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Article: Multi-Year Mass-Trapping With Autocidal Gravid Ovitraps has Limited Influence on Insecticide Susceptibility in Aedes aegypti (Diptera: Culicidae) From Puerto Rico

Hemme, Ryan R. / Smith, Eric A. / Felix, Gilberto / White, Bradley J. / Diaz-Garcia, Marta I. / Rodriguez, Damaris / Ruiz-Valcarcel, Jose / Acevedo, Veronica / Amador, Manuel / Barrera, Roberto

Journal of medical entomology. 2021 Sept. 17, v. 59, no. 1

2021

Abstract: Mass-trapping has been used to control outbreaks of Aedes aegypti (Linnaeus) (Diptera: Culicidae) in Puerto Rico since 2011. We investigated the effect of multi-year, insecticide-free mass trapping had on the insecticide susceptibility profile of Ae. ... ...

Abstract	Mass-trapping has been used to control outbreaks of Aedes aegypti (Linnaeus) (Diptera: Culicidae) in Puerto Rico since 2011. We investigated the effect of multi-year, insecticide-free mass trapping had on the insecticide susceptibility profile of Ae. aegypti. Eggs collected in southern Puerto Rico were used to generate F₁ populations that were tested for susceptibility to permethrin, sumethrin, bifenthrin, deltamethrin, and malathion according to CDC bottle bioassays protocols. All populations of Ae. aegypti were resistant to the synthetic pyrethroids and mosquitoes from two locations were partially resistant to malathion. Population genetic analysis, using a double digest restriction sites associated DNA sequencing (ddRADseq) approach, indicated a large amount of migration between study sites effectively homogenizing the mosquito populations. Mass-trapping using noninsecticidal autocidal gravid ovitraps did not restore susceptibility to five active ingredients that are found in commercial insecticides. Migration between communities was high and would have brought outside alleles, including resistant alleles to the treatment communities. Further investigation suggests that household use of commercially available insecticide products may continue to select for resistance in absence of public health space spraying of insecticides.
Keywords	Aedes aegypti ; DNA ; bifenthrin ; deltamethrin ; genetic analysis ; insecticide resistance ; malathion ; medical entomology ; ovitraps ; permethrin ; population genetics ; public health ; pyrethrins ; Puerto Rico
Language	English
Dates of publication	2021-0917
Size	p. 314-319.
Publishing place	Entomological Society of America
Document type	Article
ZDB-ID	410635-0
ISSN	0022-2585
ISSN	0022-2585
DOI	10.1093/jme/tjab162
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The ecto-enzyme CD38 modulates CD4 T cell immunometabolic responses and participates in HIV pathogenesis.

Díaz-Basilio, Fernando / Vergara-Mendoza, Moisés / Romero-Rodríguez, Jessica / Hernández-Rizo, Sharik / Escobedo-Calvario, Alejandro / Fuentes-Romero, Luis-León / Pérez-Patrigeon, Santiago / Murakami-Ogasawara, Akio / Gomez-Palacio, María / Reyes-Terán, Gustavo / Jiang, Wei / Vázquez-Pérez, Joel-Armando / Marín-Hernández, Álvaro / Romero-Rodríguez, Dámaris-Priscila / Gutiérrez-Ruiz, María-Concepción / Viveros-Rogel, Mónica / Espinosa, Enrique

Journal of leukocyte biology

2024

Abstract: Despite abundant evidence correlating T cell CD38 expression and HIV infection pathogenesis, its role as a CD4 T cell immunometabolic regulator remains unclear. We find that CD38's extracellular glycohydrolase activity restricts metabolic reprogramming ... ...

