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  1. Article ; Online: Bisphenol A and human health: a review of the literature.

    Rochester, Johanna R

    Reproductive toxicology (Elmsford, N.Y.)

    2013  Volume 42, Page(s) 132–155

    Abstract: There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. Until recently, there were relatively few epidemiological studies examining the ... ...

    Abstract There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. Until recently, there were relatively few epidemiological studies examining the relationship between BPA and health effects in humans. However, in the last year, the number of these studies has more than doubled. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This review outlines this body of literature, showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic disease, and other health effects. These studies encompass both prenatal and postnatal exposures, and include several study designs and population types. While it is difficult to make causal links with epidemiological studies, the growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental BPA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.
    MeSH term(s) Animals ; Benzhydryl Compounds/toxicity ; Endocrine Disruptors/toxicity ; Humans ; Metabolic Diseases/chemically induced ; Phenols/toxicity ; Reproduction/drug effects
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2013.08.008
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  2. Article ; Online: Prenatal exposure to bisphenol A and hyperactivity in children: a systematic review and meta-analysis.

    Rochester, Johanna R / Bolden, Ashley L / Kwiatkowski, Carol F

    Environment international

    2018  Volume 114, Page(s) 343–356

    Abstract: Background: Attention-deficit hyperactivity disorder (ADHD) has increased in prevalence in the past decade. Studies attempting to identify a specific genetic component have not been able to account for much of the heritability of ADHD, indicating there ... ...

    Abstract Background: Attention-deficit hyperactivity disorder (ADHD) has increased in prevalence in the past decade. Studies attempting to identify a specific genetic component have not been able to account for much of the heritability of ADHD, indicating there may be gene-environment interactions underlying the disorder, including early exposure to environmental chemicals. Based on several relevant studies, we chose to examine bisphenol A (BPA) as a possible contributor to ADHD in humans. BPA is a widespread environmental chemical that has been shown to disrupt neurodevelopment in rodents and humans.
    Objectives: Using the Office of Health Assessment and Translation (OHAT) framework, a systematic review and meta-analysis was designed to determine the relationship between early life exposure to BPA and hyperactivity, a key diagnostic criterion of ADHD.
    Data sources: Searches of PubMed, Web of Science, and Toxline were completed for all literature to January 1, 2017.
    Study eligibility criteria: For inclusion, the studies had to publish original data, be in the English language, include a measure of BPA exposure, and assess if BPA exposure affected hyperactive behaviors in mice, rats or humans. Exposure to BPA had to occur at <3 months of age for humans, up to postnatal day 35 for rats and up to postnatal day 40 for mice. Exposure could occur either gestationally (via maternal exposure) or directly to the offspring.
    Study appraisal and synthesis methods: Studies were evaluated using the OHAT risk of bias tool. The effects in humans were assessed qualitatively. For rodents exposed to 20 μg/kg/day BPA, we evaluated the study findings in a random effects meta-analytical model.
    Results: A review of the literature identified 29 rodent and 3 human studies. A random effects meta-analysis showed significantly increased hyperactivity in male rodents. In humans, early BPA exposure was associated with hyperactivity in boys and girls.
    Limitations, conclusions, and implications of key findings: We concluded that early life BPA exposure is a presumed human hazard for the development of hyperactivity. Possible limitations of this systematic review include deficiencies in author reporting, exclusion of some literature based on language, and insufficient similarity between human studies. SRs that result in hazard-based conclusions are the first step in assessing and mitigating risks. Given the widespread exposure of BPA and increasing diagnoses of ADHD, we recommend immediate actions to complete such risk analyses and take next steps for the protection of human health. In the meantime, precautionary measures should be taken to reduce exposure in pregnant women, infants and children. The present analysis also discusses potential mechanisms by which BPA affects hyperactivity, and the most effective avenues for future research.
    Systematic review registration number: Not available.
    MeSH term(s) Animals ; Benzhydryl Compounds/analysis ; Benzhydryl Compounds/toxicity ; Female ; Humans ; Maternal Exposure ; Mice ; Phenols/analysis ; Phenols/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats
    Chemical Substances Benzhydryl Compounds ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2018-03-07
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2017.12.028
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  3. Article ; Online: Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes.

