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Article ; Online: Pregnancy-specific glycoproteins: evolution, expression, functions and disease associations.

Moore, Tom / Williams, John M / Becerra-Rodriguez, Maria Angeles / Dunne, Matthew / Kammerer, Robert / Dveksler, Gabriela

Reproduction (Cambridge, England)

2022 Volume 163, Issue 2, Page(s) R11–R23

Abstract: Pregnancy-specific glycoproteins (PSGs) are members of the immunoglobulin superfamily and are closely related to the predominantly membrane-bound CEACAM proteins. PSGs are produced by placental trophoblasts and secreted into the maternal bloodstream at ... ...

Abstract	Pregnancy-specific glycoproteins (PSGs) are members of the immunoglobulin superfamily and are closely related to the predominantly membrane-bound CEACAM proteins. PSGs are produced by placental trophoblasts and secreted into the maternal bloodstream at high levels where they may regulate maternal immune and vascular functions through receptor binding and modulation of cytokine and chemokine expression and activity. PSGs may have autocrine and paracrine functions in the placental bed, and PSGs can activate soluble and extracellular matrix bound TGF-β, with potentially diverse effects on multiple cell types. PSGs are also found at high levels in the maternal circulation, at least in human, where they may have endocrine functions. In a non-reproductive context, PSGs are expressed in the gastrointestinal tract and their deregulation may be associated with colorectal cancer and other diseases. Like many placental hormones, PSGs are encoded by multigene families and they have an unusual phylogenetic distribution, being found predominantly in species with hemochorial placentation, with the notable exception of the horse in which PSG-like proteins are expressed in the endometrial cups of the epitheliochorial placenta. The evolution and expansion of PSG gene families appear to be a highly active process, with significant changes in gene numbers and protein domain structures in different mammalian lineages and reports of extensive copy number variation at the human locus. Against this apparent diversification, the available evidence indicates extensive conservation of PSG functions in multiple species. These observations are consistent with maternal-fetal conflict underpinning the evolution of PSGs.
MeSH term(s)	Animals ; DNA Copy Number Variations ; Female ; Glycoproteins/metabolism ; Horses ; Mammals/metabolism ; Phylogeny ; Placenta/metabolism ; Placentation ; Pregnancy ; Trophoblasts/metabolism
Chemical Substances	Glycoproteins
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-21-0390
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Article: Autochthonous Wheat Grown in Organic and Conventional Systems: Nutritional Quality of Flour and Bread.

Fernández-Canto, Nerea / García-Gómez, María Belén / Vázquez-Odériz, María Lourdes / Lombardero-Fernández, Matilde / Pereira-Lorenzo, Santiago / Cobos, Ángel / Díaz, Olga / Romero-Rodríguez, María Ángeles

Foods (Basel, Switzerland)

2024 Volume 13, Issue 7

Abstract: A growing interest in the recovery and enhancement of crops, particularly local varieties such as 'Caaveiro' wheat, has been observed. This study aims to investigate the impact of cultivation systems (organic versus conventional) on the nutritional ... ...

Abstract	A growing interest in the recovery and enhancement of crops, particularly local varieties such as 'Caaveiro' wheat, has been observed. This study aims to investigate the impact of cultivation systems (organic versus conventional) on the nutritional quality of 'Caaveiro' flour and breads protected by the PGI "Pan Galego," employing two fermentation methods (sourdough versus sourdough and biological yeast). Organic flour exhibited significantly higher levels of moisture, fat, sucrose, phosphorus (P), sodium (Na), and copper (Cu) while also exhibiting a lower total starch and zinc (Zn) content. Organic bread, produced using both fermentation methods, demonstrated significantly higher protein, carbohydrate, total, resistant, and rapidly digestible starch, ash, Na, P, iron (Fe), and Cu content. Additionally, they contained less moisture compared to conventional bread. Despite variations in nutritional characteristics based on the cultivation system, the organic approach proved effective at producing high-quality products with a positive environmental impact, which is highly appreciated by consumers.
Language	English
Publishing date	2024-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13071120
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Article ; Online: Fumonisin B1 Accumulates in Chicken Tissues over Time and This Accumulation Was Reduced by Feeding Algo-Clay.

