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Article ; Online: Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study.

Ansarin, Mohssen / Pietrobon, Giacomo / Tagliabue, Marta / Mossinelli, Chiara / Ruju, Francesca / Maffini, Fausto / Rocca, Maria Cossu / Alterio, Daniela / Simon, Christian / Zorzi, Stefano Filippo

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2024

Abstract: Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to ...

Abstract	Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to present oncological and functional outcomes of a monocentric experience in salvage transoral robotic surgery. Methods: We performed a single-center retrospective analysis of patients submitted to transoral robotic salvage surgery with or without neck dissection for cT1-3 rOPSCC. We investigated complication rate, survival outcomes (Overall Survival, Disease Specific Survival, Loco-Regional Recurrence Free Survival) and functional outcomes (tracheal tube and/or gastrostomy dependence). Results: Sixty-one patients were included in the analysis. No major complications or perioperative deaths were recorded. The estimated 2-year OS was 76.7%, DSS 81.8% and LRRFS 50.5%. In multivariable analysis rpT, PNI (perineural infiltration) and HPV-positivity were significantly associated with LRRFS (Hazard Ratios: T3 vs T1 6.43, PNI yes vs no 4.19, HPV+ yes vs no 2.63). At last follow up, 97% of patients were tracheal tube-free, while 93% were gastrostomy-free. Conclusion: Transoral robotic salvage surgery is a successful treatment in selected patients affected by rOPSCC because it grants good oncologic and functional outcomes.
Language	English
Publishing date	2024-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-024-08590-4
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Article: Image-Guided Ablations in Patients with Recurrent Renal Cell Carcinoma.

Aurilio, Gaetano / Mauri, Giovanni / Rossi, Duccio / Della Vigna, Paolo / Bonomo, Guido / Varano, Gianluca Maria / Maiettini, Daniele / Rocca, Maria Cossu / Verri, Elena / Cullurà, Daniela / Nolé, Franco / Orsi, Franco

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: Renal cell carcinoma (RCC) is one of the most frequently diagnosed tumors and a leading cause of death. The high risk of local recurrence and distant metastases represent a significant clinical issue. Different image-guided ablation techniques can be ... ...

Abstract	Renal cell carcinoma (RCC) is one of the most frequently diagnosed tumors and a leading cause of death. The high risk of local recurrence and distant metastases represent a significant clinical issue. Different image-guided ablation techniques can be applied for their treatment as an alternative to surgery, radiotherapy or systemic treatments. A retrospective analysis was conducted at our institution, including a total number of 34 RCC patients and 44 recurrent RCC tumors in different locations (kidney, lung, adrenal gland, liver, pancreas, pararenal and other) using microwave ablation, radiofrequency ablation, cryoablation and laser ablation. The estimated time to local and distant tumor progression after treatment were 22.53 ± 5.61 months and 24.23 ± 4.47 months, respectively. Systemic treatment was initiated in 10/34 (29%) treated patients with a mean time-to-systemic-therapy of 40.92 ± 23.98 months. Primary technical success was achieved in all cases and patients while the primary efficacy rate was achieved in 43/44 (98%) cases and 33/34 (97%) patients, respectively, with a secondary technical success and efficacy rate of 100%. At a mean follow-up of 57.52 months ± 27.86 months, local tumor progression occurred in 3/44 (7%) cases and distant progression in 25/34 (74%) patients. No significant complications occurred. Image-guided ablations can play a role in helping to better control recurrent disease, avoiding or delaying the administration of systemic therapies and their significant adverse effects.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12154902
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Article ; Online: Outcomes of mini-invasive transoral surgery without neck dissection in supraglottic laryngeal cancer: Real world data from a tertiary cancer center.

