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  1. AU="Rodrigo Morales"
  2. AU="Pilla, Kala Bharath"
  3. AU="Micheva, Kristina D"
  4. AU="Smigliani, Ariela"
  5. AU="Griesshaber, Hanna"
  6. AU="Fernandes, Regina"
  7. AU="Wezendonk, Lisanne H T" AU="Wezendonk, Lisanne H T"
  8. AU="The BRIDGES Consortium"
  9. AU="Takaharu Isobe"
  10. AU="O'Donnell, Joan"
  11. AU="Montesinos-Guevara, Camila"
  12. AU="Şükrü Yıldız"
  13. AU="Sarewitz, Daniel" AU="Sarewitz, Daniel"
  14. AU="Reshaeel, Muhammad"
  15. AU="Imbesi, Venerina"
  16. AU=Elpeltagy Marwa
  17. AU="Lobo, Rosario Pintos"
  18. AU="Makulović Stefan"
  19. AU="E.‑K. Kim"
  20. AU="Sijing Wu"
  21. AU="Rus, Mircea"
  22. AU="Yanqin Yang"
  23. AU="von Paris, Philip"
  24. AU=Tanaka K
  25. AU="Olesen, Jes"
  26. AU="Liao, Walter"
  27. AU="Lindfeldt, Isis"
  28. AU="A Bataineh, Ziad"

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  1. Artikel ; Online: Prion strains in mammals

    Rodrigo Morales

    PLoS Pathogens, Vol 13, Iss 7, p e

    Different conformations leading to disease.

    2017  Band 1006323

    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The prion-like phenomenon in Alzheimer's disease

    Ruben Gomez-Gutierrez / Rodrigo Morales

    PLoS Pathogens, Vol 16, Iss 10, p e

    Evidence of pathology transmission in humans.

    2020  Band 1009004

    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Uptake, Retention, and Excretion of Infectious Prions by Experimentally Exposed Earthworms

    Sandra Pritzkow / Rodrigo Morales / Manuel Camacho / Claudio Soto

    Emerging Infectious Diseases, Vol 27, Iss 12, Pp 3151-

    2021  Band 3154

    Abstract: Prions are proteinaceous infectious agents that can be transmitted through various components of the environment, including soil particles. We found that earthworms exposed to prion-contaminated soil can bind, retain, and excrete prions, which remain ... ...

    Abstract Prions are proteinaceous infectious agents that can be transmitted through various components of the environment, including soil particles. We found that earthworms exposed to prion-contaminated soil can bind, retain, and excrete prions, which remain highly infectious. Our results suggest that earthworms potentially contribute to prion disease spread in the environment.
    Schlagwörter prions and related diseases ; chronic wasting disease ; environmental transmission ; PMCA ; earthworms ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Centers for Disease Control and Prevention
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Comparison of a Plantain-Chicory Mixture with a Grass Permanent Sward on the Live Weight Gain and Meat Quality of Lambs

    Romina Rodríguez / Oscar Balocchi / Daniel Alomar / Rodrigo Morales

    Animals, Vol 10, Iss 2275, p

    2020  Band 2275

    Abstract: Under the predicted conditions of climate change, the productivity of temperate grasslands may be affected by drought stress, especially in spring and summer. In this scenario, water-deficit-tolerant species such as plantain and chicory are interesting ... ...

    Abstract Under the predicted conditions of climate change, the productivity of temperate grasslands may be affected by drought stress, especially in spring and summer. In this scenario, water-deficit-tolerant species such as plantain and chicory are interesting alternatives for use in sheep production systems. In this study, we compared a mixture of plantain and chicory herbage (PCH) with a grass-based permanent sward (GBS) on the weight gain and meat quality of lambs finished on these grasslands. Fifteen weaned lambs (31.3 kg and 4 months of age) were assigned to each treatment for seven weeks in late spring and live weight gain (LWG), carcass and meat quality were evaluated. There was a tendency ( p = 0.09) in final weight (40.3 ± 0.8 kg) and live weight gain (173 ± 10 g/d) to be higher in PCH compared to GBS. Carcass weight, dressing percentage and meat quality in terms of pH, color and tenderness did not differ ( p > 0.05) and were considered to be of good quality. We concluded that both swards result in comparable lamb performance and good meat quality.
    Schlagwörter lamb meat ; Plantago lanceolata ; Cichorium intybus ; carcass quality ; sheep ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Characteristics of tracheostomized patients followed up by a Palliative Care and Complex Chronic Patient Service.

