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Article ; Online: Results of a national survey about the management of patients with acute uncomplicated diverticulitis.

Correa Bonito, Alba / Cerdán Santacruz, Carlos / Pellino, Gianluca / Fernández Miguel, Tamara / Bermejo Marcos, Elena / Rodríguez Sánchez, Ana / García Septiem, Javier / Martín-Pérez, Elena

Cirugia espanola

2024 Volume 102, Issue 4, Page(s) 202–208

Abstract: Introduction: Management of patients diagnosed of acute uncomplicated diverticulitis has evolved lately and according to the latest guidelines, outpatient treatment and management without antibiotherapy may be used in selected patients. The aim of this ... ...

Abstract	Introduction: Management of patients diagnosed of acute uncomplicated diverticulitis has evolved lately and according to the latest guidelines, outpatient treatment and management without antibiotherapy may be used in selected patients. The aim of this study is to evaluate the adhesión among national centres to these and others recommendations related to this pathology. Methods: An online national survey, that has been broadcast by several applications, was performed. The results obtained were statistically analysed. Results: A total of 104 surgeons participated, representing 69 national hospitals. Of those, in 82.6% of the centres, outpatient management is performed for acute uncomplicated diverticulitis. 23.2% of the hospitals have a protocol stablished for treatment without antibiotherapy in selected patients. Centres that do not follow these protocols allege that the mean reasons are the logistic difficulties to set them up (49.3%) and the lack of current evidence for it (44.8%). Significative statistical differences have been found when comparing the establishment of such protocols between centres with advanced accredited units and those who are not, with higher rates of outpatient management and treatment without antibiotics in accredited units (p ≤ .05). Conclusions: In spite that this a very common disease, there is a huge national heterogeneity in its treatment. This is why it would adviseable to unify diagnostic and treatment criteria by the collaboration of scientific societies and the simplification of the development of hospitalary protocols.
MeSH term(s)	Humans ; Diverticulitis/therapy ; Anti-Bacterial Agents/therapeutic use ; Ambulatory Care/methods
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-08
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2023.11.023
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Article ; Online: Appendiceal Pinworms.

Mora-Guzmán, Ismael / Rodriguez-Sanchez, Ana

The New England journal of medicine

2018 Volume 378, Issue 13, Page(s) 1232

Language	English
Publishing date	2018-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMicm1713306
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Article: Integrating clinical research in an operative screening and diagnostic breast imaging department: First experience, results and perspectives using microwave imaging.

Álvarez Sánchez-Bayuela, Daniel / Giovanetti González, Rubén / Aguilar Angulo, Paul Martín / Cruz Hernández, Lina Marcela / Sánchez-Camacho González-Carrato, María Del Pilar / Rodríguez Sánchez, Ana / Tiberi, Gianluigi / Romero Castellano, Cristina

Heliyon

2023 Volume 9, Issue 11, Page(s) e21904

Abstract: Rationale and objectives: Clinical research is crucial for evaluating new medical procedures and devices. It is important for healthcare units and hospitals to minimize the disruptions caused by conducting clinical studies; however, complex clinical ... ...

Abstract	Rationale and objectives: Clinical research is crucial for evaluating new medical procedures and devices. It is important for healthcare units and hospitals to minimize the disruptions caused by conducting clinical studies; however, complex clinical pathways require dedicated recruitment and study designs.This work presents the effective introduction of novel microwave breast imaging (MBI), via MammoWave apparatus, into the clinical routine of an operative screening and diagnostic breast imaging department for conducting a multicentric clinical study. Materials and methods: Microwave breast imaging, using MammoWave apparatus, was performed on volunteers coming from different clinical pathways. Clinical data, comprising demographics and conventional radiologic reports (used as reference standard), was collected; a satisfaction questionnaire was filled by every volunteer. Microwave images were analyzed by an automatic clinical decision support system, which quantified their corresponding features to discriminate between breasts with no relevant radiological findings (NF) and breasts with described findings (WF). Results: Conventional breast imaging (DBT, US, MRI) and MBI were performed and adapted to assure best clinical practices and optimum pathways. 180 volunteers, both symptomatic and asymptomatic, were enrolled in the study. After microwave images' quality assessment, 48 NF (15 dense) and 169 WF (88 dense) breasts were used for the prospective study; 48 (18 dense) breasts suffered from a histology-confirmed carcinoma. An overall sensitivity of 85.8 % in breasts lesions' detection was achieved by the microwave imaging apparatus. Conclusion: An optimum recruitment strategy was implemented to assess MBI. Future trials may show the clinical usefulness of microwave imaging, which may play an important role in breast screening.
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21904
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Article: FiLaC® procedure for highly selected anal fistula patients: indications, safety and efficacy from an observational study at a tertiary referral center.

Blanco Terés, Lara / Bermejo Marcos, Elena / Cerdán Santacruz, Carlos / Correa Bonito, Alba / Rodríguez Sanchez, Ana / Chaparro, María / Gisbert, Javier P / García Septiem, Javier / Martín-Pérez, Elena

Revista espanola de enfermedades digestivas

2023 Volume 115, Issue 12, Page(s) 700–706

Abstract: Background: the ideal clinical profile of patients or fistula features for fistula laser closure (FiLaC®) technique remain to be established. The aim of this study was to analyze clinical outcomes and the safety profile of FiLaC® in search for an ideal ... ...