Laurain, Julia / Tardieu, Didier / Matard-Mann, Maria / Rodriguez, Maria Angeles / Guerre, Philippe

Toxins

2021 Volume 13, Issue 10

Abstract: The toxicokinetics of the food and feed contaminant Fumonisin B (FB) are characterized by low oral absorption and rapid plasma elimination. For these reasons, FB is not considered to accumulate in animals. However, recent studies in chicken and turkey ... ...

Abstract	The toxicokinetics of the food and feed contaminant Fumonisin B (FB) are characterized by low oral absorption and rapid plasma elimination. For these reasons, FB is not considered to accumulate in animals. However, recent studies in chicken and turkey showed that, in these species, the hepatic half-elimination time of fumonisin B1 (FB1) was several days, suggesting that FB1 may accumulate in the body. For the present study, 21-day-old chickens received a non-toxic dose of around 20 mg FB1 + FB2/kg of feed to investigate whether FB can accumulate in the body over time. Measurements taken after four and nine days of exposure revealed increased concentrations of sphinganine (Sa) and sphingosine (So) over time in the liver, but no sign of toxicity and no effect on performances were observed at this level of FB in feed. Measurements of FB in tissues showed that FB1 accumulated in chicken livers from four to nine days, with concentrations of 20.3 and 32.1 ng FB1/g observed, respectively, at these two exposure periods. Fumonisin B2 (FB2) also accumulated in the liver, from 0.79 ng/g at four days to 1.38 ng/g at nine days. Although the concentrations of FB found in the muscles was very low, an accumulation of FB1 over time was observed in this tissue, with concentrations of 0.036 and 0.072 ng FB1/g being measured after four and nine days of exposure, respectively. Feeding algo-clay to the chickens reduced the accumulation of FB1 in the liver and muscle by , approximately 40 and 50% on day nine, respectively. By contrast, only a weak non-significant effect was observed on day four. The decrease in the concentration of FB observed in tissues of chickens fed FB plus algo-clay on day nine was accompanied by a decrease in Sa and So contents in the liver compared to the levels of Sa and So measured in chickens fed FB alone. FB1 in the liver and Sa or So contents were correlated in liver tissue, confirming that both FB1 and Sa are suitable biomarkers of FB exposure in chickens. Further studies are necessary to determine whether FB can accumulate at higher levels in chicken tissues with an increase in the time of exposure and in the age of the animals.
MeSH term(s)	Animal Feed/analysis ; Animals ; Chickens/metabolism ; Clay ; Fumonisins/metabolism ; Liver/drug effects ; Liver/metabolism ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Time Factors ; Tissue Distribution
Chemical Substances	Fumonisins ; fumonisin B2 (116355-84-1) ; fumonisin B1 (3ZZM97XZ32) ; Clay (T1FAD4SS2M)
Language	English
Publishing date	2021-10-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins13100701
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Article ; Online: Outcome in a series of 1135 twin pregnancies: does the type of conception play a role?

Prats, Pilar / Zarragoitia, Janire / Rodríguez, Maria Ángeles / Rodriguez, Ignacio / Martinez, Francisca / Rodríguez-Melcon, Alberto / Serra, Bernat

AJOG global reports

2022 Volume 2, Issue 4, Page(s) 100129

Abstract: Background: The rate of twin pregnancies conceived via assisted reproductive technology has increased markedly in recent years. The elevated number of multiple pregnancies is the most serious and frequent complication of assisted reproductive technology. ...