    Pons-Tomàs, Gemma / Painamil, Rodrigo Morales / Campos, Sílvia Ricart / Arasa, Eduard Pellicer / Sanflorencio, Lucía Peñarrubia / Corredor, Laura Ponce / López, Isabel Torrús

    Anales de pediatria

    2024  Band 100, Heft 4, Seite(n) 251–258

    Abstract: Introduction and objectives: In recent years, there has been an increase in the number of children with tracheostomies. The objective was to describe the characteristics of paediatric patients with a tracheostomy followed up by the Department of ... ...

    Abstract Introduction and objectives: In recent years, there has been an increase in the number of children with tracheostomies. The objective was to describe the characteristics of paediatric patients with a tracheostomy followed up by the Department of Palliative Care and Chronic Medically Complex Illness (DPCCMCI) of a tertiary care hospital.
    Methods: Single-centre retrospective observational study in patients aged less than 18 years with a tracheostomy followed up by the PCCCPS of a tertiary care hospital (November 2020-June 2022). We analysed epidemiological, clinical, microbiological and social data by reviewing the health records.
    Results: The sample included 44 tracheostomized patients. The most frequent underlying disease was acquired upper airway disease (20.5%). The most common indication for tracheostomy was upper airway obstruction (66%). Bacterial isolates were detected in 84% of the tracheal aspirates, among which P. aeruginosa was the most frequent (56.8%). The most frequently prescribed antibiotic was ciprofloxacin (84%). In addition, 18.1% of the patients received at least 1 course of intravenous antibiotherapy and 29.5% received more than 3 systemic antibiotic regimens in the past 20 months. Fifty-nine percent of the children were schooled: 38.6% attended a regular school, 15.9% a special needs school and 4.5% were home-schooled. We identified social difficulties in 53.7%. Also, 22.7% of the families received financial support to care for a child with severe illness.
    Conclusions: Because of the complexity of caring for tracheostomized children, integral and coordinated management is essential. Schooling is possible and safe if caregivers are trained.
    Mesh-Begriff(e) Humans ; Retrospective Studies ; Male ; Female ; Child ; Palliative Care/methods ; Tracheostomy/statistics & numerical data ; Adolescent ; Child, Preschool ; Chronic Disease ; Infant ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/administration & dosage ; Tertiary Care Centers
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland Spain
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2024.03.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: A Lifecycle Assessment of a Low-Energy Mass-Timber Building and Mainstream Concrete Alternative in Central Chile

    Gabriel Felmer / Rodrigo Morales-Vera / Rodrigo Astroza / Ignacio González / Maureen Puettmann / Mark Wishnie

    Sustainability, Vol 14, Iss 1249, p

    2022  Band 1249

    Abstract: While high-rise mass-timber construction is booming worldwide as a more sustainable alternative to mainstream cement and steel, in South America, there are still many gaps to overcome regarding sourcing, design, and environmental performance. The aim of ... ...

