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Article ; Online: Spatiotemporal patterns of dengue and Zika incidence during the 2015-2018 outbreak of Zika in Mexico.

Cortes-Escamilla, Anais / Roche, Benjamín / Rodríguez-López, Mario Henry / López Gatell-Ramírez, Hugo / Alpuche-Aranda, Celia M

Salud publica de Mexico

2022 Volume 64, Issue 5, sept-oct, Page(s) 478–487

Abstract: Objective: Evaluate spatially and temporally simultaneous presence of clusters of dengue and Zika clinical cases and their relationship with expected dengue transmission risk.: Materials and methods: A classification of dengue risk transmission was ... ...

Abstract	Objective: Evaluate spatially and temporally simultaneous presence of clusters of dengue and Zika clinical cases and their relationship with expected dengue transmission risk. Materials and methods: A classification of dengue risk transmission was carried out for whole country, and spatial autocorrelation analyses to identify clusters of confirmed clinical cases of dengue and Zika from 2015 to 2018 was conducted using Moran's Index statistics. Results: Clusters of both diseases were identified in dengue-high risk munici-palities at the beginning of the outbreak, but, at the end of the outbreak, Zika clusters occurred in dengue low-risk mu-nicipalities. Conclusion: This study identified Zika clusters in low-risk dengue areas suggesting participation of several factors that favor virus introduction and dissemination, such as differences in entomological and control interventions, and the possibility of cross-immunity in the population.
MeSH term(s)	Dengue/epidemiology ; Dengue/prevention & control ; Disease Outbreaks ; Humans ; Incidence ; Mexico/epidemiology ; Zika Virus ; Zika Virus Infection/epidemiology
Language	English
Publishing date	2022-08-19
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	954220-6
ISSN	1606-7916 ; 0036-3634
ISSN (online)	1606-7916
ISSN	0036-3634
DOI	10.21149/13584
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Article ; Online: Anastomotic recurrence 13 years after curative resection for rectal cancer.

Bailón-Cuadrado, Martín / Blanco-Álvarez, José I / Rodríguez-López, Mario

Medicina clinica

2017 Volume 149, Issue 1, Page(s) 43–44

Title translation	Recidiva en la anastomosis 13 años después de cirugía curativa para cáncer de recto.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/surgery ; Anastomosis, Surgical ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery ; Rectum/surgery
Language	Spanish
Publishing date	2017-02-27
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.01.009
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Article: Cervicothoracic abscess secondary to transesophageal ultrasound-guided fine needle aspiration.

Tejero-Pintor, Francisco J / Blanco-Álvarez, José I / Bailón-Cuadrado, Martín / Rodríguez-López, Mario

Gastroenterologia y hepatologia

2018 Volume 42, Issue 1, Page(s) 35–36

Title translation	Absceso cervicotorácico secundario a punción con aguja fina guiada por ecografía endoscópica transesofágica.
MeSH term(s)	Abscess/etiology ; Abscess/microbiology ; Abscess/therapy ; Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Anti-Bacterial Agents/therapeutic use ; Chemoradiotherapy ; Combined Modality Therapy ; Drainage ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Esophagoscopy/adverse effects ; Esophagoscopy/methods ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Meropenem/therapeutic use ; Middle Aged ; Neck/diagnostic imaging ; Smoking/adverse effects ; Streptococcal Infections/etiology ; Streptococcal Infections/microbiology ; Streptococcal Infections/therapy ; Streptococcus anginosus/isolation & purification ; Subcutaneous Tissue ; Superior Vena Cava Syndrome/etiology ; Superior Vena Cava Syndrome/therapy ; Thoracic Diseases/etiology ; Thoracic Diseases/microbiology ; Thoracic Diseases/therapy ; Tomography, X-Ray Computed
Chemical Substances	Anti-Bacterial Agents ; Meropenem (FV9J3JU8B1)
Language	Spanish
Publishing date	2018-03-05
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2018.01.010
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Article: Impaired immune reaction and increased lactate and C-reactive protein for early prediction of severe morbidity and pancreatic fistula after pancreatoduodenectomy.

Rodriguez-Lopez, Mario / Tejero-Pintor, Francisco J / Bailon-Cuadrado, Martin / Barrera-Rebollo, Asterio / Perez-Saborido, Baltasar / Pacheco-Sanchez, David

Hepatobiliary & pancreatic diseases international : HBPD INT

2019 Volume 19, Issue 1, Page(s) 58–67

Abstract: Background: Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during first and second postoperative days (POD1, POD2) may be early indicators of complications.: Methods: This case- ... ...

