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  1. Article: Polycystic liver diseases: from molecular basis to development of effective treatments.

    Markaide, Enara / Bañales, Jesús M / Rodrigues, Pedro M

    Revista espanola de enfermedades digestivas

    2023  Volume 115, Issue 10, Page(s) 542–545

    Abstract: Polycystic liver diseases (PLDs) comprise a heterogeneous group of congenital genetic disorders that mainly affect bile duct epithelial cells, known as cholangiocytes. Patients with PLD usually present bile duct dilatation and/or progressive develop ... ...

    Abstract Polycystic liver diseases (PLDs) comprise a heterogeneous group of congenital genetic disorders that mainly affect bile duct epithelial cells, known as cholangiocytes. Patients with PLD usually present bile duct dilatation and/or progressive develop intrahepatic, fluid-filled biliary cysts (more than 10), which is the main cause of morbidity.
    Language English
    Publishing date 2023-04-24
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9649/2023
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 199: Show issues Location:
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  2. Article ; Online: T-cell selection in the thymus: New routes toward the identification of the self-peptide ligandome presented by thymic epithelial cells.

    Sousa, Laura G / Rodrigues, Pedro M / Alves, Nuno L

    European journal of immunology

    2023  Volume 53, Issue 3, Page(s) e2250202

    Abstract: Within the thymus, thymic epithelial cells (TECs) provide a dedicated niche for the selection of functional T cells expressing a highly variable and self-tolerant T-cell receptor (TCR) repertoire. In this minireview, we start by summarizing recent ... ...

    Abstract Within the thymus, thymic epithelial cells (TECs) provide a dedicated niche for the selection of functional T cells expressing a highly variable and self-tolerant T-cell receptor (TCR) repertoire. In this minireview, we start by summarizing recent studies that have improved our understanding on the composition of cortical TEC and medullary TEC microenvironments. Next, we focus on the molecular processes that control the function of TECs in T-cell selection. In particular, we discuss the role of cortical TECs in positive selection and the pathways employed by these cells to generate and present selecting self-peptides:MHC II complexes. Several studies have underscored the role of the β5t-containing thymoproteasome in the production of unique MHC I-bound peptides critical for CD8 T-cell selection. Contrarily, the identity of the molecular determinants that regulate the generation of MHC II-bound self-peptides capable of positive selecting CD4 T cells is far more uncertain. We highlight recent advances that interconnect the autophagy-lysosomal pathway, the presentation of specific sets of self-peptide:MHC II complexes, and the diversification of CD4 TCR repertoire. Lastly, we discuss how these findings may open up new avenues for deciphering the identity of the MHC I and MHC II ligandome in the thymus.
    MeSH term(s) Thymus Gland ; Epithelial Cells ; Peptides/metabolism ; CD4-Positive T-Lymphocytes ; Histocompatibility Antigens Class I/metabolism ; Histocompatibility Antigens Class II/metabolism ; Receptors, Antigen, T-Cell/metabolism
    Chemical Substances Peptides ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-02-01
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202250202
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    Zs.MG 85: Show issues

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  3. Article ; Online: Applications of organoids in regenerative medicine: a proof-of-concept for biliary injury.

    Rodrigues, Pedro M / Banales, Jesus M

    Nature reviews. Gastroenterology & hepatology

    2021  Volume 18, Issue 6, Page(s) 371–372

    MeSH term(s) Humans ; Organoids ; Regenerative Medicine
    Language English
    Publishing date 2021-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-021-00459-9
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    Zs.MG 97: Show issues

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  4. Article ; Online: Editorial: bezafibrate in the treatment of patients with primary biliary cholangitis-are we there yet?

    Rodrigues, Pedro M / Banales, Jesus M

    Alimentary pharmacology & therapeutics

    2021  Volume 55, Issue 2, Page(s) 247–248

    MeSH term(s) Bezafibrate/therapeutic use ; Cholangitis/chemically induced ; Cholangitis/drug therapy ; Humans ; Liver Cirrhosis, Biliary/drug therapy ; Ursodeoxycholic Acid
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Bezafibrate (Y9449Q51XH)
    Language English
    Publishing date 2021-12-30
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16657
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
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  5. Article ; Online: Characterizing the Heterogeneity of Liver Cell Populations Under a NASH-Related Hepatotoxicant Using Single-Nuclei RNA Sequencing.