Zorzi, Stefano / Pietrobon, Giacomo / Mossinelli, Chiara / Bandi, Francesco / Chu, Francesco / Tagliabue, Marta / De Berardinis, Rita / Zocchi, Jacopo / Alterio, Daniela / Rocca, Maria Cossu / Ruju, Francesca / Ansarin, Mohssen

American journal of otolaryngology

2023 Volume 45, Issue 1, Page(s) 104113

Abstract: Purpose: The neck management in early-stage cN0 supraglottic cancer represents an argument of debate. The aim of our study is to evaluate the oncological and functional outcomes in patients with early-stage cN0 supraglottic carcinoma treated with a wait- ...

Abstract	Purpose: The neck management in early-stage cN0 supraglottic cancer represents an argument of debate. The aim of our study is to evaluate the oncological and functional outcomes in patients with early-stage cN0 supraglottic carcinoma treated with a wait-and-see policy for the neck. Materials and methods: Retrospective monocentric cohort study in a referral cancer care center. We collected a consecutive sample of patients from 2000 to 2020 with Squamous Cell Carcinoma of the supraglottis without clinical evidence of nodal metastases (cN0), surgically treated with Transoral Surgery (Laser or Robotic) without neck dissection. From 316 supraglottic cancer we finally selected 66 eligible participants that met all inclusion criteria. Results: Sixty-six patients (M 75.8 % vs F 24.2 %), median age 65.8 years (IQR 60.9, 70.5). The most common subsite was the epiglottis (62.1 %). Tumor stage distribution was as follows: 35 % cT1, 53 % cT2, 15.2 % cT3. Neither deaths nor major treatment-related complications were reported after surgery. The median follow-up was 62 months. For oncological outcomes, we evaluated 56 patients (10 excluded for adjuvant radiotherapy): 5-year overall survival rate 87 % (CI 95 %: 73.1-94), disease- specific survival rate 95.3 % (CI 95 %: 82-98.8) and neck recurrence-free survival rate 87 % (CI 95 %: 73.1-94). Six patients developed neck recurrence, with a median time of 13 months. Conclusions: Supraglottic carcinoma has been historically associated to a considerable risk of occult metastasis. However, in early-stage cases data are still inconclusive. Our results suggest that in such patients a wait-and-see policy does not impact negatively on survival outcomes, while granting the reduced morbidity associated to a minimally invasive surgical approach.
MeSH term(s)	Humans ; Aged ; Laryngeal Neoplasms/pathology ; Neck Dissection/methods ; Retrospective Studies ; Cohort Studies ; Neoplasm Staging ; Carcinoma, Squamous Cell/pathology
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2023.104113
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Article: Prognostic Impact of Sarcopenia's Occurrence during Radiotherapy in Oropharyngeal Cancer Patients.

Bergamaschi, Luca / Marvaso, Giulia / Zaffaroni, Mattia / Vincini, Maria Giulia / D'Ecclesiis, Oriana / Volpe, Stefania / Ferrari, Annamaria / Zorzi, Stefano Filippo / Rocca, Maria Cossu / Sabbatini, Annarita / Cannillo, Giulia / Zagallo, Emanuela / Starzyńska, Anna / Ansarin, Mohssen / Cattani, Federica / Gandini, Sara / Orecchia, Roberto / Alterio, Daniela / Jereczek-Fossa, Barbara Alicja

Cancers

2023 Volume 15, Issue 3

Abstract: The current study aims to profile sarcopenic condition (both at baseline and developed during treatment) in oropharyngeal carcinoma (OPC) patients treated with curative radiotherapy (RT) +/- chemotherapy and to evaluate its impact on oncological outcomes ...

Abstract	The current study aims to profile sarcopenic condition (both at baseline and developed during treatment) in oropharyngeal carcinoma (OPC) patients treated with curative radiotherapy (RT) +/- chemotherapy and to evaluate its impact on oncological outcomes and toxicity. A total of 116 patients were included in this retrospective single-center study. Sarcopenia assessment at baseline and at 50 Gy re-evaluation CT was obtained from two different methodologies: (i) the L3-skeletal muscle index (SMI) derived from the contouring of the cross-sectional area (CSA) of the masticatory muscles (CSA-MM); and (ii) the paravertebral and sternocleidomastoid muscles at the level of the third cervical vertebra (CSA-C3). Based on L3-SMI from CSA-MM, developing sarcopenic condition during RT (on-RT sarcopenia) was associated with worse progression-free survival (PFS) (
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15030723
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Article ; Online: Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer.

