LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 149

Search options

  1. Article ; Online: G protein-coupled receptors: from radioligand binding to cellular signaling.

    Rockman, Howard A / Lefkowitz, Robert J

    The Journal of clinical investigation

    2024  Volume 134, Issue 5

    Abstract: Radioligand binding techniques facilitated the identification and study of G-protein coupled receptors that now represent the largest class of targets for therapeutic drugs. ...

    Abstract Radioligand binding techniques facilitated the identification and study of G-protein coupled receptors that now represent the largest class of targets for therapeutic drugs.
    MeSH term(s) Radioligand Assay/methods ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI178109
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Come sail away.

    Rockman, Howard A

    JCI insight

    2019  Volume 4, Issue 15

    Language English
    Publishing date 2019-08-08
    Publishing country United States
    Document type Editorial
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.131371
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: We're listening.

    Rockman, Howard A

    JCI insight

    2018  Volume 3, Issue 2

    MeSH term(s) Biomedical Research/methods ; Peer Review, Research ; Societies, Scientific
    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Editorial
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.99456
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: לְדוֹר וָדוֹר.

    Rockman, Howard A

    The Journal of clinical investigation

    2017  Volume 127, Issue 6, Page(s) 2019–2020

    Abstract: L'dor vador, transliterated from the Hebrew above, is an ancient concept in Judaic scripture meaning "from generation to generation," which is now generally interpreted to mean that we have a responsibility to pass on teachings to future generations. It ... ...

    Abstract L'dor vador, transliterated from the Hebrew above, is an ancient concept in Judaic scripture meaning "from generation to generation," which is now generally interpreted to mean that we have a responsibility to pass on teachings to future generations. It has been 5 years that I have been at the helm of the Duke-UNC Editorial Board of the Journal of Clinical Investigation and have had the privilege of publishing scientific knowledge that will be passed on to generations of future scientists. Now, with the selection of Dr. Gordon Tomaselli as the next editor in chief, I pass on the editorial duties for the JCI to him and his team at Johns Hopkins.
    MeSH term(s) Biomedical Research ; Clinical Medicine ; Editorial Policies ; Journal Impact Factor ; Peer Review, Research
    Language English
    Publishing date 2017-06-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI94813
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: A successful launch.

    Rockman, Howard A

    JCI insight

    2017  Volume 2, Issue 2, Page(s) e92800

    MeSH term(s) Editorial Policies ; Humans ; Open Access Publishing ; Peer Review, Research ; Periodicals as Topic ; Societies, Medical
    Language English
    Publishing date 2017-01-26
    Publishing country United States
    Document type Editorial
    ISSN 2379-3708
    ISSN 2379-3708
    DOI 10.1172/jci.insight.92800
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Pathophysiology and pharmacology of G protein-coupled receptors in the heart.

    Grogan, Alyssa / Lucero, Emilio Y / Jiang, Haoran / Rockman, Howard A

    Cardiovascular research

    2022  Volume 119, Issue 5, Page(s) 1117–1129

    Abstract: G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface receptors, serve as fundamental modulators of cardiac health and disease owing to their key roles in the regulation of heart rate, contractile dynamics, and cardiac ... ...

    Abstract G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface receptors, serve as fundamental modulators of cardiac health and disease owing to their key roles in the regulation of heart rate, contractile dynamics, and cardiac function. Accordingly, GPCRs are heavily pursued as drug targets for a wide variety of cardiovascular diseases ranging from heart failure, cardiomyopathy, and arrhythmia to hypertension and coronary artery disease. Recent advancements in understanding the signalling mechanisms, regulation, and pharmacological properties of GPCRs have provided valuable insights that will guide the development of novel therapeutics. Herein, we review the cellular signalling mechanisms, pathophysiological roles, and pharmacological developments of the major GPCRs in the heart, highlighting the β-adrenergic, muscarinic, and angiotensin receptors as exemplar subfamilies.
    MeSH term(s) Humans ; Receptors, G-Protein-Coupled/metabolism ; Heart ; Signal Transduction ; Receptors, Cell Surface ; Heart Failure/drug therapy
    Chemical Substances Receptors, G-Protein-Coupled ; Receptors, Cell Surface
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac171
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: G protein-coupled receptor signaling: transducers and effectors.

