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Article ; Online: A structural foundation for studying chlamydial polymorphic membrane proteins.

Debrine, Abigail M / Karplus, P Andrew / Rockey, Daniel D

2023 Volume 11, Issue 6, Page(s) e0324223

Abstract: Importance: Infections by bacteria in the ... ...

Abstract	Importance: Infections by bacteria in the genus
MeSH term(s)	Animals ; Humans ; Membrane Proteins/metabolism ; Chlamydia Infections ; Chlamydia trachomatis/metabolism
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03242-23
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Article ; Online: Metabolic dormancy in

Rockey, Daniel D / Wang, Xisheng / Debrine, Abigail / Grieshaber, Nicole / Grieshaber, Scott S

Infection and immunity

2024 Volume 92, Issue 2, Page(s) e0033923

Abstract: Diseases caused ... ...

Abstract	Diseases caused by
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Chlamydia trachomatis ; Chlamydia Infections/drug therapy ; Chlamydia Infections/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/iai.00339-23
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Article ; Online: The Impact of Lateral Gene Transfer in

Marti, Hanna / Suchland, Robert J / Rockey, Daniel D

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 861899

Abstract: Lateral gene transfer (LGT) facilitates many processes in bacterial ecology and pathogenesis, especially regarding pathogen evolution and the spread of antibiotic resistance across species. The obligate intracellular chlamydiae, which cause a range of ... ...

Abstract	Lateral gene transfer (LGT) facilitates many processes in bacterial ecology and pathogenesis, especially regarding pathogen evolution and the spread of antibiotic resistance across species. The obligate intracellular chlamydiae, which cause a range of diseases in humans and animals, were historically thought to be highly deficient in this process. However, research over the past few decades has demonstrated that this was not the case. The first reports of homologous recombination in the
MeSH term(s)	Animals ; Chlamydia/genetics ; Chlamydia trachomatis/genetics ; Gene Transfer, Horizontal ; Tetracycline Resistance/genetics
Language	English
Publishing date	2022-03-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.861899
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Article ; Online: Chlamydia

Wang, Xisheng / Rockey, Daniel D / Dolan, Brian P

Infection and immunity

2020 Volume 88, Issue 8

Abstract: ... ...

Abstract	Chlamydia
MeSH term(s)	Adaptive Immunity/drug effects ; Animals ; Apoptosis/drug effects ; Apoptosis/immunology ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; B-Lymphocytes/microbiology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Cell Line, Transformed ; Chlamydia Infections/genetics ; Chlamydia Infections/immunology ; Chlamydia Infections/microbiology ; Chlamydia Infections/pathology ; Chlamydia trachomatis/immunology ; Chlamydia trachomatis/pathogenicity ; Dendritic Cells/cytology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Enzyme Inhibitors/pharmacology ; Escherichia coli/chemistry ; Gene Expression ; HeLa Cells ; Humans ; Immune Evasion ; Immunity, Innate/drug effects ; Lipopolysaccharides/immunology ; Lipopolysaccharides/pharmacology ; Mice, Inbred C57BL ; Mice, Transgenic ; Species Specificity ; Staurosporine/pharmacology ; Survivin/genetics ; Survivin/immunology
Chemical Substances	Birc5 protein, mouse ; Enzyme Inhibitors ; Lipopolysaccharides ; Survivin ; Staurosporine (H88EPA0A3N)
Language	English
Publishing date	2020-07-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00198-20
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Article ; Online: Microscopic Analysis of the Chlamydia abortus Inclusion and Its Interaction with Those Formed by Other Chlamydial Species.

Garvin, Lotisha E / DeBoer, Addison G / Carrell, Steven J / Wang, Xisheng / Rockey, Daniel D

Infection and immunity

2022 Volume 90, Issue 3, Page(s) e0049921

Abstract: The Chlamydiae are obligate intracellular pathogens that develop and multiply within a poorly characterized parasitophorous vacuole (the inclusion) during growth. Chlamydia abortus is a major pathogen of sheep and other ruminants, and its inclusion ... ...

Abstract	The Chlamydiae are obligate intracellular pathogens that develop and multiply within a poorly characterized parasitophorous vacuole (the inclusion) during growth. Chlamydia abortus is a major pathogen of sheep and other ruminants, and its inclusion development is poorly characterized. We used immunofluorescence microscopy, quantitative culture, and qPCR to examine C. abortus inclusion development and to examine the interaction of C. abortus inclusions with those formed by other species. Antibodies used in these studies include sera from ewes from production facilities that were naturally infected with C. abortus. Multiple inclusions are often found in
MeSH term(s)	Animals ; Chlamydia/genetics ; Chlamydia Infections/veterinary ; Chlamydia trachomatis/genetics ; Female ; HeLa Cells ; Humans ; Inclusion Bodies ; Sheep
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00499-21
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Article ; Online: Aeromonas salmonicida, causative agent of salmonid furunculosis, isolated from the freshwater parasitic copepod, Salmincola californiensis.

