. HER2 amplification was confirmed by FISH on all 3+ IHC cases and in one 2+ IHC case of MOC. Up to 25% of mucinous ovarian tumors showed HER2 IHC overexpression with an excellent correlation between IHC and FISH using the HER2 scoring protocol for either gastric/gastroesophageal carcinoma or uterine serous carcinoma.
    MeSH term(s) Female ; Humans ; In Situ Hybridization, Fluorescence ; DNA Copy Number Variations ; Gene Amplification ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Carcinoma, Ovarian Epithelial ; Neoplasms, Cystic, Mucinous, and Serous ; Adenocarcinoma, Mucinous/genetics ; Endometrial Neoplasms ; Cystadenocarcinoma, Serous ; Carcinoma in Situ ; Biomarkers, Tumor/genetics
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Biomarkers, Tumor ; ERBB2 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604859-6
    ISSN 1538-7151 ; 0277-1691
    ISSN (online) 1538-7151
    ISSN 0277-1691
    DOI 10.1097/PGP.0000000000000966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Precursor Lesions of Urologic Malignancies.

    Khani, Francesca / Robinson, Brian D

    Archives of pathology & laboratory medicine

    2017  

    Abstract: Context: - Precursor lesions of urologic malignancies are established histopathologic entities, which are important not only to recognize for clinical purposes, but also to further investigate at the molecular level, in order to gain a better ... ...

    Abstract Context: - Precursor lesions of urologic malignancies are established histopathologic entities, which are important not only to recognize for clinical purposes, but also to further investigate at the molecular level, in order to gain a better understanding of the pathogenesis of these malignancies.
    Objective: - To provide a brief overview of precursor lesions to the most common malignancies that develop within the genitourinary tract with a focus on their clinical implications, histologic features, and molecular characteristics.
    Data sources: - Literature review from PubMed, urologic pathology textbooks, and the 4th edition of the World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs. All photomicrographs were taken from cases seen at Weill Cornell Medicine or from the authors' personal slide collections.
    Conclusions: - The clinical importance and histologic criteria are well established for the known precursor lesions of the most common malignancies throughout the genitourinary tract, but further investigation is warranted at the molecular level to better understand the pathogenesis of these lesions. Such investigation may lead to better risk stratification of patients and potentially novel treatments.
    Language English
    Publishing date 2017-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2016-0515-RA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.36: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Erythropoietin-secreting metanephric adenoma presenting as erythrocytosis.

    Liu, Angela / Kremyanskaya, Marina / Mehrazin, Reza / Si, Qiusheng / Robinson, Brian D / Cushing, Melissa M / Hoffman, Ronald / Ginzburg, Yelena Z

    American journal of hematology

    2023  Volume 98, Issue 11, Page(s) 1808–1813

    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27047
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    Zs.A 1251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Semi-Supervised, Attention-Based Deep Learning for Predicting TMPRSS2:ERG Fusion Status in Prostate Cancer Using Whole Slide Images.

    Omar, Mohamed / Xu, Zhuoran / Rand, Sophie B / Alexanderani, Mohammad K / Salles, Daniela C / Valencia, Itzel / Schaeffer, Edward M / Robinson, Brian D / Lotan, Tamara L / Loda, Massimo / Marchionni, Luigi

    Molecular cancer research : MCR

    2024  Volume 22, Issue 4, Page(s) 347–359

    Abstract: Implications: Our study illuminates the potential of deep learning in effectively inferring key prostate cancer genetic alterations from the tissue morphology depicted in routinely available histology slides, offering a cost-effective method that could ... ...

    Abstract Implications: Our study illuminates the potential of deep learning in effectively inferring key prostate cancer genetic alterations from the tissue morphology depicted in routinely available histology slides, offering a cost-effective method that could revolutionize diagnostic strategies in oncology.
    MeSH term(s) Male ; Humans ; Deep Learning ; Oncogene Proteins, Fusion/genetics ; Prostatic Neoplasms/pathology ; Prostatectomy ; Transcriptional Regulator ERG ; Serine Endopeptidases/genetics
    Chemical Substances Oncogene Proteins, Fusion ; ERG protein, human ; Transcriptional Regulator ERG ; TMPRSS2 protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2098788-2
    ISSN 1557-3125 ; 1541-7786
    ISSN (online) 1557-3125
    ISSN 1541-7786
    DOI 10.1158/1541-7786.MCR-23-0639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5744: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: A "Chicken or Egg" Conundrum: Race, Molecular Subtype, and Tumor Location in Prostate Cancer.

    Khani, Francesca / Robinson, Brian D

    European urology

    2016  Volume 70, Issue 1, Page(s) 18–20

    Language English
    Publishing date 2016-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2015.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  9. Article: A case report of a patient with plasmacytoid urothelial cancer with significant response to HER2-targeting therapy and enfortumab vedotin.

    Sun, Michael / Schaap, Ariel / Robinson, Brian D / Nanus, David M / Tagawa, Scott T

    American journal of clinical and experimental urology

    2021  Volume 9, Issue 5, Page(s) 390–396

    Abstract: In this case report, we present a patient with the rare plasmacytoid variant of urothelial cancer. Notable elements of his course include: complete response to neoadjuvant paclitaxel, gemcitabine, cisplatin, development of metastatic disease to the ... ...

    Abstract In this case report, we present a patient with the rare plasmacytoid variant of urothelial cancer. Notable elements of his course include: complete response to neoadjuvant paclitaxel, gemcitabine, cisplatin, development of metastatic disease to the rectum, sustained disease control with dual HER2 targeting therapy, and subsequent complete response to enfortumab vedotin. Plasmacytoid urothelial cancer accounts for just 1-3% of all urothelial cancer cases and is associated with more aggressive disease, with a propensity for intra-abdominal spread and poor response to neoadjuvant therapy. Preliminary data indicate that the variant may generally have high levels of HER2 expression. We review the history of HER2 targeting in metastatic urothelial cancer, which has included single-agent as well as combination with chemotherapy; there are ongoing biomarker-based clinical trials. Furthermore, we highlight the complete response to enfortumab vedotin. To date, this is the first report of efficacy for enfortumab vedotin in the plasmacytoid variant.
    Language English
    Publishing date 2021-10-15
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1910
    ISSN 2330-1910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Canonical AREs are tumor suppressive regulatory elements in the prostate.

    Augello, Michael A / Chen, Xuanrong / Liu, Deli / Lin, Kevin / Hakansson, Alex / Sjöström, Martin / Khani, Francesca / Deonarine, Lesa D / Liu, Yang / Travascio-Green, Jaida / Wu, Jiansheng / Loda, Massimo / Feng, Felix Y / Robinson, Brian D / Davicioni, Elai / Sboner, Andrea / Barbieri, Christopher E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene ... ...

    Abstract The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene expression
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.23.581466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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