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  1. Book ; Online ; E-Book: Epigenetics in cardiovascular disease

    Devaux, Yvan / Robinson, Emma Louise

    (Translational epigenetics series ; 24)

    2021  

    Author's details edited by Yvan Devaux, Emma Louise Robinson
    Series title Translational epigenetics series ; 24
    Collection
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxvi 471 Seiten), Illustrationen, Diagramme
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020892865
    ISBN 978-0-12-822259-1 ; 9780128222584 ; 0-12-822259-X ; 0128222581
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Utilization and Potential of RNA-Based Therapies in Cardiovascular Disease.

    Robinson, Emma Louise / Port, J David

    JACC. Basic to translational science

    2022  Volume 7, Issue 9, Page(s) 956–969

    Abstract: Cardiovascular disease (CVD) remains the largest cause of mortality worldwide. The development of new effective therapeutics is a major unmet need. The current review focuses broadly on the concept of nucleic acid (NA)-based therapies, considering the ... ...

    Abstract Cardiovascular disease (CVD) remains the largest cause of mortality worldwide. The development of new effective therapeutics is a major unmet need. The current review focuses broadly on the concept of nucleic acid (NA)-based therapies, considering the use of various forms of NAs, including mRNAs, miRNAs, siRNA, and guide RNAs, the latter specifically for the purpose of CRISPR-Cas directed gene editing. We describe the current state-of-the-art of RNA target discovery and development, the status of RNA therapeutics in the context of CVD, and some of the challenges and hurdles to be overcome.
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Leveraging non-coding RNAs to fight cardiovascular disease: the EU-CardioRNA network.

    Robinson, Emma Louise / Emanueli, Costanza / Martelli, Fabio / Devaux, Yvan

    European heart journal

    2021  Volume 42, Issue 48, Page(s) 4881–4883

    MeSH term(s) Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Humans ; RNA, Long Noncoding
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2021-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Missing "lnc" between Genetics and Cardiac Disease.

    Azodi, Maral / Kamps, Rick / Heymans, Stephane / Robinson, Emma Louise

    Non-coding RNA

    2020  Volume 6, Issue 1

    Abstract: ...

    Abstract :
    Language English
    Publishing date 2020-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna6010003
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  5. Article ; Online: Anthracycline-Related Heart Failure: Certain Knowledge and Open Questions : Where Do we Stand with Chemotherapyinduced Cardiotoxicity?

    Robinson, Emma Louise / Azodi, Maral / Heymans, Stephane / Heggermont, Ward

    Current heart failure reports

    2020  Volume 17, Issue 6, Page(s) 357–364

    Abstract: In the last decade, cardio-oncology has become a discipline on its own, with tremendous research going on to unravel the mechanisms underpinning different manifestations of cardiotoxicity caused by anticancer drugs. Although this domain is much broader ... ...

    Abstract In the last decade, cardio-oncology has become a discipline on its own, with tremendous research going on to unravel the mechanisms underpinning different manifestations of cardiotoxicity caused by anticancer drugs. Although this domain is much broader than the effect of chemotherapy alone, a lot of questions about anthracycline-induced cardiotoxicity remain unknown. In this invited review, we provide insights in molecular mechanisms behind anthracycline-induced cardiotoxicity and put it in a clinical framework emphasizing the need for patients to understand, detect, and treat this detrimental condition.
    MeSH term(s) Anthracyclines/adverse effects ; Antineoplastic Agents/adverse effects ; Cardiotoxicity ; Heart Diseases/chemically induced ; Humans ; Neoplasms/drug therapy ; Risk Factors
    Chemical Substances Anthracyclines ; Antineoplastic Agents
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-020-00489-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5936: Show issues Location:
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  6. Article ; Online: Unlocking the Value of White Blood Cells for Heart Failure Diagnosis.

    Meier, Stefan / Henkens, Michiel / Heymans, Stephane / Robinson, Emma Louise

    Journal of cardiovascular translational research

    2020  Volume 14, Issue 1, Page(s) 53–62

    Abstract: Cardiovascular disease (CVD) is the single greatest cause of mortality and morbidity worldwide. Inciting 85% of CVD fatalities is heart failure, often resulting in or from a myocardial infarction. Early detection along with pharmacological treatment and ... ...