    Rodrigues, Pedro M / Banales, Jesus M

    Cellular and molecular gastroenterology and hepatology

    2020  Volume 11, Issue 1, Page(s) 294–296

    MeSH term(s) Hepatocytes ; Humans ; Non-alcoholic Fatty Liver Disease/genetics ; Sequence Analysis, RNA
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2352-345X
    ISSN (online) 2352-345X
    DOI 10.1016/j.jcmgh.2020.09.005
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  6. Article ; Online: A look back at cholangiocarcinoma in Finland.

    Izquierdo-Sanchez, Laura / Banales, Jesus M / Rodrigues, Pedro M

    United European gastroenterology journal

    2021  Volume 9, Issue 10, Page(s) 1103–1104

    MeSH term(s) Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/epidemiology ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/epidemiology ; Finland/epidemiology ; Humans
    Language English
    Publishing date 2021-09-28
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12157
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  7. Article ; Online: Unscrambling a novel pathogenic role for interleukin-20 in acute hepatitis and bacterial infection: A double-edged sword?

    Rodrigues, Pedro M / Olaizola, Paula / Banales, Jesus M

    Journal of hepatology

    2021  Volume 75, Issue 1, Page(s) 22–24

    MeSH term(s) Bacterial Infections ; Hepatitis/etiology ; Humans ; Interleukins
    Chemical Substances Interleukins
    Language English
    Publishing date 2021-05-10
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2021.03.011
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    Zs.A 2027: Show issues Location:
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  8. Article ; Online: A new window into fish welfare: A proteomic discovery study of stress biomarkers in the skin mucus of gilthead seabream (Sparus aurata)

    de Magalhães, Cláudia Raposo / Farinha, Ana Paula / Carrilho, Raquel / Schrama, Denise / Cerqueira, Marco / Rodrigues, Pedro M.

    Journal of Proteomics. 2023 Apr. 17, p.104904-

    2023  , Page(s) 104904–

    Abstract: Fish skin mucus is a dynamic external mucosal layer that acts as the first line of defense in the innate immune system. Skin mucus' exudation and composition changes severely under stress, making it a valuable biofluid to search for minimally invasive ... ...

    Abstract Fish skin mucus is a dynamic external mucosal layer that acts as the first line of defense in the innate immune system. Skin mucus' exudation and composition changes severely under stress, making it a valuable biofluid to search for minimally invasive stress markers. This study focused on the skin mucus proteome response to repetitive handling, overcrowding, and hypoxia, using Sparus aurata, an important species in the Mediterranean aquaculture, as a model. Biomarker discovery analysis was performed using label-free shotgun proteomics coupled with bioinformatics to unveil the most predictive proteins for the stressed phenotype. A mean of 2166 proteins were identified at a < 0.2% false discovery rate, from which the differentially abundant proteins (DAPs) were mainly involved in the immune system and protein metabolism. A sparse partial least squares regression analysis revealed a high correlation between DAPs and plasma physiological stress indicators. Feature selection, performed by recursive feature elimination followed by logistic regression analysis of the selected proteins, disclosed 28 candidate biomarkers with values of area under the curve >0.75. These minimally invasive biomarkers could be used in forthcoming species-specific stress management protocols to improve fish welfare and promote farmed fish safety, positive societal outcomes, and business sustainability. The fish skin mucus holds a great promise into fish welfare, as a valuable source of minimally invasive biomarkers for stress assessment. In this shotgun proteomics discovery study, we have identified 28 candidate biomarkers by combining a comprehensive functional analysis of the stress regulated proteome with predictive modeling, supported by a significant correlation (p < 0.01) with physiological stress indicators (cortisol, lactate and glucose). The candidate biomarkers showed a good predictive value in the testing set (AUC > 0.75), paving the way for the next step in their validation by targeted proteomics. An early and timely assessment of fish stressful events, by using minimally invasive biomarkers, as those that can be found in the fish skin mucus, can contribute to promote fish health/welfare in the aquaculture sector and its sustainability. The adoption of preventive and surveillance measures based on proteomics approaches can therefore help to avoid unnecessary adverse outcomes with a negative impact on this primordial food sector.
    Keywords Sparus aurata ; animal welfare ; aquaculture ; bioinformatics ; biomarkers ; cortisol ; economic sustainability ; exudation ; farmed fish ; fish health ; fish skin ; food industry ; glucose ; hypoxia ; immune system ; innate immunity ; lactic acid ; models ; monitoring ; mucus ; phenotype ; protein metabolism ; proteome ; proteomics ; regression analysis ; stress management ; Welfare indicators ; Shotgun proteomics ; Feature selection ; ROC curves
    Language English
    Dates of publication 2023-0417
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2400835-7
    ISSN 1876-7737 ; 1874-3919
    ISSN (online) 1876-7737
    ISSN 1874-3919
    DOI 10.1016/j.jprot.2023.104904
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  9. Article: Consumers’ Willingness to Pay for Fish with a Low Allergenic Potential