Abstract	Despite abundant evidence correlating T cell CD38 expression and HIV infection pathogenesis, its role as a CD4 T cell immunometabolic regulator remains unclear. We find that CD38's extracellular glycohydrolase activity restricts metabolic reprogramming after TCR-engaging stimulation in Jurkat T CD4 cells, together with functional responses, while reducing intracellular NAD and NMN concentrations. Selective elimination of CD38's ectoenzyme function licenses them to decrease the OCR/ECAR ratio upon TCR signaling and to increase cycling, proliferation, survival, and CD40L induction. Pharmacological inhibition of ectoCD38 catalytic activity in memory CD4 T cells from chronic HIV-infected patients rescued TCR-triggered responses, including differentiation and effector functions, while reverting abnormally increased basal glycolysis, cycling, and spontaneous pro-inflammatory cytokine production. Additionally, ecto-CD38 blockage normalized basal and TCR-induced mitochondrial morpho-functionality, while increasing respiratory capacity in cells from HIV+ patients and healthy individuals. Ectoenzyme CD38's immunometabolic restriction of TCR-involving stimulation is relevant to CD4 T cell biology and to the deleterious effects of CD38 overexpression in HIV disease.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiae060
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Article: High Levels of TNF-α and TIM-3 as a Biomarker of Immune Reconstitution Inflammatory Syndrome in People with HIV Infection.

Ramon-Luing, Lucero A / Ocaña-Guzman, Ranferi / Téllez-Navarrete, Norma A / Preciado-García, Mario / Romero-Rodríguez, Dámaris P / Espinosa, Enrique / Reyes-Terán, Gustavo / Chavez-Galan, Leslie

Life (Basel, Switzerland)

2021 Volume 11, Issue 6

Abstract: Immune reconstitution inflammatory syndrome (IRIS) is an exacerbated immune response that can occur to HIV+ patients after initiating antiretroviral therapy (ART). IRIS pathogenesis is unclear, but dysfunctional and exhausted cells have been reported in ... ...

Abstract	Immune reconstitution inflammatory syndrome (IRIS) is an exacerbated immune response that can occur to HIV+ patients after initiating antiretroviral therapy (ART). IRIS pathogenesis is unclear, but dysfunctional and exhausted cells have been reported in IRIS patients, and the TIM-3/Gal-9 axis has been associated with chronic phases of viral infection. This study aimed to evaluate the soluble levels of TIM-3 and Gal-9 and their relationship with IRIS development. TIM-3, Gal-9, TNF-α, IFN-γ, IL-6, TNFR1, TNFR2, E-cadherin, ADAM10, and ADAM17 were measured to search for IRIS-associated biomarkers in plasma samples from 0-, 4-, 8-, 12-, and 24-weeks after ART initiation of 61 HIV+ patients (15 patients developed IRIS, and 46 did not). We found that patients who developed IRIS had higher levels of TIM-3 [median 4806, IQR: 3206-6182] at the time of the IRIS events, compared to any other follow-up time evaluated in these patients or compared with a control group of patients who did not develop IRIS. Similarly, IRIS patients had a higher TNF-α level [median 10.89, IQR: 8.36-12.34] at IRIS events than any other follow-up time evaluated. Other molecules related to the TIM-3 and TNF-α pathway (Gal-9, IL-6, IFN-γ, TNFR1, TNFR2, ADAM-10, and ADAM-17) did not change during the IRIS events. In conclusion, our data suggest that a high level of soluble TIM-3 and TNF-α could be used as an IRIS biomarker.
Language	English
Publishing date	2021-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11060527
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Article ; Online: Multi-Year Mass-Trapping With Autocidal Gravid Ovitraps has Limited Influence on Insecticide Susceptibility in Aedes aegypti (Diptera: Culicidae) From Puerto Rico.

