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Article: Sleep Hygiene, Daytime Sleepiness, and Coping Mechanisms Amongst US Adults.

Yared, Lindsey / Rodrigues, Kiran / Mangal, Rohan / Stead, Thor S / Ganti, Latha

2023 Volume 15, Issue 9, Page(s) e45608

Abstract: Background Excessive daytime sleepiness (EDS) can be measured by the Epworth Sleepiness Scale (ESS) and has been shown to be prevalent in the United States. This study aimed to survey the levels of EDS in US adults and explore factors related to sleep ... ...

Abstract	Background Excessive daytime sleepiness (EDS) can be measured by the Epworth Sleepiness Scale (ESS) and has been shown to be prevalent in the United States. This study aimed to survey the levels of EDS in US adults and explore factors related to sleep hygiene. Methods An anonymous web-based survey was conducted, polling the frequency of hypersomnia symptoms, sleep quality, and time spent in their occupation. Respondents were at least 21 years of age and United States residents. Participants reported information related to age, gender, education, income, and race in addition to their responses to the survey questions. All data were analyzed using JMP 16.0. Results In our cohort of 200 adults, the median age was 40, with an interquartile range of 34-50 years. 48% were female. More than half of the cohort (53%) had severe or higher-normal EDS. Race (p=0.112), sex (p=0.426), age (p=0.063) shift work/shift timing (p=0.260), and screen time before bed (p=0.785) were not statistically significant for excessive daytime sleepiness. However, the length of participants' workdays (p=0.001) and their income levels (p=0.008) were found to be significantly associated with EDS. In other words, longer workdays and lower income levels were associated with an increased likelihood of falling asleep during inactive periods of the day. Conclusion Sleep deprivation and excessive daytime sleepiness are intertwined with sleep hygiene. This study highlights some of the possible issues that could lead to potential solutions.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45608
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Article ; Online: Experiences of teachers and students on school closures and its consequences during the COVID-19 pandemic in Nyarugusu refugee camp, Tanzania.

Shayo, Elizabeth H / Mubyazi, Godfrey / Barongo, Vivien / Bakari, Mtumwa / Kiwale, Zenais / Fabbri, Camilla / Turner, Ellen / Rodrigues, Katherine / Devries, Karen

PLOS global public health

2024 Volume 4, Issue 3, Page(s) e0002917

Abstract: Tanzania has experienced several waves of COVID-19 since it was first detected in the country. During the first wave, Tanzania took several measures to prevent wider virus transmission with school closures being one of them. All areas and institutions ... ...

Abstract	Tanzania has experienced several waves of COVID-19 since it was first detected in the country. During the first wave, Tanzania took several measures to prevent wider virus transmission with school closures being one of them. All areas and institutions were targeted, including the refugee camps in Kigoma region. Despite the abundant evidence generated in relation to the effects of the pandemic and associated school closures globally, there has been a paucity of literature exploring the experiences of teachers and students in humanitarian settings. We conducted a qualitative study to explore COVID-19 related school closures in Nyarugusu refugee camp. We aimed to describe teachers' and students' experiences and perceived consequences of school closures. In-depth interviews with teachers and students were conducted in September 2020 in Burundian and Congolese schools in the context of a cluster randomised trial of EmpaTeach, a school-based violence prevention intervention. A total of 44 individuals (29 teachers and 15 students) were interviewed. A phenomenological theoretical framework was used to guide the content analysis. Findings indicated that the COVID-19 pandemic was generally seen as frightening by refugees. Study participants understood the importance of school closures to prevent transmission of the virus, but various negative consequences were reported by both teachers and students. These included perceived mental health difficulties such as stress, depression and anxiety associated with the worry of infection, idleness, and disruption of education. Participants also perceived an increase in occurrences of early marriages and unplanned pregnancies, which they thought contributed to increased school dropout. Participants identified the main causes of such outcomes as a lack of parental supervision, children's lack of restraint and poor character, and a lack of alternative teaching practices (such as online or remote learning) to keep the students busy while at home. Children were held accountable for their faults with little support from the adults. Our findings suggest that there is an urgent need to strengthen child protection programming to support children and their communities during emergencies and provides protective environments such as school and education. There is a critical need to develop preparedness plans for future pandemics to support child safety, academic development and wellbeing.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0002917
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Article ; Online: Conceptualisation of violence and discipline among students, teachers, and parents in Nyarugusu Refugee Camp, Tanzania.

