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  1. Article ; Online: Relevance of Cardiovascular Risk Factors Screening in People Aged over 65 Years: Results from a Large French Urban Population (The CARVAR92 Study).

    Pépin, Marion / Hauguel-Moreau, Marie / Hergault, Hélène / Beauchet, Alain / Rodon, Christophe / Cudennec, Tristan / Teillet, Laurent / Dubourg, Olivier / Mansencal, Nicolas

    Gerontology

    2022  Volume 68, Issue 12, Page(s) 1358–1365

    Abstract: Background: Cardiovascular disease is the leading cause of death and disability in older people. Traditional cardiovascular risk factors (CVRFs) still have an impact on cardiovascular risk among older people. Nevertheless, screening campaigns rarely ... ...

    Abstract Background: Cardiovascular disease is the leading cause of death and disability in older people. Traditional cardiovascular risk factors (CVRFs) still have an impact on cardiovascular risk among older people. Nevertheless, screening campaigns rarely target subjects aged over 65 years. This study aimed to assess the distribution and relevance of conventional CVRF screening in people aged over 65 years.
    Methods: Between 2007 and 2018, among a screening CVRF campaign in the western suburbs of Paris (32,692 subjects), we individualized 6,577 subjects aged 65 years and over. All conventional CVRFs have been systematically assessed.
    Results: The screening allowed to suspect hypertension in a larger proportion of subjects over 65 years compared to subjects under 65 years (27% vs. 18%, p < 0.0001). Hypertension control was higher in women compared to men but not significantly different in the age-groups (p = 0.91). Screening for diabetes mellitus was positive in 3% of older subjects and 2.4% in younger (p = 0.005). Risk assessment with dedicated score (SCORE O.P.) allowed to move toward a low-risk estimation, resulting in the diminution of intermediate risk group in women over 65 years (from 68 to 61%, p < 0.001).
    Conclusions: Screening CVRFs especially hypertension remains relevant in people aged over 65 years as it enables to detect unknown CVRFs in numerous subjects. Increasing awareness of CVRFs may be the first step to CVRF control, which is known to be efficient on cardiovascular mortality and functional autonomy in later life.
    MeSH term(s) Male ; Female ; Humans ; Aged ; Urban Population ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Risk Factors ; Heart Disease Risk Factors ; Hypertension/diagnosis ; Hypertension/epidemiology
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193798-4
    ISSN 1423-0003 ; 0304-324X
    ISSN (online) 1423-0003
    ISSN 0304-324X
    DOI 10.1159/000521995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of neighbourhood socio-economic status on cardiovascular risk factors in a French urban population.

    Hergault, Hélène / Hauguel-Moreau, Marie / Pépin, Marion / Beauchet, Alain / Josseran, Loïc / Rodon, Christophe / Gaye, Bamba / Dubourg, Olivier / Mansencal, Nicolas

    European journal of preventive cardiology

    2022  Volume 29, Issue 16, Page(s) 2142–2144

    MeSH term(s) Humans ; Urban Population ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Economic Status ; Risk Factors ; Residence Characteristics ; Heart Disease Risk Factors ; Socioeconomic Factors
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwac155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort.

    Hauguel-Moreau, Marie / Hergault, Hélène / Cazabat, Laure / Pépin, Marion / Beauchet, Alain / Aïdan, Vincent / Ouadahi, Mounir / Josseran, Loïc / Hage, Mirella / Rodon, Christophe / Dubourg, Olivier / Massy, Ziad / Mansencal, Nicolas

    Cardiovascular diabetology

    2023  Volume 22, Issue 1, Page(s) 31

    Abstract: Background: The aim of this study was to assess the prevalence of prediabetes and unknown diabetes and its long-term change in a large middle-aged urban population.: Methods: We conducted a screening campaign between 2007 and 2018 for cardiovascular ... ...

