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  1. Article ; Online: Pigmented lesions with unusual penile localisation: Usefulness of reflectance confocal microscopy - Report of 2 cases.

    Rocco, Tea / Ventura, Alessandra / Ciciarelli, Valeria / Fargnoli, Maria Concetta

    The Australasian journal of dermatology

    2021  Volume 62, Issue 3, Page(s) e456–e458

    MeSH term(s) Adolescent ; Diagnosis, Differential ; Humans ; Male ; Microscopy, Interference/instrumentation ; Microscopy, Interference/methods ; Middle Aged ; Nevus, Pigmented/diagnosis ; Penis/abnormalities ; Penis/diagnostic imaging
    Language English
    Publishing date 2021-05-10
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.13615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Risk Factors and Diagnosis of Advanced Cutaneous Squamous Cell Carcinoma.

    Brancaccio, Gabriella / Briatico, Giulia / Pellegrini, Cristina / Rocco, Tea / Moscarella, Elvira / Fargnoli, Maria Concetta

    Dermatology practical & conceptual

    2021  Volume 11, Issue Suppl 2, Page(s) e2021166S

    Abstract: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer affecting humans. The combination of the increasing incidence and high mortality in advanced stages of the disease, defines cSCC as an emerging public health problem. Advanced ... ...

    Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer affecting humans. The combination of the increasing incidence and high mortality in advanced stages of the disease, defines cSCC as an emerging public health problem. Advanced disease includes metastatic and locally advanced cSCC. Metastatic disease refers to the presence of locoregional metastasis (in transit or to regional lymph nodes) or distant metastasis. Locally advanced disease has been defined as non-metastatic cSCC that is unlikely to be cured with surgery, radiotherapy, or combination treatment. While metastatic cSCC is easily diagnosed, locally advanced disease lacks consensus definition and diagnosis is made after multidisciplinary board consultation. Identifying patients with aggressive cSCC at highest risk for relapse may prevent the occurrence of advanced disease. Prognostic factors suggested by most guidelines include tumor diameter (>2 cm), localization on temple/ear/lip/area, thickness (>6 mm), or invasion beyond subcutaneous fat, poor grade of differentiation, desmoplasia, perineural invasion, bone erosion, immunosuppression, undefined borders, recurrence, growth rate, site of prior radiotherapy, and lymphatic or vascular involvement. Although risk factors associated with worse outcomes are well known, there is still a gap of knowledge on the precise risk of each factor taken individually. The aim of this review is to summarize cSCC prognostic factors and encompass the various staging systems to guide management and follow-up in cSCC patients at higher risk for local recurrence and metastasis. Finally, we describe the hallmarks of the advanced disease. Advanced cSCC diagnosis should be made by a multidisciplinary board considering patients' performance status and disease characteristics.
    Language English
    Publishing date 2021-09-01
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.11S2a166S
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Syringotropic Lichen Planus: A Potential Histopathologic Mimicker of Syringotropic Mycosis Fungoides.

    Mazzeo, Mauro / Saggini, Andrea / Rocco, Tea / Fargnoli, Maria Concetta / Cerroni, Lorenzo

    The American Journal of dermatopathology

    2018  Volume 41, Issue 5, Page(s) e50–e53

    Abstract: Perieccrine inflammation may be observed in several different dermatoses, but true permeation of the secretory coil by lymphocytes (lymphocytic syringotropism) is a rather uncommon finding, usually observed in mycosis fungoides (MF-syringotropic MF). ... ...

    Abstract Perieccrine inflammation may be observed in several different dermatoses, but true permeation of the secretory coil by lymphocytes (lymphocytic syringotropism) is a rather uncommon finding, usually observed in mycosis fungoides (MF-syringotropic MF). Rare cases of syringotropic lichen striatus and lymphocytic autoimmune hidradenitis showing a similar pattern have been described as well. We describe an exceptional case of lichen planus (LP) characterized by marked lymphocytic syringotropism with focal hyperplasia of the eccrine epithelium. Histopathology was characterized by the combination of features of conventional LP, prominent permeation of the secretory portion of the eccrine glands by reactive lymphocytes, and focal involvement of a hair follicle. Syringotropic LP may be regarded as a histologic mimicker of syringotropic MF, thus representing a potential diagnostic pitfall.
    MeSH term(s) Adult ; Diagnosis, Differential ; Female ; Humans ; Lichen Planus/diagnosis ; Lichen Planus/pathology ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000001295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1518: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.

