LIVIVO - Search results -

Search results

Result 1 - 10 of total 21

Search options

Article ; Online: Both naive and memory B cells respond to flu vaccine.

Rodda, Lauren B / Pepper, Marion

2020 Volume 586, Issue 7827, Page(s) 34–35

MeSH term(s)	B-Lymphocytes ; Germinal Center ; Humans ; Influenza Vaccines ; Influenza, Human ; Vaccination
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	News ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-020-02556-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Metabolic constraints on the B cell response to malaria.

Rodda, Lauren B / Pepper, Marion

Nature immunology

2020 Volume 21, Issue 7, Page(s) 722–724

MeSH term(s)	B-Lymphocytes ; Humans ; Immunity, Humoral ; Infections ; Malaria ; Nutrients
Keywords	covid19
Language	English
Publishing date	2020-06-23
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-020-0718-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune-modifying therapies.

Klebanoff, Samuel D / Rodda, Lauren B / Morishima, Chihiro / Wener, Mark H / Yuzefpolskiy, Yevgeniy / Bettelli, Estelle / Buckner, Jane H / Speake, Cate / Pepper, Marion / Campbell, Daniel J

JCI insight

2023 Volume 8, Issue 15

Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes debilitating swelling and destruction of the joints. People with RA are treated with drugs that actively suppress one or more parts of their immune system, and these may ... ...

Abstract	Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes debilitating swelling and destruction of the joints. People with RA are treated with drugs that actively suppress one or more parts of their immune system, and these may alter the response to vaccination against SARS-CoV-2. In this study, we analyzed blood samples from a cohort of patients with RA after receiving a 2-dose mRNA COVID-19 vaccine regimen. Our data show that individuals on the cytotoxic T lymphocyte antigen 4-Ig therapy abatacept had reduced levels of SARS-CoV-2-neutralizing antibodies after vaccination. At the cellular level, these patients showed reduced activation and class switching of SARS-CoV-2-specific B cells, as well as reduced numbers and impaired helper cytokine production by SARS-CoV-2-specific CD4+ T cells. Individuals on methotrexate showed similar but less severe defects in vaccine response, whereas individuals on the B cell-depleting therapy rituximab had a near-total loss of antibody production after vaccination. These data define a specific cellular phenotype associated with impaired response to SARS-CoV-2 vaccination in patients with RA on different immune-modifying therapies and help inform efforts to improve vaccination strategies in this vulnerable population.
MeSH term(s)	Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Arthritis, Rheumatoid/drug therapy ; Antibodies, Viral ; RNA, Messenger
Chemical Substances	COVID-19 Vaccines ; Antibodies, Viral ; RNA, Messenger
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.168663
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Cytotoxic T Cells Targeting Spike Glycoprotein Are Associated with Hybrid Immunity to SARS-CoV-2.

Phan, Jolie M / Layton, Erik D / Yu, Krystle K Q / Aguilar, Melissa S / Golez, Inah / Franko, Nicholas M / Logue, Jennifer K / Rodda, Lauren B / Howard, Christian A / Pepper, Marion / Gale, Michael / Chu, Helen Y / Seshadri, Chetan

Journal of immunology (Baltimore, Md. : 1950)

2023 Volume 210, Issue 9, Page(s) 1236–1246

Abstract: mRNA vaccination of individuals with prior SARS-CoV-2 infection provides superior protection against breakthrough infections with variants of concern compared with vaccination in the absence of prior infection. However, the immune mechanisms by which ... ...

Abstract	mRNA vaccination of individuals with prior SARS-CoV-2 infection provides superior protection against breakthrough infections with variants of concern compared with vaccination in the absence of prior infection. However, the immune mechanisms by which this hybrid immunity is generated and maintained are unknown. Whereas genetic variation in spike glycoprotein effectively subverts neutralizing Abs, spike-specific T cells are generally maintained against SARS-CoV-2 variants. Thus, we comprehensively profiled human T cell responses against the S1 and S2 domains of spike glycoprotein in a cohort of SARS-CoV-2-naive (n = 13) or -convalescent (n = 17) individuals who received two-dose mRNA vaccine series and were matched by age, sex, and vaccine type. Using flow cytometry, we observed that the overall functional breadth of CD4 T cells and polyfunctional Th1 responses was similar between the two groups. However, polyfunctional cytotoxic CD4 T cell responses against both S1 and S2 domains trended higher among convalescent subjects. Multimodal single-cell RNA sequencing revealed diverse functional programs in spike-specific CD4 and CD8 T cells in both groups. However, convalescent individuals displayed enhanced cytotoxic and antiviral CD8 T cell responses to both S1 and S2 in the absence of cytokine production. Taken together, our data suggest that cytotoxic CD4 and CD8 T cells targeting spike glycoprotein may partially account for hybrid immunity and protection against breakthrough infections with SARS-CoV-2.
MeSH term(s)	Humans ; T-Lymphocytes, Cytotoxic ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; COVID-19 ; Breakthrough Infections ; RNA, Messenger ; Vaccination ; Adaptive Immunity ; Glycoproteins ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; RNA, Messenger ; Glycoproteins ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2200815
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.

