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Article ; Online: Disaster Planning for Animals in Hazardous Agent Containment Units.

Roble, Gordon / Pullium, Jennifer / Hester, Takechia / Harvey, Stephen

2019 Volume 59, Issue 2, Page(s) 195–202

Abstract: Disaster response planning for laboratory animal facilities is a time- and personnel-intensive undertaking. This article outlines numerous considerations in formulating a plan for disaster response in a high containment animal unit. The planning process ... ...

Abstract	Disaster response planning for laboratory animal facilities is a time- and personnel-intensive undertaking. This article outlines numerous considerations in formulating a plan for disaster response in a high containment animal unit. The planning process is discussed around a set of elements: planning team formation, situational understanding, goal and objective determination, plan development, preparation, and rehearsal or implementation. The importance of an appropriate planning team and personnel development is explored in relationship to exemplary disaster scenarios such as natural disaster and terrorism. Specific risks such as hazardous agent and animal species type serve to delineate goal-setting methods. These goals provide the framework for an institutional disaster plan. The review further uses elements of the planning process to explore the difficulties of euthanasia of animals treated with hazardous agents. Ultimately, the pitfalls of handling media relations following disaster are examined. Proactive measures for preparing to speak to the media and mitigate negative perceptions of research are presented.
MeSH term(s)	Animals ; Animals, Laboratory ; Disaster Planning
Language	English
Publishing date	2019-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2192062-X
ISSN	1930-6180 ; 1084-2020
ISSN (online)	1930-6180
ISSN	1084-2020
DOI	10.1093/ilar/ily022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Safety Evaluation of a 405-nm LED Device for Direct Antimicrobial Treatment of the Murine Brain.

Thurman, Colleen E / Muthuswamy, Anantharaman / Klinger, Mark M / Roble, Gordon S

Comparative medicine

2019 Volume 69, Issue 4, Page(s) 283–290

Abstract: Antimicrobial resistance is a growing problem in human medicine that extends to biomedical research. Compared with chemical-based therapies, light-based therapies present an alternative to traditional pharmaceuticals and are less vulnerable to acquired ... ...

Abstract	Antimicrobial resistance is a growing problem in human medicine that extends to biomedical research. Compared with chemical-based therapies, light-based therapies present an alternative to traditional pharmaceuticals and are less vulnerable to acquired bacterial resistance. Due to immunologic privilege and relative tissue sensitivity to topical antibiotics, the brain poses a unique set of difficulties with regard to antimicrobial therapy. This study focused on 405-nm 'true violet' light-which has been shown to kill multiple clinically relevant bacterial species in vitro yet leave mammalian cells unscathed-and its effect on the murine brain. We built a 405-nm LED array, validated its power and efficacy against a clinical bacterial isolate in vitro, and then, at the time of craniotomy, treated mice with various doses of 405-nm light (36, 45, and 54 J/cm
MeSH term(s)	Animals ; Anti-Infective Agents/therapeutic use ; Bacterial Load/drug effects ; Brain/drug effects ; Craniotomy/methods ; Disease Models, Animal ; Equipment Design ; Mice ; Mice, Inbred C57BL ; Phototherapy/instrumentation ; Surgical Wound Infection/prevention & control
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2019-08-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2006425-1
ISSN	2769-819X ; 0023-6764 ; 1532-0820
ISSN (online)	2769-819X
ISSN	0023-6764 ; 1532-0820
DOI	10.30802/AALAS-CM-18-000126
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Article ; Online: Assessment of pre-operative maropitant citrate use in macaque (Macaca fasicularis & Macaca mulatta) neurosurgical procedures.

Steinbach, Jaclyn R / MacGuire, Jamus / Chang, Shu / Dierks, Elizabeth / Roble, Gordon S

Journal of medical primatology

2018 Volume 47, Issue 3, Page(s) 178–184

Abstract: Background: Retrospective analysis of post-operative vomiting (POV) in non-human primates at our institution was 11%. Based on this additional risk factor for post-operative complications, we aimed to eliminate or decrease POV by adding an antiemetic, ... ...

