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Article ; Online: Long-term immune response accompanies clinical outcomes in severe asthmatics treated with anti-IL-5/IL-5R biologics.

Lorente-Sorolla, C / Bernaola, J / Sánchez-Mellado, D / Gil-Martínez, M / Naharro-González, S / Betancor, D / Fernández-Nieto, M / Pinillos-Robles, E J / Santillán Coello, J M / Villacampa-Aubá, J M / Rodríguez-Nieto, M J / Sastre, J / Valverde-Monge, M / Rodrigo-Muñoz, J M / Del Pozo, V

Allergy

2023 Volume 78, Issue 11, Page(s) 3027–3031

Language	English
Publishing date	2023-08-29
Publishing country	Denmark
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15872
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Article: Prevalence, Characteristics, and Outcome of Asthmatic Patients With Type 2 Diseases in Hospitalized Patients With COVID-19 in Madrid, Spain.

Barroso, B / Valverde-Monge, M / Cañas Jose, A / Rodrigo-Muñoz, J M / Gonzalez-Cano, B / Villalobos-Violan, V / Betancor, D / Gomez-Cardeñosa, A / Vallejo-Chamorro, G / Baptista-Serna, L / Villalobos-Vilda, C / Ortega-Martin, L / Gómez-López, A / Sanchez-Pernaute, O / Romero-Bueno, F / Rodriguez-Nieto, M J / Del Pozo, V / Sastre, J

Journal of investigational allergology & clinical immunology

2020 Volume 30, Issue 5, Page(s) 382–384

MeSH term(s)	Asthma/complications ; Asthma/diagnosis ; Asthma/epidemiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Prevalence ; Public Health Surveillance ; SARS-CoV-2 ; Spain/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-06-18
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1128657-x
ISSN	1018-9068
ISSN	1018-9068
DOI	10.18176/jiaci.0627
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Article ; Online: Recommendations for the treatment of anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated rapidly progressive interstitial lung disease.

Romero-Bueno, F / Diaz Del Campo, P / Trallero-Araguás, E / Ruiz-Rodríguez, J C / Castellvi, I / Rodriguez-Nieto, M J / Martínez-Becerra, M J / Sanchez-Pernaute, O / Pinal-Fernandez, I / Solanich, X / Gono, T / Gonzalez-Gay, M A / Plana, M N / Selva-O'Callaghan, A

Seminars in arthritis and rheumatism

2020 Volume 50, Issue 4, Page(s) 776–790

Abstract: Objectives: The study aimed to develop evidence-based recommendations for the treatment of rapidly progressive interstitial lung disease (RPILD) associated with the anti-Melanoma Differentiation-Associated Gene 5-positive dermatomyositis (DM) syndrome.!# ...

Abstract	Objectives: The study aimed to develop evidence-based recommendations for the treatment of rapidly progressive interstitial lung disease (RPILD) associated with the anti-Melanoma Differentiation-Associated Gene 5-positive dermatomyositis (DM) syndrome. Methods: The task force comprised an expert panel of specialists in rheumatology, intensive care medicine, pulmonology, immunology, and internal medicine. The study was carried out in two phases: identifying key areas in the management of DM-RPILD syndrome and developing a set of recommendations based on a review of the available scientific evidence. Four specific questions focused on different treatment options were identified. Relevant publications in English, Spanish or French up to April 2018 were searched systematically for each topic using PubMed (MEDLINE), EMBASE, and Cochrane Library (Wiley Online). The experts used evidence obtained from these studies to develop recommendations. Results: A total of 134 studies met eligibility criteria and formed the evidentiary basis for the recommendations regarding immunosuppressive therapy and complementary treatments. Overall, there was general agreement on the initial use of combined immunosuppressive therapy. Combination of high-dose glucocorticoids and calcineurin antagonists with or without cyclophosphamide is the first choice. In the case of calcineurin antagonist contraindication or treatment failure, switching or adding other immunosuppressants may be individualized. Plasmapheresis, polymyxin B hemoperfusion and/or intravenous immunoglobulins may be used as rescue options. ECMO should be considered in life-threatening situations while waiting for a clinical response or as a bridge to lung transplant. Conclusions: Thirteen recommendations regarding the treatment of the anti-MDA5 positive DM-RPILD were developed using research-based evidence and expert opinion.
MeSH term(s)	Consensus ; Cyclophosphamide/therapeutic use ; Dermatomyositis/complications ; Dermatomyositis/drug therapy ; Dermatomyositis/genetics ; Drug Therapy, Combination ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Interferon-Induced Helicase, IFIH1/genetics ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/drug therapy ; Syndrome
Chemical Substances	Glucocorticoids ; Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P) ; IFIH1 protein, human (EC 3.6.1.-) ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2020.03.007
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Article: Neumotórax bilateral espontáneo y fibrosis pulmonar idiopática.

