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Book ; Online: Proust épistolier

Robitaille, Martin

2003

Abstract: Quoi de plus fascinant que de découvrir de nouvelles facettes d'un des auteurs les plus remarquables de la littérature française ? C'est à travers la correspondance entre Marcel Proust et trois personnages clés de sa vie, à savoir sa mère, Jeanne, Robert ...

Abstract	Quoi de plus fascinant que de découvrir de nouvelles facettes d'un des auteurs les plus remarquables de la littérature française ? C'est à travers la correspondance entre Marcel Proust et trois personnages clés de sa vie, à savoir sa mère, Jeanne, Robert de Montesquiou et Reynaldo Hahn, que ce livre nous dévoile à la fois l'importance de cette correspondance, son rôle dans la création littéraire de son auteur et les implications psychanalytiques dans l'écriture proustienne. La correspondance avec Jeanne définit le schéma du comportement et de l'approche épistolière de l'auteur. Martin Robitaille met fin au mythe d'une correspondance insignifiante, relevant tout au contraire que les lettres constituent le lien le plus vital de Proust avec le monde. Proust écrit à la fois à quelqu'un et pour quelqu'un les lettres deviennent un lieu d'élaboration du discours. Exploitant judicieusement la théorie du transfert, ce livre sur la relation complexe entre Proust-épistolier, ses correspondants et Proust-auteur ajoute une pierre importante dans la mosaïque de la recherche proustienne
Keywords	Literature (General)
Size	1 electronic resource ( pages)
Publisher	Presses de l'Université de Montréal
Document type	Book ; Online
Note	French ; Open Access
HBZ-ID	HT020322632
ISBN	9791036504150
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Hs27 fibroblast response to contact guidance cues.

Kim, C / Robitaille, M / Christodoulides, J / Ng, Y / Raphael, M / Kang, W

Scientific reports

2023 Volume 13, Issue 1, Page(s) 21691

Abstract: Contact guidance is the phenomena of how cells respond to the topography of their external environment. The morphological and dynamic cell responses are strongly influenced by topographic features such as lateral and vertical dimensions, namely, ridge ... ...

Abstract	Contact guidance is the phenomena of how cells respond to the topography of their external environment. The morphological and dynamic cell responses are strongly influenced by topographic features such as lateral and vertical dimensions, namely, ridge and groove widths and groove depth ([Formula: see text], respectively). However, experimental studies that independently quantify the effect of the individual dimensions as well as their coupling on cellular function are still limited. In this work, we perform extensive parametric studies in the dimensional space-well beyond the previously studied range in the literature-to explore topographical effects on morphology and migration of Hs27 fibroblasts via static and dynamic analyses of live cell images. Our static analysis reveals that the [Formula: see text] is most significant, followed by the [Formula: see text]. The fibroblasts appear to be more elongated and aligned in the groove direction as the [Formula: see text] increases, but their trend changes after 725 nm. Interestingly, the cell shape and alignment show a very strong correlation regardless of [Formula: see text]. Our dynamic analysis confirms that directional cell migration is also strongly influenced by the [Formula: see text], while the effect of the [Formula: see text] and [Formula: see text] is statistically insignificant. Directional cell migration, as observed in the static cell behavior, shows the statistically significant transition when the [Formula: see text] is 725 nm, showing the intimate links between cell morphology and migration. We propose possible scenarios to offer mechanistic explanations of the observed cell behavior.
MeSH term(s)	Cues ; Fibroblasts ; Cell Membrane
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48913-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The intersection between cysteine proteases, Ca

Hua, Trinh / Robitaille, Mélanie / Roberts-Thomson, Sarah J / Monteith, Gregory R

Biochimica et biophysica acta. Molecular cell research

2023 Volume 1870, Issue 7, Page(s) 119532

Abstract: Apoptosis is a highly complex and regulated cell death pathway that safeguards the physiological balance between life and death. Over the past decade, the role of ... ...

