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  1. Article ; Online: Somatosensory function in old age.

    Heft, M W / Robinson, M E

    Journal of oral rehabilitation

    2017  Volume 44, Issue 4, Page(s) 327–332

    Abstract: Sensory decline is viewed as an inevitable consequence of the ageing process. However, reports of declines have not been a consistent finding across the sensory systems. Reports from psychophysical studies indicate that the most common declines with ... ...

    Abstract Sensory decline is viewed as an inevitable consequence of the ageing process. However, reports of declines have not been a consistent finding across the sensory systems. Reports from psychophysical studies indicate that the most common declines with ageing are in vision and audition and, to a lesser degree, olfaction and gustation. Findings for the somatosensory system (mechanoreception, warming and cooling thermoreception and pain) are less conclusive. Factors that contribute to individual differences in sensory ratings beyond chronological ageing include stimulus factors including stimulus type and body location, response measures and instructions, systemic disease that may affect the peripheral or central nervous system and environmental factors that may affect the skin integrity.
    Language English
    Publishing date 2017-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 187079-8
    ISSN 1365-2842 ; 0305-182X
    ISSN (online) 1365-2842
    ISSN 0305-182X
    DOI 10.1111/joor.12488
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  2. Article ; Online: Sickle cell bone disease and response to intravenous bisphosphonates in children.

    Grimbly, C / Escagedo, P Diaz / Jaremko, J L / Bruce, A / Alos, N / Robinson, M E / Konji, V N / Page, M / Scharke, M / Simpson, E / Pastore, Y D / Girgis, R / Alexander, R T / Ward, L M

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2022  Volume 33, Issue 11, Page(s) 2397–2408

    Abstract: Children with sickle cell disease (SCD) have the potential for extensive and early-onset bone morbidity. This study reports on the diversity of bone morbidity seen in children with SCD followed at three tertiary centers. IV bisphosphonates were effective ...

    Abstract Children with sickle cell disease (SCD) have the potential for extensive and early-onset bone morbidity. This study reports on the diversity of bone morbidity seen in children with SCD followed at three tertiary centers. IV bisphosphonates were effective for bone pain analgesia and did not trigger sickle cell complications.
    Introduction: To evaluate bone morbidity and the response to intravenous (IV) bisphosphonate therapy in children with SCD.
    Methods: We conducted a retrospective review of patient records from 2003 to 2019 at three Canadian pediatric tertiary care centers. Radiographs, magnetic resonance images, and computed tomography scans were reviewed for the presence of avascular necrosis (AVN), bone infarcts, and myositis. IV bisphosphonates were offered for bone pain management. Bone mineral density was assessed by dual-energy X-ray absorptiometry (DXA).
    Results: Forty-six children (20 girls, 43%) had bone morbidity at a mean age of 11.8 years (SD 3.9) including AVN of the femoral (17/46, 37%) and humeral (8/46, 17%) heads, H-shaped vertebral body deformities due to endplate infarcts (35/46, 76%), and non-vertebral body skeletal infarcts (15/46, 32%). Five children (5/26, 19%) had myositis overlying areas of AVN or bone infarcts visualized on magnetic resonance imaging. Twenty-three children (8/23 girls) received IV bisphosphonate therapy. They all reported significant or complete resolution of bone pain. There were no reports of sickle cell hemolytic crises, pain crises, or stroke attributed to IV bisphosphonate therapy.
    Conclusion: Children with SCD have the potential for extensive and early-onset bone morbidity. In this series, IV bisphosphonates were effective for bone pain analgesia and did not trigger sickle cell complications.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/pathology ; Canada ; Child ; Diphosphonates/adverse effects ; Female ; Humans ; Infarction/complications ; Myositis ; Osteonecrosis ; Pain/drug therapy ; Pain/etiology
    Chemical Substances Diphosphonates
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-022-06455-2
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  3. Article ; Online: Age differences in orofacial sensory thresholds.

    Heft, M W / Robinson, M E

    Journal of dental research

    2010  Volume 89, Issue 10, Page(s) 1102–1105

    Abstract: Declines in sensory functioning with aging are evident for many of the senses. In the present study, thresholds were determined for somatosensory (warming and cooling temperature, pain, touch, and two-point discrimination) and taste stimuli in 178 ... ...