Abstract	Background: the ideal clinical profile of patients or fistula features for fistula laser closure (FiLaC®) technique remain to be established. The aim of this study was to analyze clinical outcomes and the safety profile of FiLaC® in search for an ideal setting for this technique. Methods: a retrospective observational study was performed from a prospective database including all consecutive patients who underwent surgery for anal fistula (AF) with FiLaC® in the coloproctology unit of a tertiary referral center, between October 2015 and December 2021. The FiLaC® procedure was offered to AF patients who were considered to be at risk of fecal incontinence. Fistulas were described according to Parks' classification and categorized as complex or simple according to the American Gastroenterological Association (AGA) guidelines. Healing was defined by the closure of the internal and external openings for at least six months. Predictive factors of AF healing were investigated. Results: a total of 36 patients were included, with a mean age of 48 ± 13.9 years. Twenty patients (55.6 %) were male and 13 patients (36 %) had Crohn's disease (CD). Fourteen patients (38.8 %) had a complex fistula. The primary and secondary healing rates were 55.6 % and 91.7 %, respectively, during a median follow-up time of 12 months (IQR 7-29). No fecal continence impairment was registered in any case. The proportion of patients with primary healing was significantly higher in CD patients (76.9 % vs 43.5 %, p = 0.048). Conclusions: FiLaC® is a sphincter-preserving procedure with an excellent safety profile and reasonable success rate despite of the strict patient selection. This technique may be attractive for patients with CD due to its higher primary healing rate.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Female ; Treatment Outcome ; Tertiary Care Centers ; Anal Canal/surgery ; Rectal Fistula/surgery ; Retrospective Studies ; Crohn Disease/complications
Language	English
Publishing date	2023-06-21
Publishing country	Spain
Document type	Observational Study ; Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2023.9644/2023
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Article: Presacral neuroendocrine tumour in a patient diagnosed with Currarino's syndrome.

Correa Bonito, Alba / Maqueda González, Rocío / Rodríguez Sánchez, Ana / Bermejo Marcos, Elena / Blanco Terés, Lara / García Septiem, Javier / Martín Pérez, Elena

Gastroenterologia y hepatologia

2021 Volume 45 Suppl 1, Page(s) 62–63

Title translation	Tumor neuroendocrino presacro en una paciente con síndrome de Currarino.
MeSH term(s)	Anal Canal/abnormalities ; Digestive System Abnormalities ; Humans ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/diagnostic imaging ; Rectum/abnormalities ; Sacrum/abnormalities ; Syringomyelia/diagnosis
Language	Spanish
Publishing date	2021-05-21
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2021.03.009
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Article: An unusual enterolith ileus.

Mora-Guzmán, Ismael / Muñoz de Nova, José Luis / Rodríguez Sánchez, Ana

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2017 Volume 109, Issue 4, Page(s) 292

Abstract: The duodenum is an uncommon location of diverticula in the digestive tract, and they are often asymptomatic. Formation of an enterolith inside diverticula has been previously described, although it is a rare condition. In this context, intestinal ... ...

Abstract	The duodenum is an uncommon location of diverticula in the digestive tract, and they are often asymptomatic. Formation of an enterolith inside diverticula has been previously described, although it is a rare condition. In this context, intestinal obstruction due to distal migration of foreign bodies is extremely rare. We report a case of an 86-year-old woman with obstructive symptoms due to a jejunal foreign body that had migrated from a duodenal diverticulum. An emergency laparotomy was performed to extract a phytobezoar. Enterolith ileus secondary to duodenal diverticula is an exceptional entity. Diagnosis and management are usually delayed because of a non-specific presentation, and early surgical exploration is required for bowel disimpaction. This condition should be considered in elderly patients with prolonged immobilization or neurodegenerative diseases.
Language	English
Publishing date	2017-04
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
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Article ; Online: Isolated orbital metastasis as an initial presentation of a breast cancer.

Mora-Guzmán, Ismael / Maqueda González, Rocío / Doblado Cardellach, Beatriz / Rodríguez Sánchez, Ana

Cirugia espanola

2017 Volume 96, Issue 2, Page(s) 119

Title translation	Metástasis orbitaria solitaria como presentación inicial de cáncer de mama.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Humans ; Middle Aged ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/secondary
Language	Spanish
Publishing date	2017-07-18
Publishing country	Spain
Document type	Case Reports ; Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.ciresp.2017.06.001
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Article: Tailgut cysts: Presentation of four cases.

