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  1. Article ; Online: Interstitial nephritis associated with nivolumab in a patient with hodgkin lymphoma.

    Oliveira, Deivide de Sousa / Mesquita, Juliene Lima / Garcia, Yhasmine Delles Oliveira / Rosales, Yensy Mariana Zelaya / Lemes, Romélia Pinheiro Gonçalves / Rocha Filho, Francisco Dário / Fernandes, Paula Frassinetti Castelo Branco Camurça / Duarte, Pastora Maria Araujo / Pitombeira, Maria da Silva / Duarte, Fernando Barroso

    Revista da Associacao Medica Brasileira (1992)

    2019  Volume 65, Issue 7, Page(s) 934–936

    MeSH term(s) Adult ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Drug-Related Side Effects and Adverse Reactions ; Hodgkin Disease/drug therapy ; Humans ; Male ; Nephritis, Interstitial/chemically induced ; Nephritis, Interstitial/pathology ; Nivolumab/adverse effects ; Nivolumab/therapeutic use ; Young Adult
    Chemical Substances Antineoplastic Agents, Immunological ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2019-08-05
    Publishing country Brazil
    Document type Case Reports ; Letter
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.65.7.934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunohistochemistry contribution in the diagnosis of splenic marginal zone lymphoma.

    Mesquita, Juliene Lima / Rosales, Yensy Mariana Zelaya / Garcia, Yhasmine Delles Oliveira / Rocha Filho, Francisco Dario / Araujo, Beatriz Stela Gomes de Sousa Pitombeira / Leitão, João Paulo de Vasconcelos / Costa, Jesus Irajacy / Duarte, Beatrice Araújo / Duarte, João Vitor Araújo / Lemes, Romélia Pinheiro Gonçalves / Duarte, Fernando Barroso

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 5, Page(s) 580–582

    MeSH term(s) Humans ; Immunohistochemistry ; Lymphoma/immunology ; Lymphoma/pathology ; Lymphoma/surgery ; Male ; Middle Aged ; Splenectomy ; Splenic Neoplasms/immunology ; Splenic Neoplasms/pathology ; Splenic Neoplasms/surgery ; Splenomegaly/etiology ; Treatment Outcome
    Language English
    Publishing date 2020-07-03
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.5.580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Presence of CD34

    Duarte, Fernando Barroso / DE Jesus Dos Santos, Talyta Ellen / Barbosa, Maritza Cavalcante / Moura, Anna Thawanny Gadelha / DE Vasconcelos, João Paulo Leitão / Rocha-Filho, Francisco Dário / Coutinho, Diego F / Zalcberg, Ilana / Vasconcelos, Paulo R L / Garcia, Yhasmine Delles Oliverira / Lemes, Romélia Pinheiro Gonçalves

    In vivo (Athens, Greece)

    2018  Volume 33, Issue 1, Page(s) 277–280

    Abstract: Background/aim: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and ...

    Abstract Background/aim: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and aggressively, despite a "favorable" prognostic stratification. The aim of this study was to identify biomarkers for predicting prognosis, and for better stratification and management of these patients.
    Materials and methods: Expression of CD34 and p53 in megakaryocytes was examined by immunohistochemistry in 71 MDS patients classified as low-risk.
    Results: CD34 staining in megakaryocytes was associated with p53 expression (p=0.0166). CD34 and p53 expression were associated to worse overall survival in patients (p=0.0281).
    Conclusion: The presence of CD34 in megakaryocytes is associated with p53 expression and an adverse prognosis for MDS patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antigens, CD34/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Megakaryocytes/metabolism ; Megakaryocytes/pathology ; Middle Aged ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Prognosis ; Risk Assessment ; Risk Factors ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Antigens, CD34 ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2018-12-18
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.11472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Presence of new mutations in the TP53 gene in patients with low-risk myelodysplastic syndrome: two case reports.

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Dos Santos, Talyta Ellen de Jesus / Barbosa, Maritza Cavalcante / de Vasconcelos, João Paulo Leitão / Rocha-Filho, Francisco Dário / Zalcberg, Ilana / Coutinho, Diego / Figueiredo, Monalisa Feliciano / Carlos, Luciana Barros / de Vasconcelos, Paulo Roberto Leitão

    Journal of medical case reports

    2017  Volume 11, Issue 1, Page(s) 143

    Abstract: Background: Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute ...

    Abstract Background: Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present study, two mutations in this gene are presented and discussed with the clinical evolution of the patients.
    Case presentation: The first case is a 77-year-old Brazilian woman diagnosed as having multiple lineage dysplasia myelodysplastic syndrome according to World Health Organization 2016 and classified as very low-risk by Revised International Prognostic Scoring. The second case is an 80-year-old Brazilian man also diagnosed as having multiple lineage dysplasia myelodysplastic syndrome and classified as low risk. The mutation described in the first case was already identified in some neoplasias and it is associated with a poor prognosis, but it had never been reported before in myelodysplastic syndrome. The second mutation has never been described.
    Conclusions: This is a novel report for the scientific community and may be very helpful as we can better understand the disease and the impact of mutations through the follow-up of these patients and others in the future. Both patients are in a good clinical condition, suggesting that these mutations may not alter the clinical course of the disease or may be associated with a good prognosis, but their role in the disease must be investigated more deeply in a larger population.
    Language English
    Publishing date 2017-05-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-017-1301-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Metastatic prostate adenocarcinoma associated with numb chin syndrome.

