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  1. Book ; Online: Latino, Hispanic, or of Spanish Origin+ Identified Student Leaders in Medicine

    Sánchez, John Paul / Rodriguez, Donald

    Recognizing More Than 50 years of Presence, Activism, and Leadership

    (Sustainable Development Goals Series)

    2024  

    Author's details edited by John Paul Sánchez, Donald Rodriguez
    Series title Sustainable Development Goals Series
    Keywords Medical education
    Language English
    Size 1 Online-Ressource (XXVIII, 245 p)
    Edition 1st ed. 2024
    Publisher Springer Nature Switzerland ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT030390346
    ISBN 978-3-031-35020-7 ; 9783031350191 ; 9783031350214 ; 9783031350221 ; 3-031-35020-0 ; 3031350197 ; 3031350219 ; 3031350227
    DOI 10.1007/978-3-031-35020-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Latino, Hispanic, or of Spanish Origin+ Identified Student Leaders in Medicine

    Sánchez, John Paul / Rodriguez, Donald

    Recognizing More Than 50 years of Presence, Activism, and Leadership

    (Sustainable Development Goals Series)

    2024  

    Series title Sustainable Development Goals Series
    Keywords Teaching of a specific subject ; Latinx Leaders ; Spanish Leaders ; Hispanic Leaders ; Health Policy ; Diversity, Equity & Inclusion ; SDG4
    Language English
    Size 1 electronic resource (245 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English
    HBZ-ID HT030613016
    ISBN 9783031350191 ; 3031350197
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Response to 'Abatacept in relapsing polychondritis' by Moulis et al.

    Peng, Stanford L / Rodriguez, Donald

    Annals of the rheumatic diseases

    2013  Volume 72, Issue 11, Page(s) e28

    MeSH term(s) Female ; Humans ; Immunoconjugates/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Male ; Polychondritis, Relapsing/drug therapy
    Chemical Substances Immunoconjugates ; Immunosuppressive Agents
    Language English
    Publishing date 2013-11
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2013-204338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.114: Show issues Location:
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    Zs.MO 167: Show issues

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  4. Article ; Online: Abatacept in relapsing polychondritis.

    Peng, Stanford L / Rodriguez, Donald

    Annals of the rheumatic diseases

    2013  Volume 72, Issue 8, Page(s) 1427–1429

    MeSH term(s) Abatacept ; Adult ; Aged ; Female ; Humans ; Immunoconjugates/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Joints/pathology ; Male ; Middle Aged ; Polychondritis, Relapsing/drug therapy ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Immunoconjugates ; Immunosuppressive Agents ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2013-203319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The endogenous repertoire harbors self-reactive CD4

    Lee, Victoria / Rodriguez, Donald M / Ganci, Nicole K / Zeng, Sharon / Ai, Junting / Chao, Jaime L / Walker, Matthew T / Miller, Christine H / Klawon, David E J / Schoenbach, Mary H / Kennedy, Domenick E / Maienschein-Cline, Mark / Socci, Nicholas D / Clark, Marcus R / Savage, Peter A

    Nature immunology

    2023  Volume 24, Issue 3, Page(s) 487–500

    Abstract: The T cell repertoire of healthy mice and humans harbors self-reactive ... ...

    Abstract The T cell repertoire of healthy mice and humans harbors self-reactive CD4
    MeSH term(s) Animals ; Humans ; Mice ; Autoimmunity ; Cell Differentiation ; Clone Cells ; Phenotype ; T Follicular Helper Cells ; T-Lymphocytes, Helper-Inducer ; T-Lymphocytes, Regulatory ; CD4-Positive T-Lymphocytes/immunology
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01425-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5294: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  6. Article: Temporal and spatial variation in bird and human use of beaches in southern California.

    Lafferty, Kevin D / Rodriguez, Donald A / Chapman, Angela

    SpringerPlus

    2013  Volume 2, Issue 1, Page(s) 38

    Abstract: Southern California's beaches can support a remarkable diversity of birds along the Pacific Flyway. We asked whether seasonal, annual, and spatial factors affect bird richness and abundance on public beaches. To do so, we conducted three years of monthly ...

    Abstract Southern California's beaches can support a remarkable diversity of birds along the Pacific Flyway. We asked whether seasonal, annual, and spatial factors affect bird richness and abundance on public beaches. To do so, we conducted three years of monthly bird surveys on 12 sandy beaches in Ventura California. Across all surveys, we counted 22 shorebird species, 8 gull species, 24 other water bird species, and 24 landbird species. Sanderling, western gull, Heerman's gull, willet, marbled godwit, and whimbrel were the most abundant members of the bird community. Beach wrack was uncommon, particularly where beaches were groomed, and did not have a large effect on bird abundance, though it was positively associated with overall bird richness. Beaches near estuaries tended to be wide, and such beaches had a higher richness and abundance of birds. Beaches with shallow slopes tended to have more gulls and shorebirds. People and (illegal) unleashed dogs were common, particularly at beaches fronted by houses. The abundance and richness of shorebirds and the richness of other waterbirds was lower where human activity was high. Bird richness and abundance was strongly affected by season, with the highest density of birds being seen during the fall shorebird migration. Gull abundance peaked earlier (August-September) than shorebird abundance (October through December). A brief pulse of shorebirds also occurred in May due to spring migration. Comparing these data with surveys in the 1990's found no evidence for a decline in shorebirds over time, though black-bellied plover appear to still be recovering from the strong 1997-1998 ENSO. Opportunities to conserve birds on these beaches are limited, but could include enforcing leash laws and setting up human exclosures near estuary mouths.
    Language English
    Publishing date 2013-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661116-8
    ISSN 2193-1801
    ISSN 2193-1801
    DOI 10.1186/2193-1801-2-38
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Author Correction: Activated β-catenin in Foxp3