Abstract	Background: The rate of twin pregnancies conceived via assisted reproductive technology has increased markedly in recent years. The elevated number of multiple pregnancies is the most serious and frequent complication of assisted reproductive technology. Twin pregnancies are associated with higher rates of obstetrical complications, preterm delivery, and perinatal morbidity and mortality than singleton pregnancies. Objective: This study aimed to investigate the association between the mode of conception and obstetrical and perinatal outcomes in twin pregnancies, adjusting for parity, age, and chorionicity. Study design: This was a retrospective cohort study of 1135 twin pregnancies between May 2006 and April 2021. All spontaneous (n=369) and assisted reproductive technology-conceived (n=766) twin pregnancies with antenatal care and delivery in the Universitari Quiron-Dexeus Hospital, Barcelona, Spain, a tertiary obstetrical care center, were studied according to chorionicity. Results: The mean maternal age was higher among assisted reproductive technology twin pregnancies than among naturally conceived ones, and there were also less parous women in the assisted reproductive technology twin group. The global survival rates in both groups of twins were practically identical, namely 744 of 766 (97.1%) assisted reproductive technology twins and 357 of 369 (96.8%) spontaneously conceived twins. Patients with dichorionic assisted reproductive technology twins had a higher incidence of gestational diabetes (relative risk, 1.69; 95% confidence interval, 1.10-2.59) and gestational hypertension or preeclampsia (relative risk, 2.75; 95% confidence interval, 1.60-4.729). Monochorionic diamniotic assisted reproductive technology twins had a higher risk for gestational diabetes (relative risk, 4.12; 95% confidence interval, 1.35-12.56). We analyzed the gestational age at delivery, onset of labor, type of delivery, rate of preterm births, weight discordance, rate of small for gestational age neonates and intrauterine growth restriction, and admission to the neonatal intensive care unit. We could not find any statistical differences between monochorionic diamniotic assisted reproductive technology twins and spontaneously conceived twins. Among dichorionic twins, those conceived by assisted reproductive technology had an earlier gestational age at delivery (36.3±2.29 vs 36.6±2; Conclusion: Pregnancy outcomes are comparable between assisted reproductive technology and spontaneously conceived twins, and when adjusted for confounding factors, only the risk for gestational hypertension and preeclampsia remained increased in the assisted reproductive technology group.
Language	English
Publishing date	2022-11-06
Publishing country	United States
Document type	Journal Article
ISSN	2666-5778
ISSN (online)	2666-5778
DOI	10.1016/j.xagr.2022.100129
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Article ; Online: Pregnancy-specific glycoproteins

Moore, Tom / Williams, John M. / Becerra-Rodriguez, Maria Angeles / Dunne, Matthew / Kammerer, Robert / Dveksler, Gabriela

evolution, expression, functions, and disease associations

2022

Abstract	Pregnancy-specific glycoproteins (PSGs) are members of the immunoglobulin superfamily and are closely related to the predominantly membrane-bound CEACAM proteins. PSGs are produced by placental trophoblasts and secreted into the maternal bloodstream at high levels where they may regulate maternal immune and vascular functions through receptor binding and modulation of cytokine and chemokine expression and activity. PSGs may have autocrine and paracrine functions in the placental bed, and PSGs can activate soluble and extracellular matrix bound TGF-β, with potentially diverse effects on multiple cell types. PSGs are also found at high levels in the maternal circulation, at least in human, where they may have endocrine functions. In a non-reproductive context, PSGs are expressed in the gastrointestinal tract and their deregulation may be associated with colorectal cancer and other diseases. Like many placental hormones, PSGs are encoded by multigene families and they have an unusual phylogenetic distribution, being found predominantly in species with hemochorial placentation, with the notable exception of the horse in which PSG-like proteins are expressed in the endometrial cups of the epitheliochorial placenta. The evolution and expansion of PSG gene families appears to be a highly active process, with significant changes in gene numbers and protein domain structures in different mammalian lineages, and reports of extensive copy number variation at the human locus. Against this apparent diversification, the available evidence indicates extensive conservation of PSG functions in multiple species. These observations are consistent with maternal-fetal conflict underpinning the evolution of PSGs.
Keywords	Text ; ddc:570
Subject code	610 ; 572
Language	English
Publishing date	2022-02-01
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Traceability of the local cultivar ‘Caaveiro’ in flour mixtures used to produce Galician bread by simple sequence repeats and droplet digital polymerase chain reaction technology

Ramos‐Cabrer, Ana María / Fernández‐Canto, Nerea / Almeida‐García, Fernando / Gorostidi, Ana / Lombardero‐Fernández, Matilde / Romero‐Rodríguez, María Ángeles / Pereira‐Lorenzo, Santiago

International Journal of Food Science & Technology. 2022 Nov., v. 57, no. 11 p.7085-7098

2022

Abstract: The analysis of simple sequence repeats (SSRs) and of bulk ground samples by droplet digital polymerase chain reaction (ddPCR) was investigated as an alternative to individual kernel testing for assessing the presence of local cultivars in common wheat ( ... ...

