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  1. Article: Latest Trends in Hemodiafiltration.

    Maduell, Francisco / Rodríguez-Espinosa, Diana / Broseta, José Jesús

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: This review provides a detailed analysis of hemodiafiltration (HDF), its progress from an emerging technique to a potential conventional treatment for chronic hemodialysis patients, and its current status. The article covers the advances, methods, and ... ...

    Abstract This review provides a detailed analysis of hemodiafiltration (HDF), its progress from an emerging technique to a potential conventional treatment for chronic hemodialysis patients, and its current status. The article covers the advances, methods, and clinical benefits of HDF, specifically focusing on its impact on cardiovascular health, survival rates, and overall well-being. The review also addresses questions about the safety of HDF and provides evidence to dispel concerns related to the elimination of beneficial substances and infection risks. Additionally, the article explores the potential implications of expanded hemodialysis (HDx) as an alternative to HDF, its classification, safety profile, and an ongoing trial assessing its non-inferiority to HDF. Supported by evidence from randomized controlled trials and observational studies, the review emphasizes the superiority of HDF as a hemodialysis modality and advocates for its positioning as the gold standard in treatment. However, it acknowledges the need for extensive research to define the role of HDx in comprehensive treatment approaches in individuals undergoing dialysis. The synthesis of current knowledge underscores the importance of ongoing exploration and research to refine hemodialysis practices for optimal patient outcomes.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comments on "Nonvalvular atrial fibrillation in patients undergoing chronic haemodialysis. Should dialysis patients with atrial fibrillation receive oral anticoagulation?"

    Cases, Aleix / Broseta, José Jesús / Rodriguez-Espinosa, Diana / Górriz, José Luis

    Nefrologia

    2023  Volume 43, Issue 1, Page(s) 148–150

    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Renal Dialysis ; Anticoagulants/therapeutic use ; Risk Factors
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-04-04
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2023.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Weekly seroconversion rate of the mRNA-1273 SARS-CoV-2 vaccine in haemodialysis patients.

    Broseta, José Jesús / Rodríguez-Espinosa, Diana / Soruco, Erica / Maduell, Francisco

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2021  Volume 36, Issue 9, Page(s) 1754–1755

    MeSH term(s) Antibodies, Viral/blood ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Humans ; Renal Dialysis ; Seroconversion ; Vaccines, Synthetic/immunology ; mRNA Vaccines
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Synthetic
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfab195
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  4. Article: Humoral Response after Three Doses of mRNA-1273 or BNT162b2 SARS-CoV-2 Vaccines in Hemodialysis Patients.

    Broseta, José Jesús / Rodríguez-Espinosa, Diana / Cuadrado, Elena / Rodríguez, Néstor / Bedini, José Luis / Maduell, Francisco

    Vaccines

    2022  Volume 10, Issue 4

    Abstract: The COVID-19 pandemic continues to be a worldwide health issue. Among hemodialysis (HD) patients, two-dose immunization schemes with mRNA vaccines have contributed to preventing severe COVID-19 cases; however, some have not produced a sufficient humoral ... ...

    Abstract The COVID-19 pandemic continues to be a worldwide health issue. Among hemodialysis (HD) patients, two-dose immunization schemes with mRNA vaccines have contributed to preventing severe COVID-19 cases; however, some have not produced a sufficient humoral response, and most have developed a rapid decline in antibody levels over the months following vaccination. This observational, prospective, multi-center study evaluated the humoral response in terms of presence and levels of IgG antibodies to the receptor-binding domain of the S1 spike antigen of SARS-CoV-2 (anti-S1-RBD IgG) to the third dose of SARS-CoV-2 mRNA vaccines, either the mRNA-1273 (Moderna) or BNT162b2 (Pfizer), in 153 patients from three dialysis units affiliated to Hospital Clínic of Barcelona (Spain). Most hemodialysis patients responded intensely to this third vaccine dose, achieving the seroconversion in three out of four non- or weak responders to two doses. Moreover, 96.1% maintained the upper limit or generated higher titers than after the second. BNT162b2 vaccine, active cancer, and immunosuppressive treatment were related to a worse humoral response. Every hemodialysis patient should be administered a third vaccine dose six months after receiving the second one. Despite the lack of data, immunosuppressed patients and those with active cancer may benefit from more frequent vaccine boosters.
    Language English
    Publishing date 2022-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10040522
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  5. Article ; Online: Safety profile and clinical results of Remdesivir in Hemodialysis patients infected with SARS-CoV-2. A single-center Spanish cohort study.

