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Article ; Online: Sohlh1 loss of function male and female infertility model impacts overall health beyond gonadal dysfunction in mice†.

Rodríguez-Escribà, Marta / Rodríguez-Alonso, Beatriz / Belur, Shweta / Rajkovic, Aleksandar

2023 Volume 108, Issue 4, Page(s) 619–628

Abstract: Reproductive longevity is associated with health outcomes. Early menopause, loss of ovarian function, and male infertility are linked to shorter lifespan and increased adverse health outcomes. Here we examined the extragonadal effects of whole animal ... ...

Abstract	Reproductive longevity is associated with health outcomes. Early menopause, loss of ovarian function, and male infertility are linked to shorter lifespan and increased adverse health outcomes. Here we examined the extragonadal effects of whole animal loss of spermatogenesis and oogenesis specific basic helix-loop-helix 1 (Sohlh1) gene in mice, a well-described mouse model of female and male infertility. Sohlh1 encodes a transcription factor that is primarily expressed in the male and female germline and regulates germline differentiation. The Sohlh1 knockout mouse model, just like human individuals with SOHLH1 loss of function, presents with hypergonadotropic hypogonadism and loss of ovarian function in females and impaired spermatogenesis in males, with a seemingly gonad restricted phenotype in both sexes. However, extragonadal phenotyping revealed that Sohlh1 deficiency leads to abnormal immune profiles in the blood and ovarian tissues of female animals, sex-specific alterations of metabolites, and behavior and cognition changes. Altogether, these results show that Sohlh1 deficiency impacts overall health in both male and female mice.
MeSH term(s)	Animals ; Female ; Male ; Mice ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Infertility, Female ; Infertility, Male ; Mice, Knockout
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Sohlh1 protein, mouse
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioad008
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Article ; Online: Left atrial myxoma in syncope differential diagnosis: different perspectives.

Almeida, Hugo / Rodrigues, João / Rodríguez-Alonso, Beatriz / Fernandes, Rita

BMJ case reports

2021 Volume 14, Issue 8

MeSH term(s)	Diagnosis, Differential ; Heart Atria/diagnostic imaging ; Heart Neoplasms/diagnosis ; Heart Neoplasms/diagnostic imaging ; Humans ; Myxoma/diagnosis ; Myxoma/diagnostic imaging ; Syncope/diagnosis ; Syncope/etiology ; Ultrasonography
Language	English
Publishing date	2021-08-16
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-243529
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Article ; Online: Lupus hands: unusual presentation.

Almeida, Hugo / Antunes, Ivan / Rodríguez-Alonso, Beatriz / Fernandes, Rita

BMJ case reports

2021 Volume 14, Issue 7

MeSH term(s)	Hand/diagnostic imaging ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy
Language	English
Publishing date	2021-07-13
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-243762
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Article ; Online: Prinzmetal angina with intermittent AV block.

Almeida, Hugo / Dias, Eduardo / Monteiro, Ricardo / Rodríguez-Alonso, Beatriz

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

2021 Volume 41, Issue 1, Page(s) 83–84

Language	Portuguese
Publishing date	2021-11-24
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	632718-7
ISSN	2174-2030 ; 0870-2551 ; 0304-4750
ISSN (online)	2174-2030
ISSN	0870-2551 ; 0304-4750
DOI	10.1016/j.repc.2021.06.014
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Article: Challenges in studying preimplantation embryo-maternal interaction in cattle

Rodríguez-Alonso, Beatriz / Sánchez, José María / González, Encina / Lonergan, Patrick / Rizos, Dimitrios

Theriogenology. 2020 July 01, v. 150

2020

Abstract: A comprehensive understanding of the complex embryo-maternal interactions during the preimplantation period requires the analysis of the very early stages of pregnancy encompassing early embryonic development, maternal recognition and the events leading ... ...

