LIVIVO - Search results -

Search results

Result 1 - 10 of total 924

Search options

Book ; Online: Argentine Cinema and National Identity : 1966-1976 (Volume 16)

Rocha, Carolina

2018

Keywords	Electronic, holographic & video art ; Agriculture & farming ; Art ; Film & Video ; Technology & Engineering ; Agriculture
Size	1 Online-Ressource
Publisher	Liverpool University Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021030116
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Design of Sturm global attractors 1: Meanders with three noses, and reversibility.

Fiedler, Bernold / Rocha, Carlos

Chaos (Woodbury, N.Y.)

2023 Volume 33, Issue 8

Abstract: We systematically explore a simple class of global attractors, called Sturm due to nodal properties, for the semilinear scalar parabolic partial differential equation (PDE) ut=uxx+f(x,u,ux) on the unit interval 0

Abstract	We systematically explore a simple class of global attractors, called Sturm due to nodal properties, for the semilinear scalar parabolic partial differential equation (PDE) ut=uxx+f(x,u,ux) on the unit interval 0<x<1, under Neumann boundary conditions. This models the interplay of reaction, advection, and diffusion. Our classification is based on the Sturm meanders, which arise from a shooting approach to the ordinary differential equation boundary value problem of equilibrium solutions ut=0. Specifically, we address meanders with only three "noses," each of which is innermost to a nested family of upper or lower meander arcs. The Chafee-Infante paradigm, with cubic nonlinearity f=f(u), features just two noses. Our results on the gradient-like global PDE dynamics include a precise description of the connection graphs. The edges denote PDE heteroclinic orbits v1⇝v2 between equilibrium vertices v1,v2 of adjacent Morse index. The global attractor turns out to be a ball of dimension d, given as the closure of the unstable manifold Wu(O) of the unique equilibrium with maximal Morse index d. Surprisingly, for parabolic PDEs based on irreversible diffusion, the connection graph indicates time reversibility on the (d-1)-sphere boundary of the global attractor.<br />
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/5.0147634
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Methylomes as key features for predicting recombination in some plant species.

Peñuela, Mauricio / Finke, Jorge / Rocha, Camilo

Plant molecular biology

2024 Volume 114, Issue 2, Page(s) 25

Abstract: Knowing how chromosome recombination works is essential for plant breeding. It enables the design of crosses between different varieties to combine desirable traits and create new ones. This is because the meiotic crossovers between homologous chromatids ...

Abstract	Knowing how chromosome recombination works is essential for plant breeding. It enables the design of crosses between different varieties to combine desirable traits and create new ones. This is because the meiotic crossovers between homologous chromatids are not purely random, and various strategies have been developed to describe and predict such exchange events. Recent studies have used methylation data to predict chromosomal recombination in rice using machine learning models. This approach proved successful due to the presence of a positive correlation between the CHH context cytosine methylation and recombination rates in rice chromosomes. This paper assesses the question if methylation can be used to predict recombination in four plant species: Arabidopsis, maize, sorghum, and tomato. The results indicate a positive association between CHH context methylation and recombination rates in certain plant species, with varying degrees of strength in their relationships. The CG and CHG methylation contexts show negative correlation with recombination. Methylation data was key effectively in predicting recombination in sorghum and tomato, with a mean determination coefficient of 0.65 ± 0.11 and 0.76 ± 0.05, respectively. In addition, the mean correlation values between predicted and experimental recombination rates were 0.83 ± 0.06 for sorghum and 0.90 ± 0.05 for tomato, confirming the significance of methylomes in both monocotyledonous and dicotyledonous species. The predictions for Arabidopsis and maize were not as accurate, likely due to the comparatively weaker relationships between methylation contexts and recombination, in contrast to sorghum and tomato, where stronger associations were observed. To enhance the accuracy of predictions, further evaluations using data sets closely related to each other might prove beneficial. In general, this methylome-based method holds great potential as a reliable strategy for predicting recombination rates in various plant species, offering valuable insights to breeders in their quest to develop novel and improved varieties.
MeSH term(s)	Arabidopsis/genetics ; Epigenome ; Plant Breeding ; DNA Methylation ; Plants/genetics ; Recombination, Genetic/genetics ; Gene Expression Regulation, Plant
Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	778032-1
ISSN	1573-5028 ; 0167-4412
ISSN (online)	1573-5028
ISSN	0167-4412
DOI	10.1007/s11103-023-01396-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3458: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: iPSC-derived models for anorexia nervosa research.