Hemme, Ryan R / Smith, Eric A / Felix, Gilberto / White, Bradley J / Diaz-Garcia, Marta I / Rodriguez, Damaris / Ruiz-Valcarcel, Jose / Acevedo, Veronica / Amador, Manuel / Barrera, Roberto

Journal of medical entomology

2021 Volume 59, Issue 1, Page(s) 314–319

Abstract	Mass-trapping has been used to control outbreaks of Aedes aegypti (Linnaeus) (Diptera: Culicidae) in Puerto Rico since 2011. We investigated the effect of multi-year, insecticide-free mass trapping had on the insecticide susceptibility profile of Ae. aegypti. Eggs collected in southern Puerto Rico were used to generate F1 populations that were tested for susceptibility to permethrin, sumethrin, bifenthrin, deltamethrin, and malathion according to CDC bottle bioassays protocols. All populations of Ae. aegypti were resistant to the synthetic pyrethroids and mosquitoes from two locations were partially resistant to malathion. Population genetic analysis, using a double digest restriction sites associated DNA sequencing (ddRADseq) approach, indicated a large amount of migration between study sites effectively homogenizing the mosquito populations. Mass-trapping using noninsecticidal autocidal gravid ovitraps did not restore susceptibility to five active ingredients that are found in commercial insecticides. Migration between communities was high and would have brought outside alleles, including resistant alleles to the treatment communities. Further investigation suggests that household use of commercially available insecticide products may continue to select for resistance in absence of public health space spraying of insecticides.
MeSH term(s)	Aedes/drug effects ; Aedes/genetics ; Animal Distribution ; Animals ; Genes, Insect ; Genetics, Population ; Insecticide Resistance/genetics ; Insecticides/pharmacology ; Malathion/pharmacology ; Mosquito Vectors/drug effects ; Mosquito Vectors/genetics ; Permethrin/pharmacology ; Puerto Rico ; Pyrethrins/pharmacology
Chemical Substances	Insecticides ; Pyrethrins ; Permethrin (509F88P9SZ) ; Malathion (U5N7SU872W)
Language	English
Publishing date	2021-09-17
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjab162
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Article: Vaccination with human papillomavirus-18 E1 protein plus α-galactosyl-ceramide induces CD8+ cytotoxic response and impairs the growth of E1-expressing tumors

Amador-Molina, Alfredo / Lamoyi, Edmundo / Lizano, Marcela / Moreno, José / Pérez-Cárdenas, Enrique / Romero-Rodríguez, Damaris / Sada-Ovalle, Isabel / Trejo-Moreno, Cesar

Vaccine. 2019 Feb. 21, v. 37, no. 9

2019

Abstract: CD8+ T cell-mediated immune response plays a major role in the clearance of virus-infected cells, including human papillomavirus (HPV). The effective treatment of women with normal cytology but persistent high risk-HPV infection or with low-grade ... ...

Abstract	CD8+ T cell-mediated immune response plays a major role in the clearance of virus-infected cells, including human papillomavirus (HPV). The effective treatment of women with normal cytology but persistent high risk-HPV infection or with low-grade intraepithelial lesions could take advantage of novel strategies based on vaccination with viral immunological targets with a wide spectrum of cross-protection. The helicase E1, expressed early during viral replication in HPV infection, is among the most conserved papillomavirus proteins, which makes it a good vaccine candidate. In the present study, we examined E1-specific CD8+ T cell and NK immune responses in a mouse model with α-galactosylceramide (α-GalCer) as an adjuvant. We found that mice immunized with E1 combined with α-GalCer elicited an E1-specific CD8+ T and NK cell cytotoxic responses, which correlated with growth inhibition of grafted melanoma B16-F0 cells expressing E1, both in prophylactic and therapeutic protocols.
Keywords	adjuvants ; animal models ; CD8-positive T-lymphocytes ; cell-mediated immunity ; cross immunity ; cytotoxicity ; enzymes ; growth retardation ; immune response ; melanoma ; mice ; Papillomaviridae ; proteins ; protocols ; vaccination ; vaccines ; virus replication ; women
Language	English
Dates of publication	2019-0221
Size	p. 1219-1228.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2018.12.036
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Regulation of Cas9 by viral proteins Tat and Rev for HIV-1 inactivation.