    Ventura, Alessandra / Pellegrini, Cristina / Cardelli, Ludovica / Rocco, Tea / Ciciarelli, Valeria / Peris, Ketty / Fargnoli, Maria Concetta

    International journal of molecular sciences

    2019  Volume 20, Issue 6

    Abstract: The role of telomere biology and telomerase activation in skin cancers has been investigated in melanoma and basal cell carcinoma but limited evidence is available for cutaneous squamous cell carcinoma (cSCC). We will review the current knowledge on the ... ...

    Abstract The role of telomere biology and telomerase activation in skin cancers has been investigated in melanoma and basal cell carcinoma but limited evidence is available for cutaneous squamous cell carcinoma (cSCC). We will review the current knowledge on the role of telomere and telomerase pathway in cSCC pathogenesis. At the somatic level, both long and short telomere lengths have been described in cSCC. This telomere dichotomy is probably related to two different mechanisms of tumour initiation which determines two tumour subtypes. Telomere shortening is observed during the invasive progression from in situ forms of cSCC, such as Bowen's disease (BD) and actinic keratosis (AK), to invasive cSCC. At the germline level, controversial results have been reported on the association between constitutive telomere length and risk of cSCC. Approximately 75⁻85% of cSCC tumours are characterized by a high level of telomerase activity. Telomerase activation has been also reported in AKs and BD and in sun-damaged skin, thus supporting the hypothesis that UV modulates telomerase activity in the skin. Activating
    MeSH term(s) Bowen's Disease/genetics ; Bowen's Disease/pathology ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Disease Progression ; Germ Cells/pathology ; Humans ; Keratosis, Actinic/genetics ; Keratosis, Actinic/pathology ; Mutation ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Telomerase/genetics ; Telomere/genetics ; Telomere Shortening/genetics
    Chemical Substances Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2019-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20061333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases.

    Pellegrini, Cristina / Cardelli, Ludovica / Padova, Marina De / Nardo, Lucia Di / Ciciarelli, Valeria / Rocco, Tea / Cipolloni, Gianluca / Clementi, Marco / Cortellini, Alessio / Ventura, Alessandra / Leocata, Pietro / Fargnoli, Maria Concetta

    Acta dermato-venereologica

    2020  Volume 100, Issue 1, Page(s) adv00040

    Abstract: Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30 primary ... ...

    Abstract Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30 primary melanomas and 39 related metastases, using molecular analysis and immunohistochemistry. BRAF mutations were identified in 46.7% of primary melanomas and 48.7% of metastases and NRAS mutations in 20% and 25.6%, respectively. Intra-patient heterogeneity was detected in 13.3% of patients for both BRAF and NRAS genes and was not associated with clinico-pathological characteristics of melanomas or metastases. High consistency was observed between immunostaining and molecular methods for BRAFV600E (k = 0.90; p < 0.001) and NRASQ61R (k = 0.87; p < 0.001). These findings demonstrate a relevant intra-patient heterogeneity between primary and metastatic lesions that is independent of clinical variables and methodological approach.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; DNA Mutational Analysis ; Female ; GTP Phosphohydrolases/genetics ; Genetic Heterogeneity ; Genetic Predisposition to Disease ; Humans ; Male ; Melanoma/genetics ; Melanoma/secondary ; Membrane Proteins/genetics ; Middle Aged ; Mutation ; Phenotype ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins c-kit/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor ; Membrane Proteins ; KIT protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; GTP Phosphohydrolases (EC 3.6.1.-) ; NRAS protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2020-01-23
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Molecular alterations in basal cell carcinoma subtypes.

    Di Nardo, Lucia / Pellegrini, Cristina / Di Stefani, Alessandro / Ricci, Francesco / Fossati, Barbara / Del Regno, Laura / Carbone, Carmine / Piro, Geny / Corbo, Vincenzo / Delfino, Pietro / De Summa, Simona / Maturo, Maria Giovanna / Rocco, Tea / Tortora, Giampaolo / Fargnoli, Maria Concetta / Peris, Ketty

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 13206

    Abstract: A number of genes have been implicated in the pathogenesis of BCC in addition to the Hedgehog pathway, which is known to drive the initiation of this tumour. We performed in-depth analysis of 13 BCC-related genes (CSMD1, CSMD2, DPH3 promoter, PTCH1, SMO, ...