    Abstract Background: The aim of this study was to assess the prevalence of prediabetes and unknown diabetes and its long-term change in a large middle-aged urban population.
    Methods: We conducted a screening campaign between 2007 and 2018 for cardiovascular risk factors in the western suburbs of Paris including subjects aged 40-70 (CARVAR 92). Among subjects who reported no previous diabetes, prediabetes and undiagnosed diabetes were defined as follows: fasting plasma glucose (FPG) ≥ 6.1 mmol/l (110 mg/dl) and < 7 mmol/l (126 mg/dl) for prediabetes according to WHO criteria (FPG between 5.6 and 6.9 mmol/l according to ADA criteria) and FPG ≥ 7.0 mmol/l for undiagnosed diabetes.
    Results: Of the 32,721 subjects in the CARVAR 92 cohort, 32,675 were included in this analysis. The median age of the patients was 56 years [30, 94], 45.4% were male, 5.9% had known diabetes, 36.4% were overweight and 18.7% obese. Among patients without previously known diabetes (n = 30,759), 8.1% had prediabetes according to WHO criteria (27.2% according to ADA criteria) and 2.3% had diabetes. Subjects with prediabetes and unknown diabetes were more likely to be male, older, and overweight or obese than non-diabetic subjects. From 2007 to 2018, the prevalence of prediabetes, unknown diabetes, and known diabetes decreased, except for prediabetes which remained stable for people aged 55-64.
    Conclusion: The prevalence of prediabetes and unknown diabetes remains high but decreased during a 12-year period. About one-quarter of diabetes cases remain undiagnosed. Our results highlight that there is still a room for screening and cardiovascular prevention campaigns.
    Trial registration: IRB00012437.
    MeSH term(s) Middle Aged ; Humans ; Male ; Female ; Prediabetic State/diagnosis ; Prediabetic State/epidemiology ; Overweight ; Prevalence ; Urban Population ; Blood Glucose ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Obesity ; Fasting ; Risk Factors
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-023-01761-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prevalence of familial hypercholesterolaemia in patients presenting with premature acute coronary syndrome.

    Hauguel-Moreau, Marie / Aïdan, Vincent / Hergault, Hélène / Beauchet, Alain / Pépin, Marion / Prati, Giulio / Pillière, Rémy / Ouadahi, Mounir / Josseran, Loïc / Rodon, Christophe / Rabès, Jean-Pierre / Charron, Philippe / Dubourg, Olivier / Massy, Ziad / Mansencal, Nicolas

    Archives of cardiovascular diseases

    2022  Volume 115, Issue 2, Page(s) 87–95

    Abstract: Background: Familial hypercholesterolaemia (FH) is responsible for severe hypercholesterolaemia and premature cardiovascular morbidity and mortality. The first clinical event is typically an acute coronary syndrome. Unfortunately, FH is largely ... ...

    Abstract Background: Familial hypercholesterolaemia (FH) is responsible for severe hypercholesterolaemia and premature cardiovascular morbidity and mortality. The first clinical event is typically an acute coronary syndrome. Unfortunately, FH is largely underdiagnosed in the general population.
    Aims: To assess the prevalence of clinical FH among patients with premature (aged≤50 years) acute myocardial infarction (MI) and compare it with FH prevalence in a control population.
    Methods: We reviewed in our database all patients with premature MI (aged≤50 years) referred to Ambroise Paré Hospital from 2014 to 2018. FH prevalence was estimated via the Dutch Lipid Clinic Network score, based on personal and family history of premature cardiovascular disease and low-density lipoprotein cholesterol concentrations. FH was "possible" with a score between 3 and 5 points, "probable" with a score between 6 and 8 and "definite" with a score above 8. FH prevalence in young patients with MI was then compared with FH prevalence in a general population of the same age from the CARVAR 92 prospective cohort.
    Results: Of the 457 patients with premature MI, 29 (6%) had "probable" or "definite" FH. In the CARVAR 92 cohort, 16 (0.16%) of 9900 subjects aged≤50 years had "probable" or "definite" FH. FH prevalence was 39 times greater among patients with premature MI than in the control population (P<0.0001). In multivariable analysis, FH was strongly associated with MI (adjusted odds ratio 38.4, 95% confidence interval 19.1-79.4).
    Conclusions: FH is>30-fold more common in patients referred for premature MI than in the general population; this highlights the need for FH screening after a first MI to enhance lipid-lowering therapy and allow early identification of family members.
    MeSH term(s) Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Humans ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/epidemiology ; Hyperlipoproteinemia Type II/genetics ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2022-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2021.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-term changes of the cardiovascular risk factors and risk scores in a large urban population.

    Hauguel-Moreau, Marie / Pépin, Marion / Hergault, Hélène / Beauchet, Alain / Mustafic, Hazrije / Karam, Carma / Lannou, Simon / Mallet, Sophie / Josseran, Loïc / Rodon, Christophe / Dubourg, Olivier / Massy, Ziad / Mansencal, Nicolas

    European journal of preventive cardiology

    2021  Volume 29, Issue 3, Page(s) e115–e17

    MeSH term(s) Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Heart Disease Risk Factors ; Humans ; Risk Factors ; Rural Population ; Urban Population
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Letter
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwab056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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