    Abstract While high-rise mass-timber construction is booming worldwide as a more sustainable alternative to mainstream cement and steel, in South America, there are still many gaps to overcome regarding sourcing, design, and environmental performance. The aim of this study was to assess the carbon emission footprint of using mass-timber products to build a mid-rise low-energy residential building in central Chile (CCL). The design presented at a solar decathlon contest in Santiago was assessed through lifecycle analysis (LCA) and compared to an equivalent mainstream concrete building. Greenhouse gas emissions, expressed as global warming potential (GWP), from cradle-to-usage over a 50-year life span, were lower for the timber design, with 131 kg CO 2 eq/m 2 of floor area (compared to 353 kg CO 2 eq/m 2 ) and a biogenic carbon storage of 447 tons of CO 2 eq/m 2 based on sustainable forestry practices. From cradle-to-construction, the embodied emissions of the mass-timber building were 42% lower (101 kg CO 2 eq/m 2 ) than those of the equivalent concrete building (167 kg CO 2 eq/m 2 ). The embodied energy of the mass-timber building was 37% higher than that of its equivalent concrete building and its envelope design helped reduce space-conditioning emissions by as much as 83%, from 187 kg CO 2 eq/m 2 as estimated for the equivalent concrete building to 31 kg CO 2 eq/m 2 50-yr. Overall, provided that further efforts are made to address residual energy end-uses and end-of-life waste management options, the use of mass-timber products offers a promising potential in CCL for delivering zero carbon residential multistory buildings.
    Schlagwörter LCA ; LCIA ; mid-rise timber buildings ; carbon storage ; passive zero carbon housing ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 690 ; 333
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: La política exterior del gobierno de Enrique Peña Nieto hacia América Latina y el Caribe en un mundo en transición

    Guadalupe González González / Rodrigo Morales Castillo

    Foro Internacional, Vol 59, Iss 3-

    una trama en tres actos

    2019  Band 4

    Abstract: Los responsables de tomar decisiones suelen formular, reestructurar, reformar o ajustar la política exterior mexicana hacia América Latina y el Caribe a partir de los cambios que se generan en los tableros a nivel internacional, regional y nacional. Al ... ...

    Abstract Los responsables de tomar decisiones suelen formular, reestructurar, reformar o ajustar la política exterior mexicana hacia América Latina y el Caribe a partir de los cambios que se generan en los tableros a nivel internacional, regional y nacional. Al respecto, el sexenio del presidente Enrique Peña Nieto es un caso de estudio esclarecedor, ya que durante su gestión el gobierno mexicano tuvo que responder a varias coyunturas que se presentaron en estas tres pistas de acción, incluso de manera simultánea. De acuerdo con estas adaptaciones, a lo largo del periodo estudiado registramos tres ciclos de la diplomacia peñista en la región: promoción, repliegue y contención.
    Schlagwörter política exterior ; México ; América Latina ; Caribe ; promoción ; repliegue ; Political science ; J ; International relations ; JZ2-6530
    Sprache Spanisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag El Colegio de México
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Chronic wasting disease (CWD) prion detection in blood from pre-symptomatic white-tailed deer harboring PRNP polymorphic variants

    Carlos Kramm / Paulina Soto / Tracy A. Nichols / Rodrigo Morales

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Band 8

    Abstract: Abstract Chronic wasting disease (CWD) is a prionopathy affecting wild and farmed cervids. This disease is endemic in North America and has been recently identified in Europe. Ante-mortem CWD tests of pre-clinical cervids may be an important tool in ... ...

    Abstract Abstract Chronic wasting disease (CWD) is a prionopathy affecting wild and farmed cervids. This disease is endemic in North America and has been recently identified in Europe. Ante-mortem CWD tests of pre-clinical cervids may be an important tool in helping control the spread of this disease. Unfortunately, current CWD diagnostic methods are not suitable for non-tissue type samples. We reported that CWD prions can be detected in blood of pre-clinical CWD-infected white-tailed deer (WTD) with high sensitivity and specificity using the Protein Misfolding Cyclic Amplification (PMCA) assay. However, that report only included animals homozygous for codon 96G, the most common polymorphic version of the prion protein within this animal species. Here, we report CWD prion detection using blood of naturally infected WTD coding one or two copies of the PrP-96S polymorphic variant. Our results, from a blinded screening, show 100% specificity and ~ 58% sensitivity for animals harboring one 96S codon, regardless of their stage within the pre-clinical phase. Detection efficiency for PrP-96S homozygous animals was substantially lower, suggesting that this allele affect peripheral prion replication/tropism. These results provide additional information on the influence of codon 96 polymorphisms and the ability of PMCA to detect CWD in the blood of pre-clinical WTD.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2020-11-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Altering Brain Amyloidosis by Intra-Lingual and Extra-Nasal Exposure of Aβ Aggregates