Abstract	Apoptosis is a highly complex and regulated cell death pathway that safeguards the physiological balance between life and death. Over the past decade, the role of Ca
MeSH term(s)	Humans ; Animals ; Apoptosis ; Neoplasms/metabolism ; Neoplasms/pathology ; Calcium Signaling ; Enzyme Activation ; Cysteine Proteases/metabolism
Chemical Substances	Cysteine Proteases (EC 3.4.-)
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2023.119532
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Article ; Online: Uncoiling the link between STIM1 and metastatic pathways in estrogen receptor negative breast cancer cells.

Monteith, Gregory R / Robitaille, Mélanie / Roberts-Thomson, Sarah J

Cell calcium

2022 Volume 103, Page(s) 102563

MeSH term(s)	Actomyosin/metabolism ; Breast Neoplasms/metabolism ; Female ; Focal Adhesions/metabolism ; Humans ; Membrane Proteins/metabolism ; Neoplasm Proteins/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Stromal Interaction Molecule 1 ; Triple Negative Breast Neoplasms
Chemical Substances	Membrane Proteins ; Neoplasm Proteins ; PGRMC1 protein, human ; Receptors, Estrogen ; Receptors, Progesterone ; STIM1 protein, human ; Stromal Interaction Molecule 1 ; Actomyosin (9013-26-7)
Language	English
Publishing date	2022-02-12
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	757687-0
ISSN	1532-1991 ; 0143-4160
ISSN (online)	1532-1991
ISSN	0143-4160
DOI	10.1016/j.ceca.2022.102563
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Article ; Online: TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids.

So, Choon Leng / Robitaille, Mélanie / Monteith, Gregory R

Cell calcium

2022 Volume 109, Page(s) 102685

MeSH term(s)	Cell Line, Tumor ; Cell Movement/physiology ; Extracellular Fluid/metabolism ; Protein Serine-Threonine Kinases/metabolism ; TRPV Cation Channels
Chemical Substances	Protein Serine-Threonine Kinases (EC 2.7.11.1) ; TRPV Cation Channels
Language	English
Publishing date	2022-12-05
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	757687-0
ISSN	1532-1991 ; 0143-4160
ISSN (online)	1532-1991
ISSN	0143-4160
DOI	10.1016/j.ceca.2022.102685
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Article ; Online: Deep neural network analysis models for complex random telegraph signals.

Robitaille, Marcel / Yang, HeeBong / Wang, Lu / Deng, Bowen / Kim, Na Young

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10403

Abstract: Time-fluctuating signals are ubiquitous and diverse in many physical, chemical, and biological systems, among which random telegraph signals (RTSs) refer to a series of instantaneous switching events between two discrete levels from single-particle ... ...

Abstract	Time-fluctuating signals are ubiquitous and diverse in many physical, chemical, and biological systems, among which random telegraph signals (RTSs) refer to a series of instantaneous switching events between two discrete levels from single-particle movements. A reliable RTS analysis is a crucial prerequisite to identify underlying mechanisms related to device performance and sensitivity. When numerous levels are involved, complex patterns of multilevel RTSs occur and make their quantitative analysis exponentially difficult, hereby systematic approaches are often elusive. In this work, we present a three-step analysis protocol via progressive knowledge-transfer, where the outputs of the early step are passed onto a subsequent step. Especially, to quantify complex RTSs, we resort to three deep neural network architectures whose trained models can process raw temporal data directly. We furthermore demonstrate the model accuracy extensively with a large dataset of different RTS types in terms of additional background noise types and amplitude size. Our protocol offers structured schemes to extract the parameter values of complex RTSs as imperative information with which researchers can draw meaningful and relevant interpretations and inferences of given devices and systems.
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37142-9
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Book ; Online: Extensive Study of Multiple Deep Neural Networks for Complex Random Telegraph Signals