    Rochester, Johanna R / Bolden, Ashley L

    Environmental health perspectives

    2015  Volume 123, Issue 7, Page(s) 643–650

    Abstract: Background: Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some of the chemical replacements, ... ...

    Abstract Background: Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some of the chemical replacements, however, are also bisphenols and may have similar physiological effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA substitutes.
    Objectives: This review was carried out to evaluate the physiological effects and endocrine activities of the BPA substitutes BPS and BPF. Further, we compared the hormonal potency of BPS and BPF to that of BPA.
    Methods: We conducted a systematic review based on the Office of Health Assessment and Translation (OHAT) protocol.
    Results: We identified the body of literature to date, consisting of 32 studies (25 in vitro only, and 7 in vivo). The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo. BPS also has potencies similar to that of estradiol in membrane-mediated pathways, which are important for cellular actions such as proliferation, differentiation, and death. BPS and BPF also showed other effects in vitro and in vivo, such as altered organ weights, reproductive end points, and enzyme expression.
    Conclusions: Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects.
    Citation: Rochester JR, Bolden AL. 2015. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes.
    MeSH term(s) Animals ; Benzhydryl Compounds/toxicity ; Endocrine Disruptors/toxicity ; Humans ; Phenols/toxicity ; Sulfones/toxicity
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; Sulfones ; bis(4-hydroxyphenyl)sulfone (80-09-1) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/ehp.1408989
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  4. Article ; Online: Standardizing Extracted Data Using Automated Application of Controlled Vocabularies.

    Foster, Caroline / Wignall, Jessica / Kovach, Samuel / Choksi, Neepa / Allen, Dave / Trgovcich, Joanne / Rochester, Johanna R / Ceger, Patricia / Daniel, Amber / Hamm, Jon / Truax, Jim / Blake, Bevin / McIntyre, Barry / Sutherland, Vicki / Stout, Matthew D / Kleinstreuer, Nicole

    Environmental health perspectives

    2024  Volume 132, Issue 2, Page(s) 27006

    Abstract: Background: Extraction of toxicological end points from primary sources is a central component of systematic reviews and human health risk assessments. To ensure optimal use of these data, consistent language should be used for end point descriptions. ... ...

    Abstract Background: Extraction of toxicological end points from primary sources is a central component of systematic reviews and human health risk assessments. To ensure optimal use of these data, consistent language should be used for end point descriptions. However, primary source language describing treatment-related end points can vary greatly, resulting in large labor efforts to manually standardize extractions before data are fit for use.
    Objectives: To minimize these labor efforts, we applied an augmented intelligence approach and developed automated tools to support standardization of extracted information via application of preexisting controlled vocabularies.
    Methods: We created and applied a harmonized controlled vocabulary crosswalk, consisting of Unified Medical Language System (UMLS) codes, German Federal Institute for Risk Assessment (BfR) DevTox harmonized terms, and The Organization for Economic Co-operation and Development (OECD) end point vocabularies, to roughly 34,000 extractions from prenatal developmental toxicology studies conducted by the National Toxicology Program (NTP) and 6,400 extractions from European Chemicals Agency (ECHA) prenatal developmental toxicology studies, all recorded based on the original study report language.
    Results: We automatically applied standardized controlled vocabulary terms to 75% of the NTP extracted end points and 57% of the ECHA extracted end points. Of all the standardized extracted end points, about half (51%) required manual review for potential extraneous matches or inaccuracies. Extracted end points that were not mapped to standardized terms tended to be too general or required human logic to find a good match. We estimate that this augmented intelligence approach saved
    Discussion: Augmenting manual efforts with automation tools increased the efficiency of producing a findable, accessible, interoperable, and reusable (FAIR) dataset of regulatory guideline studies. This open-source approach can be readily applied to other legacy developmental toxicology datasets, and the code design is customizable for other study types. https://doi.org/10.1289/EHP13215.
    MeSH term(s) Humans ; Female ; Pregnancy ; Systematic Reviews as Topic ; Vocabulary, Controlled ; Household Articles ; Intelligence ; Research Design
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP13215
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  5. Article ; Online: Melamine, beyond the kidney: A ubiquitous endocrine disruptor and neurotoxicant?