Vergara-Mendoza, Moisés / Gomez-Quiroz, Luis E / Miranda-Labra, Roxana U / Fuentes-Romero, Luis L / Romero-Rodríguez, Dámaris P / González-Ruiz, Jonathan / Hernández-Rizo, Sharik / Viveros-Rogel, Mónica

Antiviral research

2020 Volume 180, Page(s) 104856

Abstract: While combined antiretroviral therapy (cART) has had a great impact on the treatment of HIV-1 infection, the persistence of long-lived cells with an intact provirus precludes virus eradication and sterilizing cure. CRISPR/Cas9 genome editing has become ... ...

Abstract	While combined antiretroviral therapy (cART) has had a great impact on the treatment of HIV-1 infection, the persistence of long-lived cells with an intact provirus precludes virus eradication and sterilizing cure. CRISPR/Cas9 genome editing has become an efficient tool to eradicate HIV-1 genome or prevent replication. Furthermore, regulation of Cas9 gene expression by HIV can induce mutations that could inactivate the proviral genome, making a gene therapy safe by preventing the induction of non-specific mutations, which could compromise the integrity of healthy cells. In this study, isolated HIV-1 LTR, INS and RRE sequences were used to regulate Cas9 expression in HEK293 cells, and guide RNAs (gRNAs) were designed to target mutations in HIV-1 conserved regions such as tat and rev regulatory genes. We demonstrate that Cas9 expression in our system is controlled by the HIV-1 Tat and Rev proteins, leading to self-regulation of gene edition, and showing a strong antiviral effect by inactivating HIV-1 replication. Sequencing analysis confirmed that viral genome was partially excised by multiplex editing (90% efficiency), and viral capsid protein (CA-p24) was undetectable. In conclusion, the self-regulated CRISPR/Cas9 system may be a reliable and accurate strategy for eliminating HIV-1 infection whose effect will be restricted to infected cells.
MeSH term(s)	CRISPR-Associated Protein 9/genetics ; CRISPR-Cas Systems ; Gene Editing ; Gene Expression Regulation, Viral ; HEK293 Cells ; HIV-1/genetics ; Humans ; RNA, Guide, CRISPR-Cas Systems/genetics ; Virus Inactivation ; Virus Replication/genetics ; rev Gene Products, Human Immunodeficiency Virus/genetics ; tat Gene Products, Human Immunodeficiency Virus/genetics
Chemical Substances	RNA, Guide, CRISPR-Cas Systems ; rev Gene Products, Human Immunodeficiency Virus ; rev protein, Human Immunodeficiency Virus-1 ; tat Gene Products, Human Immunodeficiency Virus ; CRISPR-Associated Protein 9 (EC 3.1.-)
Language	English
Publishing date	2020-06-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2020.104856
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Article ; Online: Researching, co-creating and testing innovations in paper-based health information systems (PHISICC) to support health workers' decision-making: protocol of a multi-country, transdisciplinary, mixed-methods research programme in three sub-Saharan countries.

Bosch-Capblanch, Xavier / O'Donnell, David / Krause, L Kendall / Auer, Christian / Oyo-Ita, Angela / Samba, Mamadou / Matsinhe, Graça / Garba, Abdullahi Bulama / Rodríguez, Damaris / Zuske, Meike / Njepuome, Anthonia Ngozi / Lee, Sofia Micael Mandjate / Ross, Amanda / Gajewski, Suzanne / Muloliwa, Artur Manuel / Yapi, Richard B / Brown, David W

Health research policy and systems

2021 Volume 19, Issue 1, Page(s) 112

Abstract: Background: Health information systems are crucial to provide data for decision-making and demand for data is constantly growing. However, the link between data and decisions is not always rational or linear and the management of data ends up ... ...