Barongo, Vivien / Kiwale, Zenais / Shayo, Elizabeth / Fabbri, Camilla / Turner, Ellen / Bakari, Mtumwa / Mubyazi, Godfrey / Rodrigues, Katherine / Devries, Karen

Child abuse & neglect

2024 Volume 149, Page(s) 106555

Abstract: Background: Little academic research has been conducted on how people conceptualise 'violence' and 'discipline', especially in humanitarian settings. This may limit the transferability of violence prevention interventions. This paper examines the ... ...

Abstract	Background: Little academic research has been conducted on how people conceptualise 'violence' and 'discipline', especially in humanitarian settings. This may limit the transferability of violence prevention interventions. This paper examines the understanding of violence and discipline concepts among students, teachers, and parents in the Nyarugusu Refugee Camp in Tanzania. Methods: A qualitative study was undertaken as part of the larger trial testing the effectiveness of the EmpaTeach intervention to prevent physical violence from teachers to students implemented in 27 schools in Nyarugusu Refugee Camp. Data from baseline and midline surveys in control schools that did not receive the intervention informed this paper where a total of 14 in-depth interviews (eight with students and six teachers) and six focus group discussions (two with teachers and four with parents from the Parent Teacher Association) were analyzed. Both audio recordings from in-depth interviews and focus group discussions were transcribed verbatim, and translated from Kiswahili to English (Congolese) and Kirundi to English (Burundian). Translated data were verified and coded using thematic analysis based on the views of students, teachers, and parents. Results: Participants revealed that the same behavioural acts could be differentially classified as violence or discipline. Violence was understood in relation to the consequences of acts, which could include physical or psychological harm, or other harms which were seen as detrimental to children's futures and life chances, particularly adolescent pregnancy. Sexual acts without consent were also seen as violence. In contrast, discipline was understood according to intent, and perceived acts done towards students to correct bad behaviour. Conclusion: Results imply that education about the harmful consequences of behavioural acts intended as discipline, may be important for violence prevention interventions and that framing interventions in terms of positive child development could help change discipline strategies in schools.
MeSH term(s)	Child ; Adolescent ; Humans ; Tanzania ; Refugee Camps ; Concept Formation ; Violence/psychology ; Students/psychology ; Schools ; Parents/psychology
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2023.106555
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Article: A 5700-year-old beach-ridge set at Cape Canaveral, Florida, and its implication for Holocene sea-level history in the southeastern USA

Rodrigues, Kathleen / Stapor, Frank W / Rink, William J / Dunbar, James S / Doran, Glen

Holocene. 2022 Feb., v. 32, no. 1-2

2022

Abstract: The Cape Canaveral Peninsula is the largest Holocene coastal sand deposit composed of beach ridges on the Atlantic coast of Florida. It is composed of 16 beach-ridge sets that are separated by erosional surfaces. Despite its prominence as a Holocene ... ...

