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  1. Article ; Online: Inhibition of Aflatoxin B1 Synthesis in

    Al Khoury, Anthony / El Khoury, André / Rocher, Ophélie / Hindieh, Pamela / Puel, Olivier / Maroun, Richard G / Atoui, Ali / Bailly, Jean-Denis

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: Plant extracts may represent an ecofriendly alternative to chemical fungicides to limit aflatoxin B1 (AFB1) contamination of foods and feeds. Mate ( ...

    Abstract Plant extracts may represent an ecofriendly alternative to chemical fungicides to limit aflatoxin B1 (AFB1) contamination of foods and feeds. Mate (
    Language English
    Publishing date 2022-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: Implication of VelB in the development, pathogenicity, and secondary metabolism of Penicillium expansum

    Tahtah, Nadia / Zetina-Serrano, Chrystian / Rocher, Ophélie / Naylies, Claire / Lippi, Yannick / El Khoury, André / Atoui, Ali / Jamin, Emilien L. / Oswald, Isabelle P. / Lorber, Sophie / Puel, Olivier

    Postharvest biology and technology. 2022 Sept. 20,

    2022  

    Abstract: Penicillium expansum is the main cause of blue mold disease and the main producer of patulin in apple-derived products. This fungus also produces a wide variety of secondary metabolites, including citrinin and chaetoglobosin A. Secondary metabolism is ... ...

    Abstract Penicillium expansum is the main cause of blue mold disease and the main producer of patulin in apple-derived products. This fungus also produces a wide variety of secondary metabolites, including citrinin and chaetoglobosin A. Secondary metabolism is regulated by global transcription factors that are affected by environmental signals. The light-dependent global transcription factor VelB, a member of the velvet complex, plays an important role in the regulation of secondary metabolism and fungal development in many fungal species. However, the specific roles of VelB in P. expansum remain unknown. A Pe∆velB mutant and a complemented Pe∆velB:velB strain were generated to investigate the role of VelB in pathogenicity and secondary metabolism. The Pe∆velB mutant colonized apples, but at a lower rate than the wild type and complemented strains. Conidiation was significantly reduced in the Pe∆velB strain. Under light conditions, the Pe∆velB strain showed a reduced level of spore viability. Deletion of the velB gene strongly inhibited the production of patulin, citrinin, and chaetoglobosin A on synthetic media or in planta, but increased the production of fumarylalanine; these changes were associated with down-regulation or upregulation of the genes involved in their respective biosynthesis. Analysis of the global secondary metabolism of the Pe∆velB strain revealed that 22 backbone genes were modulated. In addition, genes involved in siderophore biosynthesis, ergosterol biosynthesis, and nitrate assimilation were also upregulated in the PeΔvelB strain. Taken together, our results demonstrate that VelB is involved in the development, pathogenicity, and secondary metabolism of P. expansum.
    Keywords Penicillium expansum ; biosynthesis ; citrinin ; conidiation ; ergosterol ; genes ; molds (fungi) ; mutants ; nitrates ; pathogenicity ; patulin ; secondary metabolites ; siderophores ; spores ; technology ; transcription factors ; viability
    Language English
    Dates of publication 2022-0920
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 1082798-5
    ISSN 1873-2356 ; 0925-5214
    ISSN (online) 1873-2356
    ISSN 0925-5214
    DOI 10.1016/j.postharvbio.2022.112121
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5311: Show issues

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  3. Article ; Online: Mutagenicity and genotoxicity assessment of the emerging mycotoxin Versicolorin A, an Aflatoxin B1 precursor.

    Al-Ayoubi, Carine / Alonso-Jauregui, Maria / Azqueta, Amaya / Vignard, Julien / Mirey, Gladys / Rocher, Ophelie / Puel, Olivier / Oswald, Isabelle P / Vettorazzi, Ariane / Soler, Laura

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 335, Page(s) 122276

    Abstract: Aflatoxin B1 (AFB1) is the most potent natural carcinogen among mycotoxins. Versicolorin A (VerA) is a precursor of AFB1 biosynthesis and is structurally related to the latter. Although VerA has already been identified as a genotoxin, data on the ... ...

    Abstract Aflatoxin B1 (AFB1) is the most potent natural carcinogen among mycotoxins. Versicolorin A (VerA) is a precursor of AFB1 biosynthesis and is structurally related to the latter. Although VerA has already been identified as a genotoxin, data on the toxicity of VerA are still scarce, especially at low concentrations. The SOS/umu and miniaturised version of the Ames test in Salmonella Typhimurium strains used in the present study shows that VerA induces point mutations. This effect, like AFB1, depends primarily on metabolic activation of VerA. VerA also induced chromosomal damage in metabolically competent intestinal cells (IPEC-1) detected by the micronucleus assay. Furthermore, results from the standard and enzyme-modified comet assay confirmed the VerA-mediated DNA damage, and we observed that DNA repair pathways were activated upon exposure to VerA, as indicated by the phosphorylation and/or relocation of relevant DNA-repair biomarkers (γH2AX and 53BP1/FANCD2, respectively). In conclusion, VerA induces DNA damage without affecting cell viability at concentrations as low as 0.03 μM, highlighting the danger associated with VerA exposure and calling for more research on the carcinogenicity of this emerging food contaminant.
    MeSH term(s) Mycotoxins/toxicity ; Aflatoxin B1/toxicity ; Mutagens/toxicity ; DNA Damage ; Mutagenicity Tests/methods
    Chemical Substances Mycotoxins ; Aflatoxin B1 (9N2N2Y55MH) ; Mutagens ; versicolorin A (DU1M9U6126)
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The

    Zetina-Serrano, Chrystian / Rocher, Ophélie / Naylies, Claire / Lippi, Yannick / Oswald, Isabelle P / Lorber, Sophie / Puel, Olivier

    International journal of molecular sciences

    2020  Volume 21, Issue 18

    Abstract: Dissemination and survival of ascomycetes is through asexual spores. ... ...

    Abstract Dissemination and survival of ascomycetes is through asexual spores. The
    MeSH term(s) Biosynthetic Pathways/genetics ; Fruit/microbiology ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Deletion ; Gene Expression Regulation, Fungal/genetics ; Genes, Fungal/genetics ; Indole Alkaloids/metabolism ; Malus/microbiology ; Metabolome/genetics ; Multigene Family/genetics ; Patulin/biosynthesis ; Patulin/genetics ; Patulin/metabolism ; Penicillium/genetics ; Penicillium/metabolism ; Transcriptome/genetics ; Up-Regulation/genetics
    Chemical Substances Fungal Proteins ; Indole Alkaloids ; chaetoglobosins (50335-03-0) ; Patulin (95X2BV4W8R)
    Language English
    Publishing date 2020-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21186660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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