    Jiang, Haoran / Galtes, Daniella / Wang, Jialu / Rockman, Howard A

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 3, Page(s) C731–C748

    Abstract: G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range of physiological functions and in a large number of Food and Drug Administration (FDA)-approved drugs as therapeutic entities. With continued study ... ...

    Abstract G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range of physiological functions and in a large number of Food and Drug Administration (FDA)-approved drugs as therapeutic entities. With continued study of their function and mechanism of action, there is a greater understanding of how effector molecules interact with a receptor to initiate downstream effector signaling. This review aims to explore the signaling pathways, dynamic structures, and physiological relevance in the cardiovascular system of the three most important GPCR signaling effectors: heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. We will first summarize their prominent roles in GPCR pharmacology before transitioning into less well-explored areas. As new technologies are developed and applied to studying GPCR structure and their downstream effectors, there is increasing appreciation for the elegance of the regulatory mechanisms that mediate intracellular signaling and function.
    MeSH term(s) Arrestins/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/physiology ; Transducers ; beta-Arrestins/metabolism
    Chemical Substances Arrestins ; Receptors, G-Protein-Coupled ; beta-Arrestins
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00210.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Proximity labeling for investigating protein-protein interactions.

    Pfeiffer, Conrad T / Paulo, Joao A / Gygi, Steven P / Rockman, Howard A

    Methods in cell biology

    2022  Volume 169, Page(s) 237–266

    Abstract: The study of protein complexes and protein-protein interactions is of great importance due to their fundamental roles in cellular function. Proximity labeling, often coupled with mass spectrometry, has become a powerful and versatile tool for studying ... ...

    Abstract The study of protein complexes and protein-protein interactions is of great importance due to their fundamental roles in cellular function. Proximity labeling, often coupled with mass spectrometry, has become a powerful and versatile tool for studying protein-protein interactions by enriching and identifying proteins in the vicinity of a specified protein-of-interest. Here, we describe and compare traditional approaches to investigate protein-protein interactions to current day state-of-the-art proximity labeling methods. We focus on the wide array of proximity labeling strategies and underscore studies using diverse model systems to address numerous biological questions. In addition, we highlight current advances in mass spectrometry-based technology that exhibit promise in improving the depth and breadth of the data acquired in proximity labeling experiments. In all, we show the diversity of proximity labeling strategies and emphasize the broad range of applications and biological inquiries that can be addressed using this technology.
    MeSH term(s) Mass Spectrometry ; Models, Biological
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2021.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Happy birthday JCI.

    Rockman, Howard A

    The Journal of clinical investigation

    2014  Volume 124, Issue 10, Page(s) 4135–4136

    Abstract: On the occasion of the ninetieth anniversary of the JCI, I am again humbled by the remarkable insight and passion of our pioneering founders when they created the Journal of Clinical Investigation in 1924. ...

    Abstract On the occasion of the ninetieth anniversary of the JCI, I am again humbled by the remarkable insight and passion of our pioneering founders when they created the Journal of Clinical Investigation in 1924.
    MeSH term(s) Biomedical Research/trends ; Editorial Policies ; History, 20th Century ; Humans ; Journalism, Medical/history ; Periodicals as Topic/history
    Language English
    Publishing date 2014-10-01
    Publishing country United States
    Document type Editorial ; Historical Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI78708
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Waste not, want not.

    Rockman, Howard A

    The Journal of clinical investigation

    2014  Volume 124, Issue 2, Page(s) 463

    Abstract: As of the writing of this Editorial, the current JCI Editorial Board has evaluated approximately 7,000 manuscripts over the past 22 months for their suitability for publication in our journal. While many of you have received a negative decision on your ... ...

    Abstract As of the writing of this Editorial, the current JCI Editorial Board has evaluated approximately 7,000 manuscripts over the past 22 months for their suitability for publication in our journal. While many of you have received a negative decision on your manuscript, I suspect few are aware of the changes we have made to our review process to limit reviewers' requests for what is in our view unnecessary and excessive experimentation.
    MeSH term(s) Editorial Policies ; Humans ; Peer Review, Research ; Periodicals as Topic ; Research Design
    Language English
    Publishing date 2014-02-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI75011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top