Mena, M J / Melchor, R / Rodríguez-Nieto, M J

Archivos de bronconeumologia

1999 Volume 35, Issue 7, Page(s) 363

Title translation	Spontaneous bilateral pneumothorax and idiopathic pulmonary fibrosis.
MeSH term(s)	Female ; Humans ; Middle Aged ; Pneumothorax/complications ; Pneumothorax/diagnosis ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/diagnosis
Language	Spanish
Publishing date	1999-07
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	733126-5
ISSN	0300-2896
ISSN	0300-2896
DOI	10.1016/s0300-2896(15)30079-x
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Article: Presenting prevalence, characteristics and outcome of asthmatic patients with T2 diseases in hospitalized subjects with COVID-19 in Madrid, Spain

Barroso, B / Valverde-Monge, M / Cañas, J A / Rodrigo-Muñoz, J M / Gonzalez-Cano, B / Villalobos-Violan, V / Betancor, D / Gomez-Cardeñosa, A / Vallejo-Chamorro, G / Baptista, L / Villalobos-Vilda, C / Ortega-Martin, L / Gómez-López, A / Sanchez-Pernaute, O / Romero-Bueno, F / Rodriguez-Nieto, M J / Del Pozo, V / Sastre, J

J Investig Allergol Clin Immunol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32554336
Database	COVID19

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Article: Prevalence, Characteristics, and Outcome of Asthmatic Patients With Type 2 Diseases in Hospitalized Patients With COVID-19 in Madrid, Spain

J Investig Allergol Clin Immunol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #838371
Database	COVID19

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Article: Lower pulmonary diffusing capacity in the prone vs. supine posture.

Peces-Barba, G / Rodríguez-Nieto, M J / Verbanck, S / Paiva, M / González-Mangado, N

Journal of applied physiology (Bethesda, Md. : 1985)

2004 Volume 96, Issue 5, Page(s) 1937–1942

Abstract: We evaluated the effect of prone positioning on gas-transfer characteristics in normal human subjects. Single-breath (SB) and rebreathing (RB) maneuvers were employed to assess carbon monoxide diffusing capacity (DlCO), its components related to ... ...

Abstract	We evaluated the effect of prone positioning on gas-transfer characteristics in normal human subjects. Single-breath (SB) and rebreathing (RB) maneuvers were employed to assess carbon monoxide diffusing capacity (DlCO), its components related to capillary blood volume (Vc) and membrane diffusing capacity (Dm), pulmonary tissue volume (Vti), and cardiac output (Qc). Alveolar volume (Va) was significantly greater prone than supine, irrespective of the test maneuver used. Nevertheless, Dl(CO) was consistently lower prone than supine, a difference that was enhanced when appropriately corrected for the higher Va prone. When adequately corrected for Va, diffusing capacity significantly decreased by 8% from supine to prone [SB: Dl(CO,corr) supine vs. prone: 32.6 +/- 2.3 (SE) vs. 30.0 +/- 2 ml x min(-1) x mmHg(-1) stpd; RB: Dl(CO,corr) supine vs. prone: 30.2 +/- 2.2 (SE) vs. 27.8 +/- 2.0 ml x min(-1) x mmHg(-1) stpd]. Both Vc and Dm showed a tendency to decrease from supine to prone, but neither reached significance. Finally, there were no significant differences in Vti or Qc between supine and prone. We interpret the lower diffusing capacity of the healthy lung in the prone posture based on the relatively larger space occupied by the heart in the dependent lung zones, leaving less space for zone 3 capillaries, and on the relatively lower position of the heart, leaving the zone 3 capillaries less engorged.
MeSH term(s)	Adult ; Blood Volume ; Capillaries ; Female ; Humans ; Male ; Middle Aged ; Prone Position ; Pulmonary Alveoli ; Pulmonary Circulation ; Pulmonary Diffusing Capacity ; Reference Values ; Respiratory Mechanics ; Supine Position
Language	English
Publishing date	2004-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219139-8
ISSN	1522-1601 ; 8750-7587 ; 0021-8987 ; 0161-7567
ISSN (online)	1522-1601
ISSN	8750-7587 ; 0021-8987 ; 0161-7567
DOI	10.1152/japplphysiol.00255.2003
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Article: Similar ventilation distribution in normal subjects prone and supine during tidal breathing.

