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  1. Article: Solitary fibrous tumor of the pancreas.

    Rodríguez, Angela De La Hoz / Martino, Marcello Di / Mazeyra, Mariel Valdivia / Martín-Pérez, Elena

    Autopsy & case reports

    2021  Volume 11, Page(s) e2021245

    Language English
    Publishing date 2021-03-12
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2021.245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hepatic granuloma mimicking an intrahepatic cholangiocarcinoma: An unusual presentation.

    Blanco Terés, Lara / Di Martino, Marcello / Rodríguez, Ángela de la Hoz / Martín-Pérez, Elena

    Cirugia espanola

    2020  Volume 99, Issue 5, Page(s) 383

    Title translation Granuloma hepático simulando un colangiocarcinoma intrahepático: una presentación infrecuente.
    MeSH term(s) Bile Duct Neoplasms/diagnosis ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/diagnosis ; Granuloma/diagnosis ; Humans
    Language Spanish
    Publishing date 2020-07-15
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2020.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Critical appraisal of surgical margins according to KRAS status in liver resection for colorectal liver metastases: Should surgical strategy be influenced by tumor biology?

    Rhaiem, Rami / Duramé, Adrien / Primavesi, Florian / Dorcaratto, Dimitri / Syn, Nicholas / Rodríguez, Ángela de la Hoz / Dupré, Aurélien / Piardi, Tullio / Fernández, Gerardo Blanco / Villaverde, Arancha Prada / Rodríguez Sanjuán, Juan C / Santiago, Roberto Fernández / Fernández-Moreno, María-Carmen / Ferret, Georgina / Ben, Santiago López / Suárez Muñoz, Miguel Á / Perez-Alonso, Alejandro J / Koh, Ye-Xin / Jones, Robert /
    Martín-Pérez, Elena / Kianmanesh, Reza / Di Martino, Marcello

    Surgery

    2024  

    Abstract: Background: KRAS mutation is a negative prognostic factor for colorectal liver metastases. Several studies have investigated the resection margins according to KRAS status, with conflicting results. The aim of the study was to assess the oncologic ... ...

    Abstract Background: KRAS mutation is a negative prognostic factor for colorectal liver metastases. Several studies have investigated the resection margins according to KRAS status, with conflicting results. The aim of the study was to assess the oncologic outcomes of R0 and R1 resections for colorectal liver metastases according to KRAS status.
    Methods: All patients who underwent resection for colorectal liver metastases between 2010 and 2015 with available KRAS status were enrolled in this multicentric international cohort study. Logistic regression models were used to investigate the outcomes of R0 and R1 colorectal liver metastases resections according to KRAS status: wild type versus mutated. The primary outcomes were overall survival and disease-free survival.
    Results: The analysis included 593 patients. KRAS mutation was associated with shorter overall survival (40 vs 60 months; P = .0012) and disease-free survival (15 vs 21 months; P = .003). In KRAS-mutated tumors, the resection margin did not influence oncologic outcomes. In multivariable analysis, the only predictor of disease-free survival and overall survival was primary tumor location (P = .03 and P = .03, respectively). In KRAS wild-type tumors, R0 resection was associated with prolonged overall survival (74 vs 45 months, P < .001) and disease-free survival (30 vs 17 months, P < .001). The multivariable model confirmed that R0 resection margin was associated with prolonged overall survival (hazard ratio = 1.43, 95% confidence interval: 1.01-2.03) and disease-free survival (hazard ratio = 1.42; 95% confidence interval: 1.06-1.91).
    Conclusions: KRAS-mutated colorectal liver metastases showed more aggressive tumor biology with inferior overall survival and disease-free survival after liver resection. Although R0 resection was not associated with improved oncologic outcomes in the KRAS-mutated tumors group, it seems to be of paramount importance for achieving prolonged long-term survival in KRAS wild-type tumors.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2024.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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