    Nazaret Gamez / Javiera Bravo-Alegria / Yumeng Huang / Nelson Perez-Urrutia / Deepa Dongarwar / Claudio Soto / Rodrigo Morales

    Cells, Vol 11, Iss 3442, p

    2022  Band 3442

    Abstract: Extensive experimental and human-derived evidence suggest that misfolded Aβ particles spread similarly to infectious prions. Moreover, peripheral administration of Aβ seeds accelerates brain amyloidosis in both susceptible experimental animals and humans. ...

    Abstract Extensive experimental and human-derived evidence suggest that misfolded Aβ particles spread similarly to infectious prions. Moreover, peripheral administration of Aβ seeds accelerates brain amyloidosis in both susceptible experimental animals and humans. The mechanisms and elements governing the transport of misfolded Aβ from the periphery to the brain are not fully understood, although circulation and retrograde axonal transport have been proposed. Here, we demonstrate that injection of Aβ seeds in the tongue, a highly innervated organ, substantially accelerates the appearance of plaques in Tg2576 mice. In addition, the extra-nasal exposure of Aβ aggregates increased amyloid pathology in the olfactory bulb. Our results show that exposing highly innervated tissues to Aβ seeds accelerates AD-like pathological features, and suggest that Aβ seeds can be transported from peripheral compartments to the brain by retrograde axonal transport. Research in this direction may be relevant on different fronts, including disease mechanisms, diagnosis, and risk-evaluation of potential iatrogenic transmission of Aβ misfolding.
    Schlagwörter amyloid-beta ; Alzheimer’s disease ; prion ; tongue ; nasal cavity ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Use of tannins to improve fatty acids profile of meat and milk quality in ruminants

    Rodrigo Morales / Emilio M Ungerfeld

    Chilean Journal of Agricultural Research, Vol 75, Iss 2, Pp 239-

    A review

    2015  Band 248

    Abstract: This paper reviews how tannins, through their effects on rumen lipid metabolism, can affect the composition of ruminants' meat and milk fat. Tannins are a heterogeneous group of plant secondary compounds known for both beneficial and detrimental effects ... ...

    Abstract This paper reviews how tannins, through their effects on rumen lipid metabolism, can affect the composition of ruminants' meat and milk fat. Tannins are a heterogeneous group of plant secondary compounds known for both beneficial and detrimental effects on animals' digestive physiology. Tannins supplementation of ruminants' diets alters both in vivo and in vitro unsaturated fatty acids biohydrogenation and hence the profile of fatty acids outflowing the rumen, which can influence milk and meat content of beneficial fatty acids such as linolenic acid (c9,c12,c15-18:3), vaccenic acid (ti 1-18:1) and rumenic acid (c9,t11-18:2), among others. Published information indicates that tannins could inhibit biohydrogenation though affecting ruminal microorganisms. Some studies found increments in linolenic, rumenic and/or vaccenic acids in meat and milk fat using different sources of tannins; however, the effects of tannins supplementation on milk and meat fatty acid profile are not consistent, and there are contradictory results published in the literature. Effects of tannin supplementation on fatty acids biohydrogenation are affected by the chemical type of tannins, the complexity of their interactions with dietary components, and the potential microbial adaptation to tannins. In addition, the duration of the tannins-feeding period may also affect milk and meat fatty acid profile. Characterizing the effects of each specific tannic compound on different biohydrogenation steps and on the microbial species conducting them, as well as the interaction between specific tannin compounds and other dietary components can help to take greater advantage of tannins potential to contribute to improve human health through promoting beneficial fatty acids in ruminants products.
    Schlagwörter Biohydrogenation ; condensed tannins ; conjugated linoleic acids ; hydrolysable tannins ; product quality ; Agriculture ; S ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2015-06-01T00:00:00Z
    Verlag Instituto de Investigaciones Agropecuarias, INIA
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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