Maussion, Gilles / Rocha, Cecilia / Ramoz, Nicolas

Trends in molecular medicine

2024 Volume 30, Issue 4, Page(s) 339–349

Abstract: Anorexia nervosa (AN) is a complex neuropsychiatric disorder with genetic and epigenetic components that results in reduced food intake combined with alterations in the reward-processing network. While studies of patient cohorts and mouse models have ... ...

Abstract	Anorexia nervosa (AN) is a complex neuropsychiatric disorder with genetic and epigenetic components that results in reduced food intake combined with alterations in the reward-processing network. While studies of patient cohorts and mouse models have uncovered genes and epigenetic changes associated with the disease, neuronal networks and brain areas preferentially activated and metabolic changes associated with reduced food intake, the underlying molecular and cellular mechanisms remain unknown. The use of both 2D in vitro cultures and 3D models, namely organoids and spheroids, derived from either human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), would allow identification of cell type-specific changes associated with AN and comorbid diseases, to study preferential connections between brain areas and organs, and the development of therapeutic strategies.
MeSH term(s)	Mice ; Animals ; Humans ; Induced Pluripotent Stem Cells ; Anorexia Nervosa/metabolism ; Brain ; Neurons/metabolism ; Disease Models, Animal ; Organoids
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2024.02.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4345: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna.

Rocha, Cecilia / Prinos, Panagiotis

Frontiers in cellular neuroscience

2022 Volume 16, Page(s) 809917

Abstract: Primary cilia direct cellular signaling events during brain development and neuronal differentiation. The primary cilium is a dynamic organelle formed in a multistep process termed ciliogenesis that is tightly coordinated with the cell cycle. Genetic ... ...

Abstract	Primary cilia direct cellular signaling events during brain development and neuronal differentiation. The primary cilium is a dynamic organelle formed in a multistep process termed ciliogenesis that is tightly coordinated with the cell cycle. Genetic alterations, such as ciliary gene mutations, and epigenetic alterations, such as post-translational modifications and RNA processing of cilia related factors, give rise to human neuronal disorders and brain tumors such as glioblastoma and medulloblastoma. This review discusses the important role of genetics/epigenetics, as well as RNA processing and post-translational modifications in primary cilia function during brain development and cancer formation. We summarize mouse and human studies of ciliogenesis and primary cilia activity in the brain, and detail how cilia maintain neuronal progenitor populations and coordinate neuronal differentiation during development, as well as how cilia control different signaling pathways such as WNT, Sonic Hedgehog (SHH) and PDGF that are critical for neurogenesis. Moreover, we describe how post-translational modifications alter cilia formation and activity during development and carcinogenesis, and the impact of missplicing of ciliary genes leading to ciliopathies and cell cycle alterations. Finally, cilia genetic and epigenetic studies bring to light cellular and molecular mechanisms that underlie neurodevelopmental disorders and brain tumors.
Language	English
Publishing date	2022-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2022.809917
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The effect of osteochondral lesion size and ankle joint position on cartilage behavior - numerical and in vitro experimental results.

Ramos, A / Rocha, C / Mesnard, M

Medical engineering & physics

2021 Volume 98, Page(s) 73–82

Abstract: Osteochondral lesion of the talus is defined as damage in the cartilage that covers the talus bone, compromising the integrity of the joint in the long term. Due to the low incidence of this pathology, there are few studies to understand the importance ... ...