Herron, Crystal L / Ruse, Natassia E / Rockey, Daniel D / Sanders, Justin L / Peterson, James T / Schreck, Carl B / Kent, Michael L

Journal of fish diseases

2023 Volume 47, Issue 2, Page(s) e13885

Abstract: Here, we provide evidence that the freshwater parasitic copepod, Salmincola californiensis, acts as a vector for Aeromonas salmonicida. While investigating the effects of S. californiensis on Chinoook salmon (Oncorhynchus tshawytscha), we tangentially ... ...

Abstract	Here, we provide evidence that the freshwater parasitic copepod, Salmincola californiensis, acts as a vector for Aeromonas salmonicida. While investigating the effects of S. californiensis on Chinoook salmon (Oncorhynchus tshawytscha), we tangentially observed that fish infected with the copepod developed furunculosis, caused by A. salmonicida. This occurred despite being reared in pathogen-free well water in a research facility with no prior history of spontaneous infection. We further investigated the possibility of S. californiensis to serve as a vector for the bacterium via detection of fluorescently labelled A. salmonicida inside the egg sacs from copepods in which the fish hosts were experimentally infected with GFP-A449 A. salmonicida. We then evaluated copepod egg sacs that were collected from adult Chinook salmon from a freshwater hatchery with A. salmonicida infections confirmed by either culture or PCR. The bacterium was cultured on tryptic soy agar plates from 75% of the egg sacs, and 61% were positive by PCR. These three separate experiments indicate an alternative tactic of transmission in addition to direct transmission of A. salmonicida in captivity. The copepod may play an important role in transmission of the bacterium when fish are more dispersed, such as in the wild.
MeSH term(s)	Animals ; Furunculosis/microbiology ; Salmonidae ; Aeromonas salmonicida ; Copepoda ; Fish Diseases/microbiology ; Salmon/microbiology ; Fresh Water ; Gram-Negative Bacterial Infections/veterinary ; Gram-Negative Bacterial Infections/microbiology ; Aeromonas
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	432109-1
ISSN	1365-2761 ; 0140-7775
ISSN (online)	1365-2761
ISSN	0140-7775
DOI	10.1111/jfd.13885
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Article ; Online: Unraveling the basic biology and clinical significance of the chlamydial plasmid.

Rockey, Daniel D

The Journal of experimental medicine

2011 Volume 208, Issue 11, Page(s) 2159–2162

Abstract: Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding ... ...

Abstract	Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding chlamydial plasmid participation in host-microbe interactions, disease, and immune responses. Work in mouse model systems and, very recently, in nonhuman primates demonstrates that plasmid-deficient chlamydial strains function as live attenuated vaccines against genital and ocular infections. Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections.
MeSH term(s)	Animals ; Chlamydia Infections/genetics ; Chlamydia Infections/prevention & control ; Chlamydia trachomatis/genetics ; Chlamydia trachomatis/pathogenicity ; DNA, Bacterial ; Humans ; Plasmids/genetics ; Vaccines, Attenuated/genetics
Chemical Substances	DNA, Bacterial ; Vaccines, Attenuated
Language	English
Publishing date	2011-10-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20112088
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Article ; Online: Genomic Analysis of MSM Rectal Chlamydia trachomatis Isolates Identifies Predicted Tissue-Tropic Lineages Generated by Intraspecies Lateral Gene Transfer-Mediated Evolution.

Suchland, Robert J / Carrell, Steven J / Ramsey, Stephen A / Hybiske, Kevin / Debrine, Abigail M / Sanchez, Jorge / Celum, Connie / Rockey, Daniel D

Infection and immunity

2022 Volume 90, Issue 11, Page(s) e0026522

Abstract: Chlamydia trachomatis is an obligate intracellular bacterium that causes serious diseases in humans. Rectal infection and disease caused by this pathogen are important yet understudied aspects of C. trachomatis natural history. The University of ... ...

Abstract	Chlamydia trachomatis is an obligate intracellular bacterium that causes serious diseases in humans. Rectal infection and disease caused by this pathogen are important yet understudied aspects of C. trachomatis natural history. The University of Washington Chlamydia Repository has a large collection of male-rectal-sourced strains (MSM rectal strains) isolated in Seattle, USA and Lima, Peru. Initial characterization of strains collected over 30 years in both Seattle and Lima led to an association of serovars G and J with male rectal infections. Serovar D, E, and F strains were also collected from MSM patients. Genome sequence analysis of a subset of MSM rectal strains identified a clade of serovar G and J strains that had high overall genomic identity. A genome-wide association study was then used to identify genomic loci that were correlated with tissue tropism in a collection of serovar-matched male rectal and female cervical strains. The polymorphic membrane protein PmpE had the strongest correlation, and amino acid sequence alignments identified a set of PmpE variable regions (VRs) that were correlated with host or tissue tropism. Examination of the positions of VRs by the protein structure-predicting Alphafold2 algorithm demonstrated that the VRs were often present in predicted surface-exposed loops in both PmpE and PmpH protein structure. Collectively, these studies identify possible tropism-predictive loci for MSM rectal C. trachomatis infections and identify predicted surface-exposed variable regions of Pmp proteins that may function in MSM rectal versus cervical tropism differences.
MeSH term(s)	Humans ; Male ; Chlamydia Infections/microbiology ; Chlamydia trachomatis/genetics ; Gene Transfer, Horizontal ; Genome-Wide Association Study ; Genomics ; Homosexuality, Male
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/iai.00265-22
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Article ; Online: Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011.