Abstract	Background: Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during first and second postoperative days (POD1, POD2) may be early indicators of complications. Methods: This case-control study included 50 patients. Baseline, POD1 and POD2 values of leukocytes, neutrophils, lymphocytes, platelets, hemoglobin, C-reactive protein (CRP), procalcitonin and arterial lactate were compared between individuals presenting Clavien ≥ III morbidity, pancreatic fistula (PF) or clinically relevant PF (CRPF) and those without these morbidities. Common variables reaching significance were further analyzed in order to calculate a predictive score. Results: Severe morbidity, PF and CRPF rates were 28.0%, 26.0% and 14.0%, respectively. Patients with severe morbidity had lower leukocytes on POD2 (P = 0.04). Patients with PF presented higher CRP on POD2 (P = 0.001), higher lactate on POD1 (P = 0.007) and POD2 (P = 0.008), and lower lymphocytes on POD1 (P = 0.007) and POD2 (P = 0.008). Patients with CRPF had lower leukocytes and neutrophils on POD1 (P = 0.048, P = 0.038), lower lymphocytes on POD1 (P = 0.001) and POD2 (P = 0.003), and higher CRP on POD2 (P = 0.001). Baseline parameters and procalcitonin obtained no statistical associations. Score was defined according to lymphocytes on POD1 < 650/µL and CRP on POD2 ≥ 250 mg/L allocating patients in 3 risk categories. PF and CRPF rates were statistically higher as risk category increased (P<0.001). Receiver operating characteristic curves and Hosmer-Lemeshow tests showed a good accuracy. Conclusions: Impaired immunological reaction during early postoperative period (lower leukocytes and, particularly, lymphocytes) in response to surgical aggression would favor complications after PD. Likewise, acidosis (higher arterial lactate) could behave as risk factor of PF. An elevated CRP on POD2 is also an early biomarker of PF. Our novel score based on postoperative lymphocyte count and CRP seems reliable for early prediction of PF.
MeSH term(s)	Aged ; C-Reactive Protein/analysis ; Case-Control Studies ; Female ; Humans ; Lactates/blood ; Male ; Middle Aged ; Morbidity ; Pancreatic Fistula/etiology ; Pancreatic Fistula/immunology ; Pancreaticoduodenectomy/adverse effects
Chemical Substances	Lactates ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2019-05-20
Publishing country	Singapore
Document type	Journal Article ; Observational Study
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2019.05.003
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Article ; Online: A new dimensional-reducing variable obtained from original inflammatory scores is highly associated to morbidity after curative surgery for colorectal cancer.

Bailon-Cuadrado, Martin / Perez-Saborido, Baltasar / Sanchez-Gonzalez, Javier / Rodriguez-Lopez, Mario / Mayo-Iscar, Agustin / Pacheco-Sanchez, David

International journal of colorectal disease

2018 Volume 33, Issue 9, Page(s) 1225–1234

Abstract: Purpose: Several scores have been developed to define the inflammatory status of oncological patients. We suspect they share iterative information. Our hypothesis is that we may summarise their information into one or two new variables which will be ... ...

Abstract	Purpose: Several scores have been developed to define the inflammatory status of oncological patients. We suspect they share iterative information. Our hypothesis is that we may summarise their information into one or two new variables which will be independent. This will help us to predict, more accurately, which patients are at an increased risk of suffering postoperative complications after curative surgery for CRC. Methods: Observational prospective study with those patients undergoing curative surgery for CRC between September 2015 and February 2017. We analysed the influence of inflammatory scores (PNI, GPS, NLR, PLR) on postoperative morbidity (overall and severe complications, anastomotic leakage and reoperation). Results: Finally, 168 patients were analysed. We checked these four original scores are interrelated among them. Using a complex and innovative statistical method, we created two new independent variables (resultant A and resultant B) which resume the information coming from them. One of these two new variables (resultant A) was statistically associated to overall complications (OR, 2.239; 95% CI, 1.541-3.253; p = 0.0001), severe complications (OR, 1.773; 95% CI, 1.129-2.785; p = 0.013), anastomotic leakage (OR, 3.208; 95% CI, 1.416-7.268; p = 0.005) and reoperation (OR, 2.349; 95% CI, 1.281-4.305; p = 0.006). Conclusions: We evinced the four original scores we used share redundant information. We created two new independent new variables which resume their information. In our sample of patients, one of these variables turned out to be a great predictive factor for the four complications we analysed.
MeSH term(s)	Aged ; Anastomotic Leak/etiology ; Biomarkers/blood ; Blood Platelets ; C-Reactive Protein/metabolism ; Colectomy/adverse effects ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/surgery ; Decision Support Techniques ; Female ; Health Status ; Humans ; Inflammation/blood ; Inflammation/complications ; Inflammation/diagnosis ; Inflammation Mediators/blood ; Lymphocyte Count ; Lymphocytes ; Male ; Neutrophils ; Platelet Count ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Predictive Value of Tests ; Proctectomy/adverse effects ; Prospective Studies ; Reoperation ; Risk Assessment ; Risk Factors ; Serum Albumin, Human/metabolism ; Time Factors ; Treatment Outcome
Chemical Substances	Biomarkers ; Inflammation Mediators ; C-Reactive Protein (9007-41-4) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2018-06-20
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-018-3100-0
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Article: Severe morbidity after pancreatectomy is accurately predicted by preoperative pancreatic resection score (PREPARE): A prospective validation analysis from a medium-volume center.