    Bolden, Ashley L / Rochester, Johanna R / Kwiatkowski, Carol F

    Toxicology letters

    2017  Volume 280, Page(s) 181–189

    Abstract: Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, ... ...

    Abstract Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and pets. This resulted in a large amount of published primary studies and reviews of the impacts of melamine exposure on kidney function. However, a growing body of literature suggests that melamine may have impacts beyond renal dysfunction. We conducted a scoping review of this literature which yielded more than 40 studies with human, animal, and in vitro findings. Neurological impacts, reproductive function, and anthropometric outcomes were identified as possible candidates for systematic review based on evidence stream and replication of endpoints. The results of this analysis provide a basis for prioritizing future research on health impacts associated with melamine exposure.
    MeSH term(s) Animals ; Endocrine Disruptors/toxicity ; Food Contamination ; Kidney Diseases/chemically induced ; Neurotoxicity Syndromes ; Triazines/toxicity
    Chemical Substances Endocrine Disruptors ; Triazines ; melamine (N3GP2YSD88)
    Language English
    Publishing date 2017-10-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2017.07.893
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  6. Article: Prenatal exposure to bisphenol A and hyperactivity in children: a systematic review and meta-analysis

    Rochester, Johanna R / Ashley L. Bolden / Carol F. Kwiatkowski

    Environment international. 2018 May, v. 114

    2018  

    Abstract: Attention-deficit hyperactivity disorder (ADHD) has increased in prevalence in the past decade. Studies attempting to identify a specific genetic component have not been able to account for much of the heritability of ADHD, indicating there may be gene- ... ...

    Abstract Attention-deficit hyperactivity disorder (ADHD) has increased in prevalence in the past decade. Studies attempting to identify a specific genetic component have not been able to account for much of the heritability of ADHD, indicating there may be gene-environment interactions underlying the disorder, including early exposure to environmental chemicals. Based on several relevant studies, we chose to examine bisphenol A (BPA) as a possible contributor to ADHD in humans. BPA is a widespread environmental chemical that has been shown to disrupt neurodevelopment in rodents and humans.Using the Office of Health Assessment and Translation (OHAT) framework, a systematic review and meta-analysis was designed to determine the relationship between early life exposure to BPA and hyperactivity, a key diagnostic criterion of ADHD.Searches of PubMed, Web of Science, and Toxline were completed for all literature to January 1, 2017.For inclusion, the studies had to publish original data, be in the English language, include a measure of BPA exposure, and assess if BPA exposure affected hyperactive behaviors in mice, rats or humans. Exposure to BPA had to occur at <3 months of age for humans, up to postnatal day 35 for rats and up to postnatal day 40 for mice. Exposure could occur either gestationally (via maternal exposure) or directly to the offspring.Studies were evaluated using the OHAT risk of bias tool. The effects in humans were assessed qualitatively. For rodents exposed to 20 μg/kg/day BPA, we evaluated the study findings in a random effects meta-analytical model.A review of the literature identified 29 rodent and 3 human studies. A random effects meta-analysis showed significantly increased hyperactivity in male rodents. In humans, early BPA exposure was associated with hyperactivity in boys and girls.We concluded that early life BPA exposure is a presumed human hazard for the development of hyperactivity. Possible limitations of this systematic review include deficiencies in author reporting, exclusion of some literature based on language, and insufficient similarity between human studies. SRs that result in hazard-based conclusions are the first step in assessing and mitigating risks. Given the widespread exposure of BPA and increasing diagnoses of ADHD, we recommend immediate actions to complete such risk analyses and take next steps for the protection of human health. In the meantime, precautionary measures should be taken to reduce exposure in pregnant women, infants and children. The present analysis also discusses potential mechanisms by which BPA affects hyperactivity, and the most effective avenues for future research.Not available.
    Keywords bisphenol A ; boys ; children ; health effects assessments ; heritability ; humans ; infants ; males ; maternal exposure ; meta-analysis ; mice ; neurodevelopment ; pregnant women ; rats ; risk ; risk analysis ; systematic review
    Language English
    Dates of publication 2018-05
    Size p. 343-356.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2017.12.028
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  7. Article: Potential Developmental and Reproductive Impacts of Triclocarban: A Scoping Review.