    Soares, Eduardo Costa Studart / Costa, Fábio Wildson Gurgel / Rocha-Filho, Francisco Dário / Ferreira, Francisco Valdeci de Almeida / Alves, Ana Paula Negreiros Nunes

    The Journal of craniofacial surgery

    2011  Volume 22, Issue 6, Page(s) 2366–2368

    Abstract: Metastatic tumors to the oral cavity are rare and account for approximately 1% of all malignant oral neoplasms. About 765 cases have been published in the English- and Chinese-language literature since 1950, with less than 6% of these cases corresponding ...

    Abstract Metastatic tumors to the oral cavity are rare and account for approximately 1% of all malignant oral neoplasms. About 765 cases have been published in the English- and Chinese-language literature since 1950, with less than 6% of these cases corresponding to prostate cancer metastasis. Because of their uncommon incidence, the diagnosis of oral metastases, especially those originating from the prostate gland, may represent a challenge for general dentists, oral pathologists, and oral radiologists. Thus, the aim of this study was to describe an interesting case of prostate adenocarcinoma metastasizing to the posterior mandible. In addition, association with numb chin syndrome present in this case was discussed.
    MeSH term(s) Aged ; Biopsy ; Chin ; Diagnosis, Differential ; Fatal Outcome ; Head and Neck Neoplasms/secondary ; Humans ; Hypesthesia/etiology ; Male ; Prostatic Neoplasms/pathology ; Syndrome ; Tomography, X-Ray Computed
    Language English
    Publishing date 2011-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0b013e318231e5a1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hematopoietic cells in thyroid fine needle aspirates.

    Magalhães, Leila Carla C S / Oliveira, Denise Nunes / Nogueira, Teresa Neuma A G / Rocha Filho, Francisco Dário

    Acta cytologica

    2007  Volume 51, Issue 2, Page(s) 251–252

    MeSH term(s) Aged ; Biopsy, Fine-Needle ; Blood Cells/pathology ; Choristoma/pathology ; Choristoma/physiopathology ; Diagnosis, Differential ; Female ; Hematopoiesis, Extramedullary ; Hematopoietic Stem Cells/pathology ; Humans ; Predictive Value of Tests ; Thyroid Gland/pathology ; Thyroid Gland/physiopathology ; Thyroid Nodule/etiology ; Thyroid Nodule/pathology ; Thyroid Nodule/physiopathology
    Language English
    Publishing date 2007-03
    Publishing country Switzerland
    Document type Case Reports ; Letter
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Tumor suppressor p53 protein expression: prognostic significance in patients with low-risk myelodysplastic syndrome.

    Duarte, Fernando Barroso / Gonçalves, Romelia Pinheiro / Barbosa, Maritza Cavalcante / Rocha Filho, Francisco Dário / de Jesus Dos Santos, Talyta Ellen / Dos Santos, Thayna Nogueira / de Vasconcelos, Paulo Roberto Leitão

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 3, Page(s) 196–201

    Abstract: Background: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, ... ...

    Abstract Background: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability.
    Objective: To evaluate the impact of p53 protein expression at diagnosis in patients with low-risk myelodysplastic syndrome.
    Methods: This study enrolled 38 patients diagnosed with low-risk myelodysplastic syndrome. Clinical data were collected by reviewing medical records, and immunohistochemical p53 staining was performed on bone marrow biopsies.
    Results: Of the 38 participants, 13 (34.21%) showed p53 expression in their bone marrow. At diagnosis, this group of patients also presented clinical features characteristic of a poor prognosis more often than patients who did not express p53. Furthermore, patients expressing p53 had a shorter median survival time compared to those without p53 expression.
    Conclusion: This study shows that the expression of p53 at diagnosis is a useful indicator of distinct clinical characteristics and laboratory profiles found in low-risk myelodysplastic syndrome patients. These data indicate that the immunohistochemical analysis of p53 may be a prognostic tool for myelodysplastic syndrome and should be used as an auxiliary test to help determine the best therapeutic choice.
    Language English
    Publishing date 2014-04-03
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.1016/j.bjhh.2014.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cutaneous Rosai-Dorfman disease.