Abstract	The analysis of simple sequence repeats (SSRs) and of bulk ground samples by droplet digital polymerase chain reaction (ddPCR) was investigated as an alternative to individual kernel testing for assessing the presence of local cultivars in common wheat (Triticum aestivum L.) varietal blends. The recent Protected Geographical Indication (PGI) of ‘Pan Galego’ (Galician bread) requires that the flour comprise a minimum 25% local wheat cultivars. As a test for compliance with this minimum level, wheat flours were prepared by mixing commercial flours with 0%, 5%, 20%, 25% and 30% ‘Caaveiro’ and 100% ‘Caaveiro’ and 100% commercial flours were used as controls. A second analysis was performed with a second set of wheat flours with 5% and 25% ‘Caaveiro’. These were mixed with two different commercial flours to assess the potential ability of five SSRs to identify the percentage of ‘Caaveiro’, constituting the first reference of the use of SSRs in the traceability of specific autochthonous cultivars in flour blends. ddPCR using the QX200 system platform was used to the targeted proportions across the simulated range with two out of five SSRs, indicating that they can be used in the traceability of ‘Caaveiro’ in mixed flours and breads.
Keywords	Triticum aestivum ; breads ; compliance ; cultivars ; droplets ; flour ; food science ; indigenous species ; polymerase chain reaction ; protected designation of origin ; seeds ; technology ; traceability ; wheat
Language	English
Dates of publication	2022-11
Size	p. 7085-7098.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	883561-5
ISSN	0950-5423
ISSN	0950-5423
DOI	10.1111/ijfs.16048
Database	NAL-Catalogue (AGRICOLA)

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Article: Educational attainment and maternity in Spain

Davia Rodríguez, María Angeles / Legazpe, Nuria

Review of Economics of the Household Vol. 13, No. 4 , p. 871-900

not only "when" but also "how"

2015 Volume 13, Issue 4, Page(s) 871–900

Author's details	María A. Davia, Nuria Legazpe
Keywords	Fertility ; Human capital ; Intervening variables ; Duration analysis ; Decomposition
Language	English
Publisher	Springer Science + Business Media B.V.
Publishing place	Norwell, Mass.
Document type	Article
ZDB-ID	2108192X ; 2099806-5
ISSN	1573-7152 ; 1569-5239
ISSN (online)	1573-7152
ISSN	1569-5239
Database	ECONomics Information System

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Article: Element Content in Different Wheat Flours and Bread Varieties.

Fernández-Canto, María Nerea / García-Gómez, María Belén / Boado-Crego, Sonia / Vázquez-Odériz, María Lourdes / Muñoz-Ferreiro, María Nieves / Lombardero-Fernández, Matilde / Pereira-Lorenzo, Santiago / Romero-Rodríguez, María Ángeles

Foods (Basel, Switzerland)

2022 Volume 11, Issue 20

Abstract: The most consumed cereal-based product worldwide is bread. "Caaveiro", an autochthonous variety with a recent growing interest, is one of the wheat varieties that fulfill the 25% local flour requirement in the PGI "Pan Galego" bread baking industry. The ... ...

Abstract	The most consumed cereal-based product worldwide is bread. "Caaveiro", an autochthonous variety with a recent growing interest, is one of the wheat varieties that fulfill the 25% local flour requirement in the PGI "Pan Galego" bread baking industry. The element content of the refined wheat flours used to make "Pan Galego" (''Caaveiro'', FCv; Castilla, FC; and a mixture of both, FM) was evaluated in ICP-MS. In addition, wholegrain flour (FWM) was included in the analysis. Loaves of bread were made with these flours (a, 100% FC; b, 100% FCv); and c, FM: 75% FC + 25% FCv) and their element content was analyzed. Wholegrain flour ranked the highest in almost all elements, highlighting the P (494.80 mg/100 g), while the FM and the FC presented the opposite behavior, with the highest Se values (14.4 and 15.8 mg/100 g, respectively). FCv was situated in an intermediate position regarding P, K, Mg, Mn, Zn, Fe and Na content, standing closer to FWM, although it presents the highest values for Cu (1076.3 µg/100 g). The differences observed in flour were maintained in bread. Hence, the local cultivar ''Caaveiro'' has an interesting nutritional profile from the point of view of the element content.
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11203176
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Article ; Online: The Clinical Impact of Neoadjuvant Endocrine Treatment on Luminal-like Breast Cancers and Its Prognostic Significance: Results from a Single-Institution Prospective Cohort Study.