Robitaille, Marcel / Yang, HeeBong / Wang, Lu / Kim, Na Young

2022

Abstract	Time-fluctuating signals are ubiquitous and diverse in many physical, chemical, and biological systems, among which random telegraph signals (RTSs) refer to a series of instantaneous switching events between two discrete levels from single-particle movements. Reliable RTS analyses are crucial prerequisite to identify underlying mechanisms related to performance sensitivity. When numerous levels partake, complex patterns of multilevel RTSs occur, making their quantitative analysis exponentially difficult, hereby systematic approaches are found elusive. Here, we present a three-step analysis protocol via progressive knowledge-transfer, where the outputs of early step are passed onto a subsequent step. Especially, to quantify complex RTSs, we build three deep neural network architectures that can process temporal data well and demonstrate the model accuracy extensively with a large dataset of different RTS types affected by controlling background noise size. Our protocol offers structured schemes to quantify complex RTSs from which meaningful interpretation and inference can ensue. Comment: 10 pages, 6 figures
Keywords	Physics - Applied Physics ; Computer Science - Machine Learning ; Physics - Computational Physics
Subject code	006
Publishing date	2022-05-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells.

So, Choon Leng / Robitaille, Mélanie / Sadras, Francisco / McCullough, Michael H / Milevskiy, Michael J G / Goodhill, Geoffrey J / Roberts-Thomson, Sarah J / Monteith, Gregory R

Communications biology

2024 Volume 7, Issue 1, Page(s) 467

Abstract: Differences in shape can be a distinguishing feature between different cell types, but the shape of a cell can also be dynamic. Changes in cell shape are critical when cancer cells escape from the primary tumor and undergo major morphological changes ... ...

Abstract	Differences in shape can be a distinguishing feature between different cell types, but the shape of a cell can also be dynamic. Changes in cell shape are critical when cancer cells escape from the primary tumor and undergo major morphological changes that allow them to squeeze between endothelial cells, enter the vasculature, and metastasize to other areas of the body. A shift from rounded to spindly cellular geometry is a consequence of epithelial-mesenchymal plasticity, which is also associated with changes in gene expression, increased invasiveness, and therapeutic resistance. However, the consequences and functional impacts of cell shape changes and the mechanisms through which they occur are still poorly understood. Here, we demonstrate that altering the morphology of a cell produces a remodeling of calcium influx via the ion channel PIEZO1 and identify PIEZO1 as an inducer of features of epithelial-to-mesenchymal plasticity. Combining automated epifluorescence microscopy and a genetically encoded calcium indicator, we demonstrate that activation of the PIEZO1 force channel with the PIEZO1 agonist, YODA 1, induces features of epithelial-to-mesenchymal plasticity in breast cancer cells. These findings suggest that PIEZO1 is a critical point of convergence between shape-induced changes in cellular signaling and epithelial-mesenchymal plasticity in breast cancer cells.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Calcium/metabolism ; Endothelial Cells/metabolism ; Ion Channels/metabolism ; Mechanotransduction, Cellular/physiology ; Epithelial-Mesenchymal Transition/genetics ; Cell Plasticity/genetics
Chemical Substances	Calcium (SY7Q814VUP) ; Ion Channels ; PIEZO1 protein, human
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-06163-z
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Article ; Online: Macroscopic and microscopic features of surgically explanted transcatheter aortic valve prostheses.

Guimaron, Samantha / Kalavrouziotis, Dimitri / Maranda-Robitaille, Michaël / Dumont, Eric / Joubert, Phillipe / Babaki, Shervin / Rodés-Cabau, Josep / Mohammadi, Siamak

Journal of cardiac surgery

2022 Volume 37, Issue 10, Page(s) 3178–3187

Abstract: Objectives: With the extended indications of transcatheter aortic valve (TAV) replacement (TAVR) to lower-risk patients, there is an increasing number of patients requiring surgical explantation of failed TAV. We sought to describe macroscopic and ... ...