    Abstract Declines in sensory functioning with aging are evident for many of the senses. In the present study, thresholds were determined for somatosensory (warming and cooling temperature, pain, touch, and two-point discrimination) and taste stimuli in 178 healthy individuals aged 20-89 yrs. Somatosensory stimuli were applied to the upper lip (glabrous skin) and the chin (hairy skin). The sample was divided into two groups, based on a bimodal split "< 45 yrs" and "≥ 65 yrs". In all instances, there were elevations in thresholds for the older individuals. Further, males were less sensitive than females for cool at the chin site, for touch, and for sour taste. We conclude that there are elevations in sensory thresholds with age for multimodal somatosensory and gustatory senses.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Aging/physiology ; Chin/physiology ; Citric Acid/chemistry ; Cold Temperature ; Face ; Female ; Hot Temperature ; Humans ; Lip/physiology ; Male ; Middle Aged ; Pain Threshold/physiology ; Sensory Thresholds/physiology ; Sex Factors ; Skin Physiological Phenomena ; Sodium Chloride/chemistry ; Taste Threshold/physiology ; Thermosensing/physiology ; Tongue/physiology ; Touch/physiology ; Water/chemistry ; Young Adult
    Chemical Substances Water (059QF0KO0R) ; Citric Acid (2968PHW8QP) ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2010-07-22
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/0022034510375287
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  4. Article ; Online: Investigating dynamic pain sensitivity in the context of the fear-avoidance model.

    Gay, C W / Horn, M E / Bishop, M D / Robinson, M E / Bialosky, J E

    European journal of pain (London, England)

    2015  Volume 19, Issue 1, Page(s) 48–58

    Abstract: Background: Although nearly everyone at some point in their lives experiences back pain; the amount of interference with routine activity varies significantly. The fear-avoidance (FA) model of chronic pain explains how psychological variables, such as ... ...

    Abstract Background: Although nearly everyone at some point in their lives experiences back pain; the amount of interference with routine activity varies significantly. The fear-avoidance (FA) model of chronic pain explains how psychological variables, such as fear, act as mediating factors influencing the relationship between clinical pain intensity and the amount of interference with daily activities. What remains less clear is how other mediating factors fit within this model. The primary objective of this report was to examine the extent to which a dynamic measure of pain sensitivity provides additional information within the context of the FA model.
    Method: To address our primary objective, classic mediation and moderated mediation analyses were conducted on baseline clinical, psychological and quantitative sensory measures obtained on 67 subjects with back pain (mean age, 31.4 ± 12.1 years; 70% female).
    Results: There was a moderately strong relationship (r = 0.52; p < 0.01) between clinical pain intensity and interference, explaining about 27% of the variance in the outcome. Mediation analyses confirmed fear partially mediated the total effect of clinical pain intensity on interference (Δβ = 0.27; p < 0.01), and accounted for an additional 16% of the variance. In our FA model, pain sensitivity did not demonstrate additional indirect effects; however, it did moderate the strength of indirect effects of fear.
    Conclusion: This preliminary modelling suggests complex interactions exist between pain-related fear and pain sensitivity measures that further explain individual differences in behaviour.
    MeSH term(s) Adult ; Avoidance Learning ; Catastrophization/psychology ; Disability Evaluation ; Fear/psychology ; Female ; Humans ; Low Back Pain/psychology ; Male ; Models, Psychological ; Pain Measurement ; Pain Threshold/psychology ; Young Adult
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.519
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  5. Article ; Online: The provisional diagnostic criteria for fibromyalgia: one step forward, two steps back: comment on the article by Wolfe et al.

    Staud, R / Price, D D / Robinson, M E

    Arthritis care & research

    2010  Volume 62, Issue 11, Page(s) 1675–6; author reply 1676–8

    MeSH term(s) Cognition Disorders/complications ; Cognition Disorders/diagnosis ; Fatigue/complications ; Fatigue/diagnosis ; Fibromyalgia/classification ; Fibromyalgia/complications ; Fibromyalgia/diagnosis ; Humans ; Pain Measurement/methods
    Language English
    Publishing date 2010-11
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.20290
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  6. Article: Vegetation composition, nutrient, and sediment dynamics along a floodplain landscape (5 figs.,2 tabs.)

    Rybicki, N. B. / Noe, G. B. / Hupp, C. R. / Robinson, M. E.

