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  1. Article ; Online: Changes in the Gut Microbiota after the Use of Herbal Medicines in Overweight and Obese Individuals: A Systematic Review.

    Huang, Miguel / Cople-Rodrigues, Cláudia Dos Santos / Waitzberg, Dan L / Rocha, Ilanna Marques Gomes da / Curioni, Cintia Chaves

    Nutrients

    2023  Volume 15, Issue 9

    Abstract: Background: Herbal medicine is a low-cost treatment and has been increasingly applied in obesity treatment. Gut microbiota (GM) is strongly associated with obesity pathogenesis.: Methods: We conducted a systematic review guided by the question: "Does ...

    Abstract Background: Herbal medicine is a low-cost treatment and has been increasingly applied in obesity treatment. Gut microbiota (GM) is strongly associated with obesity pathogenesis.
    Methods: We conducted a systematic review guided by the question: "Does the use of herbal medicine change the GM composition in obese individuals?" Randomized clinical trials with obese individuals assessing the effects of herbal medicine intervention in GM were retrieved from the Medline, Embase, Scopus, Web of Science, and Cochrane Library databases, including the Cochrane Controlled Trials Register. Two reviewers independently extracted data using standardized piloted data extraction forms and assessed the study-level risk of bias using an Excel template of the Cochrane "Risk of bias" tool 2-RoB 2.
    Results: We identified 1094 articles in the databases. After removing duplicates and reading the title and abstract, 14 publications were fully evaluated, of which seven publications from six studies were considered eligible. The herbs analyzed were
    Conclusions: Herbal medicine modulates GM and is associated with increased genera in obese individuals.
    MeSH term(s) Humans ; Overweight/drug therapy ; Gastrointestinal Microbiome ; Obesity/drug therapy ; Plants, Medicinal ; Plant Extracts/therapeutic use
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15092203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pro-Inflammatory Diet Is Correlated with High

    Rocha, Ilanna Marques Gomes da / Torrinhas, Raquel / Fonseca, Danielle / Lyra, Clelia de Oliveira / de Sousa Alves Neri, Julianna Lys / Balmant, Bianca Depieri / Callado, Letícia / Charlton, Karen / Queiroz, Natalia / Waitzberg, Dan L

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: Inflammatory bowel diseases (IBD) are chronic conditions arising from an intricate interplay of genetics and environmental factors, and are associated with gut dysbiosis, inflammation, and gut permeability. In this study, we investigated whether the ... ...

    Abstract Inflammatory bowel diseases (IBD) are chronic conditions arising from an intricate interplay of genetics and environmental factors, and are associated with gut dysbiosis, inflammation, and gut permeability. In this study, we investigated whether the inflammatory potential of the diet is associated with the gut microbiota profile, inflammation, and permeability in forty patients with IBD in clinical remission. The dietary inflammatory index (DII) score was used to assess the inflammatory potential of the diet. The fecal microbiota profile was analyzed using 16SrRNA (V3-V4) gene sequencing, while fecal zonulin and calprotectin levels were measured with enzyme-linked immunosorbent assays. We found a positive correlation between the DII score and elevated calprotectin levels (Rho = 0.498;
    MeSH term(s) Humans ; Biomarkers ; Inflammatory Bowel Diseases ; Inflammation ; Feces/microbiology ; Chronic Disease ; Diet ; Recurrence ; Leukocyte L1 Antigen Complex
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.

    Rodrigues-Krause, Josianne / Krause, Mauricio / Rocha, Ilanna Marques Gomes da / Umpierre, Daniel / Fayh, Ana Paula Trussardi

    Nutrients

    2018  Volume 11, Issue 1

    Abstract: l-Arginine supplementation is a potential therapy for treating cardiovascular and metabolic diseases. However, the use of distinct l-arginine sources, intervened populations, and treatment regimens may have yielded confusion about their efficacy. This ... ...