Abstract	Background: Retrospective analysis of post-operative vomiting (POV) in non-human primates at our institution was 11%. Based on this additional risk factor for post-operative complications, we aimed to eliminate or decrease POV by adding an antiemetic, maropitant citrate, to the pre-medication protocol. Methods: Retrospective and prospective data were collected over a 5-year period from 46 macaques of two species during 155 procedures. Additionally, blood was collected from five Macaca mulatta to perform a pharmacokinetic analysis. Results: A 1 mg/kg subcutaneous dose of maropitant given pre-operatively significantly decreased POV. Findings indicated post-neurosurgical emesis in Macaca fasicularis was significantly greater than in Macaca mulatta. Pharmacokinetic analysis of maropitant in Macaca mulatta determined the mean maximum plasma concentration to be 113 ng/mL. Conclusions: Maropitant administration prior to anesthesia for neurosurgeries decreased our incidence of POV to 1%. The plasma concentration reaches the proposed plasma level for clinical efficacy approximately 20 minutes after administration.
MeSH term(s)	Animals ; Antiemetics/adverse effects ; Antiemetics/pharmacokinetics ; Macaca fascicularis/surgery ; Macaca mulatta/surgery ; Male ; Monkey Diseases/prevention & control ; Postoperative Nausea and Vomiting/prevention & control ; Preoperative Period ; Prospective Studies ; Quinuclidines/adverse effects ; Quinuclidines/pharmacokinetics ; Retrospective Studies
Chemical Substances	Antiemetics ; Quinuclidines ; maropitant (4XE2T9H4DH)
Language	English
Publishing date	2018-04-02
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	121206-0
ISSN	1600-0684 ; 0047-2565
ISSN (online)	1600-0684
ISSN	0047-2565
DOI	10.1111/jmp.12343
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Article ; Online: Proceed, but cautiously.

Henry, Jo Ann / Roble, Gordon / Steinbach, Jaclyn

Lab animal

2014 Volume 43, Issue 11, Page(s) 392–393

MeSH term(s)	Animal Welfare ; Animals ; Blood Pressure Monitors ; Ethics, Research ; Telemetry/methods
Language	English
Publishing date	2014-11
Publishing country	United States
Document type	Comment ; Journal Article
ISSN	1548-4475
ISSN (online)	1548-4475
DOI	10.1038/laban.645
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Article ; Online: Emergency planning: Be prepared.

Pullium, Jennifer K / Roble, Gordon S / Raymond, Mark A

Nature

2014 Volume 514, Issue 7523, Page(s) 430

MeSH term(s)	Animals ; Animals, Laboratory ; Cyclonic Storms ; Decision Making ; Disaster Planning/methods ; Disasters/prevention & control ; Humans ; Leadership ; Mice ; New York City ; Psychology, Industrial/methods ; Rescue Work/methods ; Rescue Work/standards ; Risk Assessment ; Stress, Psychological/psychology
Language	English
Publishing date	2014-10-23
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/514430a
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Article: Infectious disease survey of Mus musculus from pet stores in New York City.

Roble, Gordon S / Gillespie, Virginia / Lipman, Neil S

Journal of the American Association for Laboratory Animal Science : JAALAS

2012 Volume 51, Issue 1, Page(s) 37–41

Abstract: Most mice used in research are purchased devoid of specific pathogens. Experimental studies required us to evaluate the profile of infective agents harbored in mice sold as pets or food for captive reptiles. Anecdotal reports regarding disease in these ... ...