Mora-Guzmán, Ismael / Alonso Casado, Adolfo Pedro / Rodríguez Sánchez, Ana / Bermejo Marcos, Elena

Gastroenterologia y hepatologia

2017 Volume 41, Issue 2, Page(s) 103–105

Title translation	Hamartoma quístico retrorrectal: presentación de 4 casos.
MeSH term(s)	Adult ; Asymptomatic Diseases ; Cysts/diagnostic imaging ; Cysts/pathology ; Cysts/surgery ; Female ; Hamartoma/diagnostic imaging ; Hamartoma/pathology ; Hamartoma/surgery ; Humans ; Male ; Middle Aged ; Sacrococcygeal Region/diagnostic imaging ; Sacrococcygeal Region/pathology ; Sacrococcygeal Region/surgery
Language	Spanish
Publishing date	2017-03-27
Publishing country	Spain
Document type	Letter
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2017.02.006
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Article ; Online: Meiotic segregation analyses of reciprocal translocations in spermatozoa and embryos: no support for predictive value regarding PGD outcome.

Haapaniemi Kouru, Katarina / Malmgren, Helena / White, Irene / Rodriguez Sanchez, Ana / Syk Lundberg, Elisabeth

Reproductive biomedicine online

2017 Volume 34, Issue 6, Page(s) 645–652

Abstract: Translocation heterozygotes have an increased risk of producing gametes with unbalanced chromosome content. This often leads to reproductive problems such as infertility, repeated miscarriages or birth of an affected child. To increase the chances of ... ...

Abstract	Translocation heterozygotes have an increased risk of producing gametes with unbalanced chromosome content. This often leads to reproductive problems such as infertility, repeated miscarriages or birth of an affected child. To increase the chances of having a healthy live-born child, translocation heterozygotes often opt for preimplantation genetic diagnosis (PGD). The aim of this study was to investigate whether there is a correlation between chromosome segregation in spermatozoa from translocation heterozygotes and the number of balanced embryos produced during PGD that may be used to predict the PGD outcome. Ten male reciprocal translocation heterozygotes that went through PGD at a Stockholm PGD centre were included. We analysed 1000 spermatozoa from each patient and between 3 and 29 embryos from the total of PGD cycles that the couples went through. Fluorescence in-situ hybridization (FISH) analysis of spermatozoa and embryos was performed with the same DNA probes. We found that the proportion of balanced spermatozoa was much higher than the proportion of balanced embryos during PGD. Our results indicate that a sperm FISH analysis prior to PGD is not a reliable predictor of the PGD outcome. PGD is a valuable reproductive alternative for translocation heterozygotes with reproductive problems and should be offered to these couples.
Language	English
Publishing date	2017-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2017.02.013
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Article ; Online: The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin.

Metabolism: clinical and experimental

2024 , Page(s) 155932

Abstract: Background: Obesity-induced hypogonadism (OIH) is a prevalent, but often neglected condition in men, which aggravates the metabolic complications of overweight. While hypothalamic suppression of Kiss1-encoded kisspeptin has been suggested to contribute ... ...

Abstract	Background: Obesity-induced hypogonadism (OIH) is a prevalent, but often neglected condition in men, which aggravates the metabolic complications of overweight. While hypothalamic suppression of Kiss1-encoded kisspeptin has been suggested to contribute to OIH, the molecular mechanisms for such repression in obesity, and the therapeutic implications thereof, remain unknown. Methods: A combination of bioinformatic, expression and functional analyses was implemented, assessing the role of the evolutionary-conserved miRNAs, miR-137 and miR-325, in mediating obesity-induced suppression of hypothalamic kisspeptin, as putative mechanism of central hypogonadism and metabolic comorbidities. The implications of such miR-137/325-kisspeptin interplay for therapeutic intervention in obesity were also explored using preclinical OIH models. Results: MiR-137/325 repressed human KISS1 3'-UTR in-vitro and inhibited hypothalamic kisspeptin content in male rats, while miR-137/325 expression was up-regulated, and Kiss1/kisspeptin decreased, in the medio-basal hypothalamus of obese rats. Selective over-expression of miR-137 in Kiss1 neurons reduced Kiss1/ kisspeptin and partially replicated reproductive and metabolic alterations of OIH in lean mice. Conversely, interference of the repressive actions of miR-137/325 selectively on Kiss1 3'-UTR in vivo, using target-site blockers (TSB), enhanced kisspeptin content and reversed central hypogonadism in obese rats, together with improvement of glucose intolerance, insulin resistance and cardiovascular and inflammatory markers, despite persistent exposure to obesogenic diet. Reversal of OIH by TSB miR-137/325 was more effective than chronic kisspeptin or testosterone treatments in obese rats. Conclusions: Our data disclose that the miR-137/325-Kisspeptin repressive interaction is a major player in the pathogenesis of obesity-induced hypogonadism and a putative druggable target for improved management of this condition and its metabolic comorbidities in men suffering obesity. Significance statement: Up to half of the men suffering obesity display also central hypogonadism, an often neglected complication of overweight that can aggravate the clinical course of obesity and its complications. The mechanisms for such obesity-induced hypogonadism remain poorly defined. We show here that the evolutionary conserved miR137/miR325 tandem centrally mediates obesity-induced hypogonadism via repression of the reproductive-stimulatory signal, kisspeptin; this may represent an amenable druggable target for improved management of hypogonadism and other metabolic complications of obesity.
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80230-x
ISSN	1532-8600 ; 0026-0495
ISSN (online)	1532-8600
ISSN	0026-0495
DOI	10.1016/j.metabol.2024.155932
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