    Abstract l-Arginine supplementation is a potential therapy for treating cardiovascular and metabolic diseases. However, the use of distinct l-arginine sources, intervened populations, and treatment regimens may have yielded confusion about their efficacy. This research constitutes a systematic review and meta-analysis summarizing the effects of l-arginine supplementation compared to placebo in individuals with cardiovascular disease (CVD), obesity, or diabetes. Eligibility criteria included randomized clinical trials and interventions based on oral supplementation of l-arginine with a minimum duration of three days; comparison groups consisted of individuals with the same disease condition receiving an oral placebo substance. The primary outcome was flow-mediated dilation, and secondary outcomes were nitrite/nitrate (NOx) rate and asymmetric dimethylarginine (ADMA). Statistical heterogeneity among studies included in the meta-analyses was assessed using the inconsistency index (I2). Fifty-four full-text articles from 3761 retrieved references were assessed for eligibility. After exclusions, 13 studies were included for data extraction. There was no difference in blood flow after post-ischemic hyperemia between the supplementation of l-arginine and placebo groups before and after the intervention period (standardized mean difference (SMD) = 0.30; 95% confidence intervals (CIs) = -0.85 to 1.46; I2 = 96%). Sensitivity analysis showed decreased heterogeneity when the studies that most favor arginine and placebo were removed, and positive results in favor of arginine supplementation were found (SMD = 0.59; 95% CIs = 0.10 to 1.08; I2 = 75%). No difference was found in meta-analytical estimates of NOx and ADMA responses between arginine or placebo treatments. Overall, the results indicated that oral l-arginine supplementation was not associated with improvements on selected variables in these patients (PROSPERO Registration: CRD42017077289).
    MeSH term(s) Adult ; Aged ; Arginine/administration & dosage ; Arginine/analogs & derivatives ; Arginine/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/therapy ; Diabetes Mellitus/blood ; Diabetes Mellitus/physiopathology ; Diabetes Mellitus/therapy ; Dietary Supplements ; Endothelium, Vascular/physiopathology ; Female ; Humans ; Hyperemia/etiology ; Male ; Middle Aged ; Nitrates/blood ; Nitrites/blood ; Obesity/blood ; Obesity/physiopathology ; Obesity/therapy ; Treatment Outcome
    Chemical Substances Nitrates ; Nitrites ; N,N-dimethylarginine (63CV1GEK3Y) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2018-12-20
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11010015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Agreement between software programmes of body composition analyses on abdominal computed tomography scans of obese adults.

    Barbalho, Erica Roberta / Rocha, Ilanna Marques Gomes da / Medeiros, Galtieri Otávio Cunha de / Friedman, Rogerio / Fayh, Ana Paula Trussardi

    Archives of endocrinology and metabolism

    2019  Volume 64, Issue 1, Page(s) 24–29

    Abstract: Objective A large number of studies have used abdominal computed tomography (CT) to quantify body composition, and different software programmes have been used to perform these analyses. Thus, this comparison is important to enable researchers to know ... ...

    Abstract Objective A large number of studies have used abdominal computed tomography (CT) to quantify body composition, and different software programmes have been used to perform these analyses. Thus, this comparison is important to enable researchers to know the performance of more accessible software. Subjects and methods Fifty-four abdominal CT scans of obese (BMI 30 to 39.9 kg/m2), sedentary adults (24-41 years) patients from a Brazilian single center were selected. Two software programs were compared: Slice-O-Matic (Tomovision, Canada) version 5.0 and OsiriX version 5.8.5. The body composition analysis were segmented using standard Hounsfield unit (HU) (adipose tissue: -190 to +30 and skeletal muscle: -29 to +150) and measured at the mid third lumbar vertebra (L3) level on a slice showing both transversal processes. Bland-Altman limits of agreement analyses were used to assess the level of agreement between Slice-O-Matic and OsiriX. Results A total of fifty-four participants were evaluated, with majority women (69%), mean of age 31.3 (SD 6.5) years and obesity grade I most prevalent (74.1%). The agreement, in Bland-Altman analysis, between Slice-O-Matic and OsiriX analisys for the muscle mass tissue, visceral adipose tissue and subcutaneous adipose tissue were excellent (≥ 0.954) with P-values < 0.001. Conclusion These findings show that Slice-O-Matic and OsiriX softwares agreement in measurements of skeletal muscle and adipose tissue and sarcopenia diagnosis in obese patients, suggesting good applicability in studies with body composition in this population and clinical practice.
    MeSH term(s) Adult ; Body Composition ; Female ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Male ; Middle Aged ; Obesity/diagnostic imaging ; Observer Variation ; Reproducibility of Results ; Sedentary Behavior ; Subcutaneous Fat/diagnostic imaging ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2019-09-30
    Publishing country Brazil
    Document type Comparative Study ; Journal Article
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Association of <span style="font-variant: small-caps">l</span>-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis

    Rodrigues-Krause, Josianne / Krause, Mauricio / Rocha, Ilanna Marques Gomes da / Umpierre, Daniel / Fayh, Ana Paula Trussardi

    Nutrients. 2018 Dec. 20, v. 11, no. 1

    2018  

    Abstract: l-Arginine supplementation is a potential therapy for treating cardiovascular and metabolic diseases. However, the use of distinct l-arginine sources, intervened populations, and treatment regimens may have yielded confusion about their efficacy. This ... ...