    Abstract Cardiovascular disease (CVD) is the single greatest cause of mortality and morbidity worldwide. Inciting 85% of CVD fatalities is heart failure, often resulting in or from a myocardial infarction. Early detection along with pharmacological treatment and lifestyle adaptation can result in better prognosis. Biomarkers are molecular or physiological measures that indicate disease presence, status, and severity. However, not all forms of heart failure are created equal. Current mainstay biomarkers for heart failure, including NT-pro-BNP and ejection fraction, lack sensitivity for many patients. Circulating white blood cells and peripheral blood mononuclear cells (PBMCs) are emerging as surrogate biopsies, reflecting molecular changes in the heart. We discuss the advantages of PBMCs over other sources, as well as limitations and considerations. We urge medical center biobanks to collect, isolate and store circulating white blood cells as a rich source of biomarkers to catalyze the discovery of novel diagnostic tools for heart failure.
    MeSH term(s) Biomarkers/blood ; Biopsy ; Heart Failure/blood ; Heart Failure/diagnosis ; Humans ; Leukocyte Count ; Leukocytes, Mononuclear/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2422411-X
    ISSN 1937-5395 ; 1937-5387
    ISSN (online) 1937-5395
    ISSN 1937-5387
    DOI 10.1007/s12265-020-10007-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cardiac epigenetics: Driving signals to the cardiac epigenome in development and disease.

    Robinson, Emma Louise / Anene-Nzelu, Chukwuemeka George / Rosa-Garrido, Manuel / Foo, Roger S Y

    Journal of molecular and cellular cardiology

    2020  Volume 151, Page(s) 88

    Abstract: Conrad Waddington's famous illustration of a ball poised at the top of an undulating epigenetic landscape is often evoked when one thinks of epigenetics. Although the original figure was a metaphor for gene regulation during cell fate determination, we ... ...

    Abstract Conrad Waddington's famous illustration of a ball poised at the top of an undulating epigenetic landscape is often evoked when one thinks of epigenetics. Although the original figure was a metaphor for gene regulation during cell fate determination, we now know that epigenetic regulation is important for the homeostasis of every tissue and organ in the body. This is evident in the cardiovascular system, one of the first organs to develop and one whose function is vital to human life. Epigenetic mechanisms are central in regulating transcription and signaling programs that drive cardiovascular disease and development. The epigenome not only instructs cell and context specific gene expression signatures, but also retains "memory" of past events and can pass it down to subsequent generations. Understanding the various input and output signals from the cardiac epigenome is crucial for unraveling the molecular underpinnings of cardiovascular disease and development. This knowledge is useful for patient risk stratification, understanding disease pathophysiology, and identifying novel approaches for cardiac regeneration and therapy. In this special issue, a series of high-quality reviews and original research articles examining the field of cardiac epigenetics will broaden our insights into this fundamental aspect of molecular and cellular cardiology. Topics include DNA methylation, histone modifications, chromatin architecture, transcription factors, and long non-coding RNA biology in the diverse cell types that comprise the cardiovascular system. We hope that our readers will expand their horizons and be challenged to envision innovative strategies to further probe the epigenome and develop diagnostic and therapeutic solutions for cardiovascular pathologies.
    MeSH term(s) Animals ; Epigenesis, Genetic ; Epigenome ; Heart/embryology ; Heart Diseases/genetics ; Humans ; Signal Transduction
    Language English
    Publishing date 2020-11-21
    Publishing country England
    Document type Editorial
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2020.11.005
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  8. Article ; Online: Hepatocyte-Specific SR-BI Gene Transfer Corrects Cardiac Dysfunction in Scarb1-Deficient Mice and Improves Pressure Overload-Induced Cardiomyopathy.

    Muthuramu, Ilayaraja / Amin, Ruhul / Aboumsallem, Joseph Pierre / Mishra, Mudit / Robinson, Emma Louise / De Geest, Bart

    Arteriosclerosis, thrombosis, and vascular biology

    2018  Volume 38, Issue 9, Page(s) 2028–2040

    Abstract: Objective- We investigated the hypothesis that HDL (high-density lipoprotein) dysfunction in ... ...