Cram, Erik D / Rockey, Daniel D / Dolan, Brian P

BMC microbiology

2017 Volume 17, Issue 1, Page(s) 98

Abstract: Background: Chlamydia species are obligate intracellular bacteria that infect a broad range of mammalian hosts. Members of related genera are pathogens of a variety of vertebrate and invertebrate species. Despite the diversity of Chlamydia, all species ... ...

Abstract	Background: Chlamydia species are obligate intracellular bacteria that infect a broad range of mammalian hosts. Members of related genera are pathogens of a variety of vertebrate and invertebrate species. Despite the diversity of Chlamydia, all species contain an outer membrane lipooligosaccharide (LOS) that is comprised of a genus-conserved, and genus-defining, trisaccharide 3-deoxy-D-manno-oct-2-ulosonic acid Kdo region. Recent studies with lipopolysaccharide inhibitors demonstrate that LOS is important for the C. trachomatis developmental cycle during RB- > EB differentiation. Here, we explore the effects of one of these inhibitors, LPC-011, on the developmental cycle of five chlamydial species. Results: Sensitivity to the drug varied in some of the species and was conserved between others. We observed that inhibition of LOS biosynthesis in some chlamydial species induced formation of aberrant reticulate bodies, while in other species, no change was observed to the reticulate body. However, loss of LOS production prevented completion of the chlamydial reproductive cycle in all species tested. In previous studies we found that C. trachomatis and C. caviae infection enhances MHC class I antigen presentation of a model self-peptide. We find that treatment with LPC-011 prevents enhanced host-peptide presentation induced by infection with all chlamydial-species tested. Conclusions: The data demonstrate that LOS synthesis is necessary for production of infectious progeny and inhibition of LOS synthesis induces aberrancy in certain chlamydial species, which has important implications for the use of LOS synthesis inhibitors as potential antibiotics.
MeSH term(s)	Amino Acid Sequence ; Ampicillin/pharmacology ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/drug effects ; Bacterial Proteins/genetics ; Cell Line/drug effects ; Cell Line/microbiology ; Chlamydia/drug effects ; Chlamydia/genetics ; Chlamydia/growth & development ; Chlamydia/pathogenicity ; Chlamydia Infections/drug therapy ; Cytoplasm/microbiology ; Fibroblasts ; Gene Expression Regulation, Bacterial/drug effects ; Host-Pathogen Interactions ; Humans ; Hydroxamic Acids/administration & dosage ; Hydroxamic Acids/antagonists & inhibitors ; Lipopolysaccharides/biosynthesis ; Mice ; Microbial Sensitivity Tests ; Phenotype ; Phylogeny ; Protein Biosynthesis/drug effects ; Sequence Alignment ; Sequence Analysis, Protein ; Sugar Acids ; Threonine/administration & dosage ; Threonine/analogs & derivatives ; Threonine/antagonists & inhibitors
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Hydroxamic Acids ; LPC-011 ; Lipopolysaccharides ; Sugar Acids ; lipid-linked oligosaccharides ; 2-keto-3-deoxyoctonate (1069-03-0) ; Threonine (2ZD004190S) ; Ampicillin (7C782967RD)
Language	English
Publishing date	2017-04-24
Publishing country	England
Document type	Journal Article
ISSN	1471-2180
ISSN (online)	1471-2180
DOI	10.1186/s12866-017-0992-8
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Article ; Online: TargeTron Inactivation of Chlamydia trachomatis

DeBoer, Addison G / Lei, Lei / Yang, Chunfu / Martens, Craig A / Anzick, Sarah L / Antonioli-Schmit, Sophia / Suchland, Robert J / McClarty, Grant / Caldwell, Harlan D / Rockey, Daniel D

Infection and immunity

2023 Volume 91, Issue 7, Page(s) e0009623

Abstract: All members of the family Chlamydiaceae have lipopolysaccharides (LPS) that possess a shared carbohydrate trisaccharide antigen, 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) that is functionally uncharacterized. A single gene, genus-specific epitope ( ...

Abstract	All members of the family Chlamydiaceae have lipopolysaccharides (LPS) that possess a shared carbohydrate trisaccharide antigen, 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) that is functionally uncharacterized. A single gene, genus-specific epitope (
MeSH term(s)	Lipopolysaccharides/metabolism ; Chlamydia trachomatis ; Carbohydrate Sequence ; Epitopes ; Sugar Acids ; Antibodies, Monoclonal
Chemical Substances	Lipopolysaccharides ; 2-keto-3-deoxyoctonate (1069-03-0) ; Epitopes ; Sugar Acids ; Antibodies, Monoclonal
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/iai.00096-23
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