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  1. Article ; Online: Efficacy and safety of semaglutide in a diabetic and obese patient on incremental hemodialysis. Does it also contribute to preserving residual renal function?

    de la Flor, José Carlos / Deira, Javier / Monzón, Tania / Valga, Francisco / Albarracín, Cristina / Ruiz, Elisa / Rodeles, Miguel

    Nefrologia

    2023  Volume 43, Issue 4, Page(s) 501–503

    MeSH term(s) Humans ; Renal Dialysis ; Glucagon-Like Peptides/therapeutic use ; Kidney/physiology ; Diabetes Mellitus
    Chemical Substances semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8)
    Language English
    Publishing date 2023-08-30
    Publishing country Spain
    Document type Letter
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2023.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Efficacy and Safety of the Use of SGLT2 Inhibitors in Patients on Incremental Hemodialysis: Maximizing Residual Renal Function, Is There a Role for SGLT2 Inhibitors?

    De La Flor, José C / Villa, Daniel / Cruzado, Leónidas / Apaza, Jacqueline / Valga, Francisco / Zamora, Rocío / Marschall, Alexander / Cieza, Michael / Deira, Javier / Rodeles, Miguel

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: SGLT-2i are the new standard of care for diabetic kidney disease (DKD), but previous studies have not included patients on kidney replacement therapy (KRT). Due to their high risk of cardiovascular, renal complications, and mortality, these patients ... ...

    Abstract SGLT-2i are the new standard of care for diabetic kidney disease (DKD), but previous studies have not included patients on kidney replacement therapy (KRT). Due to their high risk of cardiovascular, renal complications, and mortality, these patients would benefit the most from this therapy. Residual kidney function (RKF) conveys a survival benefit and cardiovascular health among hemodialysis (HD) patients, especially those on incremental hemodialysis (iHD). We retrospectively describe the safety and efficacy of SGLT2i regarding RKF preservation in seven diabetic patients with different clinical backgrounds who underwent iHD (one or two sessions per week) during a 12-month follow-up. All patients preserved RKF, measured as residual kidney urea clearance (KrU) in 24 h after the introduction of SGLT2i. KrU levels improved significantly from 4.91 ± 1.14 mL/min to 7.28 ± 1.68 mL/min at 12 months (
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11071908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature.

    De La Flor, José C / Alonso, Marina / Sandoval, Edna / Marschall, Alexander / Rodeles, Miguel

    Case reports in nephrology

    2020  Volume 2020, Page(s) 6679857

    Abstract: We present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her ... ...

    Abstract We present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her evolution a relapse. Although the bone marrow biopsy in this case showed plasma cells as pathologic clone and there was also a reduction after chemotherapeutic treatment, rituximab was proposed as a second line. We suspected that the relapse was possibly due to another precursor as B-cell or lymphoplasmacytic cell clone. We review the literature and suggest that the treatment for MGRS should be patient-tailored, preferably by consulting a multidisciplinary team. Future research is needed to better understand the disease course and establish the efficacy and safety of the therapeutic approach for the relapse of MGRS.
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2020/6679857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Targeting Cytokine Storm in COVID-19: A Role of Online Hemodiafiltration with Asymmetric Cellulose Triacetate in Maintenance Hemodialysis Patients-A Report of 10 Cases.

    De La Flor, José C / Valga, Francisco / Marschall, Alexander / Monzon, Tania / Albarracín, Cristina / Ruiz, Elisa / Rodeles, Miguel

    Case reports in nephrology

    2021  Volume 2021, Page(s) 5575928

    Abstract: Early reports have suggested that maintenance hemodialysis (MHD) patients could be more susceptible to a severe course of COVID-19. Among the therapeutic approaches, the use of drugs that reduce the cytokine storm characteristic of this disease has been ... ...

    Abstract Early reports have suggested that maintenance hemodialysis (MHD) patients could be more susceptible to a severe course of COVID-19. Among the therapeutic approaches, the use of drugs that reduce the cytokine storm characteristic of this disease has been proposed. Some dialyzers, such as the new generation of asymmetric cellulose triacetate (ATA) membranes, could favor the effective elimination of medium-sized molecules and other inflammatory mediators. In this case series, we describe in depth the clinical, analytical, and radiological details, therapeutic aspects, and outcomes of the case series of 10 MHD patients of our dialysis unit, who tested positive for SARS-CoV-2 from 5 October to 30 November 2020. Furthermore, we evaluate the removal of hyperinflammatory parameters with the ATA membrane in postdilution online hemodiafiltration (OL-HDF) in these patients through a variety of biomarkers of systemic inflammation from the diagnosis until stripping. Biochemical blood analysis was carried out at baseline and at days 7 and 14 after diagnosis, respectively. 50% of the patients presented COVID-19 pneumonia and required hospital admission. Median hospitalization time was 21 days. A total of 4 patients developed severe pneumonia (3 of them died) and 1 patient developed moderate pneumonia. Patients who died (
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2021/5575928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Multiple brown tumors-Forgotten pathology in times of calcimimetics: A case report and literature review.