    Rochester, Johanna R / Bolden, Ashley L / Pelch, Katherine E / Kwiatkowski, Carol F

    Journal of toxicology

    2017  Volume 2017, Page(s) 9679738

    Abstract: Triclocarban (TCC) is an antimicrobial agent used in personal care products. Although frequently studied with another antimicrobial, triclosan, it is not as well researched, and there are very few reviews of the biological activity of TCC. TCC has been ... ...

    Abstract Triclocarban (TCC) is an antimicrobial agent used in personal care products. Although frequently studied with another antimicrobial, triclosan, it is not as well researched, and there are very few reviews of the biological activity of TCC. TCC has been shown to be a possible endocrine disruptor, acting by enhancing the activity of endogenous hormones. TCC has been banned in the US for certain applications; however, many human populations, in and outside the US, exhibit exposure to TCC. Because of the concern of the health effects of TCC, we conducted a scoping review in order to map the current body of literature on the endocrine, reproductive, and developmental effects of TCC. The aim of this scoping review was to identify possible endpoints for future systematic review and to make recommendations for future research. A search of the literature until August 2017 yielded 32 relevant studies in humans, rodents, fish, invertebrates, and
    Language English
    Publishing date 2017-11-23
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2495098-1
    ISSN 1687-8205 ; 1687-8191
    ISSN (online) 1687-8205
    ISSN 1687-8191
    DOI 10.1155/2017/9679738
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  8. Article ; Online: Polycyclic aromatic hydrocarbons and female reproductive health: A scoping review.

    Bolden, Ashley L / Rochester, Johanna R / Schultz, Kim / Kwiatkowski, Carol F

    Reproductive toxicology (Elmsford, N.Y.)

    2017  Volume 73, Page(s) 61–74

    Abstract: Polycyclic aromatic hydrocarbons (PAHs) are a class of common persistent environmental pollutants found in water, air, soil, and plants and can be released by natural sources. However, the majority of atmospheric PAHs are from vehicular emissions, coal- ... ...

    Abstract Polycyclic aromatic hydrocarbons (PAHs) are a class of common persistent environmental pollutants found in water, air, soil, and plants and can be released by natural sources. However, the majority of atmospheric PAHs are from vehicular emissions, coal-burning plants, and the production and use of petroleum-derived substances. Exposure to PAHs has been implicated in cancer and other diseases, including reproductive disorders. This scoping review is a preliminary step that explores the utility and feasibility of completing a systematic review evaluating the effect of PAHs on female reproduction. We performed literature searches in PubMed, Web of Science, and Scopus, then screened, identified, and categorized relevant studies. Our results identified fertility and pregnancy/fetal viability as outcomes with sufficient research for systematic review. In addition to presenting the relevant studies, the review identifies data gaps, and provides the groundwork to develop the most appropriate research questions for systematic review.
    MeSH term(s) Animals ; Environmental Pollutants/toxicity ; Female ; Fertility/drug effects ; Humans ; Polycyclic Aromatic Hydrocarbons/toxicity ; Pregnancy ; Reproduction/drug effects ; Reproductive Health
    Chemical Substances Environmental Pollutants ; Polycyclic Aromatic Hydrocarbons
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2017.07.012
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  9. Article ; Online: Phytoestrogens and avian reproduction: Exploring the evolution and function of phytoestrogens and possible role of plant compounds in the breeding ecology of wild birds.