    River systems

    2015  Volume 21, Issue 2/3, Page(s) 109

    Language English
    Document type Article
    ZDB-ID 2532823-2
    ISSN 1868-5749
    Database Current Contents Nutrition, Environment, Agriculture

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  7. Article ; Online: Integrating genetic studies of nicotine addiction into public health practice: stakeholder views on challenges, barriers and opportunities.

    Dingel, M J / Hicks, A D / Robinson, M E / Koenig, B A

    Public health genomics

    2011  Volume 15, Issue 1, Page(s) 46–55

    Abstract: Objective: Will emerging genetic research strengthen tobacco control programs? In this empirical study, we interview stakeholders in tobacco control to illuminate debates about the role of genomics in public health.: Methods: The authors performed ... ...

    Abstract Objective: Will emerging genetic research strengthen tobacco control programs? In this empirical study, we interview stakeholders in tobacco control to illuminate debates about the role of genomics in public health.
    Methods: The authors performed open-ended interviews with 86 stakeholders from 5 areas of tobacco control: basic scientists, clinicians, tobacco prevention specialists, health payers, and pharmaceutical industry employees. Interviews were qualitatively analyzed using standard techniques.
    Results: The central tension is between the hope that an expanding genomic knowledge base will improve prevention and smoking cessation therapies and the fear that genetic research might siphon resources away from traditional and proven public health programs. While showing strong support for traditional public health approaches to tobacco control, stakeholders recognize weaknesses, specifically the difficulty of countering the powerful voice of the tobacco industry when mounting public campaigns and the problem of individuals who are resistant to treatment and continue smoking.
    Conclusions: In order for genetic research to be effectively translated into efforts to minimize the harm of smoking-related disease, the views of key stakeholders must be voiced and disagreements reconciled. Effective translation requires honest evaluation of both the strengths and limitations of genetic approaches.
    MeSH term(s) Genetic Predisposition to Disease ; Genetic Services/statistics & numerical data ; Humans ; Public Health Practice ; Tobacco Industry/organization & administration ; Tobacco Use Disorder/genetics ; Tobacco Use Disorder/prevention & control
    Language English
    Publishing date 2011-07-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2457023-0
    ISSN 1662-8063 ; 1662-4246
    ISSN (online) 1662-8063
    ISSN 1662-4246
    DOI 10.1159/000328861
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  8. Article ; Online: Analgesic and anti-hyperalgesic effects of muscle injections with lidocaine or saline in patients with fibromyalgia syndrome.

    Staud, R / Weyl, E E / Bartley, E / Price, D D / Robinson, M E

    European journal of pain (London, England)

    2013  Volume 18, Issue 6, Page(s) 803–812

    Abstract: Background: Patients with musculoskeletal pain syndrome including fibromyalgia (FM) complain of chronic pain from deep tissues including muscles. Previous research suggests the relevance of impulse input from deep tissues for clinical FM pain. We ... ...

    Abstract Background: Patients with musculoskeletal pain syndrome including fibromyalgia (FM) complain of chronic pain from deep tissues including muscles. Previous research suggests the relevance of impulse input from deep tissues for clinical FM pain. We hypothesized that blocking abnormal impulse input with intramuscular lidocaine would decrease primary and secondary hyperalgesia and FM patients' clinical pain.
    Methods: We enrolled 62 female patients with FM into a double-blind controlled study of three groups who received 100 or 200 mg of lidocaine or saline injections into both trapezius and gluteal muscles. Study variables included pressure and heat hyperalgesia as well as clinical pain. In addition, placebo factors like patients' anxiety and expectation for pain relief were used as predictors of analgesia.
    Results: Primary mechanical hyperalgesia at the shoulders and buttocks decreased significantly more after lidocaine than saline injections (p = 0.004). Similar results were obtained for secondary heat hyperalgesia at the arms (p = 0.04). After muscle injections, clinical FM pain significantly declined by 38% but was not statistically different between lidocaine and saline conditions. Placebo-related analgesic factors (e.g., patients' expectations of pain relief) accounted for 19.9% of the variance of clinical pain after the injections. Injection-related anxiety did not significantly contribute to patient analgesia.
    Conclusion: These results suggest that muscle injections can reliably reduce clinical FM pain, and that peripheral impulse input is required for the maintenance of mechanical and heat hyperalgesia of patients with FM. Whereas the effects of muscle injections on hyperalgesia were greater for lidocaine than saline, the effects on clinical pain were similar for both injectates.
    MeSH term(s) Adult ; Anesthetics, Local/administration & dosage ; Anesthetics, Local/pharmacology ; Double-Blind Method ; Female ; Fibromyalgia/complications ; Fibromyalgia/drug therapy ; Humans ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Injections, Intramuscular ; Lidocaine/administration & dosage ; Lidocaine/pharmacology ; Middle Aged ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiopathology ; Pain/drug therapy ; Pain/etiology ; Placebo Effect ; Sodium Chloride/administration & dosage ; Sodium Chloride/pharmacology ; Treatment Outcome
    Chemical Substances Anesthetics, Local ; Sodium Chloride (451W47IQ8X) ; Lidocaine (98PI200987)
    Language English
    Publishing date 2013-11-05
    Publishing country England
    Document type Controlled Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/j.1532-2149.2013.00422.x
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  9. Article: Detecting submaximal efforts in grip strength testing with the coefficient of variation.