Rodriguez-Lopez, Mario / Tejero-Pintor, Francisco J / Perez-Saborido, Baltasar / Barrera-Rebollo, Asterio / Bailon-Cuadrado, Martin / Pacheco-Sanchez, David

Hepatobiliary & pancreatic diseases international : HBPD INT

2018 Volume 17, Issue 6, Page(s) 559–565

Abstract: Background: Major morbidity in pancreatic surgery remains high. Different scores for predicting complications have been described. Preoperative pancreatic resection (PREPARE) score is based on objective preoperative variables and offers good predictive ... ...

Abstract	Background: Major morbidity in pancreatic surgery remains high. Different scores for predicting complications have been described. Preoperative pancreatic resection (PREPARE) score is based on objective preoperative variables and offers good predictive accuracy for Clavien ≥ III complications. This study aimed to validate this score and analyze other preoperative variables in a prospective study performed in a medium-volume center. Methods: A total of 50 pancreatic resections were included. Preoperative variables were registered and PREPARE was calculated. The main outcome was severe morbidity (Clavien ≥ III) up to 30 days after discharge. The secondary outcomes were length of stay (LOS) and readmission. Statistical validation was performed to compare severe morbidity rate among the scores categories. Association with other preoperative variables (not included in PREPARE) was also tested. Results: Of the 50 pancreatic resections, the severe morbidity was 34.0%, with median LOS of 11 days. Readmission rate was 25.5%. Severe morbidity rates according to PREPARE categories were 18.5% in low-risk group, 41.7% in intermediate-risk group, and 63.6% in high-risk group, respectively (P = 0.023). The accuracy was 72% (Hosmer-Lemeshow, P = 0.86). ROC curve was obtained both for PREPARE score expressed as incremental values and categorized as the three risk groups, showing an area under curve (AUC) of 0.736 (95% CI: 0.586-0.887; P = 0.007) and 0.712 (95% CI: 0.555-0.869; P = 0.015), respectively. PREPARE was significant in multivariate analysis. Median LOS was statistically higher as PREPARE category increases (9, 11 and 15 days in low-, intermediate- and high-risk groups, respectively; P = 0.009). Readmission was not associated with any variables. Conclusions: PREPARE behaves as an independent risk factor for severe morbidity after pancreatic surgery. Score validation shows good accuracy prediction. Increasing PREPARE category is also associated with longer LOS.
MeSH term(s)	Adult ; Aged ; Body Mass Index ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Morbidity ; Pancreatectomy/adverse effects ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Patient Readmission ; Prospective Studies ; ROC Curve
Language	English
Publishing date	2018-09-26
Publishing country	Singapore
Document type	Journal Article ; Observational Study ; Validation Studies
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2018.09.017
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Article ; Online: Gangrena de Fournier por Salmonella typhimurium.

Bailón Cuadrado, Martín / Sánchez González, Javier / Rodríguez López, Mario / Velasco López, Rosalía

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

2015 Volume 27, Issue 2, Page(s) 138–139

Title translation	Fournier's Gangrene due to Salmonella typhimurium.
Language	Spanish
Publishing date	2015
Publishing country	Spain
Document type	Letter
ZDB-ID	2127173-2
ISSN	2386-5857 ; 1137-6821
ISSN (online)	2386-5857
ISSN	1137-6821
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Article: Solitary fibrous tumor of the gastroesophageal junction.