Zorzi, Stefano Filippo / Lazio, Maria Silvia / Pietrobon, Giacomo / Chu, Francesco / Zurlo, Valeria / Bibiano, Debora / De Benedetto, Luigi / Cattaneo, Augusto / De Berardinis, Rita / Mossinelli, Chiara / Alterio, Daniela / Rocca, Maria Cossu / Gandini, Sara / Gallo, Oreste / Chiocca, Susanna / Tagliabue, Marta / Ansarin, Mohssen

American journal of otolaryngology

2021 Volume 43, Issue 1, Page(s) 103272

Abstract: Purpose: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The ... ...

Abstract	Purpose: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The current work presents the experience of a tertiary-care center in conservative surgery for advanced-stage laryngeal cancer. Materials and methods: We collected clinical data of patients submitted to open partial horizontal laryngectomies (OPHLs) and any possible adjuvant treatment from 2005 to 2018. Outcomes were also compared to the most recent studies reporting on both medical and surgical organ-preservation strategies. Results: One hundred ten patients were included in the analysis. Adjuvant therapy was employed in 51% of cases. The local control rate was 96.4%, while overall survival (OS) was 67%, and laryngo-esophageal dysfunction free survival (LEDFS) was 66%. Stage IV and vascular invasion were associated with a statistically-significant worse survival. Conclusions: OPHLs are valid as upfront treatment in fit patients affected by advanced-stage laryngeal cancer. Disease control and function preservation are granted in a significant percentage of cases, even when followed by adjuvant therapy.
MeSH term(s)	Combined Modality Therapy ; Female ; Humans ; Laryngeal Neoplasms/mortality ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/surgery ; Laryngectomy/methods ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Organ Sparing Treatments/methods ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2021-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2021.103272
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Article ; Online: An Inflammatory Signature to Predict the Clinical Benefit of First-Line Cetuximab Plus Platinum-Based Chemotherapy in Recurrent/Metastatic Head and Neck Cancer.

Cells

2022 Volume 11, Issue 19

Abstract: Epidermal growth factor receptor (EGFR) pathway has been shown to play a crucial role in several inflammatory conditions and host immune-inflammation status is related to tumor prognosis. This study aims to evaluate the prognostic significance of a four- ... ...

Abstract	Epidermal growth factor receptor (EGFR) pathway has been shown to play a crucial role in several inflammatory conditions and host immune-inflammation status is related to tumor prognosis. This study aims to evaluate the prognostic significance of a four-gene inflammatory signature in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) patients treated with the EGFR inhibitor cetuximab plus chemotherapy. The inflammatory signature was assessed on 123 R/M HNSCC patients, enrolled in the multicenter trial B490 receiving first-line cetuximab plus platinum-based chemotherapy. The primary endpoint of the study was progression free survival (PFS), while secondary endpoints were overall survival (OS) and objective response rate (ORR). The patient population was subdivided into 3 groups according to the signature score groups. The four-genes-signature proved a significant prognostic value, resulting in a median PFS of 9.2 months in patients with high vs. 6.2 months for intermediate vs. 3.9 months for low values (
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cetuximab/therapeutic use ; ErbB Receptors/genetics ; Head and Neck Neoplasms/drug therapy ; Humans ; Inflammation/chemically induced ; Neoplasm Recurrence, Local/drug therapy ; Platinum/therapeutic use ; Squamous Cell Carcinoma of Head and Neck/drug therapy
Chemical Substances	Platinum (49DFR088MY) ; ErbB Receptors (EC 2.7.10.1) ; Cetuximab (PQX0D8J21J)
Language	English
Publishing date	2022-10-10
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11193176
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Article ; Online: Retrospective analysis of factors influencing oncologic outcome in 590 patients with early-intermediate glottic cancer treated by transoral laser microsurgery.