Abstract	The Cape Canaveral Peninsula is the largest Holocene coastal sand deposit composed of beach ridges on the Atlantic coast of Florida. It is composed of 16 beach-ridge sets that are separated by erosional surfaces. Despite its prominence as a Holocene coastal depocenter, there are a limited amount of chronological data constraining the timing of its formation. In this study, we apply optically stimulated luminescence (OSL) dating on sand-sized quartz and radiocarbon dating on individual marine shells to develop a refined chronology of the Cape Canaveral beach-ridge plain with particular focus on constraining the depositional age of the northwesterly-most, and geographically oldest, beach-ridge set on the peninsula. We obtain an average OSL age of 5680 ± 240 years (n = 4) for the initiation of coastal deposition at Cape Canaveral. The new ages, and the organization of beach ridges into 16 distinct sets indicates that the Cape Canaveral beach-ridge plain experienced an ~5700-year history of alternating deposition and erosion, with 75% of present-day Cape Canaveral (Beach-ridge Sets 5–16) deposited over the past 2000 years and Beach-ridge Sets 8–16 comprising 50% of the area over the past 1000 years. Because the minimum swale elevations of the ~5700-year Beach-ridge Set 1, and those of all the younger beach-ridge sets, are within several decimeters of present-day mean higher high water, we hypothesize that all the beach ridges present at Cape Canaveral could have been deposited at or within decimeters of present-day sea level. There is no evidence for Holocene “highstand” events over the past 5700 years in the published sea level curves from northeast and south Florida, which are based on subsurface estuarine foraminifera/leaf litter and mangrove peat data, respectively. This dichotomy illustrates the need to integrate both subaerial and subsurface data to produce a more realistic Holocene sea-level curve for the southeastern United States.
Keywords	Holocene epoch ; Retaria ; carbon radioisotopes ; coasts ; estuaries ; luminescence ; peat ; plant litter ; quartz ; sand ; sea level ; Florida
Language	English
Dates of publication	2022-02
Size	p. 40-56.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	2027956-5
ISSN	1477-0911 ; 0959-6836
ISSN (online)	1477-0911
ISSN	0959-6836
DOI	10.1177/09596836211049975
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Article ; Online: Anatomic Snuffbox (Distal Radial Artery) and Radial Artery Access for Treatment of Intracranial Aneurysms with FDA-Approved Flow Diverters.

Kühn, A L / Satti, S R / Eden, T / de Macedo Rodrigues, K / Singh, J / Massari, F / Gounis, M J / Puri, A S

AJNR. American journal of neuroradiology

2021 Volume 42, Issue 3, Page(s) 487–492

Abstract: Background and purpose: Transradial access for neurointerventional procedures has been proved a safer and more comfortable alternative to femoral artery access. We present our experience with transradial (distal radial/anatomic snuffbox and radial ... ...

Abstract	Background and purpose: Transradial access for neurointerventional procedures has been proved a safer and more comfortable alternative to femoral artery access. We present our experience with transradial (distal radial/anatomic snuffbox and radial artery) access for treatment of intracranial aneurysms using all 3 FDA-approved flow diverters. Materials and methods: This was a high-volume, dual-center, retrospective analysis of each institution's data base between June 2018 and June 2020 and a collection of all patients treated with flow diversion via transradial access. Patient demographic information and procedural and radiographic data were obtained. Results: Seventy-four patients were identified (64 female patients) with a mean age of 57.5 years with a total of 86 aneurysms. Most aneurysms were located in the anterior circulation (93%) and within the intracranial ICA (67.4%). The mean aneurysm size was 5.5 mm. Flow diverters placed included the Pipeline Embolization Device (Flex) (PED, Conclusions: Flow diverters can be successfully placed via the transradial approach with high technical success, low access site complications, and a low femoral crossover rate.
MeSH term(s)	Aged ; Blood Vessel Prosthesis ; Catheters ; Embolization, Therapeutic/methods ; Endovascular Procedures/methods ; Female ; Humans ; Intracranial Aneurysm/therapy ; Male ; Middle Aged ; Radial Artery/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A6953
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Article: Timeline of SARS-CoV-2 Transmission in Sabah, Malaysia: Tracking the Molecular Evolution.