    Robinson, M E / Geisser, M E / Hanson, C S / O'Connor, P D

    Journal of occupational rehabilitation

    2013  Volume 3, Issue 1, Page(s) 45–50

    Abstract: The use of the coefficient of variation (CV) to determine level of effort in grip strength testing was examined empirically. Twenty-nine asymptomatic subjects participated in two conditions of testing: 100% effort and 50% effort. Order of conditions was ... ...

    Abstract The use of the coefficient of variation (CV) to determine level of effort in grip strength testing was examined empirically. Twenty-nine asymptomatic subjects participated in two conditions of testing: 100% effort and 50% effort. Order of conditions was counterbalanced and each subject was run in both conditions twice in the same order in order to assess the stability of the method. The number of trials (grasps) per condition was three for a total of 12 grasps for the study. The submaximal (50%) effort condition showed significantly more variability than the maximal effort condition in both sets of conditions (p<.01). Intra-class correlation coefficients were very low for both maximal effort and submaximal efforts (.036 and .025) indicating very low stability for the coefficient of variation. Classification rates were also found to have unacceptably large errors with 69% of the submaximal efforts being classified as maximal with the traditional 15% CV cutoff and 55% misclassification of submaximal efforts with an optimized 11% CV cutoff. It was concluded that the currently practiced method of using a low number of repetitions to calculate the CV may result in very unstable measures. Furthermore the "false negative" rate in using this method is unacceptably high for practical application. The implications of using the method and suggestions for improvement are discussed.
    Language English
    Publishing date 2013-11-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171536-4
    ISSN 1053-0487
    ISSN 1053-0487
    DOI 10.1007/BF01076741
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  10. Article: Effect of instructions to simulate a back injury on torque reproducibility in an isometric lumbar extension task.

    Robinson, M E / O'Connor, P / Macmillan, M / Fuller, A / Cassisi, J E

    Journal of occupational rehabilitation

    2013  Volume 2, Issue 4, Page(s) 191–199

    Abstract: The purpose of this study was to investigate the differences in test-retest reliability between maximal and "simulated back injury" efforts in an isometric lumbar extension task and to test the hypothesis that voluntary attempts to "simulate" a back ... ...

    Abstract The purpose of this study was to investigate the differences in test-retest reliability between maximal and "simulated back injury" efforts in an isometric lumbar extension task and to test the hypothesis that voluntary attempts to "simulate" a back injury would yield less consistent torque production than maximal efforts. Twenty subjects were asked to undergo lumbar extensor testing at seven different positions in a lumbar extension machine. Each subject was tested twice in a maximal effort condition and twice with instructions to "simulate" a back injury. The order of the conditions was counterbalanced across subjects so that half of the subjects performed the maximal effort tests first and half performed the "simulated" effort first. Results indicated high test-retest correlations at all angles in both conditions. There were no differences in test-retest reliability between effort conditions. Therapist ratings of consistency did not differ between conditions and therapists could not discriminate between conditions on the basis of effort consistency. In the "simulated" condition subjects produced reliable, submaximal torque plots consistent with previous data indicating similar reliability at submaximal levels. It was concluded that use of test-retest torque consistency as a measure of sincerity of effort is premature and may be misleading.
    Language English
    Publishing date 2013-11-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171536-4
    ISSN 1053-0487
    ISSN 1053-0487
    DOI 10.1007/BF01078997
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