Abstract	Background: Health information systems are crucial to provide data for decision-making and demand for data is constantly growing. However, the link between data and decisions is not always rational or linear and the management of data ends up overloading frontline health workers, which may compromise quality of healthcare delivery. Despite limited evidence, there is an increasing push for the digitalization of health information systems, which poses enormous challenges, particularly in remote, rural settings in low- and middle-income countries. Paper-based tools will continue to be used in combination with digital solutions and this calls for efforts to make them more responsive to local needs. Paper-based Health Information Systems in Comprehensive Care (PHISICC) is a transdisciplinary, multi-country research initiative to create and test innovative paper-based health information systems in three sub-Saharan African countries. Methods/design: The PHISICC initiative is being carried out in remote, rural settings in Côte d'Ivoire, Mozambique and Nigeria through partnership with ministries of health and research institutions. We began with research syntheses to acquire the most up-to-date knowledge on health information systems. These were coupled with fieldwork in the three countries to understand the current design, patterns and contexts of use, and healthcare worker perspectives. Frontline health workers, with designers and researchers, used co-creation methods to produce the new PHISICC tools. This suite of tools is being tested in the three countries in three cluster-randomized controlled trials. Throughout the project, we have engaged with a wide range of stakeholders and have maintained the highest scientific standards to ensure that results are relevant to the realities in the three countries. Discussion: We have deployed a comprehensive research approach to ensure the robustness and future policy uptake of findings. Besides the innovative PHISICC paper-based tools, our process is in itself innovative. Rather than emphasizing the technical dimensions of data management, we focused instead on frontline health workers' data use and decision-making. By tackling the whole scope of primary healthcare areas rather than a subset of them, we have developed an entirely new design and visual language for a suite of tools across healthcare areas. The initiative is being tested in remote, rural areas where the most vulnerable live.
MeSH term(s)	Data Management ; Delivery of Health Care ; Health Information Systems ; Health Personnel ; Humans ; Mozambique
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Journal Article
ISSN	1478-4505
ISSN (online)	1478-4505
DOI	10.1186/s12961-021-00768-0
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Article ; Online: A service concept and tools to improve maternal and newborn health in Nigeria and Uganda.

Salgado, Mariana / Wendland, Melanie / Rodriguez, Damaris / Bohren, Meghan A / Oladapo, Olufemi T / Ojelade, Olubunmi A / Mugerwa, Kidza / Fawole, Bukola

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2017 Volume 139 Suppl 1, Page(s) 67–73

Abstract: Objective: The "Better Outcomes in Labor Difficulty" (BOLD) project used a service design process to design a set of tools to improve quality of care during childbirth by strengthening linkages between communities and health facilities in Nigeria and ... ...

Abstract	Objective: The "Better Outcomes in Labor Difficulty" (BOLD) project used a service design process to design a set of tools to improve quality of care during childbirth by strengthening linkages between communities and health facilities in Nigeria and Uganda. This paper describes the Passport to Safer Birth concept and the tools developed as a result. Methods: Service design methods were used to identify facilitators and barriers to quality care, and to develop human-centered solutions. The service design process had three phases: Research for Design, Concept Design, and Detail Design, undertaken in eight hospitals and catchment communities. Results: The service concept "Better Beginnings" comprises three tools. The "Pregnancy Purse" provides educational information to women throughout pregnancy. The "Birth Board" is a visual communication tool that presents the labor and childbirth process. The "Family Pass" is a set of wearable passes for the woman and her supporter to facilitate communication of care preferences. Conclusion: The Better Beginnings service concept and tools form the basis for the promotion of access to information and knowledge acquisition, and could improve communication between the healthcare provider, the woman, and her family during childbirth.
MeSH term(s)	Catchment Area, Health ; Communication ; Delivery, Obstetric/standards ; Female ; Health Facilities/standards ; Humans ; Infant, Newborn ; Maternal-Child Health Services/organization & administration ; Maternal-Child Health Services/standards ; Models, Organizational ; Nigeria ; Pregnancy ; Quality Improvement/organization & administration ; Uganda
Language	English
Publishing date	2017-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.12382
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Article ; Online: Impacts of Hurricanes Irma and Maria on