Balakrishnan, Krishnan Nair / Yew, Chee Wei / Chong, Eric Tzyy Jiann / Daim, Sylvia / Mohamad, Nurul Elyani / Rodrigues, Kenneth / Lee, Ping-Chin

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Background: The COVID-19 pandemic poses an unprecedented public health challenge in Malaysia. The impact of COVID-19 varies between countries, including geographically divided states within a country. The deadly transmission of COVID-19 has taken a ... ...

Abstract	Background: The COVID-19 pandemic poses an unprecedented public health challenge in Malaysia. The impact of COVID-19 varies between countries, including geographically divided states within a country. The deadly transmission of COVID-19 has taken a heavy toll in Sabah, Malaysia's third most populous state, contributing nearly 10% to the recorded national death toll as of 31 December 2022. Although several SARS-CoV-2 genome sequences have been analysed in Malaysia, molecular epidemiology data from Sabah focusing on the diversity and evolution of SARS-CoV-2 variants are still lacking. This study examines the major SARS-CoV-2 variants and emerging mutations from Sabah, the Malaysian Borneo, which is geographically divided from West Malaysia by the South China Sea. Methods: A total of 583 COVID-19 samples were subjected to whole genome sequencing and analysed with an additional 1123 Sabah COVID-19 sequences retrieved from the GISAID EpiCoV consortium. Nextclade and Pangolin were used to classify these sequences according to the clades and lineages. To determine the molecular evolutionary characteristics, Bayesian time-scaled phylogenetic analysis employing the maximum likelihood algorithm was performed on selected SARS-CoV-2 genome sequences, using the Wuhan-Hu-1 sequence as a reference. Results: Sabah was affected starting from the second COVID-19 wave in Malaysia, and the early sequences were classified under the O clade. The clade was gradually replaced during subsequent waves by G, GH, GK and GRA, with the latter being dominant as of December 2022. Phylogenetically, the Delta isolates in this study belong to the three main subclades 21A, 21J and 21I, while Omicron isolates belong to 21M, 21L and 22B. The time-scaled phylogeny suggested that SARS-CoV-2 introduced into Sabah originated from Peninsular Malaysia in early March 2020, and phylodynamic analysis indicated that increased viral spread was observed in early March and declined in late April, followed by an evolutionary stationary phase in June 2020. Conclusion: Continuous molecular epidemiology of SARS-CoV-2 in Sabah will provide a deeper understanding of the emergence and dominance of each variant in the locality, thus facilitating public health intervention measures.
Language	English
Publishing date	2023-08-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12081047
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Article ; Online: Dibutyl phthalate disrupts energy metabolism and morphology in the gills and induces hepatotoxicity in zebrafish.

Rodrigues, Keyla / Batista-Silva, Hemily / de Moura, Kieiv Resende Sousa / Van Der Kraak, Glen / Silva, Fátima Regina Mena Barreto

Fish physiology and biochemistry

2023 Volume 49, Issue 5, Page(s) 883–893

Abstract: This study investigated the acute effects of dibutyl phthalate (DBP) exposure on energy metabolism and gill histology in zebrafish (Danio rerio). The in vitro incubation of gill tissue with 10 μM DBP for 60 min altered tissue energy supply, as shown by ... ...