Rodríguez-Nieto, M J / Peces-Barba, G / González Mangado, N / Paiva, M / Verbanck, S

Journal of applied physiology (Bethesda, Md. : 1985)

2002 Volume 92, Issue 2, Page(s) 622–626

Abstract: Multiple-breath washout (MBW) tests, with end-expiratory lung volume at functional residual capacity (FRC) and 90% O(2), 5% He, and 5% SF(6) as an inspired gas mixture, were performed in healthy volunteers in supine and prone postures. The semilog plot ... ...

Abstract	Multiple-breath washout (MBW) tests, with end-expiratory lung volume at functional residual capacity (FRC) and 90% O(2), 5% He, and 5% SF(6) as an inspired gas mixture, were performed in healthy volunteers in supine and prone postures. The semilog plot of MBW N(2) concentrations was evaluated in terms of its curvilinearity. The MBW N(2) normalized slope analysis yielded indexes of acinar and conductive ventilation heterogeneity (Verbanck S, Schuermans D, Van Muylem A, Paiva M, Noppen M, and Vincken W. J App Physiol 83: 1907-1916, 1997). Also, the difference between SF(6) and He normalized phase III slopes was computed in the first MBW expiration. Only MBW tests with similar FRC in the prone and supine postures (P > 0.1; n = 8) were considered. Prone and supine postures did not reveal any significant differences in curvilinearity, N(2) normalized slope-derived indexes of conductive or acinar ventilation heterogeneity, nor SF(6)-He normalized phase III slope difference in the first MBW expiration (P > 0.1 for all). The absence of significant changes in any of the MBW indexes suggests that ventilation heterogeneity is similar in the supine and prone postures of normal subjects breathing near FRC.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Prone Position/physiology ; Reference Values ; Respiratory Physiological Phenomena ; Supine Position/physiology ; Tidal Volume
Language	English
Publishing date	2002-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219139-8
ISSN	1522-1601 ; 8750-7587 ; 0021-8987 ; 0161-7567
ISSN (online)	1522-1601
ISSN	8750-7587 ; 0021-8987 ; 0161-7567
DOI	10.1152/japplphysiol.00574.2001
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Article ; Online: COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid.

Heili-Frades, S. / Minguez, P. / Mahillo-Fernandez, I. / Prieto-Rumeau, T. / Herrero Gonzalez, A. / de la Fuente, L. / Rodriguez Nieto, M. J. / Peces-Barba Romero, G. / Peces-Barba, M. / Carballosa de Miguel, M. d. P. / Fernandez Ormaechea, I. / Naya Prieto, A. / Ezzine de Blas, F. / Jimenez Hiscock, L. / Perez Calvo, C. / Santos, A. / Munoz Alameda, L. E. / Romero Bueno, F. / Hernandez-Mora, M. G. /

Cabello Ubeda, A. / Alvarez Alvarez, B. / Petkova, E. / Carrasco, N. / Martin Rios, D. / Gonzalez Mangado, N. / Sanchez Pernaute, O.