Abstract	Osteochondral lesion of the talus is defined as damage in the cartilage that covers the talus bone, compromising the integrity of the joint in the long term. Due to the low incidence of this pathology, there are few studies to understand the importance of lesion size and position in cartilage strains. The purpose of this study is then to analyze the influence of the lesion size in joint behavior. A 3D virtual and in vitro model of a patient's injured ankle joint was developed. The models were built using CT scan and MRI images, to obtain the CAD models of intact and with 10 mm lesion size for 3D print models using additive manufacturing. The physical model was tested with 685N applied vertically to determine experimentally the principal strains and contact pressures in the cartilage. Five finite element models were developed with lesion dimensions (5 to 20 mm) and with 3 ankle joint positions. The numerical and experimental results were correlated with an R
MeSH term(s)	Ankle Joint/diagnostic imaging ; Cartilage, Articular/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Talus/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2021.10.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 2231: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Pharyngeal Constrictor Dose-Volume Histogram Metrics and Patient-Reported Dysphagia in Head and Neck Radiotherapy.

Paetkau, O / Weppler, S / Kwok, J / Quon, H C / Gomes da Rocha, C / Smith, W / Tchistiakova, E / Kirkby, C

Clinical oncology (Royal College of Radiologists (Great Britain))

2024 Volume 36, Issue 3, Page(s) 173–182

Abstract: Aims: Head and neck radiotherapy long-term survival continues to improve and the management of long-term side-effects is moving to the forefront of patient care. Dysphagia is associated with dose to the pharyngeal constrictors and can be measured using ... ...

Abstract	Aims: Head and neck radiotherapy long-term survival continues to improve and the management of long-term side-effects is moving to the forefront of patient care. Dysphagia is associated with dose to the pharyngeal constrictors and can be measured using patient-reported outcomes to evaluate its effect on quality of life. The aim of the present study was to relate pharyngeal constrictor dose-volume parameters with patient-reported outcomes to identify prognostic dose constraints. Materials and methods: A 64-patient training cohort and a 24-patient testing cohort of oropharynx and nasopharynx cancer patients treated with curative-intent chemoradiotherapy were retrospectively examined. These patients completed the MD Anderson Dysphagia Inventory outcome survey at 12 months post-radiotherapy to evaluate late dysphagia: a composite score lower than 60 indicated dysphagia. The pharyngeal constrictor muscles were subdivided into four substructures: superior, middle, inferior and cricopharyngeal. Dose-volume histogram (DVH) metrics for each of the structure combinations were extracted. A decision tree classifier was run for each DVH metric to identify dose constraints optimising the accuracy and sensitivity of the cohort. A 60% accuracy threshold and feature selection method were used to ensure statistically significant DVH metrics were identified. These dose constraints were then validated on the 24-patient testing cohort. Results: Existing literature dose constraints only had two dose constraints performing above 60% accuracy and sensitivity when evaluated on our training cohort. We identified two well-performing dose constraints: the pharyngeal constrictor muscle D63% < 55 Gy and the superior-middle pharyngeal constrictor combination structure V31Gy < 100%. Both dose constraints resulted in ≥73% mean accuracy and ≥80% mean sensitivity on the training and testing patient cohorts. In addition, a pharyngeal constrictor muscle mean dose <57 Gy resulted in a mean accuracy ≥74% and mean sensitivity ≥60%. Conclusion: Mid-dose pharyngeal constrictor muscle and substructure combination dose constraints should be used in the treatment planning process to reduce late patient-reported dysphagia.
MeSH term(s)	Humans ; Deglutition Disorders/etiology ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/radiotherapy ; Quality of Life ; Retrospective Studies ; Radiotherapy Dosage ; Radiotherapy, Intensity-Modulated/methods
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2024.01.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2774: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: RE: Pharyngeal Constrictor Muscle Sparing in Head and Neck Radiotherapy.