    Abstract l-Arginine supplementation is a potential therapy for treating cardiovascular and metabolic diseases. However, the use of distinct l-arginine sources, intervened populations, and treatment regimens may have yielded confusion about their efficacy. This research constitutes a systematic review and meta-analysis summarizing the effects of l-arginine supplementation compared to placebo in individuals with cardiovascular disease (CVD), obesity, or diabetes. Eligibility criteria included randomized clinical trials and interventions based on oral supplementation of l-arginine with a minimum duration of three days; comparison groups consisted of individuals with the same disease condition receiving an oral placebo substance. The primary outcome was flow-mediated dilation, and secondary outcomes were nitrite/nitrate (NOx) rate and asymmetric dimethylarginine (ADMA). Statistical heterogeneity among studies included in the meta-analyses was assessed using the inconsistency index (I2). Fifty-four full-text articles from 3761 retrieved references were assessed for eligibility. After exclusions, 13 studies were included for data extraction. There was no difference in blood flow after post-ischemic hyperemia between the supplementation of l-arginine and placebo groups before and after the intervention period (standardized mean difference (SMD) = 0.30; 95% confidence intervals (CIs) = −0.85 to 1.46; I2 = 96%). Sensitivity analysis showed decreased heterogeneity when the studies that most favor arginine and placebo were removed, and positive results in favor of arginine supplementation were found (SMD = 0.59; 95% CIs = 0.10 to 1.08; I2 = 75%). No difference was found in meta-analytical estimates of NOx and ADMA responses between arginine or placebo treatments. Overall, the results indicated that oral l-arginine supplementation was not associated with improvements on selected variables in these patients (PROSPERO Registration: CRD42017077289).
    Keywords arginine ; blood flow ; confidence interval ; diabetes ; hyperemia ; meta-analysis ; nitrates ; nitrites ; nitrogen oxides ; obesity ; patients ; placebos ; randomized clinical trials ; systematic review ; therapeutics
    Language English
    Dates of publication 2018-1220
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11010015
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Cardiovascular risk assessment using the lipid accumulation product index among primary healthcare users: a cross-sectional study.

    Vieira, Jallyne Nunes / Braz, Marina Augusta Dias / Gomes, Flayane Oliveira / Silva, Priscilla Rafaella da / Santos, Ohanna Thays de Medeiros / Rocha, Ilanna Marques Gomes da / Sousa, Iasmin Matias de / Fayh, Ana Paula Trussardi

    Sao Paulo medical journal = Revista paulista de medicina

    2019  Volume 137, Issue 2, Page(s) 126–131

    Abstract: Background: The lipid accumulation product (LAP) index is an abdominal adiposity marker.: Objective: The aim of this study was to describe the cardiovascular risk of primary healthcare users through the LAP index and correlate it with anthropometric ... ...

    Abstract Background: The lipid accumulation product (LAP) index is an abdominal adiposity marker.
    Objective: The aim of this study was to describe the cardiovascular risk of primary healthcare users through the LAP index and correlate it with anthropometric and biochemical indicators.
    Design and setting: Cross-sectional study in primary care units in a city in northeastern Brazil.
    Methods: The subjects responded to a structured questionnaire that contained questions about their sociodemographic condition, and then underwent an anthropometric nutritional assessment. The LAP index values were expressed as three degrees of cardiovascular risk intensity: high risk (above the 75th percentile), moderate risk (between the 25th and 75th percentiles) and low risk (below the 25th percentile).
    Results: The median LAP index was 52.5 cm.mmol/l (range: 28.2-86.6), and there was no statistically significant difference between the sexes: 57.7 cm.mmol/l (24.5-91.1) and 49.5 cm.mmol/l (29.8-85.2) for females and males, respectively (P = 0.576). Among all the subjects, 67.2% were overweight and there was a statistically significant difference in mean LAP index between those who were and those who were not overweight. Statistically significant differences in anthropometric and biochemical markers for cardiovascular risk were observed among individuals who had higher LAP index values. There were significant correlations between the LAP index and all of the biochemical variables.
    Conclusions: These significant correlations between the LAP index and the traditional biochemical risk markers may be useful within conventional clinical practice, for cardiovascular risk screening in primary healthcare.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Body Mass Index ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Female ; Humans ; Lipid Accumulation Product ; Male ; Middle Aged ; Obesity, Abdominal/blood ; Obesity, Abdominal/complications ; Primary Health Care ; Risk Assessment ; Risk Factors ; Socioeconomic Factors ; Waist Circumference ; Young Adult
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-07-15
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1203171-9
    ISSN 1806-9460 ; 1516-3180 ; 0035-0362
    ISSN (online) 1806-9460
    ISSN 1516-3180 ; 0035-0362
    DOI 10.1590/1516-3180.2018.0293240119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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