Abstract: There is limited information describing features and outcomes of patients requiring hospitalization for COVID19 disease and still no treatments have clearly demonstrated efficacy. Demographics and clinical variables on admission, as well as laboratory ... ...

Abstract	There is limited information describing features and outcomes of patients requiring hospitalization for COVID19 disease and still no treatments have clearly demonstrated efficacy. Demographics and clinical variables on admission, as well as laboratory markers and therapeutic interventions were extracted from electronic Clinical Records (eCR) in 4712 SARS-CoV2 infected patients attending 4 public Hospitals in Madrid. Patients were stratified according to age and stage of severity. Using multivariate logistic regression analysis, cut-off points that best discriminated mortality were obtained for each of the studied variables. Principal components analysis and a neural network (NN) algorithm were applied. A high mortality incidence associated to age >70, comorbidities (hypertension, neurological disorders and diabetes), altered vitals such as fever, heart rhythm disturbances or elevated systolic blood pressure, and alterations in several laboratory tests. Remarkably, analysis of therapeutic options either taken individually or in combination drew a universal relationship between the use of Cyclosporine A and better outcomes as also a benefit of tocilizumab and/or corticosteroids in critically ill patients. We present a large Spanish population-based study addressing factors influencing survival in current SARS CoV2 pandemic, with particular emphasis on the effectivity of treatments. In addition, we have generated an NN capable of identifying severity predictors of SARS CoV2. A rapid extraction and management of data protocol from eCR and artificial intelligence in-house implementations allowed us to perform almost real time monitoring of the outbreak evolution.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.05.22.20109850
Database	COVID19

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Article ; Online: Increased collagen deposition correlated with lung destruction in human emphysema.

Martin-Mosquero, C / Peces-Barba, G / Rubio, M L / Ortega, M / Rodriguez-Nieto, M J / Martinez Galan, L / Gonzalez-Mangado, N

Histology and histopathology

2006 Volume 21, Issue 8, Page(s) 823–828

Abstract: Background: To study the relationship between collagen amount and degree of emphysema as assessed by mean linear intercept (Lm) and correlating these with lung function test workup in patients with and without COPD.: Methods: Lung function tests were ...

Abstract	Background: To study the relationship between collagen amount and degree of emphysema as assessed by mean linear intercept (Lm) and correlating these with lung function test workup in patients with and without COPD. Methods: Lung function tests were assessed in 16 smokers or ex-smokers and 1 non-smoker in order to separate them into two groups: COPD (FEV1/FVC lower than 70%) and non-COPD. A piece of lung tissue was used to analyse the collagen amount (HYP) by means of a colorimetric method. Morphometry was assessed to divide patients into two groups according to Lm: Lm > 260 micrometers was considered non-emphysema and Lm < 260 mm mild-emphysema. Results: The non-emphysema group had a mean Lm value of 246.08+/-3.12 micrometers and the mild-emphysema group of 276.29+/-4.26 micrometers. The amount of hydroxyproline was significantly higher in the mild-emphysema group than in the non-emphysema group (7.82+/-0.67 vs. 5.50+/-0.54 microgram/g tissue). There was a clear positive correlation between Lm and HYP (r=0.55) and a negative correlation between Lm and DlCO (R=-0.5092). No correlation was found between the functional test and HYP, nor were there significant differences between COPD and non-COPD patients for Lm and HYP. Conclusions: Emphysema is associated with collagen deposition in the lungs, and air space size correlates with the amount of lung collagen even when there is no emphysema.
MeSH term(s)	Aged ; Collagen/analysis ; Collagen/metabolism ; Humans ; Hydroxyproline/analysis ; Lung/metabolism ; Lung/pathology ; Lung/physiopathology ; Middle Aged ; Pulmonary Alveoli/pathology ; Pulmonary Emphysema/metabolism ; Pulmonary Emphysema/pathology ; Pulmonary Emphysema/physiopathology ; Respiratory Function Tests ; Smoking/adverse effects
Chemical Substances	Collagen (9007-34-5) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2006
Publishing country	Spain
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-21.823
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