Abstract	Most mice used in research are purchased devoid of specific pathogens. Experimental studies required us to evaluate the profile of infective agents harbored in mice sold as pets or food for captive reptiles. Anecdotal reports regarding disease in these mice abound, but there are few published reports on disease prevalence. Purchasers are unaware of the potential zoonotic or adventitious infections carried by these mice. This survey investigated the prevalence of ectoparasites, endoparasites, and viral, bacterial, and fungal agents carried by apparently healthy mice (n = 18) obtained from 6 pet stores in New York City, with an emphasis on those pathogens with zoonotic potential. Serology revealed the presence of antibodies to numerous murine specific viral agents in most mice tested. Ectoparasites were present on most mice. Examination of intestinal contents revealed nematode and cestode parasites, including a potential cause of human cestodiasis, Rodentolepis nana. A multidrug-resistant β-hemolytic Enterococcus faecium was isolated from the skin of mice from a single pet store; this organism causes community-acquired infections in humans. This study confirms that pet-store mice are exposed to or carry numerous pathogens that are excluded from laboratory rodent colonies. The potential for laboratory animal personnel to serve as mechanical vectors of unwanted infective agents likely is increased when these persons handle pet-store mice at home.
MeSH term(s)	Animals ; Antibodies, Viral/blood ; Enzyme-Linked Immunosorbent Assay/veterinary ; Gastrointestinal Contents/parasitology ; Infections/epidemiology ; Infections/veterinary ; Mice ; New York City/epidemiology ; Pets ; Polymerase Chain Reaction/veterinary ; Rodent Diseases/epidemiology ; Rodent Diseases/microbiology ; Rodent Diseases/parasitology ; Rodent Diseases/virology ; Serologic Tests/veterinary ; Skin/microbiology ; Skin/parasitology ; Zoonoses/epidemiology
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2012-02-02
Publishing country	United States
Document type	Journal Article
ISSN	1559-6109
ISSN	1559-6109
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Article: Total IgE as a serodiagnostic marker to aid murine fur mite detection.

Roble, Gordon S / Boteler, William / Riedel, Elyn / Lipman, Neil S

Journal of the American Association for Laboratory Animal Science : JAALAS

2012 Volume 51, Issue 2, Page(s) 199–208

Abstract: Mites of 3 genera-Myobia, Myocoptes, and Radfordia -continue to plague laboratory mouse facilities, even with use of stringent biosecurity measures. Mites often spread before diagnosis, predominantly because of detection difficulty. Current detection ... ...

Abstract	Mites of 3 genera-Myobia, Myocoptes, and Radfordia -continue to plague laboratory mouse facilities, even with use of stringent biosecurity measures. Mites often spread before diagnosis, predominantly because of detection difficulty. Current detection methods have suboptimal sensitivity, are time-consuming, and are costly. A sensitive serodiagnostic technique would facilitate detection and ease workload. We evaluated whether total IgE increases could serve as a serodiagnostic marker to identify mite infestations. Variables affecting total IgE levels including infestation duration, sex, age, mite species, soiled-bedding exposure, and ivermectin treatment were investigated in Swiss Webster mice. Strain- and pinworm-associated effects were examined by using C57BL/6 mice and Swiss Webster mice dually infested with Syphacia obvelata and Aspiculuris tetraptera, respectively. Mite infestations led to significant increases in IgE levels within 2 to 4 wk. Total IgE threshold levels and corresponding sensitivity and specificity values were determined along the continuum of a receiver-operating characteristic curve. A threshold of 81 ng/mL was chosen for Swiss Webster mice; values above this point should trigger screening by a secondary, more specific method. Sex-associated differences were not significant. Age, strain, and infecting parasite caused variability in IgE responses. Mice exposed to soiled bedding showed a delayed yet significant increase in total IgE. Treatment with ivermectin reduced total IgE levels within 2 wk. Our data suggest that increases in total IgE in Swiss Webster and C57BL/6 mice warrant investigation, especially because mite infestations can rapidly elevate total IgE levels. We propose that using total IgE levels routinely in serologic panels will enhance biosecurity.
MeSH term(s)	Acaricides/therapeutic use ; Animals ; Antibodies, Helminth/blood ; Antiparasitic Agents/therapeutic use ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/veterinary ; Female ; Hair/parasitology ; Immunoglobulin E/blood ; Ivermectin/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Mite Infestations/diagnosis ; Mite Infestations/drug therapy ; Mite Infestations/immunology ; Mite Infestations/veterinary ; Mites/immunology ; Oxyuriasis/diagnosis ; Oxyuriasis/drug therapy ; Oxyuriasis/immunology ; Oxyuriasis/veterinary ; Oxyuroidea/immunology ; Oxyuroidea/physiology ; Rodent Diseases/diagnosis ; Rodent Diseases/drug therapy ; Rodent Diseases/immunology ; Serologic Tests/methods ; Serologic Tests/veterinary ; Species Specificity ; Time Factors
Chemical Substances	Acaricides ; Antibodies, Helminth ; Antiparasitic Agents ; Immunoglobulin E (37341-29-0) ; Ivermectin (70288-86-7)
Language	English
Publishing date	2012-07-09
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ISSN	1559-6109
ISSN	1559-6109
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Article: A Comprehensive Laboratory Animal Facility Pandemic Response Plan