    Pereira, Luis Nobre / Mendes, Júlio / Schrama, Denise / Rodrigues, Pedro M. L.

    Journal of international food & agribusiness marketing. 2022 Jan. 1, v. 34, no. 1

    2022  

    Abstract: This study explores the demand-side perspective on the factors influencing the willingness to pay (WTP) premium price for fish with a low allergenic potential (FWLAP). A survey to assess consumers’ behavior and preferences for fish products was ... ...

    Abstract This study explores the demand-side perspective on the factors influencing the willingness to pay (WTP) premium price for fish with a low allergenic potential (FWLAP). A survey to assess consumers’ behavior and preferences for fish products was implemented in a representative sample of the Portuguese general population (n = 640). The contingent valuation method was applied to elicit consumers’ WTP. Results indicated that only half of the consumers were willing to pay higher prices for FWLAP. Econometric results suggested that WTP for FWLAP is explained by the presence of fish-allergy pathologies in the household, and the fish unique characteristics and quality.
    Keywords agribusiness ; allergenicity ; contingent valuation ; econometrics ; fish ; fish allergies ; prices ; surveys ; willingness to pay
    Language English
    Dates of publication 2022-0101
    Size p. 1-22.
    Publishing place Routledge
    Document type Article
    ZDB-ID 2091244-4
    ISSN 1528-6983 ; 0897-4438
    ISSN (online) 1528-6983
    ISSN 0897-4438
    DOI 10.1080/08974438.2020.1844108
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  10. Article: Fish Allergenicity Modulation Using Tailored Enriched Diets-Where Are We?

    Schrama, Denise / Czolk, Rebecca / Raposo de Magalhães, Cláudia / Kuehn, Annette / Rodrigues, Pedro M

    Frontiers in physiology

    2022  Volume 13, Page(s) 897168

    Abstract: Food allergy is an abnormal immune response to specific proteins in a certain food. The chronicity, prevalence, and the potential fatality of food allergy, make it a serious socio-economic problem. Fish is considered the third most allergenic food in the ...

    Abstract Food allergy is an abnormal immune response to specific proteins in a certain food. The chronicity, prevalence, and the potential fatality of food allergy, make it a serious socio-economic problem. Fish is considered the third most allergenic food in the world, affecting part of the world population with a higher incidence in children and adolescents. The main allergen in fish, responsible for the large majority of fish-allergic reactions in sensitized patients, is a small and stable calcium-binding muscle protein named beta-parvalbumin. Targeting the expression or/and the 3D conformation of this protein by adding specific molecules to fish diets has been the innovative strategy of some researchers in the fields of fish allergies and nutrition. This has shown promising results, namely when the apo-form of
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.897168
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