Abstract	A comprehensive understanding of the complex embryo-maternal interactions during the preimplantation period requires the analysis of the very early stages of pregnancy encompassing early embryonic development, maternal recognition and the events leading to implantation. Despite the fact that embryo development until blastocyst stage is somewhat autonomous (i.e., does not require contact with the maternal reproductive tract and can be successfully recapitulated in vitro), many studies on ruminant embryo production have focused on the fundamental question of why: (i) only 30%–40% of immature oocytes develop to the blastocyst stage and (ii) the quality of such blastocysts continually lags behind that of blastocysts produced in vivo. Clear evidence indicates that in vitro culture conditions are far from optimal with deficiencies being manifested in short- and long-term effects on the embryo. Thus, enhanced knowledge of mechanisms controlling embryo−maternal interactions would allow the design of novel strategies to improve in vitro embryo conditions and reproductive outcomes in cattle.
Keywords	blastocyst ; cattle ; embryogenesis ; in vitro culture ; long term effects ; oocytes ; pregnancy
Language	English
Dates of publication	2020-0701
Size	p. 139-149.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2020.01.019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Challenges in studying preimplantation embryo-maternal interaction in cattle.

Rodríguez-Alonso, Beatriz / Sánchez, José María / González, Encina / Lonergan, Patrick / Rizos, Dimitrios

Theriogenology

2020 Volume 150, Page(s) 139–149

Abstract	A comprehensive understanding of the complex embryo-maternal interactions during the preimplantation period requires the analysis of the very early stages of pregnancy encompassing early embryonic development, maternal recognition and the events leading to implantation. Despite the fact that embryo development until blastocyst stage is somewhat autonomous (i.e., does not require contact with the maternal reproductive tract and can be successfully recapitulated in vitro), many studies on ruminant embryo production have focused on the fundamental question of why: (i) only 30%-40% of immature oocytes develop to the blastocyst stage and (ii) the quality of such blastocysts continually lags behind that of blastocysts produced in vivo. Clear evidence indicates that in vitro culture conditions are far from optimal with deficiencies being manifested in short- and long-term effects on the embryo. Thus, enhanced knowledge of mechanisms controlling embryo-maternal interactions would allow the design of novel strategies to improve in vitro embryo conditions and reproductive outcomes in cattle.
MeSH term(s)	Animals ; Cattle/embryology ; Cattle/physiology ; Embryo Implantation/physiology ; Embryo, Mammalian/physiology ; Fallopian Tubes/physiology ; Female ; Pregnancy ; Uterus/physiology
Language	English
Publishing date	2020-01-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2020.01.019
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Article ; Online: Molecular diagnosis of Chagas disease: a systematic review and meta-analysis.

Pascual-Vázquez, Guillermo / Alonso-Sardón, Montserrat / Rodríguez-Alonso, Beatriz / Pardo-Lledías, Javier / Romero Alegría, Angela / Fernández-Soto, Pedro / Muñoz Bellido, Juan Luis / Muro, Antonio / Belhassen-García, Moncef

Infectious diseases of poverty

2023 Volume 12, Issue 1, Page(s) 95

Abstract: Background: The complexity of the Chagas disease and its phases is impossible to have a unique test for both phases and a lot of different epidemiological scenarios. Currently, serology is the reference standard technique; occasionally, results are ... ...

Abstract	Background: The complexity of the Chagas disease and its phases is impossible to have a unique test for both phases and a lot of different epidemiological scenarios. Currently, serology is the reference standard technique; occasionally, results are inconclusive, and a different diagnostic technique is needed. Some guidelines recommend molecular testing. A systematic review and meta-analysis of available molecular tools/techniques for the diagnosis of Chagas disease was performed to measure their heterogeneity and efficacy in detecting Trypanosoma cruzi infection in blood samples. Methods: A systematic review was conducted up to July 27, 2022, including studies published in international databases. Inclusion and exclusion criteria were defined to select eligible studies. Data were extracted and presented according to PRISMA 2020 guidelines. Study quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). A random-effects model was used to calculate pooled sensitivity, specificity, and diagnostic odds ratio (DOR). Forest plots and a summary of the receiving operating characteristics (SROC) curves displayed the outcomes. Heterogeneity was determined by I Results: We identified 858 records and selected 32 papers. Studies pertained to endemic countries and nonendemic areas with adult and paediatric populations. The sample sizes ranged from 17 to 708 patients. There were no concerns regarding the risk of bias and applicability of all included studies. A positive and nonsignificant correlation coefficient (S = 0.020; P = 0.992) was obtained in the set of studies that evaluated diagnostic tests in the acute phase population (ACD). A positive and significant correlation coefficient (S = 0.597; P < 0.000) was obtained in the case of studies performed in the chronic phase population (CCD). This resulted in high heterogeneity between studies, with the master mix origin and guanidine addition representing significant sources. Interpretation/conclusions and relevance: The results described in this meta-analysis (qualitative and quantitative analyses) do not allow the selection of the optimal protocol of molecular method for the study of Trypanosoma cruzi infection in any of its phases, among other reasons due to the complexity of this infection. Continuous analysis and optimization of the different molecular techniques is crucial to implement this efficient diagnosis in endemic areas.
MeSH term(s)	Adult ; Child ; Humans ; Sensitivity and Specificity ; Chagas Disease/diagnosis ; Chagas Disease/epidemiology
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2689396-4
ISSN	2049-9957 ; 2049-9957
ISSN (online)	2049-9957
ISSN	2049-9957
DOI	10.1186/s40249-023-01143-7
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Article ; Online: Is babesiosis a rare zoonosis in Spain? Its impact on the Spanish Health System over 23 years.