Roble, Gordon S / Lingenhol, Naomi M / Baker, Bryan / Wilkerson, Amy / Tolwani, Ravi J

Journal of the American Association for Laboratory Animal Science. 2010 Sept., v. 49, no. 5

2010

Abstract: The potential of a severe influenza pandemic necessitates the development of an organized, rational plan for continued laboratory animal facility operation without compromise of the welfare of animals. A comprehensive laboratory animal program pandemic ... ...

Abstract	The potential of a severe influenza pandemic necessitates the development of an organized, rational plan for continued laboratory animal facility operation without compromise of the welfare of animals. A comprehensive laboratory animal program pandemic response plan was integrated into a university-wide plan. Preparation involved input from all levels of organizational hierarchy including the IACUC. Many contingencies and operational scenarios were considered based on the severity and duration of the influenza pandemic. Trigger points for systematic action steps were based on the World Health Organization's phase alert criteria. One extreme scenario requires hibernation of research operations and maintenance of reduced numbers of laboratory animal colonies for a period of up to 6 mo. This plan includes active recruitment and cross-training of volunteers for essential personnel positions, protective measures for employee and family health, logistical arrangements for delivery and storage of food and bedding, the removal of waste, and the potential for euthanasia. Strategies such as encouraging and subsidizing cryopreservation of unique strains were undertaken to protect valuable research assets and intellectual property. Elements of this plan were put into practice after escalation of the pandemic alerts due to influenza A (H1N1) in April 2009.
Keywords	Institutional Animal Care and Use Committee ; World Health Organization ; assets ; cryopreservation ; euthanasia ; food storage ; hibernation ; human resources ; influenza ; laboratory animals ; operations research ; pandemic ; volunteers ; wastes
Language	English
Size	p. 623-632.
Document type	Article
ISSN	1559-6109
Database	NAL-Catalogue (AGRICOLA)

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Article: A comprehensive laboratory animal facility pandemic response plan.

Roble, Gordon S / Lingenhol, Naomi M / Baker, Bryan / Wilkerson, Amy / Tolwani, Ravi J