    Cuadrado-Payán, Elena / Rodríguez-Espinosa, Diana / Broseta, José Jesús / Guillén-Olmos, Elena / Maduell, Francisco

    Journal of nephrology

    2022  Volume 36, Issue 1, Page(s) 171–172

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Cohort Studies ; COVID-19 Drug Treatment ; Renal Dialysis/adverse effects ; Antiviral Agents/adverse effects
    Chemical Substances remdesivir (3QKI37EEHE) ; Antiviral Agents
    Language English
    Publishing date 2022-06-18
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01364-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
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  6. Article ; Online: Most recently developed polyester polymer alloy dialyzer: A new medium cut-off membrane?

    Maduell, Francisco / Rodríguez-Espinosa, Diana / Rodas, Lida María / Gómez, Miquel / Arias-Guillén, Marta / Fontseré, Néstor / Vera, Manel / Del Carmen Salgado, Maria / Rico, Nayra / Broseta, José Jesús

    Artificial organs

    2024  

    Abstract: Background: New versions of the polyester polymer alloy (PEPA) membrane have appeared over the years, with increases in both the pore size and the amount of polyvinylpyrrolidone (PVP) to optimize hydrophilicity performance. This study aimed to assess ... ...

    Abstract Background: New versions of the polyester polymer alloy (PEPA) membrane have appeared over the years, with increases in both the pore size and the amount of polyvinylpyrrolidone (PVP) to optimize hydrophilicity performance. This study aimed to assess the efficacy of the most recently developed PEPA dialyzer, the FDY series, in hemodialysis (HD) modality in terms of uremic toxin removal and albumin loss and to compare it with that of several high-flux dialyzers currently used in HD and post-dilution hemodiafiltration (HDF) treatments.
    Methods: A prospective study was carried out in 21 patients. All patients underwent six dialysis sessions with the same routine dialysis parameters; only the dialyzer and/or the dialysis modality varied: FX80 in HD, FDY 180 in HD, Clearum HS17 in HDF, Elisio 19H in HDF, Vitapes 180 in HDF, and FX80 in post-dilution HDF. The reduction ratios (RR) of urea, creatinine, ß
    Results: Both membranes FDY and FX80 are high-flux dialyzers and are applied here in high-flux HD. The average RR of β
    Conclusions: The most recently developed PEPA dialyzers in the HD modality were as effective as all treatments in the HDF modality and were clearly superior to high-flux helixone HD treatment. These results confirm that this dialyzer should be categorized within the medium cut-off (MCO) membrane classification.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.14726
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    Zs.A 1463: Show issues Location:
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  7. Article ; Online: Long-Term Outcomes of Incidental Liver Malignancies in Simultaneous Liver-Kidney Transplant Recipients.

    Rodríguez-Espinosa, Diana / Morantes, Laura / García, Jenmy / Broseta, José Jesús / Cuadrado-Payán, Elena / Colmenero, Jordi / Torregrosa, Josep Vicens / Diekmann, Fritz / Esforzado, Nuria

    Transplantation proceedings

    2024  Volume 56, Issue 2, Page(s) 330–334

    Abstract: Background: The pretransplant diagnosis of liver malignancies in nodular cirrhotic livers remains a diagnostic challenge despite current advances. Although the prognostic impact of incidental hepatocellular carcinoma (HCC) or intrahepatic ... ...