Almeida, Hugo / López-Bernús, Amparo / Rodríguez-Alonso, Beatriz / Alonso-Sardón, Montserrat / Romero-Alegría, Ángela / Velasco-Tirado, Virginia / Pardo-Lledías, Javier / Muro, Antonio / Belhassen-García, Moncef

PloS one

2023 Volume 18, Issue 2, Page(s) e0280154

Abstract: Background: Babesiosis is a zoonosis caused by an intraerythrocytic protozoan of the genus Babesia and transmitted mainly by ticks of the Ixodes spp. complex. There is no comprehensive global incidence in the literature, although the United States, ... ...

Abstract	Background: Babesiosis is a zoonosis caused by an intraerythrocytic protozoan of the genus Babesia and transmitted mainly by ticks of the Ixodes spp. complex. There is no comprehensive global incidence in the literature, although the United States, Europe and Asia are considered to be endemic areas. In Europe, the percentage of ticks infected with Babesia spp. ranges from 0.78% to 51.78%. The incidence of babesiosis in hospitalized patients in Spain is 2.35 cases per 10,000,000 inhabitants/year. The mortality rate is estimated to be approximately 9% in hospitalized patients but can reach 20% if the disease is transmitted by transfusion. Objective: To analyze the epidemiological impact of inpatients diagnosed with babesiosis on the National Health System (NHS) of Spain between 1997 and 2019. Methodology: A retrospective longitudinal descriptive study that included inpatients diagnosed with babesiosis [ICD-9-CM code 088.82, ICD-10 code B60.0, cases ap2016-2019] in public Spanish NHS hospitals between 1 January 1997 and 31 December 2019 was developed. Data were obtained from the minimum basic dataset (CMBD in Spanish), which was provided by the Ministerio de Sanidad, Servicios Sociales e Igualdad after the receipt of a duly substantiated request and the signing of a confidentiality agreement. Main findings: Twenty-nine inpatients diagnosed with babesiosis were identified in Spain between 1997 and 2019 (IR: 0.28 cases/10,000,000 person-years). A total of 82.8% of the cases were men from urban areas who were approximately 46 years old. The rate of primary diagnoses was 55.2% and the number of readmissions was 79.3%. The mean hospital stay was 20.3±19.2 days, with an estimated cost of €186,925.66. Two patients, both with secondary diagnoses of babesiosis, died in our study. Conclusions: Human babesiosis is still a rare zoonosis in Spain, with an incidence rate that has been increasing over the years. Most cases occurred in middle-aged men from urban areas between summer and autumn. The Castilla-La-Mancha and Extremadura regions recorded the highest number of cases. Given the low rate of primary diagnoses (55.2%) and the high number of readmissions (79.3%), a low clinical suspicion is likely. There was a 6.9% mortality in our study. Both patients who died were patients with secondary diagnoses of the disease.
MeSH term(s)	Male ; Animals ; Middle Aged ; Humans ; United States ; Female ; Babesiosis/epidemiology ; Spain/epidemiology ; Retrospective Studies ; Zoonoses/epidemiology ; Babesia ; Ixodes
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0280154
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Article ; Online: Impact of pneumocystosis on the Spanish health care system, 1997-2020: Profile of HIV and non-HIV immunocompromised patients.