Barrera, Roberto / Felix, Gilberto / Acevedo, Veronica / Amador, Manuel / Rodriguez, Damaris / Rivera, Luis / Gonzalez, Orlando / Nazario, Nicole / Ortiz, Marianyoly / Muñoz-Jordan, Jorge L / Waterman, Stephen H / Hemme, Ryan R

The American journal of tropical medicine and hygiene

2019 Volume 100, Issue 6, Page(s) 1413–1420

Abstract: Puerto Rico was severely impacted by Hurricanes Irma and Maria in September 2017. The island has been endemic for dengue viruses (DENV) and recently suffered epidemics of chikungunya (CHIKV 2014) and Zika (ZIKV 2016) viruses. Although severe storms tend ... ...

Abstract	Puerto Rico was severely impacted by Hurricanes Irma and Maria in September 2017. The island has been endemic for dengue viruses (DENV) and recently suffered epidemics of chikungunya (CHIKV 2014) and Zika (ZIKV 2016) viruses. Although severe storms tend to increase the number of vector and nuisance mosquitoes, we do not know how they influence
MeSH term(s)	Aedes/physiology ; Aedes/virology ; Animals ; Chikungunya virus/physiology ; Cities ; Cyclonic Storms ; Dengue Virus/physiology ; Ecosystem ; Female ; Mosquito Vectors/physiology ; Mosquito Vectors/virology ; Puerto Rico ; Pupa ; RNA, Viral/isolation & purification ; Zika Virus/physiology
Chemical Substances	RNA, Viral
Language	English
Publishing date	2019-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.19-0015
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Article ; Online: Vaccination with human papillomavirus-18 E1 protein plus α-galactosyl-ceramide induces CD8

Amador-Molina, Alfredo / Trejo-Moreno, Cesar / Romero-Rodríguez, Damaris / Sada-Ovalle, Isabel / Pérez-Cárdenas, Enrique / Lamoyi, Edmundo / Moreno, José / Lizano, Marcela

Vaccine

2019 Volume 37, Issue 9, Page(s) 1219–1228

Abstract	CD8+ T cell-mediated immune response plays a major role in the clearance of virus-infected cells, including human papillomavirus (HPV). The effective treatment of women with normal cytology but persistent high risk-HPV infection or with low-grade intraepithelial lesions could take advantage of novel strategies based on vaccination with viral immunological targets with a wide spectrum of cross-protection. The helicase E1, expressed early during viral replication in HPV infection, is among the most conserved papillomavirus proteins, which makes it a good vaccine candidate. In the present study, we examined E1-specific CD8+ T cell and NK immune responses in a mouse model with α-galactosylceramide (α-GalCer) as an adjuvant. We found that mice immunized with E1 combined with α-GalCer elicited an E1-specific CD8+ T and NK cell cytotoxic responses, which correlated with growth inhibition of grafted melanoma B16-F0 cells expressing E1, both in prophylactic and therapeutic protocols.
MeSH term(s)	Adjuvants, Immunologic/administration & dosage ; Animals ; Cancer Vaccines/immunology ; Cytotoxicity, Immunologic ; Female ; Galactosylceramides/administration & dosage ; Galactosylceramides/immunology ; Human papillomavirus 18 ; Humans ; Killer Cells, Natural/immunology ; Melanoma, Experimental/prevention & control ; Melanoma, Experimental/therapy ; Melanoma, Experimental/virology ; Mice ; Mice, Inbred C57BL ; Oncogene Proteins, Viral/administration & dosage ; Oncogene Proteins, Viral/immunology ; Papillomavirus Infections/immunology ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/therapy ; T-Lymphocytes, Cytotoxic/immunology ; Transplants ; Tumor Cells, Cultured/immunology ; Vaccination
Chemical Substances	Adjuvants, Immunologic ; Cancer Vaccines ; Galactosylceramides ; Oncogene Proteins, Viral ; alpha-galactosylceramide ; oncogene protein E1, Human papillomavirus type 18
Language	English
Publishing date	2019-01-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2018.12.036
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