Journal of the American Association for Laboratory Animal Science : JAALAS

2010 Volume 49, Issue 5, Page(s) 623–632

Abstract	The potential of a severe influenza pandemic necessitates the development of an organized, rational plan for continued laboratory animal facility operation without compromise of the welfare of animals. A comprehensive laboratory animal program pandemic response plan was integrated into a university-wide plan. Preparation involved input from all levels of organizational hierarchy including the IACUC. Many contingencies and operational scenarios were considered based on the severity and duration of the influenza pandemic. Trigger points for systematic action steps were based on the World Health Organization's phase alert criteria. One extreme scenario requires hibernation of research operations and maintenance of reduced numbers of laboratory animal colonies for a period of up to 6 mo. This plan includes active recruitment and cross-training of volunteers for essential personnel positions, protective measures for employee and family health, logistical arrangements for delivery and storage of food and bedding, the removal of waste, and the potential for euthanasia. Strategies such as encouraging and subsidizing cryopreservation of unique strains were undertaken to protect valuable research assets and intellectual property. Elements of this plan were put into practice after escalation of the pandemic alerts due to influenza A (H1N1) in April 2009.
MeSH term(s)	Animal Welfare/standards ; Animals ; Animals, Laboratory ; Health Planning/methods ; Housing, Animal/standards ; Humans ; Influenza A Virus, H1N1 Subtype ; Orthomyxoviridae Infections/prevention & control ; Pandemics/prevention & control ; Pandemics/veterinary
Keywords	covid19
Language	English
Publishing date	2010-09-22
Publishing country	United States
Document type	Journal Article
ISSN	1559-6109
ISSN	1559-6109
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Article ; Online: Image-guided PO2 probe measurements correlated with parametric images derived from 18F-fluoromisonidazole small-animal PET data in rats.

Bartlett, Rachel M / Beattie, Bradley J / Naryanan, Manoj / Georgi, Jens-Christoph / Chen, Qing / Carlin, Sean D / Roble, Gordon / Zanzonico, Pat B / Gonen, Mithat / O'Donoghue, Joseph / Fischer, Alexander / Humm, John L

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2012 Volume 53, Issue 10, Page(s) 1608–1615

Abstract: Unlabelled: (18)F-fluoromisonidazole PET, a noninvasive means of identifying hypoxia in tumors, has been widely applied but with mixed results, raising concerns about its accuracy. The objective of this study was to determine whether kinetic analysis of ...

Abstract	Unlabelled: (18)F-fluoromisonidazole PET, a noninvasive means of identifying hypoxia in tumors, has been widely applied but with mixed results, raising concerns about its accuracy. The objective of this study was to determine whether kinetic analysis of dynamic (18)F-fluoromisonidazole data provides better discrimination of tumor hypoxia than methods based on a simple tissue-to-plasma ratio. Methods: Eleven Dunning R3327-AT prostate tumor-bearing nude rats were immobilized in custom-fabricated whole-body molds, injected intravenously with (18)F-fluoromisonidazole, and imaged dynamically for 105 min. They were then transferred to a robotic system for image-guided measurement of intratumoral partial pressure of oxygen (Po(2)). The dynamic (18)F-fluoromisonidazole uptake data were fitted with 2 variants of a 2-compartment, 3-rate-constant model, one constrained to have K(1) equal to k(2) and the other unconstrained. Parametric images of the rate constants were generated. The Po(2) measurements were compared with spatially registered maps of kinetic rate constants and tumor-to-plasma ratios. Results: The constrained pharmacokinetic model variant was shown to provide fits similar to that of the unconstrained model and did not introduce significant bias in the results. The trapping rate constant, k(3), of the constrained model provided a better discrimination of low Po(2) than the tissue-to-plasma ratio or the k(3) of the unconstrained model. Conclusion: The use of kinetic modeling on a voxelwise basis can identify tumor hypoxia with improved accuracy over simple tumor-to-plasma ratios. An effective means of controlling noise in the trapping rate constant, k(3), without introducing significant bias, is to constrain K(1) equal to k(2) during the fitting process.
MeSH term(s)	Animals ; Cell Hypoxia ; Kinetics ; Male ; Misonidazole/analogs & derivatives ; Misonidazole/pharmacokinetics ; Models, Biological ; Oxygen/metabolism ; Positron-Emission Tomography ; Pressure ; Rats ; Skin Neoplasms/diagnostic imaging ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
Chemical Substances	fluoromisonidazole (082285VIDF) ; Misonidazole (8FE7LTN8XE) ; Oxygen (S88TT14065)
Language	English
Publishing date	2012-08-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.112.103523
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