Varas Vicente, Pablo / Parra Fariñas, Raúl / Alonso-Sardón, Montserrat / Benéitez Andrés, Enrique / Rodriguez Alonso, Beatriz / Romero-Alegría, Ángela / Almeida, Hugo / Muro, Antonio / Pardo-Lledias, Javier / Belhassen-García, Moncef

Journal of infection and public health

2023 Volume 16, Issue 6, Page(s) 831–840

Abstract: Background: Pneumocystis jirovecii is an opportunistic fungus recognized for causing P. jirovecii pneumonia. The global prevalence is thought to be higher than 400,000 annual cases, although detailed information about epidemiological patterns is scarce.! ...

Abstract	Background: Pneumocystis jirovecii is an opportunistic fungus recognized for causing P. jirovecii pneumonia. The global prevalence is thought to be higher than 400,000 annual cases, although detailed information about epidemiological patterns is scarce. Methodology: A retrospective longitudinal descriptive study was performed among patients with diagnosis of pneumocystosis according to Classification of Diseases 9th edition, Clinical Modification (code 136.3 for the cases from 1997 to 2015; and 10th edition code B59.0 for cases from 2016 to 2020 in Spanish public hospitals from 1 January 1997-31 December 2020. Results: A total of 25289 cases were diagnosed. The period incidence rate was 2.36 (95 % CI, 2.33-2.39) cases per 100,000 person-years. Infection was more frequent among men (72.2 %) than among women (27.8 %). Comorbidity was the main characteristic of this cohort. Up to 72.3 % of pneumocystis-infected patients (18293) had HIV coinfection. During the study period, there was a progressive decrease in the number of HIV coinfected cases as the group of patients without HIV infection increased, with the largest group in 2017. The lethality rate in the cohort was 16.7 %. The global cost was €229,234,805 and the average ( ± SD) cost per patient was €9065 ( ± 9315). Conclusions: The epidemiology of pneumocystosis in Spain has changed in the last two decades. We noted in our study the possibility of a reemergence among non-HIV immunocompromised patients as patients with hematological and nonhematological neoplasia and other risk groups. The lethality of pneumocystosis continues to be high, and the underlying diseases are the main variable associated with lethality.
MeSH term(s)	Male ; Humans ; Female ; Pneumonia, Pneumocystis/epidemiology ; Pneumonia, Pneumocystis/complications ; Pneumonia, Pneumocystis/diagnosis ; HIV Infections/complications ; HIV Infections/epidemiology ; Retrospective Studies ; Pneumocystis carinii ; Immunocompromised Host
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2023.03.022
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Article ; Online: Crimean-Congo Hemorrhagic Fever, Spain, 2013-2021.

Lorenzo Juanes, Helena Miriam / Carbonell, Cristina / Sendra, Begoña Febrer / López-Bernus, Amparo / Bahamonde, Alberto / Orfao, Alberto / Lista, Carmen Vieira / Ledesma, María Sánchez / Negredo, Ana Isabel / Rodríguez-Alonso, Beatriz / Bua, Beatriz Rey / Sánchez-Seco, María Paz / Muñoz Bellido, Juan Luis / Muro, Antonio / Belhassen-García, Moncef

Emerging infectious diseases

2023 Volume 29, Issue 2, Page(s) 252–259

Abstract: Crimean-Congo hemorrhagic fever (CCHF) is a viral infectious disease for which distribution of the main vector, Hyalomma spp. ticks, is expanding. We analyzed all 10 cases of CCHF diagnosed in Spain during 2013-2021; case-patient median age was 56.5 ... ...

Abstract	Crimean-Congo hemorrhagic fever (CCHF) is a viral infectious disease for which distribution of the main vector, Hyalomma spp. ticks, is expanding. We analyzed all 10 cases of CCHF diagnosed in Spain during 2013-2021; case-patient median age was 56.5 years, and 7 were men. We identified CCHF virus genotypes III and V. Six case-patients acquired the infection in urban areas. Sixty percent of patients were infected in summer and 40% in spring. Two patients met criteria for hemophagocytic syndrome. Seven patients survived. The epidemiologic pattern of CCHF in Spain is based on occasional cases with an elevated mortality rate. Genotype III and, to a less extent also genotype V, CCHF circulates in humans in a common geographic area in Spain. Those data suggest that the expansion pathways are complex and may change over time. Physicians should remain alert to the possibility of new CCHF cases.
MeSH term(s)	Animals ; Male ; Humans ; Middle Aged ; Female ; Hemorrhagic Fever, Crimean/diagnosis ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever Virus, Crimean-Congo/genetics ; Spain/epidemiology ; Ticks ; Ixodidae
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2902.220677
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