Ansarin, Mohssen / Cattaneo, Augusto / De Benedetto, Luigi / Zorzi, Stefano / Lombardi, Francesca / Alterio, Daniela / Rocca, Maria Cossu / Scelsi, Daniele / Preda, Lorenzo / Chiesa, Fausto / Santoro, Luigi

Head & neck

2017 Volume 39, Issue 1, Page(s) 71–81

Abstract: Background: The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM).: Methods: This was a retrospective mono-institutional ... ...

Abstract	Background: The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM). Methods: This was a retrospective mono-institutional study. A total of 590 patients with cTis-cT3 glottic cancer underwent TLM with curative intent. Results: TLM alone was performed in 538 patients (91.2%) and TLM followed by adjuvant radiotherapy (RT) was done in 52 (8.8%). Five-year recurrence-free survival (RFS) and 10-year overall survival (OS) were 85.3% and 74.7%, respectively. The larynx-preservation ratio was 95.9%. In particular, from our data, we found that occult metastases were rare (1.2%); preventive tracheotomy was not necessary; the local recurrence rate of Tis was similar to that in the T2 and T3 group; and no major or lethal complications were observed. Conclusion: Age (>60 vs ≤60), type of cordectomy (≥IV vs ≤III), status of margins, fixed arytenoid, and pathologic T classification, were the variables associated with RFS, OS, and organ-preservation rate. © 2016 Wiley Periodicals, Head Neck 39: 71-81, 2017.
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.24534
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Article ; Online: Serum HER2 extracellular domain levels and HER2 circulating tumor cell status in patients with metastatic breast cancer.

Aurilio, Gaetano / Sandri, Maria Teresa / Pruneri, Giancarlo / Zorzino, Laura / Botteri, Edoardo / Munzone, Elisabetta / Adamoli, Laura / Facchi, Giuseppina / Cullurà, Daniela / Verri, Elena / Rocca, Maria Cossu / Zurrida, Stefano / Iacovelli, Roberto / Nolè, Franco

Future oncology (London, England)

2016 Volume 12, Issue 17, Page(s) 2001–2008

Abstract: Aim: To shed light on the clinical role of HER2 status in serum as extracellular domain (ECD) and corresponding circulating tumor cells (CTCs) in metastatic breast cancer patients.: Methods: 68 patients were analyzed. Serum HER2 was determined by ... ...

Abstract	Aim: To shed light on the clinical role of HER2 status in serum as extracellular domain (ECD) and corresponding circulating tumor cells (CTCs) in metastatic breast cancer patients. Methods: 68 patients were analyzed. Serum HER2 was determined by ADVIA Centaur(®) Serum HER2 test. CellSearch System was performed for CTC quantification. Results: HER2 was overexpressed in 21 primary tumors. In total, 19 patients had ECD >15 ng/ml (the cut-off used), 48 patients had at least one CTC. ECD positivity was associated with CTC number (p = 0.01), HER2-positive CTC (p = 0.01) and the ratio HER2-positive CTC/total CTC (p = 0.02). ECD was not associated with survival. Conclusion: ECD in combination with HER2 CTC status would deserve further investigation in larger series for addressing its putative prognostic relevance.
MeSH term(s)	Adult ; Aged ; Biomarkers, Tumor/blood ; Breast Neoplasms/blood ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Disease-Free Survival ; Extracellular Space ; Female ; Humans ; Immunoassay ; Kaplan-Meier Estimate ; Luminescent Measurements ; Middle Aged ; Neoplastic Cells, Circulating/pathology ; Receptor, ErbB-2/blood
Chemical Substances	Biomarkers, Tumor ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2184533-5
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2016-0081
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Article ; Online: Prognostic value of circulating tumor cells in primary and metastatic breast cancer.

Aurilio, Gaetano / Sciandivasci, Angela / Munzone, Elisabetta / Sandri, Maria Teresa / Zorzino, Laura / Cassatella, Maria Cristina / Verri, Elena / Rocca, Maria Cossu / Nolè, Franco

Expert review of anticancer therapy

2012 Volume 12, Issue 2, Page(s) 203–214

Abstract: In patients with breast cancer, there is evidence correlating the presence of circulating tumor cells (CTCs) with disease-free survival, progression-free survival and overall survival. The detection of CTCs may be useful in gaining a better understanding ...

