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  1. Article: Influence of the microstructure and roughness of weakness planes on the strength anisotropy of a foliated clay-rich fault gouge

    Insua-Arévalo, J.M / Tsige, M / Sánchez-Roldán, J.L / Rodríguez-Escudero, E / Martínez-Díaz, J.J

    Engineering geology. 2021 Aug., v. 289

    2021  

    Abstract: Cataclastic rocks, as clay-rich fault gouges, are commonly present in brittle rock masses when fault zones appear during geological engineering projects. Highly deformed rocks that are of poor mechanical quality can lead to technical, safety, and ... ...

    Abstract Cataclastic rocks, as clay-rich fault gouges, are commonly present in brittle rock masses when fault zones appear during geological engineering projects. Highly deformed rocks that are of poor mechanical quality can lead to technical, safety, and economic problems in rock engineering. The aim of this study is to characterise the resistant behaviour of a highly deformed clay-rich gouge >40 m wide with a marked tectonic fabric that indicates strength anisotropy. We present the results of consolidated-undrained (CU) triaxial tests that were performed at low confining pressures (50, 150, and 300 kPa) on several sets of foliated gouge specimens with four different orientations in the tectonic fabric. Specimens were collected from the encapsulated rock cores of two research boreholes drilled through the Alhama de Murcia Fault (AMF), a main regional fault located in SE Spain. The strain–stress relationships and failure modes were established, indicating that the gouge behaves as hard soil or very soft rock. The test results were adjusted at each orientation using the non-linear Hoek and Brown criteria by considering the fault gouge as an intact material or as a tectonised rockmass. Here, we use the Geological Strength Index (GSI) as an indicator of the rockmass strength that depends on the direction of the tectonic fabric. However, the results from specimens with tectonic fabric that is oriented most favourably for failure were not the weakest in terms of rock strength. Such an anomalous result could be the result of asymmetry in the roughness of the weakness planes that is related to the original gouge microstructure characterised by the strong reorientation of clays in an S-C′ like tectonic fabric.Our results will be useful for practical applications that are related to the stability of slopes and/or shallow underground excavations in brittle fault zones, and provide an inexpensive and easy way to preliminarily evaluate the anisotropic behaviour of this type of brittle fault zones for future engineering projects.
    Keywords anisotropy ; asymmetry ; brittleness ; encapsulation ; fabrics ; microstructure ; roughness ; soil ; tectonics ; Spain
    Language English
    Dates of publication 2021-08
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ISSN 0013-7952
    DOI 10.1016/j.enggeo.2021.106186
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Anal cytology in women: Experience from a single tertiary center.

    Díaz Del Arco, C / García, D / Sanabria, C / Rodríguez Escudero, E / Domínguez, I / Sanz Ortega, G / Fernández Aceñero, M J

    Pathology, research and practice

    2019  Volume 215, Issue 5, Page(s) 905–909

    Abstract: Introduction: Anal cytology (AC) can be used as a screening tool for detection of anal HPV associated lesions, mainly in men who have sex with men and in immunosuppressed patients. Our aim is to review our experience with AC in women.: Material & ... ...

    Abstract Introduction: Anal cytology (AC) can be used as a screening tool for detection of anal HPV associated lesions, mainly in men who have sex with men and in immunosuppressed patients. Our aim is to review our experience with AC in women.
    Material & methods: We have retrospectively reviewed all AC diagnosed between 2010-2017 in a single tertiary hospital (n = 644) and selected those performed in women (n = 158).
    Results: 24.53% of AC were performed in women. 14.7% of all women were HIV positive and 56.7% referred anal intercourse. Squamous lesions were found in 27.2% of women, most of them ASCUS and LSIL (14% and 11.5%). HPV DNA was detected in 38.6% of patients, and 63.9% of them showed positivity for multiple high-risk types. Anal biopsy showed high grade lesions in 20% of biopsied patients. We observed a significant relationship between HPV status and receptive anal sex, and the association between HPV status and anal histological diagnosis tended to significance. Sensitivity, specificity, negative predictive value and positive predictive value for anal cytology were 57%; 83%; 28% and 94%, respectively. 70.9% of women had synchronous cervical cytology, and squamous cervical lesions were detected in 46.4% of the cases, most of them LSIL or ASCUS (21.4% and 15.2%). We did not confirm a significant association between cytological diagnosis of cervical and anal samples.
    Conclusions: AC is less widely used in women than in homosexual men. However, women show important rates of anal lesions, regardless of their HIV status. More studies should be performed to assess the potential impact of screening protocols in this population.
    MeSH term(s) Adult ; Anus Neoplasms/diagnosis ; Anus Neoplasms/virology ; Cytodiagnosis/methods ; Female ; Humans ; Middle Aged ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Retrospective Studies
    Language English
    Publishing date 2019-01-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2019.01.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud III Zs.20: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Clinical Relevance of ASC-H Cytologies: Experience in a Single Tertiary Hospital.

    Díaz Del Arco, Cristina / Sanabria Montoro, M Carmen / García López, Dolores / Rodríguez Escudero, Eva / Fernández Aceñero, M Jesús

    Acta cytologica

    2016  Volume 60, Issue 3, Page(s) 217–224

    Abstract: Objectives: To review the cases of atypical squamous cells (ASC), cannot exclude squamous intraepithelial lesion (ASC-H) diagnosed at a single institution and to discuss the interpretation challenges and clinical management of these cases.: Study ... ...

    Abstract Objectives: To review the cases of atypical squamous cells (ASC), cannot exclude squamous intraepithelial lesion (ASC-H) diagnosed at a single institution and to discuss the interpretation challenges and clinical management of these cases.
    Study design: The ASC-H cases diagnosed at our institution from 2006 to 2015 were studied retrospectively; of 159,000 Pap smears, there were 959 cases of ASC of undetermined significance (ASC-US) and 148 cases of ASC-H. We have reviewed the clinical records of the ASC-H cases, and data have been analyzed using SPSS 20.0.
    Results: Median age was 43.1 years; 49.6% of the patients had previous cervical cytologies, and 55.9% of them were negative. Following ASC-H diagnosis, another smear was obtained in 97.1% of the cases and in 67.6% a biopsy was performed. Biopsy revealed low-grade dysplasia in 18.8% of the cases, high-grade dysplasia in 27.8%, and infiltrating carcinoma in 2.3%. Patients with significant lesions in histology were younger than patients with negative results (p = 0.08). A diagnosis of ASC-H/squamous intraepithelial lesion in the repeated cytology had a sensitivity of 74.2%, specificity of 39.6%, positive predictive value of 44.8%, and negative predictive value of 70% for the diagnosis of dysplasia.
    Conclusions: ASC-H diagnosis is associated with a high incidence of histological high-grade lesions. A repeat cytology can aid in the selection of high-risk patients, but there may be false-negative results.
    MeSH term(s) Adult ; Atypical Squamous Cells of the Cervix/pathology ; Biopsy/methods ; Cervical Intraepithelial Neoplasia/pathology ; Colposcopy/methods ; Female ; Humans ; Papanicolaou Test/methods ; Retrospective Studies ; Tertiary Care Centers ; Uterine Cervical Neoplasms/pathology ; Vaginal Smears/methods
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000448022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Clinical Relevance of ASC-H Cytologies: Experience in a Single Tertiary Hospital

    Díaz del Arco, Cristina / Sanabria Montoro, Mª Carmen / García López, Dolores / Rodríguez Escudero, Eva / Fernández Aceñero, Mª Jesús

    Acta Cytologica

    2016  Volume 60, Issue 3, Page(s) 217–224

    Abstract: Objectives: To review the cases of atypical squamous cells (ASC), cannot exclude squamous intraepithelial lesion (ASC-H) diagnosed at a single institution and to discuss the interpretation challenges and clinical management of these cases. Study Design: ... ...

    Institution Department of Surgical Pathology, Hospital Clínico San Carlos, Madrid, Spain
    Abstract Objectives: To review the cases of atypical squamous cells (ASC), cannot exclude squamous intraepithelial lesion (ASC-H) diagnosed at a single institution and to discuss the interpretation challenges and clinical management of these cases. Study Design: The ASC-H cases diagnosed at our institution from 2006 to 2015 were studied retrospectively; of 159,000 Pap smears, there were 959 cases of ASC of undetermined significance (ASC-US) and 148 cases of ASC-H. We have reviewed the clinical records of the ASC-H cases, and data have been analyzed using SPSS 20.0. Results: Median age was 43.1 years; 49.6% of the patients had previous cervical cytologies, and 55.9% of them were negative. Following ASC-H diagnosis, another smear was obtained in 97.1% of the cases and in 67.6% a biopsy was performed. Biopsy revealed low-grade dysplasia in 18.8% of the cases, high-grade dysplasia in 27.8%, and infiltrating carcinoma in 2.3%. Patients with significant lesions in histology were younger than patients with negative results (p = 0.08). A diagnosis of ASC-H/squamous intraepithelial lesion in the repeated cytology had a sensitivity of 74.2%, specificity of 39.6%, positive predictive value of 44.8%, and negative predictive value of 70% for the diagnosis of dysplasia. Conclusions: ASC-H diagnosis is associated with a high incidence of histological high-grade lesions. A repeat cytology can aid in the selection of high-risk patients, but there may be false-negative results.
    Keywords ASC-H ; Atypical squamous cells ; Bethesda system ; Cervical cancer ; Cervical intraepithelial neoplasia ; Cervical cytology ; High-grade squamous intraepithelial lesion ; Squamous intraepithelial lesion
    Language English
    Publishing date 2016-08-05
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Gynecologic Cytopathology
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000448022
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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