    Abstract Background: The pretransplant diagnosis of liver malignancies in nodular cirrhotic livers remains a diagnostic challenge despite current advances. Although the prognostic impact of incidental hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (iCC) in liver transplant recipients is well documented, there are no data on the impact in simultaneous liver kidney transplant (LKT) recipients.
    Methods: This is a single-center observational, retrospective study of all LKT performed from May 1993 to April 2022. Among these patients, demographic data, immunosuppressive therapy, rejection episodes, and prevalence of incidental HCC or iCC were evaluated.
    Results: One hundred eight LKTs were performed and 6 were excluded. There were 13 patients with incidental carcinomas in the explanted liver: one of them with both an HCC and iCC, one with an iCC, and the remaining with an HCC. One case of iCC died. No other recurrences occurred. There were no cases of incidental HCC nor iCC in patients with a hereditary or metabolic LKT indication. We found no differences in the 5-year patient survival, and death-censored kidney and liver graft survival rates for those LKT with an incidental HCC and those without it (76.9% vs 84.2%, P = .5; 100% vs 91.6%, P = .28; and 100% vs 94.7%, P = 0.39, respectively). Finally, there were no significant associations between explant carcinoma and rejections of the liver (7.7% vs 17.9%, P = .34) or kidney graft (0% vs 16.8%, P = 0.11).
    Conclusion: Despite a high prevalence of incidental HCC or iCC, patient, kidney, and liver graft 5-year survival were unaffected by incidental HCC.
    MeSH term(s) Humans ; Liver Neoplasms/pathology ; Carcinoma, Hepatocellular/pathology ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Cholangiocarcinoma ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms ; Kidney/pathology
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2024.01.004
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    Zs.A 835: Show issues Location:
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  8. Article ; Online: Comparison of efficacy and safety of the new generation helixone dialyzers.

    Maduell, Francisco / Broseta, José Jesús / Rodríguez-Espinosa, Diana / Rodas, Lida María / Gómez, Miquel / Arias-Guillén, Marta / Fontseré, Néstor / Vera, Manel / Salgado, Maria Del Carmen / Rico, Nayra / Ramos, Rosa

    Nefrologia

    2024  

    Abstract: Introduction: New generation helixone dialyzers has recently been developed as part of the ongoing effort to improve dialyzer hemocompatibility and avoid adverse reactions to synthetic dialyzers. This study aimed to assess the performance and albumin ... ...

    Abstract Introduction: New generation helixone dialyzers has recently been developed as part of the ongoing effort to improve dialyzer hemocompatibility and avoid adverse reactions to synthetic dialyzers. This study aimed to assess the performance and albumin loss of this new dialyzer series in hemodiafiltration and compare it with the previous generation helixone series.
    Material and methods: A prospective study was conducted in 19 patients. Each patient underwent eight dialysis sessions with the same routine dialysis parameters; only the dialyzer varied: FX60 CorDiax, FX CorAL 60, FX600 CorDiax, FX CorAL 600, FX80 CorDiax, FX CorAL 80, FX800 CorDiax, and FX CorAL 800. The reduction ratios (RR) of urea, creatinine, ß
    Results: All treatments were well tolerated. The mean amount of replacement fluid ranged from 31 to 34 L. Comparison of dialysis treatments showed no differences between small molecules and even up to those the size of β2-microglobulins. Little differences were found between myoglobin, κFLC, prolactin, α
    Conclusion: The new generation helixone dialyzers series has been updated to minimise the risk of adverse reactions, while maintaining the effectiveness and albumin loss achieved by the previous most advanced helixone generation.
    Language English
    Publishing date 2024-04-27
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2024.04.005
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  9. Article ; Online: Prevalence of COVID-19 Infection in Hemodialysis Patients Detected Using Serologic Screening.

    Rodríguez-Espinosa, Diana / Broseta, José Jesús / Cuadrado, Elena / Maduell, Francisco

    Journal of the American Society of Nephrology : JASN

    2020  Volume 31, Issue 12, Page(s) 2966–2967

    MeSH term(s) COVID-19 ; Humans ; Mass Screening ; Pandemics ; Prevalence ; Renal Dialysis/adverse effects ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020081193
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    Zs.A 3344: Show issues Location:
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  10. Article: Antibody maintenance and breakthrough infections 6 months after complete COVID-19 vaccination with the mRNA-1273 and BNT162b2 vaccines in hemodialysis patients.

    Rodríguez-Espinosa, Diana / Broseta, José Jesús / Bedini, José Luis / Rodríguez, Néstor / Maduell, Francisco

    Clinical kidney journal

    2021  Volume 15, Issue 4, Page(s) 818–819

    Language English
    Publishing date 2021-12-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfab282
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    Zs.A 6587: Show issues Location:
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