Abstract	In patients with breast cancer, there is evidence correlating the presence of circulating tumor cells (CTCs) with disease-free survival, progression-free survival and overall survival. The detection of CTCs may be useful in gaining a better understanding of the mechanisms of tumor growth and in the improvement of patient management. This review analyzes the prognostic and predictive relevance of CTCs through the principal published studies, cytometric techniques and nucleic acid-based approaches to detect CTCs, phenotypic expression of specific receptors, molecular pathways and genetic signatures for potential tailored therapies.
MeSH term(s)	Animals ; Biomarkers, Tumor/blood ; Breast Neoplasms/blood ; Breast Neoplasms/diagnosis ; Breast Neoplasms/secondary ; Clinical Trials as Topic/methods ; Female ; Humans ; Neoplastic Cells, Circulating/pathology ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2012-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1586/era.11.208
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Article ; Online: Role of EGFR as prognostic factor in head and neck cancer patients treated with surgery and postoperative radiotherapy: proposal of a new approach behind the EGFR overexpression.

Alterio, Daniela / Marvaso, Giulia / Maffini, Fausto / Gandini, Sara / Chiocca, Susanna / Ferrari, Annamaria / Preda, Lorenzo / Rocca, Maria Cossu / Lepanto, Daniela / Fodor, Cristiana / Volpe, Stefania / Dicuonzo, Samantha / Laudati, Antonio / Giugliano, Gioacchino / Ansarin, Mohssen / Jereczek-Fossa, Barbara A

Medical oncology (Northwood, London, England)

2017 Volume 34, Issue 6, Page(s) 107

Abstract: In an era of personalized treatment, there is a great interest in identifying factors which might predict patient response to radiotherapy (RT). The role of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma (HNSCC) remains ... ...

Abstract	In an era of personalized treatment, there is a great interest in identifying factors which might predict patient response to radiotherapy (RT). The role of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma (HNSCC) remains still controversial. We performed a retrospective analysis on the prognostic value of EGFR in HNSCC patients treated with surgery and postoperative RT through a semiquantitative immunohistochemical analysis of EGFR membrane expression. We retrospectively analyzed 65 HNSCC patients treated in our Institute from 1997 to 2003 who underwent adjuvant RT after surgery. Median follow-up was 43.5 months (range 0.2-173 months). None of these patients were treated with postoperative concomitant chemotherapy. Tumor samples were obtained from surgical specimens. Membrane features (intensity, extension) of EGFR expression were evaluated, and a statistical analysis (univariate and multivariate) was conducted to correlate these parameters with overall survival (OS) and disease-free survival (DFS). Patients with an intense and complete labeling of EGFR presented worse OS and DFS compared with groups obtained by all other possible combination, and the difference was borderline statistically significant (P = 0.08 for OS and P = 0.006 for DFS). Moreover, a stratification of patients was performed considering EGFR expression on the tumor tissue and classifying its distribution as "homogeneous" or "heterogeneous." We found that patients showing an "heterogeneous" EGFR expression distribution had worse OS and DFS compared to the "homogeneous" group of patients. Based on our results, EGFR expression, especially referring to membrane features (semiquantitative analysis), might have a prognostic value for OS and DFS in locally advanced HNSCC treated with surgery and adjuvant RT. Prospective trials could be useful to confirm the prognostic role of EGFR expression and also to assess a predictive role to select that might benefit from more aggressive treatments.
MeSH term(s)	Biomarkers, Tumor/analysis ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/therapy ; ErbB Receptors/analysis ; ErbB Receptors/metabolism ; Female ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/therapy ; Humans ; Male ; Middle Aged ; Prognosis ; Radiotherapy, Adjuvant ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	Biomarkers, Tumor ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2017-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-017-0965-7
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