Martí, Covadonga / Yébenes, Laura / Oliver, José María / Moreno, Elisa / Frías, Laura / Berjón, Alberto / Loayza, Adolfo / Meléndez, Marcos / Roca, María José / Córdoba, Vicenta / Hardisson, David / Rodríguez, María Ángeles / Sánchez-Méndez, José Ignacio

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 4, Page(s) 2199–2210

Abstract: Purpose: Neoadjuvant endocrine treatment (NET) has become a useful tool for the downstaging of luminal-like breast cancers in postmenopausal patients. It enables us to increase breast- conserving surgery (BCS) rates, provides an opportunity for us to ... ...

Abstract	Purpose: Neoadjuvant endocrine treatment (NET) has become a useful tool for the downstaging of luminal-like breast cancers in postmenopausal patients. It enables us to increase breast- conserving surgery (BCS) rates, provides an opportunity for us to assess in vivo NET effectiveness, and allows us to study any biological changes that may act as valid biomarkers. The purpose of this study was to evaluate the safety and effectiveness of NET, and to assess the role of Ki67 proliferation rate changes as an indicator of endocrine responsiveness. Methods: From 2016 to 2020, a single-institution cohort of patients, treated with NET and further surgery, was evaluated. In patients with Ki67 ≥ 10%, a second core biopsy was performed after four weeks. Information regarding histopathological and clinical changes was gathered. Results: A total of 115 estrogen receptor-positive (ER+)/HER2-negative patients were included. The median treatment duration was 5.0 months (IQR: 2.0−6.0). The median maximum size in the surgical sample was 40% smaller than the pretreatment size measured by ultrasound (p < 0.0001). The median pretreatment Ki67 expression was 20.0% (IQR: 12.0−30.0), and was reduced to 5.0% (IQR: 1.8−10.0) after four weeks, and to 2.0% (IQR: 1.0−8.0) in the surgical sample (p < 0.0001). BCS was performed on 98 patients (85.2%). No pathological complete responses were recorded. A larger Ki67 fold change after four weeks was significantly related to a PEPI score of zero (p < 0.002). No differences were observed between luminal A- and B-like tumors, with regard to fold change and PEPI score. Conclusions: In our cohort, NET was proven to be effective for tumor size and Ki67 downstaging. This resulted in a higher rate of conservative surgery, aided in therapeutic decision making, provided prognostic information, and constituted a safe and well-tolerated approach.
MeSH term(s)	Breast Neoplasms/pathology ; Female ; Humans ; Ki-67 Antigen ; Neoadjuvant Therapy ; Prognosis ; Prospective Studies
Chemical Substances	Ki-67 Antigen
Language	English
Publishing date	2022-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29040179
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Article: Role of

Sopeña Sutil, Raquel / Gómez Grande, Adolfo / González Díaz, Alejandro / Téigel Tobar, Julio / Cabeza Rodríguez, María Ángeles / González Billalabeitia, Enrique / Rodríguez Antolín, Alfredo

Archivos espanoles de urologia

2022 Volume 75, Issue 8, Page(s) 684–692

Abstract: Objective: To assess the diagnostic accuracy of : Secondary objectives: To assess the concordance between : Material and methods: Retrospective observational study of 78 patients with high-risk PC undergoing : Results: The median age was 67 ... ...

Abstract	Objective: To assess the diagnostic accuracy of Secondary objectives: To assess the concordance between Material and methods: Retrospective observational study of 78 patients with high-risk PC undergoing Results: The median age was 67 years old and mean PSA was 42.39 ng/mL. The sensitivity, specificity and NPV in global initial staging for PET/CT Conclusions: 18
MeSH term(s)	Male ; Humans ; Aged ; Choline ; Positron Emission Tomography Computed Tomography/methods ; Prostate-Specific Antigen ; Prostatic Neoplasms/pathology ; Lymph Nodes/pathology ; Neoplasm Staging ; Positron-Emission Tomography
Chemical Substances	Choline (N91BDP6H0X) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2022-08-01
Publishing country	Spain
Document type	Observational Study ; Journal Article
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
DOI	10.56434/j.arch.esp.urol.20227508.99
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