Plúa Muñiz, Katherine T / Otero Russel, Raúl / Velasco López, Rosalía / Rodríguez López, Mario / García-Abril Alonso, José María

Gastroenterologia y hepatologia

2017 Volume 41, Issue 1, Page(s) 33–35

Title translation	Tumor fibroso solitario de la unión gastroesofágica.
MeSH term(s)	Biomarkers, Tumor ; Cardia/diagnostic imaging ; Cardia/pathology ; Cardia/surgery ; Diagnosis, Differential ; Esophagogastric Junction/diagnostic imaging ; Esophagogastric Junction/pathology ; Esophagogastric Junction/surgery ; Gastrointestinal Stromal Tumors/diagnosis ; Gastroscopy ; Hematemesis/etiology ; Humans ; Male ; Melena/etiology ; Middle Aged ; Solitary Fibrous Tumors/complications ; Solitary Fibrous Tumors/diagnostic imaging ; Solitary Fibrous Tumors/pathology ; Solitary Fibrous Tumors/surgery ; Stomach Neoplasms/complications ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Tomography, X-Ray Computed
Chemical Substances	Biomarkers, Tumor
Language	Spanish
Publishing date	2017-01-11
Publishing country	Spain
Document type	Case Reports ; Letter ; Review
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2016.11.005
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Article: Intraductal papillary neoplasia of the bile duct with malignancy: a differentiated entity of cholangiocarcinoma with a better prognosis. A review of three new cases.

Pérez Saborido, Baltasar / Bailón Cuadrado, Martín / Rodríguez López, Mario / Asensio Díaz, Enrique / Madrigal Rubiales, Beatriz / Barrera Rebollo, Asterio

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2017 Volume 109, Issue 8, Page(s) 592–595

Abstract: Introduction: Intraductal papillary neoplasms of the bile duct have been recognized as a differentiated entity to other biliary tumors since 2001. They are characterized by intraductal growth, with or without mucus production, and have malignant ... ...

Abstract	Introduction: Intraductal papillary neoplasms of the bile duct have been recognized as a differentiated entity to other biliary tumors since 2001. They are characterized by intraductal growth, with or without mucus production, and have malignant potential, although they have a better prognosis than other types of cholangiocarcinoma. Case reports: From January 2010 to August 2015, we included three patients with a confirmed diagnosis of bile duct intraductal papillary neoplasia with malignancy that were treated at our center. Two cases were male and one female with a mean age of 67.3 years. All three patients presented malignancy at the time of diagnosis. One patient was asymptomatic and the diagnosis was reported in the hepatectomy specimen after a liver transplant due to autoimmune hepatitis. The other two patients presented with cholestasis and acute cholangitis and the diagnosis was made based on imaging tests (computed tomography [CT] and magnetic resonance imaging [MRI]) and endoscopic retrograde cholangiopancreatography (ERCP) with brushing and a biopsy. The treatment in both cases was surgical with a left hepatectomy, and resection of the left bile duct and segment I. They did not receive adjuvant treatment. None of the cases had recurrence of the disease. Discussion: Malignant intraductal papillary neoplasias of the biliary tract represent a different entity of cholangiocarcinoma with a better prognosis. Its diagnosis is based on imaging tests and histology by ERCP. The treatment is surgical, achieving a high rate of success with a low relapse rate.
Language	English
Publishing date	2017-08
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2017.4835/2016
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Article: Trypanosoma cruzi: A review of biological and methodological factors in Mexican strains

De Fuentes-Vicente, José A / Vidal-López, Dolores G / Flores-Villegas, A. Laura / Moreno-Rodríguez, Adriana / De Alba-Alvarado, Mariana C / Salazar-Schettino, Paz. M / Rodríguez-López, Mario H / Gutiérrez-Cabrera, Ana E

Acta tropica. 2019 July, v. 195

2019

Abstract: Trypanosoma cruzi, responsible for Chagas disease, is a serious public health problem in Latin America with eight million people infected in the world. Clinical manifestations observed in humans due to T. cruzi infection are largely associated with the ... ...

Abstract	Trypanosoma cruzi, responsible for Chagas disease, is a serious public health problem in Latin America with eight million people infected in the world. Clinical manifestations observed in humans due to T. cruzi infection are largely associated with the wide biological and genetic heterogeneity of the parasite. This review presents an overview of the parasitological aspects of various strains of T. cruzi isolated mainly in Mexico, as well as an analysis of the methodological processes used to determine their virulence that could be influencing their biological characterization. We emphasize the importance of using uniform protocols to study T. cruzi virulence, taking into account factors related to: strain (i.e. developmental stage, lineage, biological origin, genetic variability), animal model used (i.e. role of hormones, host immune response, age) and methodology (i.e. inoculum size, inoculation route, and laboratory conditions used during strain maintenance). These uniform protocols will then allow proposing elements for understanding clinical evolution and management of the disease, for providing adequate treatment, and for developing tools for future vaccines against Chagas disease.
Keywords	Chagas disease ; Trypanosoma cruzi ; animal models ; disease course ; genetic heterogeneity ; hormones ; humans ; immune response ; inoculum ; laboratory experimentation ; parasites ; public health ; vaccines ; virulence ; Latin America ; Mexico
Language	English
Dates of publication	2019-07
Size	p. 51-57.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2019.04.024
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