Abstract	Objectives: With the extended indications of transcatheter aortic valve (TAV) replacement (TAVR) to lower-risk patients, there is an increasing number of patients requiring surgical explantation of failed TAV. We sought to describe macroscopic and microscopic features of surgically explanted percutaneous aortic valve prostheses. Methods: Preoperative and surgical characteristic of patients undergoing surgical explantation of TAV were retrospectively analyzed from 2007 to 2020. Surgical and pathologic features of these valves, and outcomes of the surgical valve replacement were described. Results: Out of 1764 patients who underwent a TAVR procedure, 21 were operated for TAV failure. Isolated or combined indications for surgery included: significant paravalvular leak (n = 15), delayed prosthesis migration (n = 5), significant increase of trans-TAV gradients (n = 6), and endocarditis (n = 3). Mean time elapsed between TAVR and explantations was 674.9 ± 803.9 days. Macroscopic lesions found on explanted percutaneous valves were severe adhesions to the aorta (n = 10), calcifications (n = 7), leaflet thrombosis (n = 4), and vegetations (n = 3). Except for patients with endocarditis, one or more pathological lesions were found in 15 patients. Pathology analyses on these valves showed fibro-calcific degenerations (n = 12), pannus formation (n = 9), and chronic inflammation (n = 3). One patient (4.8%) died after surgical explantation, and 13 (61.9%) had concomitant procedures. The survival rate at 1 year was 94.4%. Conclusions: Microscopic findings of fibro-calcific leaflet degeneration, and pannus formation in addition to macroscopic calcification and thrombosis present early, (within a mean of 2 years) after TAVR. Further investigation with a higher number of patients and echocardiographic follow-up is warranted.
MeSH term(s)	Aortic Valve/pathology ; Aortic Valve/surgery ; Aortic Valve Stenosis/etiology ; Calcinosis/pathology ; Endocarditis/etiology ; Heart Valve Prosthesis/adverse effects ; Humans ; Retrospective Studies ; Risk Factors ; Thrombosis/etiology ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
Language	English
Publishing date	2022-07-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.16784
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Zs.A 2221: Show issues

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Article ; Online: Increased matrix stiffness suppresses ATP-induced sustained Ca

So, Choon Leng / Meinert, Christoph / Xia, Qing / Robitaille, Mélanie / Roberts-Thomson, Sarah J / Monteith, Gregory R

Cell calcium

2022 Volume 104, Page(s) 102569

Abstract: Both matrix stiffening and remodeling of calcium signaling occur in breast cancers, with downstream consequences linked to the progression of the disease. However, the potential intersection between calcium signaling and matrix stiffness has not been ... ...

Abstract	Both matrix stiffening and remodeling of calcium signaling occur in breast cancers, with downstream consequences linked to the progression of the disease. However, the potential intersection between calcium signaling and matrix stiffness has not been fully assessed in models of cancer. Here, we describe the assessment of calcium signaling in breast cancer cells at high and low matrix stiffness using novel gel culture models (gelatin methacryloyl and polydimethylsiloxane) and MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6m. Remodeling of ATP-stimulated cytosolic calcium responses in cells on different matrices was assessed using a high throughput fluorescence imaging plate reader. Our data reveal that matrices of higher stiffness attenuate ATP-induced sustained calcium influx in MDA-MB-231 breast cancer cells. This matrix-mediated attenuation of sustained calcium influx was dependent on the store-operated calcium channel component ORAI1. These studies suggest that calcium signaling in breast cancer cells can be altered as a consequence of matrix stiffness; modulation of such pathways may represent a new mechanism to target calcium signaling to regulate tumor progression in breast cancer.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Breast Neoplasms/metabolism ; Calcium/metabolism ; Calcium Signaling ; Cell Line, Tumor ; Female ; Gelatin ; Humans ; Methacrylates ; ORAI1 Protein/metabolism
Chemical Substances	Methacrylates ; ORAI1 Protein ; gelatin methacryloyl ; Adenosine Triphosphate (8L70Q75FXE) ; Gelatin (9000-70-8) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-03-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	757687-0
ISSN	1532-1991 ; 0143-4160
ISSN (online)	1532-1991
ISSN	0143-4160
DOI	10.1016/j.ceca.2022.102569
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