    Abstract A number of genes have been implicated in the pathogenesis of BCC in addition to the Hedgehog pathway, which is known to drive the initiation of this tumour. We performed in-depth analysis of 13 BCC-related genes (CSMD1, CSMD2, DPH3 promoter, PTCH1, SMO, GLI1, NOTCH1, NOTCH2, TP53, ITIH2, DPP10, STEAP4, TERT promoter) in 57 BCC lesions (26 superficial and 31 nodular) from 55 patients and their corresponding blood samples. PTCH1 and TP53 mutations were found in 71.9% and 45.6% of BCCs, respectively. A high mutation rate was also detected in CSMD1 (63.2%), NOTCH1 (43.8%) and DPP10 (35.1%), and frequent non-coding mutations were identified in TERT (57.9%) and DPH3 promoter (49.1%). CSMD1 mutations significantly co-occurred with TP53 changes (p = 0.002). A significant association was observed between the superficial type of BCC and PTCH1 (p = 0.018) and NOTCH1 (p = 0.020) mutations. In addition, PTCH1 mutations were significantly associated with intermittent sun exposure (p = 0.046) and the occurrence of single lesions (p = 0.021), while NOTCH1 mutations were more frequent in BCCs located on the trunk compared to the head/neck and extremities (p = 0.001). In conclusion, we provide further insights into the molecular alterations underlying the tumorigenic mechanism of superficial and nodular BCCs with a view towards novel rationale-based therapeutic strategies.
    MeSH term(s) Aged ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Female ; Humans ; Male ; Mutation/genetics ; Neoplasms, Basal Cell/genetics ; Neoplasms, Basal Cell/pathology ; Promoter Regions, Genetic/genetics ; Signal Transduction/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-92592-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Staging and follow-up of cutaneous melanoma patients.

    Gutiérrez García-Rodrigo, Carlota / Antonini, Ambra / Rocco, Tea / Pellegrini, Cristina / Micantonio, Tamara / Fargnoli, Maria C

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2017  Volume 152, Issue 3, Page(s) 231–240

    Abstract: Melanoma is responsible for the greatest number of deaths caused by skin malignancies. The purpose of monitoring patients diagnosed with melanoma is to allow early detection of recurrence and any subsequent primary tumors. Several dermatological and ... ...

    Abstract Melanoma is responsible for the greatest number of deaths caused by skin malignancies. The purpose of monitoring patients diagnosed with melanoma is to allow early detection of recurrence and any subsequent primary tumors. Several dermatological and oncological societies developed their own set of guidelines for the surveillance and management of melanoma patients depending on the stage of the disease. The object of this article is to provide a comprehensive, systematic overview that summarizes and interprets previous studies, to characterize current practices regarding progression of melanoma, division into stages of development, and subsequent surveillance. We have performed a systematic review search to December 2016 using the MEDLINE database and performed a manual search of selected references. We examined the staging system and the different surveillance programs for melanoma patients. Consistent recommendations with proven evidence are available for staging melanoma patients. Conversely, recommendations are more controversial for follow-up procedures. Given the inadequate number of randomized controlled trials, consensus on the best, universally-applicable follow-up procedure has not been reached and interpretation of the roles of imaging and laboratory tests, as well as of the appropriate frequency and duration of physical examinations, vary widely. Based on a universally-accepted staging system different surveillance procedures have been developed, which may be mainly classified in two groups: low- and high-intensity strategies.
    MeSH term(s) Biopsy ; Follow-Up Studies ; Humans ; Melanoma/genetics ; Melanoma/pathology ; Neoplasm Staging ; Population Surveillance ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology
    Language English
    Publishing date 2017-06
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0026-4741 ; 0392-0488
    ISSN (online) 1827-1820
    ISSN 0026-4741 ; 0392-0488
    DOI 10.23736/S0392-0488.17.05581-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 119: Show issues Location:
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