Abstract	This study investigated the acute effects of dibutyl phthalate (DBP) exposure on energy metabolism and gill histology in zebrafish (Danio rerio). The in vitro incubation of gill tissue with 10 μM DBP for 60 min altered tissue energy supply, as shown by decreased lactate content and lactate dehydrogenase (LDH) activity. Higher concentrations of DBP (100 μM and 1 mM) increased lactate content and LDH activity; however, they blocked glucose uptake, depleted the glycogen content in cellular stores, and induced injury to the gills, as measured by LDH release to the extracellular medium. In addition, in vivo exposure of fish to 1 pM DBP for 12 h induced liver damage by increasing alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) activities. Gill histology indicated hyperemia, lamellar fusion, lamellar telangiectasis, and necrosis. Data indicate that acute exposure of zebrafish gills to the higher DBP concentrations studied induces anaerobic cellular activity and high lactate production, causing gill damage, diminishing cell viability, and incurring liver dysfunction.
MeSH term(s)	Animals ; Zebrafish/metabolism ; Dibutyl Phthalate/toxicity ; Dibutyl Phthalate/metabolism ; Gills/metabolism ; Energy Metabolism ; Lactates/metabolism ; Lactates/pharmacology ; Chemical and Drug Induced Liver Injury
Chemical Substances	Dibutyl Phthalate (2286E5R2KE) ; Lactates
Language	English
Publishing date	2023-08-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	292907-7
ISSN	1573-5168 ; 0920-1742
ISSN (online)	1573-5168
ISSN	0920-1742
DOI	10.1007/s10695-023-01227-z
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Article ; Online: New curcumin-loaded nanocapsules as a therapeutic alternative in an amnesia model.

da Costa Rodrigues, Karline / da Silva Neto, Manoel Rodrigues / Dos Santos Barboza, Victor / Hass, Sandra Elisa / de Almeida Vaucher, Rodrigo / Giongo, Janice Luehring / Schumacher, Ricardo Frederico / Wilhelm, Ethel Antunes / Luchese, Cristiane

Metabolic brain disease

2024 Volume 39, Issue 4, Page(s) 589–609

Abstract: This study aimed to investigate the action of two different formulations of curcumin (Cur)-loaded nanocapsules (Nc) (Eudragit [EUD] and poly (ɛ-caprolactone) [PCL]) in an amnesia mice model. We also investigated the formulations' effects on scopolamine- ... ...

Abstract	This study aimed to investigate the action of two different formulations of curcumin (Cur)-loaded nanocapsules (Nc) (Eudragit [EUD] and poly (ɛ-caprolactone) [PCL]) in an amnesia mice model. We also investigated the formulations' effects on scopolamine-induced (SCO) depressive- and anxiety-like comorbidities, the cholinergic system, oxidative parameters, and inflammatory markers. Male Swiss mice were randomly divided into five groups (n = 8): group I (control), group II (Cur PCL Nc 10 mg/kg), group III (Cur EUD Nc 10 mg/kg), group IV (free Cur 10 mg/kg), and group V (SCO). Treatments with Nc or Cur (free) were performed daily or on alternate days. After 30 min of treatment, the animals received the SCO and were subjected to behavioral tests 30 min later (Barnes maze, open-field, object recognition, elevated plus maze, tail suspension tests, and step-down inhibitory avoidance tasks). The animals were then euthanized and tissue was removed for biochemical assays. Our results demonstrated that Cur treatment (Nc or free) protected against SCO-induced amnesia and depressive-like behavior. The ex vivo assays revealed lower acetylcholinesterase (AChE) and catalase (CAT) activity, reduced thiobarbituric species (TBARS), reactive species (RS), and non-protein thiols (NSPH) levels, and reduced interleukin-6 (IL-6) and tumor necrosis factor (TNF) expression. The treatments did not change hepatic markers in the plasma of mice. After treatments on alternate days, Cur Nc had a more significant effect than the free Cur protocol, implying that Cur may have prolonged action in Nc. This finding supports the concept that it is possible to achieve beneficial effects in nanoformulations, and treatment on alternate days differs from the free Cur protocol regarding anti-amnesic effects in mice.
MeSH term(s)	Animals ; Curcumin/pharmacology ; Curcumin/administration & dosage ; Curcumin/therapeutic use ; Nanocapsules ; Mice ; Male ; Amnesia/drug therapy ; Amnesia/chemically induced ; Disease Models, Animal ; Oxidative Stress/drug effects ; Scopolamine
Chemical Substances	Curcumin (IT942ZTH98) ; Nanocapsules ; Scopolamine (DL48G20X8X)
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632824-6
ISSN	1573-7365 ; 0885-7490
ISSN (online)	1573-7365
ISSN	0885-7490
DOI	10.1007/s11011-023-01329-w
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Article ; Online: Mental health disparities in Latinx immigrant communities residing in the United States during COVID-19: Implications for policy and practice.