    De La Flor Merino, José Carlos / Justo, Pablo / Domínguez, Juan J / Gómez-Berrocal, Ana / Seva, Antonio E / Marschall, Alexander / Rodeles, Miguel

    SAGE open medical case reports

    2021  Volume 9, Page(s) 2050313X211039383

    Abstract: Multiple brown tumors represent a rare variant of osteitis fibrosa cystica. Brown tumors are associated with primary, secondary, or tertiary hyperparathyroidism. Brown tumors have been reported in patients with chronic kidney disease resulting in mineral ...

    Abstract Multiple brown tumors represent a rare variant of osteitis fibrosa cystica. Brown tumors are associated with primary, secondary, or tertiary hyperparathyroidism. Brown tumors have been reported in patients with chronic kidney disease resulting in mineral and bone disorders. Chronic kidney disease resulting in mineral and bone disorder is a result of increased osteoclast activity and excessive production of parathormone due to parathyroid gland hyperactivity. Brown tumors are frequently overlooked in patients with end-stage renal disease since calcimimetics and vitamin D analogs were introduced as pharmacological therapy for secondary hyperparathyroidism. We present a case of a 79 year-old pre-dialysis woman, with multiple brown tumors secondary to a parathyroid adenoma despite being treated with cinacalcet for secondary hyperparathyroidism. In addition, we review the corresponding literature.
    Language English
    Publishing date 2021-08-11
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X211039383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection.

    de La Flor, José C / Gomez-Berrocal, Ana / Marschall, Alexander / Valga, Francisco / Linares, Tania / Albarracin, Cristina / Ruiz, Elisa / Gallegos, Gioconda / Gómez, Alberto / de Los Santos, Andrea / Rodeles, Miguel

    Medicina clinica (English ed.)

    2022  Volume 159, Issue 1, Page(s) 12–18

    Abstract: Background: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium <135 mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20-37% according to the series, but there are no data on ... ...

    Abstract Background: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium <135 mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20-37% according to the series, but there are no data on the prognosis after correction of hyponatremia. Therefore, our objectives were: to analyse the incidence and severity of hyponatremia at hospital admission, and to determine the association of this hyponatremia with the prognosis of COVID-19.
    Methods: Observational and retrospective cohort study. Patients who were admitted with a diagnosis of COVID-19 infection and hyponatremia, in the period March-May 2020, were included. We recorded epidemiological, demographic, clinical, biochemical, and radiological variables of SARS-CoV-2 infection and hyponatremia at the time of diagnosis and during hospitalization. The clinical follow-up ranged from admission to death or discharge.
    Results: 91 patients (21.8%) of the 414 admitted for SARS-CoV-2 infection presented hyponatremia (81.32% mild hyponatremia, 9.89% moderate and 8.79% severe). The absence of correction of hyponatremia 72-96 h after hospital admission was associated with higher mortality in patients with COVID-19 (Odds Ratio 0.165; 95% confidence interval: 0.018-0.686;
    Conclusion: We conclude that persistence of hyponatremia at 72-96 h of hospital admission was associated with higher mortality in patients with SARS-Cov-2.
    Language English
    Publishing date 2022-06-29
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2021.07.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection.

    de La Flor, José C / Gomez-Berrocal, Ana / Marschall, Alexander / Valga, Francisco / Linares, Tania / Albarracin, Cristina / Ruiz, Elisa / Gallegos, Gioconda / Gómez, Alberto / de Los Santos, Andrea / Rodeles, Miguel

    Medicina clinica

    2021  Volume 159, Issue 1, Page(s) 12–18

    Abstract: Introduction: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium<135mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20-37% according to the series, but there are no data on ... ...

    Title translation Impacto de la corrección temprana de la hiponatremia en el pronóstico de la infección del síndrome respiratorio agudo grave del coronavirus 2 (SARS-CoV-2).
    Abstract Introduction: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium<135mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20-37% according to the series, but there are no data on the prognosis after correction of hyponatremia. Therefore, our objectives were: to analyze the incidence and severity of hyponatremia at hospital admission, and to determine the association of this hyponatremia with the prognosis of COVID-19.
    Material and method: Observational and retrospective cohort study. Patients who were admitted with a diagnosis of COVID-19 infection and hyponatremia, in the period March-May 2020, were included. We recorded epidemiological, demographic, clinical, biochemical, and radiological variables of SARS-CoV-2 infection and hyponatremia at the time of diagnosis and during hospitalization. The clinical follow-up ranged from admission to death or discharge.
    Results: 91 patients (21.8%) of the 414 admitted for SARS-CoV-2 infection presented hyponatremia (81.32% mild hyponatremia, 9.89% moderate and 8.79% severe). The absence of correction of hyponatremia 72-96h after hospital admission was associated with higher mortality in patients with COVID-19 (Odds Ratio .165; 95% confidence interval: .018-.686; P=.011). 19 patients (20.9%) died. An increase in mortality was observed in patients with severe hyponatremia compared with moderate and mild hyponatremia during hospital admission (37.5% versus 11.1% versus 8.1%, P=.041).
    Conclusions: We conclude that persistence of hyponatremia at 72-96h of hospital admission was associated with higher mortality in patients with SARS-CoV-2.
    MeSH term(s) COVID-19/complications ; COVID-19/therapy ; Hospitalization ; Hospitals ; Humans ; Hyponatremia/etiology ; Hyponatremia/therapy ; Prognosis ; Retrospective Studies ; SARS-CoV-2
    Language Spanish
    Publishing date 2021-07-29
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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