Liu, Dan / Duan, Lihui / Rodda, Lauren B / Lu, Erick / Xu, Ying / An, Jinping / Qiu, Longhui / Liu, Fengchun / Looney, Mark R / Yang, Zhiyong / Allen, Christopher D C / Li, Zhongmei / Marson, Alexander / Cyster, Jason G

Science (New York, N.Y.)

2022 Volume 375, Issue 6581, Page(s) eabi5965

Abstract: Dendritic cells (DCs) are crucial for initiating adaptive immune responses. However, the factors that control DC positioning and homeostasis are incompletely understood. We found that type-2 conventional DCs (cDC2s) in the spleen depend on ... ...

Abstract	Dendritic cells (DCs) are crucial for initiating adaptive immune responses. However, the factors that control DC positioning and homeostasis are incompletely understood. We found that type-2 conventional DCs (cDC2s) in the spleen depend on Gα
MeSH term(s)	Actins/metabolism ; Animals ; Antigen Presentation ; Antigens/immunology ; Blood Circulation ; CD55 Antigens/blood ; CD55 Antigens/metabolism ; Cell Movement ; Dendritic Cells/immunology ; Dendritic Cells/physiology ; Erythrocytes/metabolism ; Erythrocytes/physiology ; GTP-Binding Protein alpha Subunits, G12-G13/metabolism ; Homeostasis ; Interferon Regulatory Factors/metabolism ; Ligands ; Mice ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Spleen/blood supply ; Spleen/cytology ; Spleen/immunology ; Spleen/metabolism ; Transcription, Genetic ; Transcriptome
Chemical Substances	Actins ; Adgre5 protein, mouse ; Antigens ; CD55 Antigens ; Interferon Regulatory Factors ; Ligands ; Receptors, G-Protein-Coupled ; interferon regulatory factor-4 ; GTP-Binding Protein alpha Subunits, G12-G13 (EC 3.6.5.1)
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abi5965
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

Rodda, Lauren B. / Morawski, Peter A. / Pruner, Kurt B. / Fahning, Mitchell L. / Howard, Christian A. / Franko, Nicholas / Logue, Jennifer / Eggenberger, Julie / Stokes, Caleb / Golez, Inah / Hale, Malika / Gale, Michael / Chu, Helen Y. / Campbell, Daniel J. / Pepper, Marion

Cell. 2022 Mar. 14,

2022

Abstract: Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen exposures. Both ... ...

Abstract	Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen exposures. Both SARS-CoV-2 infection and vaccination induce multifaceted, functional immune memory, but together they engender improved protection from disease, termed hybrid immunity. We therefore investigated how vaccine-induced memory is shaped by previous infection. We found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-γ and IL-10-expressing memory SARS-CoV-2 spike-specific CD4⁺ T cells than previously naive individuals. While additional vaccination could increase humoral memory in previously naive individuals, it did not recapitulate the distinct CD4⁺ T cell cytokine profile observed in previously infected subjects. Thus, imprinted features of SARS-CoV-2-specific memory lymphocytes define hybrid immunity.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; antigens ; cytokines ; immunologic memory ; memory ; pandemic ; vaccination
Language	English
Dates of publication	2022-0314
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.03.018
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 75/702: Show issues
Z 93: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune modifying therapies

Klebanoff, Samuel D / Rodda, Lauren B / Morishima, Chihiro / Wener, Mark H / Fink, Susan L / Bryan, Andrew / Yuzefpolskiy, Yevgeniy / Bettelli, Estelle / Buckner, Jane H / Speake, Cate / Pepper, Marion / Campbell, Daniel J

medRxiv

Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes debilitating swelling and destruction of the joints. People with RA are treated with drugs that actively suppress one or more parts of their immune system, and these may ... ...

Abstract	Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes debilitating swelling and destruction of the joints. People with RA are treated with drugs that actively suppress one or more parts of their immune system, and these may alter their response to vaccination against SARS-CoV-2. In this study, we analyzed blood samples from a cohort of RA subjects after receiving a 2-dose mRNA COVID-19 vaccine regimen. Our data show that individuals on the CTLA4-Ig therapy abatacept have reduced levels of SARS-CoV-2-neutralizing antibodies after vaccination. At a cellular level, these subjects show reduced activation and class-switching of SARS-CoV-2-specific B cells, as well as reduced numbers and impaired helper cytokine production by SARS-CoV-2-specific CD4<sup>+</sup> T cells. Individuals on methotrexate showed similar but less severe defects in vaccine response, whereas individuals on the B celldepleting therapy rituximab had a near-total loss of antibody production after vaccination. These data define a specific cellular phenotype associated with impaired response to SARS-CoV-2 vaccination in RA subjects on different immune-modifying therapies, and help inform efforts to improve vaccination strategies in this vulnerable population.
Keywords	covid19
Language	English
Publishing date	2023-01-05
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2023.01.03.23284167
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity.