    Sumida, Tomokazu / Lincoln, Matthew R / Ukeje, Chinonso M / Rodriguez, Donald M / Akazawa, Hiroshi / Noda, Tetsuo / Naito, Atsuhiko T / Komuro, Issei / Dominguez-Villar, Margarita / Hafler, David A

    Nature immunology

    2019  Volume 20, Issue 7, Page(s) 943

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2019-06-06
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-019-0438-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5294: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  8. Article ; Online: Activated β-catenin in Foxp3

    Sumida, Tomokazu / Lincoln, Matthew R / Ukeje, Chinonso M / Rodriguez, Donald M / Akazawa, Hiroshi / Noda, Tetsuo / Naito, Atsuhiko T / Komuro, Issei / Dominguez-Villar, Margarita / Hafler, David A

    Nature immunology

    2018  Volume 19, Issue 12, Page(s) 1391–1402

    Abstract: ... ...

    Abstract Foxp3
    MeSH term(s) Animals ; Autoimmunity/immunology ; Gene Expression Regulation/immunology ; Humans ; Inflammation/immunology ; Interferon-gamma/biosynthesis ; Interferon-gamma/immunology ; Interleukin-10/biosynthesis ; Interleukin-10/immunology ; Mice, Inbred C57BL ; Multiple Sclerosis, Relapsing-Remitting/immunology ; Receptors, Prostaglandin E, EP2 Subtype/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; beta Catenin/immunology
    Chemical Substances CTNNB1 protein, human ; CTNNB1 protein, mouse ; Receptors, Prostaglandin E, EP2 Subtype ; beta Catenin ; Interleukin-10 (130068-27-8) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2018-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-018-0236-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  9. Article ; Online: Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

    Hernandez, Amanda L / Kitz, Alexandra / Wu, Chuan / Lowther, Daniel E / Rodriguez, Donald M / Vudattu, Nalini / Deng, Songyan / Herold, Kevan C / Kuchroo, Vijay K / Kleinewietfeld, Markus / Hafler, David A

    The Journal of clinical investigation

    2015  Volume 125, Issue 11, Page(s) 4212–4222

    Abstract: FOXP3+ Tregs are central for the maintenance of self-tolerance and can be defective in autoimmunity. In multiple sclerosis and type-1 diabetes, dysfunctional self-tolerance is partially mediated by a population of IFNγ-secreting Tregs. It was previously ... ...

    Abstract FOXP3+ Tregs are central for the maintenance of self-tolerance and can be defective in autoimmunity. In multiple sclerosis and type-1 diabetes, dysfunctional self-tolerance is partially mediated by a population of IFNγ-secreting Tregs. It was previously reported that increased NaCl concentrations promote the induction of proinflammatory Th17 cells and that high-salt diets exacerbate experimental models of autoimmunity. Here, we have shown that increasing NaCl, either in vitro or in murine models via diet, markedly impairs Treg function. NaCl increased IFNγ secretion in Tregs, and reducing IFNγ - either by neutralization with anti-IFNγ antibodies or shRNA-mediated knockdown - restored suppressive activity in Tregs. The heightened IFNγ secretion and loss of Treg function were mediated by the serum/glucocorticoid-regulated kinase (SGK1). A high-salt diet also impaired human Treg function and was associated with the induction of IFNγ-secreting Tregs in a xenogeneic graft-versus-host disease model and in adoptive transfer models of experimental colitis. Our results demonstrate a putative role for an environmental factor that promotes autoimmunity by inducing proinflammatory responses in CD4 effector cells and Treg pathways.
    MeSH term(s) Adoptive Transfer ; Animals ; Antibodies, Neutralizing/immunology ; Autoimmunity/drug effects ; CD4-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Coculture Techniques ; Colitis/immunology ; Cytokines/biosynthesis ; Cytokines/genetics ; Forkhead Transcription Factors/analysis ; Forkhead Transcription Factors/genetics ; Gene Expression Profiling ; Genes, Reporter ; Graft vs Host Disease/immunology ; Heterografts ; Humans ; Immediate-Early Proteins/physiology ; Inflammation ; Interferon-gamma/genetics ; Interferon-gamma/pharmacology ; Interferon-gamma/secretion ; Leukocytes, Mononuclear/transplantation ; Male ; Mice ; Protein-Serine-Threonine Kinases/physiology ; RNA Interference ; RNA, Small Interfering/genetics ; Sodium Chloride/pharmacology ; Sodium Chloride, Dietary/adverse effects ; Sodium Chloride, Dietary/pharmacology ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/secretion
    Chemical Substances Antibodies, Neutralizing ; Cytokines ; FOXP3 protein, human ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Immediate-Early Proteins ; RNA, Small Interfering ; Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X) ; Interferon-gamma (82115-62-6) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; serum-glucocorticoid regulated kinase (EC 2.7.11.1)
    Language English
    Publishing date 2015-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI81151
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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