Paetkau, O / Weppler, S / Kwok, J / Quon, H C / Gomes da Rocha, C / Smith, W / Tchistiakova, E / Kirkby, C

Clinical oncology (Royal College of Radiologists (Great Britain))

2024

Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Letter
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2024.03.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2774: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Coastal indices to assess sea-level rise impacts - A brief review of the last decade

Rocha, Carolina / Antunes, Carlos / Catita, Cristina

Ocean and Coastal Management. 2023 Apr., v. 237 p.106536-

2023

Abstract: The present review intends to serve as the most comprehensive work of the current scientific and the most updated research on coastal vulnerability and risk assessment due to sea-level rise. The article describes the existing scientific knowledge on an ... ...

Abstract	The present review intends to serve as the most comprehensive work of the current scientific and the most updated research on coastal vulnerability and risk assessment due to sea-level rise. The article describes the existing scientific knowledge on an important subject that must be in the present climate change agenda, giving examples of methods, methodologies and applications that have been made around the world that can be considered for application according to the specifics of each geographical area. This research demonstrates, with 37 studies of the last decade, that a wide range of concepts, methods, parameters and indices have been used in this context, considering different types of time and space scales for the operation of coastal processes, categorizing them in different intervals and classifying each variable results in a large spectrum of vulnerability and risk levels. In light of the research included in this study, Coastal Vulnerability Index (CVI) is the most popular designation of the index (78%). It was discovered that the index designation provided by the authors is erroneous in 31 studies. Only 7 of the 29 studies that were designated as CVI were genuinely CVI. Coastal forcing factors were employed in 24 studies, however, only half (18 studies) included socioeconomic parameters and only 7 used economic damage parameters. This demonstrated that there is no magic or right formula for assessing vulnerability and risk, as this is largely conditioned by the availability of data and the place it is applied. However, the lack of harmonization in the nomenclature of the indices is worrying. This article also guides how the different indices should be designated, considering what they represent, and what kind of parameters are being used, taking into account the scale on which the study is being applied.
Keywords	climate change ; coastal zone management ; risk ; risk assessment ; sea level ; Sea-level rise ; Coastal hazards ; Coastal vulnerability index ; Coastal risk index
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ISSN	0964-5691
DOI	10.1016/j.ocecoaman.2023.106536
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Conference proceedings ; Online: Temperature and Salinity Variability from bottom sensors in the central South Atlantic, on the SAMBA line. January-2019 to January 2023

Campos, E. / Campos van Caspel, M. / Rocha, C. / Sato, O.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: In January 2019, as part of Project SAMBAR (Inter-annual variability of the Meridional Transports across the SAMOC Basin-Wide Array - SAMBA), two observational platforms composed by currentmeter-pressure enabled inverted echo-sounders (C-PIES) and ... ...

Abstract	In January 2019, as part of Project SAMBAR (Inter-annual variability of the Meridional Transports across the SAMOC Basin-Wide Array - SAMBA), two observational platforms composed by currentmeter-pressure enabled inverted echo-sounders (C-PIES) and conductivity-temperature sensors (SBE39SM MicroCATs) were deployed at 31 o 7.8’W (Site E) and 18 o 49’W (Site F) along the SAMBA line (34.5 o S). The instruments were recovered in January 2023. Preliminary, exploratory analysis of the microCATs data shows temperature series with no drift during the whole period. However, in both sites, the conductivity sensor worked well for only for about one-and-a-half year. The temperature time series in the two sites present strong seasonality and significant high frequency variability, with mean and standard deviation of 2.18 o +/-0.20 o C on Site E, and 1.22 o +/- 0.11 o C, on Site F. Considering only the periods with no drift in the salinity sensors (around 1.5 year), it is also possible to see a seasonal sign and intense high frequency variability. The mean and standard deviation are of 36.580 +/- 0.004 for Site E, and 36.801 +/- 0.007 for Site F. On site F, the salinity series present two consecutive periods of predominantly stationary behavior, after an abrupt change in the mean value. After a bias correction, the two segments were joined, increasing the series to almost 2.5 years. Both temperature and salinity present significant positive trends. This is being further investigatedin a more extensive study, based on classical statistical analysis and the use machine learning approaches.
Subject code	333
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED