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  1. Article ; Online: Antiretroviral regimens for HIV and HBV co-infection in patients receiving rituximab.

    Rodríguez-Gómez, Francisco J

    The Lancet. Haematology

    2020  Volume 7, Issue 12, Page(s) e857

    MeSH term(s) Coinfection/drug therapy ; HIV Infections/complications ; HIV Infections/drug therapy ; Hematologic Neoplasms ; Hepatitis B virus ; Humans ; Patients ; Rituximab/adverse effects
    Chemical Substances Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Letter ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30325-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Implementing Horizon Scanning as a tool for the strategic development of regulatory guidelines for nanotechnology-enabled health products.

    Rodríguez-Gómez, Francisco D / Monferrer, Dominique / Penon, Oriol / Rivera-Gil, Pilar

    Frontiers in medicine

    2024  Volume 10, Page(s) 1308047

    Abstract: Strategic regulatory development is essential to ensure that new innovations in nanotechnology-enabled health products (NHPs) successfully reach the market and benefit patients. Currently, the lack of specific regulatory guidelines for NHPs is considered ...

    Abstract Strategic regulatory development is essential to ensure that new innovations in nanotechnology-enabled health products (NHPs) successfully reach the market and benefit patients. Currently, the lack of specific regulatory guidelines for NHPs is considered one of the primary causes of the so-called "valley of death" in these products, impacting both current and future advancements. In this study, we have implemented a methodology to anticipate key trends in NHP development and compare them with the current regulatory landscape applicable to NHPs. This methodology relies on Horizon Scanning, a tool commonly used by policymakers to foresee future needs and proactively shape a regulatory framework tailored to those needs. Through the application of this methodology, different trends in NHP have been identified, notably NHPs for drug delivery and dental applications. Furthermore, the most disruptive elements involve NHPs that are multicomposite and multifunctional, harnessing nano-scale properties to combine therapeutic and diagnostic purposes within a single product. When compared with the regulatory landscape, current regulations are gradually adapting to accommodate emerging trends, with specific guidelines being developed. However, for the most disruptive elements, multicomposite and multifunctional NHPs, their novelty still poses significant regulatory challenges, requiring a strategic development of guidelines by regulatory agencies to ensure their safe and effective integration into healthcare practices. This study underscores the importance of proactive regulatory planning to bridge the gap between NHP innovation and market implementation.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1308047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Classification system for nanotechnology-enabled health products with both scientific and regulatory application.

    Rodríguez-Gómez, Francisco D / Penon, Oriol / Monferrer, Dominique / Rivera-Gil, Pilar

    Frontiers in medicine

    2023  Volume 10, Page(s) 1212949

    Abstract: The lack of specific regulatory guidelines for nanotechnology-enabled health products (NHPs) is hampering development and patient access to these innovative technologies. Namely, there is an urgent need for harmonized regulatory definitions and ... ...

    Abstract The lack of specific regulatory guidelines for nanotechnology-enabled health products (NHPs) is hampering development and patient access to these innovative technologies. Namely, there is an urgent need for harmonized regulatory definitions and classification systems that allow establishing a standardized framework for NHPs regulatory assessment. In this work, a novel classification system for NHPs is proposed. This classification can be applied for sorting nano-based innovations and regulatory guidelines according to the type of NHPs they address. Said methodology combines scientific and regulatory principles and it is based on the following criteria: principal mode of action, chemical composition, medical purpose and nanomanufacturing approach. This classification system could serve as a useful tool to sensor the state of the art of NHPs which is particularly useful for regulators to support strategy development of regulatory guidelines. Additionally, this tool would also allow manufacturers of NHPs to align their development plans with their applicable guidelines and standards and thus fulfill regulators expectations.
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1212949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Strengthening Privacy and Data Security in Biomedical Microelectromechanical Systems by IoT Communication Security and Protection in Smart Healthcare.

    Jaime, Francisco J / Muñoz, Antonio / Rodríguez-Gómez, Francisco / Jerez-Calero, Antonio

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 21

    Abstract: Biomedical Microelectromechanical Systems (BioMEMS) serve as a crucial catalyst in enhancing IoT communication security and safeguarding smart healthcare systems. Situated at the nexus of advanced technology and healthcare, BioMEMS are instrumental in ... ...

    Abstract Biomedical Microelectromechanical Systems (BioMEMS) serve as a crucial catalyst in enhancing IoT communication security and safeguarding smart healthcare systems. Situated at the nexus of advanced technology and healthcare, BioMEMS are instrumental in pioneering personalized diagnostics, monitoring, and therapeutic applications. Nonetheless, this integration brings forth a complex array of security and privacy challenges intrinsic to IoT communications within smart healthcare ecosystems, demanding comprehensive scrutiny. In this manuscript, we embark on an extensive analysis of the intricate security terrain associated with IoT communications in the realm of BioMEMS, addressing a spectrum of vulnerabilities that spans cyber threats, data manipulation, and interception of communications. The integration of real-world case studies serves to illuminate the direct repercussions of security breaches within smart healthcare systems, highlighting the imperative to safeguard both patient safety and the integrity of medical data. We delve into a suite of security solutions, encompassing rigorous authentication processes, data encryption, designs resistant to attacks, and continuous monitoring mechanisms, all tailored to fortify BioMEMS in the face of ever-evolving threats within smart healthcare environments. Furthermore, the paper underscores the vital role of ethical and regulatory considerations, emphasizing the need to uphold patient autonomy, ensure the confidentiality of data, and maintain equitable access to healthcare in the context of IoT communication security. Looking forward, we explore the impending landscape of BioMEMS security as it intertwines with emerging technologies such as AI-driven diagnostics, quantum computing, and genomic integration, anticipating potential challenges and strategizing for the future. In doing so, this paper highlights the paramount importance of adopting an integrated approach that seamlessly blends technological innovation, ethical foresight, and collaborative ingenuity, thereby steering BioMEMS towards a secure and resilient future within smart healthcare systems, in the ambit of IoT communication security and protection.
    MeSH term(s) Humans ; Privacy ; Computing Methodologies ; Ecosystem ; Micro-Electrical-Mechanical Systems ; Quantum Theory ; Communication ; Delivery of Health Care ; Computer Security
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23218944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: LP309 a new strain of Lactiplantibacillus pentosus that improves the lactic fermentation of Spanish-style table olives.

    Rodríguez-Gómez, Francisco / Valero, Antonio / Vives Lara, Elena / Marín, Ana / Ramírez, Eva María

    Journal of food science

    2023  Volume 88, Issue 12, Page(s) 5191–5202

    Abstract: Different varieties of table olives have suitable morphological characteristics that allow them to be processed as Spanish-style green table olives. However, the Campiñesa cultivar presents difficulties when submitted to a lactic fermentation, in spite ... ...

    Abstract Different varieties of table olives have suitable morphological characteristics that allow them to be processed as Spanish-style green table olives. However, the Campiñesa cultivar presents difficulties when submitted to a lactic fermentation, in spite of being inoculated with dedicated starter cultures such as OleicaStarter. The strategy followed in this study to facilitate the start of lactic fermentation was to reinforce the OleicaStarter culture with the use of the Lactoplantibacillus pentosus Lp309 a strain that enhanced the survival of lactic acid bacteria (LAB) at the beginning of fermentation, reaching final pH values (4.08 ± 0.01), free acidity (1.00 ± 0.01 g/100 mL of brine), LAB population (6.17 ± 0.09 log CFU/mL), nutrient depletion (0.80 ± 0.09 g/kg of pulp), and lactic acid production (11.85 ± 0.72 g/L). These values allowed stabilization of the final product, thus complying with the quality and food safety standards established by the Codex Alimentarius for table olives.
    MeSH term(s) Lactobacillus ; Olea/microbiology ; Fermentation ; Hydrogen-Ion Concentration ; Food Microbiology ; Lactobacillus pentosus
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    DOI 10.1111/1750-3841.16802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Functional features of the exopolysaccharide extracts produced by

    López-García, Elio / Marín-Gordillo, Ana / Sánchez-Hidalgo, Marina / Ávila-Román, Javier / Romero-Gil, Verónica / Bermúdez-Oria, Alejandra / Benítez-Cabello, Antonio / Garrido-Fernández, Antonio / Rodríguez-Gómez, Francisco / Arroyo-López, Francisco Noé

    Food & function

    2024  Volume 15, Issue 4, Page(s) 1938–1947

    Abstract: This study evaluates the functional characteristics of the exopolysaccharide (EPS) extracts produced by various strains ... ...

    Abstract This study evaluates the functional characteristics of the exopolysaccharide (EPS) extracts produced by various strains of
    MeSH term(s) Humans ; Polysaccharides, Bacterial/chemistry ; Olea ; Dietary Supplements ; Culture Media ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Anti-Inflammatory Agents
    Chemical Substances Polysaccharides, Bacterial ; Culture Media ; Antioxidants ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04223e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hand and arm injuries of torpid evolution after a puncture wound in a male fond of hiking.

    Rodríguez-Gómez, Francisco Javier / Pérez Cáceres, Juan Antonio / Martínez-Marcos, Francisco Javier / Merino Muñoz, Dolores

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  Volume 39, Issue 10, Page(s) 516–517

    MeSH term(s) Arm Injuries ; Humans ; Male ; Punctures
    Language English
    Publishing date 2021-09-23
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2021.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hand and arm injuries of torpid evolution after a puncture wound in a male fond of hiking.

    Rodríguez-Gómez, Francisco Javier / Pérez Cáceres, Juan Antonio / Martínez-Marcos, Francisco Javier / Merino Muñoz, Dolores

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  

    Title translation Lesiones en mano y brazo de curso tórpido tras herida punzante en un varón aficionado al senderismo.
    Language Spanish
    Publishing date 2021-03-06
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2021.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ulcerated lesion on the right hand with a torpid course and subsequent «sporotrichoid» dissemination, in a fish fancier woman.

    Rodríguez-Gómez, Francisco Javier / Saavedra-Martín, José María / Martínez-Marcos, Francisco Javier / Merino-Muñoz, Dolores

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  Volume 39, Issue 7, Page(s) 355–356

    MeSH term(s) Animals ; Female ; Fishes ; Hand ; Humans ; Ulcer
    Language English
    Publishing date 2021-05-21
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2021.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Multi-Statistical Approach for the Study of Volatile Compounds of Industrial Spoiled Manzanilla Spanish-Style Table Olive Fermentations

    Garrido-Fernández, Antonio / Montaño, Alfredo / Cortés-Delgado, Amparo / Rodríguez-Gómez, Francisco / Arroyo-López, Francisco Noé

    Foods. 2021 May 24, v. 10, no. 6

    2021  

    Abstract: Table olives can suffer different types of spoilage during fermentation. In this work, a multi-statistical approach (standard and compositional data analysis) was used for the study of the volatile organic compounds (VOCs) associated with altered ( ... ...

    Abstract Table olives can suffer different types of spoilage during fermentation. In this work, a multi-statistical approach (standard and compositional data analysis) was used for the study of the volatile organic compounds (VOCs) associated with altered (butyric, sulfidic, and putrid) and non-altered (normal) Manzanilla Spanish-style table olive fermentations. Samples were collected from two industrial fermentation yards in Seville (Spain) in the 2019/2020 season. The VOC profiles of altered (n = 4) and non-altered (n = 6) samples were obtained by headspace solid-phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME-GC-MS). Ninety-one VOCs were identified and grouped into alcohols (30), esters (21), carbonyl compounds (12), acids (10), terpenes (6), phenols (6), sulfur compounds (2), and others (4). The association of the VOCs with spoilage samples depended on the standard or compositional statistical methodology used. However, butyric spoilage was strongly linked by several techniques to methyl butanoate, ethyl butanoate, and butanoic acid; sulfidic spoilage with 2-propyl-1-pentanol, dimethyl sulfide, methanol, 2-methylbutanal, 2-methyl-2-butenal, ethanol, 2-methyl-3-buten-2-ol, and isopentanol, while putrid was mainly related to D-limonene and 2-pentanol. Our data contribute to a better characterisation of non-zapatera spoiled table olive fermentations and show the convenience of using diverse statistical techniques for a most robust selection of spoilage VOC markers.
    Keywords butyrates ; dimethyl sulfide ; ethanol ; fermentation ; gas chromatography-mass spectrometry ; headspace analysis ; limonene ; methanol ; olives ; pentanols ; solid phase microextraction ; spoilage ; sulfur ; volatile organic compounds ; Spain
    Language English
    Dates of publication 2021-0524
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10061182
    Database NAL-Catalogue (AGRICOLA)

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