    Landim, Fábio Machado / Rios, Helena de Oliveira / Costa, Carolina Oliveira / Feitosa, Roney Gonçalves Fechine / Rocha Filho, Francisco Dário / Costa, Adriana Alencar Araújo

    Anais brasileiros de dermatologia

    2009  Volume 84, Issue 3, Page(s) 275–278

    Abstract: Rosai-Dorfman disease is a self-limited benign disease. Rosai and Dorfman first described it in 1969, and the etiology of the disease remains unknown. Main manifestations are cervical adenopathy associated with fever, leukocytosis with neutrophilia and ... ...

    Abstract Rosai-Dorfman disease is a self-limited benign disease. Rosai and Dorfman first described it in 1969, and the etiology of the disease remains unknown. Main manifestations are cervical adenopathy associated with fever, leukocytosis with neutrophilia and polyclonal gamaglobulinemia. Although the skin is the most common site of extra nodal disease, Rosai-Dorfman disease restricted to the skin is very rare with only a few cases described in the literature. This paper reports a rare case of cutaneous Rosai-Dorfman with skin as the sole site, and reviews the controversies of diagnosis and treatment.
    MeSH term(s) Adult ; Histiocytosis, Sinus/pathology ; Histiocytosis, Sinus/surgery ; Humans ; Male ; Skin Diseases/pathology ; Skin Diseases/surgery
    Language Portuguese
    Publishing date 2009-08-05
    Publishing country Spain
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/s0365-05962009000300010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Orbital metastasis as primary clinical manifestation of thyroid carcinoma--case report and literature review.

    Rocha Filho, Francisco Dário / Lima, Gabrielle Gurgel / Ferreira, Francisco V de Almeida / Lima, Michelle Gurgel / Hissa, Miguel N

    Arquivos brasileiros de endocrinologia e metabologia

    2008  Volume 52, Issue 9, Page(s) 1497–1500

    Abstract: Capillary thyroid carcinoma (PTC) is the most common neoplasm of thyroid. It usually grows slowly and is clinically indolent; although rare, its aggressive forms with local invasion or distant metastases can occur. Metastatic thyroid carcinoma rarely ... ...

    Abstract Capillary thyroid carcinoma (PTC) is the most common neoplasm of thyroid. It usually grows slowly and is clinically indolent; although rare, its aggressive forms with local invasion or distant metastases can occur. Metastatic thyroid carcinoma rarely involves the orbit. We reported an uncommon case of orbital metastasis of PTC. A 66-years-old woman presented proptosis of the right eye. The biopsy of the tumor in orbit revealed metastatic thyroid carcinoma. The ultrasensitive TSH level was 1,34 mUI/L and free T4 level was 1,65 ng/dL. A total thyroidectomy was performed and histopathological analysis of the nodule revealed follicular variant of papillary thyroid carcinoma. Currently, the patient has been receiving palliative chemotherapy with Clodronate Disodium. The importance of the case is due to its unusual presentation, which emerged as a primary clinical manifestation. Although rare, thyroid carcinoma should be suspected in orbit metastasis.
    MeSH term(s) Aged ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/secondary ; Carcinoma, Papillary/surgery ; Female ; Humans ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/secondary ; Prognosis ; Radiography ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery
    Language English
    Publishing date 2008-12-18
    Publishing country Brazil
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/s0004-27302008000900014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Simultaneous occurrence of follicular lymphoma and mixed-cellularity Hodgkin's lymphoma

    Grangeiro Maria do Patrocínio F. / Magalhães Sílvia Maria M. / Ferreira Francisco Valdeci A. / Rocha Filho Francisco Dário

    Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 40, Iss 1, Pp 33-

    lymph node and extranodal involvement

    2004  Volume 36

    Abstract: An unusual and well-characterised case of composite lymphoma in the spleen and lymph node is presented. The simultaneous occurrence of mixed-cellularity Hodgkin's lymphoma (HL) and follicular non-Hodgkin's lymphoma (NHL) was demonstrated in a 66-year-old ...

    Abstract An unusual and well-characterised case of composite lymphoma in the spleen and lymph node is presented. The simultaneous occurrence of mixed-cellularity Hodgkin's lymphoma (HL) and follicular non-Hodgkin's lymphoma (NHL) was demonstrated in a 66-year-old man admitted in our Service with anaemia, hepatosplenomegaly and multiple abdominal lymph nodes. The morphological study of the spleen and lymph node of the splenic hilum showed an infiltrate composed of two distinct neoplasias. The liver was involved by NHL infiltrate and the peripancreatic lymph node exhibited HL. The Reed-Sternberg (RS) cells expressed CD 15 and CD 30, whereas the NHL cells presented standard immunohistochemical features of follicular lymphoma. To our knowledge, this is the fifth case report of concurrent spleen involvement by composite lymphoma. The incidence, clinicopathological and immunohistochemical features of this rare association are discussed.
    Keywords Composite lymphoma ; Spleen ; Lymph node ; Follicular lymphoma ; Hodgkin's lymphoma ; Pathology ; RB1-214 ; Medicine ; R ; DOAJ:Pathology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2004-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Patologia Clínica
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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