Pineros-Leano, María / Pérez-Flores, Nancy Jacquelyn / Damian, Katherine / Rodrigues, Kelli / Ortiz, Gabi / Simonovich, Shannon D

Frontiers in public health

2022 Volume 10, Page(s) 1000233

Abstract: Objectives: Studies have demonstrated that Latinx populations face significant health disparities in access to mental health care. The objective of this study was to describe the impact of the COVID-19 pandemic on the mental health needs of Latinx ... ...

Abstract	Objectives: Studies have demonstrated that Latinx populations face significant health disparities in access to mental health care. The objective of this study was to describe the impact of the COVID-19 pandemic on the mental health needs of Latinx families, from the perspectives of direct service providers working with Latinx communities. Methods: Twenty-one semi-structured interviews were conducted virtually with direct service providers to the Latinx community from August to October 2020. Interviews were transcribed verbatim and analyzed using thematic analysis. Results: Two-thirds of providers were female, with a median age of 33 years, and provided direct services to Latinx clients and had extensive experience working with immigrant families, particularly in Massachusetts. Key themes identified describing the impact of COVID-19 on the mental health needs of Latinx families included: (1) exacerbation of mental health symptoms, (2) financial stressors, (3) preoccupation regarding transnational lives, (4) secondary needs becoming more salient, and (5) immigration status as a main driver of inequality. Conclusions: Our findings highlight the importance of focusing on the mental health needs of Latinx immigrants and ensuring their access to mental health services. Telehealth seems to be a potential tool that promotes mental health access among Latinx clients. Future research needs to continue investigating the role of telehealth in decreasing mental health access disparities.
MeSH term(s)	Adult ; COVID-19/epidemiology ; Emigrants and Immigrants ; Female ; Humans ; Male ; Mental Health ; Pandemics ; Policy ; United States/epidemiology
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.1000233
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Article ; Online: Context Matters: A Qualitative Study About the Perinatal Experiences of Latina Immigrant Women.

Pineros-Leano, María / Pérez-Flores, Nancy Jacquelyn / Damian, Katherine / Piñeros-Leaño, Natalia / Yao, Laura / Rodrigues, Kelli

Journal of immigrant and minority health

2022 Volume 25, Issue 1, Page(s) 8–15

Abstract: Although immigrants' health is better compared to their native-born counterparts, their wellbeing starts to deteriorate as they spend more time in the United States. To date, few qualitative studies investigate how migration can influence the perinatal ... ...

Abstract	Although immigrants' health is better compared to their native-born counterparts, their wellbeing starts to deteriorate as they spend more time in the United States. To date, few qualitative studies investigate how migration can influence the perinatal period. This study qualitatively assesses Latina immigrant mothers' perinatal experiences. Thirty Latina women were recruited in 2015 to participate in interviews, all of which were conducted in Spanish. The data were analyzed using thematic analysis. Latina mothers' experiences during the perinatal period were impacted by the cultural expectations that may or may not depend on the context where they are located. Context-independent themes included: (1) Cravings and (2) Body dissatisfaction. Context-dependent themes included: (1) Breastfeeding and (2) Loss of extended social ties. In order to reduce health disparities in the perinatal period among Latina immigrant mothers and their children, it is necessary to provide interventions that promote healthy behaviors and increase social capital and peer support.
MeSH term(s)	Child ; Female ; Humans ; Pregnancy ; Breast Feeding ; Emigrants and Immigrants ; Hispanic or Latino ; Mothers ; Qualitative Research ; United States ; Perinatal Care
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2220162-2
ISSN	1557-1920 ; 1557-1912
ISSN (online)	1557-1920
ISSN	1557-1912
DOI	10.1007/s10903-022-01372-2
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