    Abstract Objective- We investigated the hypothesis that HDL (high-density lipoprotein) dysfunction in Scarb1
    MeSH term(s) Animals ; Apoptosis ; Blood Pressure ; Cardiomegaly/blood ; Cardiomegaly/genetics ; Cardiomegaly/physiopathology ; Cardiomegaly/therapy ; Cells, Cultured ; Cholesterol, HDL/blood ; Female ; Fibrosis ; Gene Expression ; Gene Transfer Techniques ; Hepatocytes/metabolism ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidative Stress ; Scavenger Receptors, Class B/genetics
    Chemical Substances Cholesterol, HDL ; Scarb1 protein, mouse ; Scavenger Receptors, Class B
    Language English
    Publishing date 2018-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.118.310946
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  9. Article ; Online: Distinct Cardiac Transcriptomic Clustering in Titin and Lamin A/C-Associated Dilated Cardiomyopathy Patients.

    Verdonschot, Job A J / Derks, Kasper W J / Hazebroek, Mark R / Wang, Ping / Robinson, Emma Louise / Adriaens, Michiel E / Krapels, Ingrid P C / van den Wijngaard, Arthur / Brunner, Han G / Heymans, Stephane R B

    Circulation

    2020  Volume 142, Issue 12, Page(s) 1230–1232

    MeSH term(s) Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/metabolism ; Connectin/biosynthesis ; Connectin/genetics ; Female ; Gene Expression Profiling ; Humans ; Lamin Type A/biosynthesis ; Lamin Type A/genetics ; Male
    Chemical Substances Connectin ; LMNA protein, human ; Lamin Type A ; TTN protein, human
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.045118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stress.

    Tangos, Melina / Budde, Heidi / Kolijn, Detmar / Sieme, Marcel / Zhazykbayeva, Saltanat / Lódi, Mária / Herwig, Melissa / Gömöri, Kamilla / Hassoun, Roua / Robinson, Emma Louise / Meister, Toni Luise / Jaquet, Kornelia / Kovács, Árpád / Mustroph, Julian / Evert, Katja / Babel, Nina / Fagyas, Miklós / Lindner, Diana / Püschel, Klaus /
    Westermann, Dirk / Mannherz, Hans Georg / Paneni, Francesco / Pfaender, Stephanie / Tóth, Attila / Mügge, Andreas / Sossalla, Samuel / Hamdani, Nazha

    International journal of cardiology

    2022  Volume 362, Page(s) 196–205

    Abstract: Introduction: The respiratory illness triggered by severe acute respiratory syndrome virus-2 (SARS-CoV-2) is often particularly serious or fatal amongst patients with pre-existing heart conditions. Although the mechanisms underlying SARS-CoV-2-related ... ...

    Abstract Introduction: The respiratory illness triggered by severe acute respiratory syndrome virus-2 (SARS-CoV-2) is often particularly serious or fatal amongst patients with pre-existing heart conditions. Although the mechanisms underlying SARS-CoV-2-related cardiac damage remain elusive, inflammation (i.e. 'cytokine storm') and oxidative stress are likely involved.
    Methods and results: Here we sought to determine: 1) if cardiomyocytes are targeted by SARS-CoV-2 and 2) how inflammation and oxidative stress promote the viral entry into cardiac cells. We analysed pro-inflammatory and oxidative stress and its impact on virus entry and virus-associated cardiac damage from SARS-CoV-2 infected patients and compared it to left ventricular myocardial tissues obtained from non-infected transplanted hearts either from end stage heart failure or non-failing hearts (donor group). We found that neuropilin-1 potentiates SARS-CoV-2 entry into human cardiomyocytes, a phenomenon driven by inflammatory and oxidant signals. These changes accounted for increased proteases activity and apoptotic markers thus leading to cell damage and apoptosis.
    Conclusion: This study provides new insights into the mechanisms of SARS-CoV-2 entry into the heart and defines promising targets for antiviral interventions for COVID-19 patients with pre-existing heart conditions or patients with co-morbidities.
    MeSH term(s) COVID-19 ; Humans ; Inflammation ; Myocytes, Cardiac ; Oxidative Stress ; SARS-CoV-2
    Language English
    Publishing date 2022-05-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2022.05.055
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