    Rochester, Johanna R / Millam, James R

    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

    2009  Volume 154, Issue 3, Page(s) 279–288

    Abstract: Phytoestrogens are secondary plant compounds, which can act to mimic estrogen and cause the disruption of estrogenic responses in organisms. Although there is a substantial body of research studying phytoestrogens, including their mechanisms of ... ...

    Abstract Phytoestrogens are secondary plant compounds, which can act to mimic estrogen and cause the disruption of estrogenic responses in organisms. Although there is a substantial body of research studying phytoestrogens, including their mechanisms of estrogenic effects, evolution, and detection in biological systems, little is known about their ecological significance. There is evidence, however, that an ecological relationship involving phytoestrogens exists between plants and animals-plants may produce phytoestrogens to reduce fecundity of organisms that eat them. Birds and other vertebrates may also exploit phytoestrogens to regulate their own reproduction-there are well known examples of phytoestrogens inhibiting reproduction in higher vertebrates, including birds. Also, common plant stressors (e.g., high temperature) increase the production of secondary plant compounds, and, as evidence suggests, also induce phytoestrogen biosynthesis. These observations are consistent with the single study ever done on phytoestrogens and reproduction in wild birds [Leopold, A.S., Erwin, M., Oh, J., Browning, B., 1976. Phytoestrogens adverse effects on reproduction in California quail. Science 191, 98-100.], which found that drought stress correlated with increased levels of phytoestrogens in plants, and that increased phytoestrogen levels correlated with decreased young. This review discusses the hypothesis that plants may have an effect on the reproduction of avian species by producing phytoestrogens as a plant defense against herbivory, and that birds may "use" changing levels of phytoestrogens in the vegetation to ensure that food resources will support potential young produced. Evidence from our laboratory and others appear to support this hypothesis.
    MeSH term(s) Animal Feed ; Animals ; Animals, Wild ; Biological Evolution ; Birds/physiology ; Ecology ; Egg Shell/drug effects ; Endocrine Disruptors/pharmacology ; Isoflavones/metabolism ; Lignans/metabolism ; Phenols/metabolism ; Phytoestrogens/pharmacology ; Plants/genetics ; Plants/metabolism ; Receptors, Estrogen/metabolism ; Reproduction/drug effects ; Selective Estrogen Receptor Modulators/pharmacology ; Stilbenes/metabolism
    Chemical Substances Endocrine Disruptors ; Isoflavones ; Lignans ; Phenols ; Phytoestrogens ; Receptors, Estrogen ; Selective Estrogen Receptor Modulators ; Stilbenes
    Language English
    Publishing date 2009-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2009.06.017
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  10. Article ; Online: Twenty-Five Years of Endocrine Disruption Science: Remembering Theo Colborn.

    Kwiatkowski, Carol F / Bolden, Ashley L / Liroff, Richard A / Rochester, Johanna R / Vandenbergh, John G

    Environmental health perspectives

    2016  Volume 124, Issue 9, Page(s) A151–4

    MeSH term(s) Animals ; Endocrine Disruptors/history ; Endocrine Disruptors/toxicity ; Environmental Health/history ; History, 20th Century ; History, 21st Century ; Humans ; National Institute of Environmental Health Sciences (U.S.) ; United States
    Chemical Substances Endocrine Disruptors
    Language English
    Publishing date 2016-08-11
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP746
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