Rodda, Lauren B / Morawski, Peter A / Pruner, Kurt B / Fahning, Mitchell L / Howard, Christian A / Franko, Nicholas / Logue, Jennifer / Eggenberger, Julie / Stokes, Caleb / Golez, Inah / Hale, Malika / Gale, Michael / Chu, Helen Y / Campbell, Daniel J / Pepper, Marion

Cell

2022 Volume 185, Issue 9, Page(s) 1588–1601.e14

Abstract	Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen exposures. Both SARS-CoV-2 infection and vaccination induce multifaceted, functional immune memory, but together, they engender improved protection from disease, termed hybrid immunity. We therefore investigated how vaccine-induced memory is shaped by previous infection. We found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-γ and IL-10-expressing memory SARS-CoV-2 spike-specific CD4
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; Humans ; Immunity, Humoral ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; T-Lymphocytes
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.03.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness.

Wang, Xiaoming / Rodda, Lauren B / Bannard, Oliver / Cyster, Jason G

Journal of immunology (Baltimore, Md. : 1950)

2014 Volume 192, Issue 10, Page(s) 4601–4609

Abstract: Integrin-ligand interactions between germinal center (GC) B cells and Ag-presenting follicular dendritic cells (FDCs) have been suggested to play central roles during GC responses, but their in vivo requirement has not been directly tested. In this study, ...

Abstract	Integrin-ligand interactions between germinal center (GC) B cells and Ag-presenting follicular dendritic cells (FDCs) have been suggested to play central roles during GC responses, but their in vivo requirement has not been directly tested. In this study, we show that, whereas integrins αLβ2 and α4β1 are highly expressed and functional on mouse GC B cells, removal of single integrins or their ligands had little effect on B cell participation in the GC response. Combined β2 integrin deficiency and α4 integrin blockade also did not affect the GC response against a particulate Ag. However, the combined integrin deficiency did cause B cells to be outcompeted in splenic GC responses against a soluble protein Ag and in mesenteric lymph node GC responses against gut-derived Ags. Similar findings were made for β2-deficient B cells in mice lacking VCAM1 on FDCs. The reduced fitness of the GC B cells did not appear to be due to decreased Ag acquisition, proliferation rates, or pAKT levels. In summary, our findings provide evidence that αLβ2 and α4β1 play overlapping and context-dependent roles in supporting interactions with FDCs that can augment the fitness of responding GC B cells. We also find that mouse GC B cells upregulate αvβ3 and adhere to vitronectin and milk-fat globule epidermal growth factor VIII protein. Integrin β3-deficient B cells contributed in a slightly exaggerated manner to GC responses, suggesting this integrin has a regulatory function in GC B cells.
MeSH term(s)	Animals ; B-Lymphocytes, Regulatory/cytology ; B-Lymphocytes, Regulatory/immunology ; Cell Adhesion/genetics ; Cell Adhesion/immunology ; Dendritic Cells, Follicular/cytology ; Dendritic Cells, Follicular/immunology ; Germinal Center/cytology ; Germinal Center/immunology ; Integrin alpha4beta1/genetics ; Integrin alpha4beta1/immunology ; Integrin alphaVbeta3/genetics ; Integrin alphaVbeta3/immunology ; Mice ; Mice, Knockout ; Spleen/cytology ; Spleen/immunology ; Up-Regulation/genetics ; Up-Regulation/immunology ; Vitronectin/genetics ; Vitronectin/immunology
Chemical Substances	Integrin alpha4beta1 ; Integrin alphaVbeta3 ; Vitronectin
Language	English
Publishing date	2014-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1400090
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.

Reboldi, Andrea / Arnon, Tal I / Rodda, Lauren B / Atakilit, Amha / Sheppard, Dean / Cyster, Jason G

Science (New York, N.Y.)

2016 Volume 352, Issue 6287, Page(s) aaf4822

Abstract: Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 ... ...

Abstract	Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of PPs. There, B cells undergo prolonged interactions with SED dendritic cells (DCs). PP IgA class switching requires innate lymphoid cells, which promote lymphotoxin-β receptor (LTβR)-dependent maintenance of DCs. PP DCs augment IgA production by integrin αvβ8-mediated activation of transforming growth factor-β (TGFβ). In mice where B cells cannot access the SED, IgA responses against oral antigen and gut commensals are impaired. These studies establish the PP SED as a niche supporting DC-B cell interactions needed for TGFβ activation and induction of mucosal IgA responses.
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; Cell Communication/immunology ; Cell Movement/immunology ; Dendritic Cells/immunology ; Immunoglobulin A, Secretory/biosynthesis ; Immunoglobulin A, Secretory/genetics ; Immunoglobulin Class Switching ; Integrins/immunology ; Intestinal Mucosa/immunology ; Lymphocyte Activation ; Lymphotoxin beta Receptor/genetics ; Lymphotoxin beta Receptor/immunology ; Mice ; Mice, Mutant Strains ; Peyer's Patches/immunology ; Receptors, CCR6/genetics ; Receptors, CCR6/immunology
Chemical Substances	CCR6 protein, mouse ; Immunoglobulin A, Secretory ; Integrins ; Lymphotoxin beta Receptor ; Receptors, CCR6 ; integrin alphavbeta8
Language	English
Publishing date	2016-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aaf4822
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito