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  1. Article ; Online: Centralizing coronary artery bypass surgery for better outcomes-an ongoing controversy.

    Rodriguez Cetina Biefer, Hector / Dzemali, Omer

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 64, Issue 5

    MeSH term(s) Humans ; Coronary Artery Bypass/adverse effects ; Risk Factors ; Longitudinal Studies
    Language English
    Publishing date 2023-10-28
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad363
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
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  2. Article: Thirteen Years of Impactful, Minimally Invasive Coronary Surgery: Short- and Long-Term Results for Single and Multi-Vessel Disease.

    Ilcheva, Lilly / Häussler, Achim / Cholubek, Magdalena / Ntinopoulos, Vasileios / Odavic, Dragan / Dushaj, Stak / Rodriguez Cetina Biefer, Hector / Dzemali, Omer

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Objectives: Minimally invasive coronary surgery (MICS) via lateral thoracotomy is a less invasive alternative to the traditional median full sternotomy approach for coronary surgery. This study investigates its effectiveness for short- and long-term ... ...

    Abstract Objectives: Minimally invasive coronary surgery (MICS) via lateral thoracotomy is a less invasive alternative to the traditional median full sternotomy approach for coronary surgery. This study investigates its effectiveness for short- and long-term revascularization in cases of single and multi-vessel diseases.
    Methods: A thorough examination was performed on the databases of two cardiac surgery programs, focusing on patients who underwent minimally invasive coronary bypass grafting procedures between 2010 and 2023. The study involved patients who underwent either minimally invasive direct coronary artery bypass grafting (MIDCAB) for the revascularization of left anterior descending (LAD) artery stenosis or minimally invasive multi-vessel coronary artery bypass grafting (MICSCABG). Our assessment criteria included in-hospital mortality, long-term mortality, and freedom from reoperations due to failed aortocoronary bypass grafts post-surgery. Additionally, we evaluated significant in-hospital complications as secondary endpoints.
    Results: A total of 315 consecutive patients were identified between 2010 and 2023 (MIDCAB 271 vs. MICSCABG 44). Conversion to median sternotomy (MS) occurred in eight patients (2.5%). The 30-day all-cause mortality was 1.3% (n = 4). Postoperative AF was the most common complication postoperatively (n = 26, 8.5%). Five patients were reoperated for bleeding (1.6%), and myocardial infarction (MI) happened in four patients (1.3%). The mean follow-up time was six years (±4 years). All-cause mortality was 10.3% (n = 30), with only five (1.7%) patients having a confirmed cardiac cause. The reoperation rate due to graft failure or the progression of aortocoronary disease was 1.4% (n = 4).
    Conclusions: Despite the complexity of the MICS approach, the results of our study support the safety and effectiveness of this procedure with low rates of mortality, morbidity, and conversion for both single and multi-vessel bypass surgeries. These results underscore further the necessity to implement such programs to benefit patients.
    Language English
    Publishing date 2024-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030761
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  3. Article ; Online: Isolated Minimally Invasive Mitral Valve Surgery in Octogenarians: Perioperative Outcome.

    Ntinopoulos, Vasileios / Rodriguez Cetina Biefer, Hector / Papadopoulos, Nestoras / Dushaj, Stak / Haeussler, Achim / Dzemali, Omer

    Gerontology

    2023  Volume 69, Issue 10, Page(s) 1211–1217

    Abstract: Introduction: Despite the feasibility, safety, and excellent outcomes of mitral valve surgery through a right mini-thoracotomy, there is data paucity about its use in octogenarians. In this study, we assess the outcomes of mitral valve surgery via right ...

    Abstract Introduction: Despite the feasibility, safety, and excellent outcomes of mitral valve surgery through a right mini-thoracotomy, there is data paucity about its use in octogenarians. In this study, we assess the outcomes of mitral valve surgery via right mini-thoracotomy in octogenarians.
    Methods: We performed a retrospective analysis of the in-hospital perioperative data of 38 octogenarian patients with severe mitral regurgitation undergoing isolated mitral valve surgery via right mini-thoracotomy from 2013 to 2021 in our institution.
    Results: The median patient age was 82 (81-83) years, and the median EuroSCORE II was 3.1% (2.3-4.9). A total of 19 (50%) patients underwent mitral valve repair. The median cardiopulmonary bypass duration was 78 (54-100) min and the median aortic cross-clamping duration was 57 (40-70) min. Two (5.3%) patients were converted to sternotomy, 1 (2.6%) underwent renal replacement therapy, 5 (13.2%) underwent reexploration for bleeding or tamponade, and 12 (31.6%) underwent permanent pacemaker implantation. The surgical repair success rate was 89.5%, with 2 (10.5%) patients requiring reoperation due to repair failure. No other patients required reoperation on the mitral valve. The median intensive care unit stay was 1 (1-2) day, and the median postoperative stay was 9.5 (8-14) days. There was no perioperative stroke or death.
    Conclusion: Despite a relatively increased risk of pacemaker implantation and reexploration for bleeding, our data support the feasibility of mitral valve surgery via a right mini-thoracotomy in octogenarians, with short ischemic times, low overall in-hospital morbidity, and no mortality. Preferring replacement in mitral diseases with a high risk for repair failure could minimize reoperations in this high-risk subgroup.
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193798-4
    ISSN 1423-0003 ; 0304-324X
    ISSN (online) 1423-0003
    ISSN 0304-324X
    DOI 10.1159/000533560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.201: Show issues Location:
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  4. Article: Beyond Conventional Operations: Embracing the Era of Contemporary Minimally Invasive Cardiac Surgery.

    Ilcheva, Lilly / Risteski, Petar / Tudorache, Igor / Häussler, Achim / Papadopoulos, Nestoras / Odavic, Dragan / Rodriguez Cetina Biefer, Hector / Dzemali, Omer

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: Over the past two decades, minimally invasive cardiac surgery (MICS) has gained a significant place due to the emergence of innovative tools and improvements in surgical techniques, offering comparable efficacy and safety to traditional surgical methods. ...

    Abstract Over the past two decades, minimally invasive cardiac surgery (MICS) has gained a significant place due to the emergence of innovative tools and improvements in surgical techniques, offering comparable efficacy and safety to traditional surgical methods. This review provides an overview of the history of MICS, its current state, and its prospects and highlights its advantages and limitations. Additionally, we highlight the growing trends and potential pathways for the expansion of MICS, underscoring the crucial role of technological advancements in shaping the future of this field. Recognizing the challenges, we strive to pave the way for further breakthroughs in minimally invasive cardiac procedures.
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237210
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  5. Article ; Online: Conversion from off-pump to on-pump coronary artery bypass grafting: impact of surgeon and anaesthetist experience.

    Ntinopoulos, Vasileios / Haeussler, Achim / Odavic, Dragan / Papadopoulos, Nestoras / Rings, Laura / Dushaj, Stak / Rodriguez Cetina Biefer, Hector / Dzemali, Omer

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Volume 37, Issue 6

    Abstract: Objectives: Intraoperative conversion from off-pump to on-pump coronary artery bypass grafting (CABG) is associated with increased postoperative morbidity and mortality. The aim of this study is to assess the impact of surgeon and anaesthetist ... ...

    Abstract Objectives: Intraoperative conversion from off-pump to on-pump coronary artery bypass grafting (CABG) is associated with increased postoperative morbidity and mortality. The aim of this study is to assess the impact of surgeon and anaesthetist experience on the conversion rate.
    Methods: We performed a retrospective analysis of the data of all patients who underwent planned off-pump CABG in a single centre in 2007-2021, some of whom were non-electively converted to on-pump. Surgeon and anaesthetist experience were assessed by the number of off-pump bypass procedures per year. Multivariable logistic regression analysis was used to assess the impact of surgeon and anaesthetist experience on conversion rate.
    Results: A total of 2742 patients met the inclusion criteria. Ninety-four (3.4%) patients underwent non-elective conversion to on-pump surgery. Converted patients had significantly higher mortality [11 (11.7%) vs 35 (1.3%), P < 0.0001] in comparison to non-converted patients. Anaesthetist experience was found to be a risk factor for conversion (P = 0.011). Surgeon experience did not significantly affect conversion rate (P = 0.51). Other risk factors for conversion were female gender [odds ratio 2.65 (95% confidence interval 1.65-4.26), P = 0.0001] and left ventricular ejection fraction ≤35% [odds ratio 1.91 (95% confidence interval 1.05-3.49), P = 0.040].
    Conclusions: Conversion from off-pump to on-pump CABG is associated with worse postoperative outcomes. Limited experience of anaesthetists in off-pump bypass surgery is associated with a higher conversion rate.
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad205
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  6. Article: Ex Vivo Lung Perfusion with β-Nicotinamide Adenine Dinucleotide (NAD

    Ehrsam, Jonas Peter / Chen, Jin / Rodriguez Cetina Biefer, Hector / Opitz, Isabelle / Arni, Stephan / Inci, Ilhan

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: Ischemia-reperfusion injury compromises short- and long-term outcomes after lung transplantation. The scarce existing data on ... ...

    Abstract Ischemia-reperfusion injury compromises short- and long-term outcomes after lung transplantation. The scarce existing data on NAD
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11050843
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  7. Article: Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale.

    Rodriguez Cetina Biefer, Hector / Vasudevan, Anju / Elkhal, Abdallah

    International journal of tryptophan research : IJTR

    2017  Volume 10, Page(s) 1178646917713491

    Abstract: Increasing evidence underscores the interesting ability of tryptophan to regulate immune responses. However, the exact mechanisms of tryptophan's immune regulation remain to be determined. Tryptophan catabolism via the kynurenine pathway is known to play ...

    Abstract Increasing evidence underscores the interesting ability of tryptophan to regulate immune responses. However, the exact mechanisms of tryptophan's immune regulation remain to be determined. Tryptophan catabolism via the kynurenine pathway is known to play an important role in tryptophan's involvement in immune responses. Interestingly, quinolinic acid, which is a neurotoxic catabolite of the kynurenine pathway, is the major pathway for the
    Language English
    Publishing date 2017-06-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2517435-6
    ISSN 1178-6469
    ISSN 1178-6469
    DOI 10.1177/1178646917713491
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  8. Article ; Online: Leaflet Perforation by Cor-Knot Automated Fasteners: More Usual Than You Think.

    Rodriguez Cetina Biefer, Hector / Weber, Alberto / Maisano, Francesco / Benussi, Stefano

    The Annals of thoracic surgery

    2018  Volume 105, Issue 2, Page(s) 664–665

    MeSH term(s) Suture Techniques
    Language English
    Publishing date 2018-01-23
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2017.04.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Endothelial damage inhibitor preserves the integrity of venous endothelial cells from patients undergoing coronary bypass surgery.

    Nazari-Shafti, Timo Z / Thau, Henriette / Zacharova, Ema / Beez, Christien M / Exarchos, Vasileios / Neuber, Sebastian / Meyborg, Heike / Puhl, Kerstin / Wittig, Corey / Szulcek, Robert / Neumann, Konrad / Giampietro, Costanza / Krüger, Katrin / Cesarovic, Nikola / Falk, Volkmar / Caliskan, Etem / Rodriguez Cetina Biefer, Hector / Emmert, Maximilian Y

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 64, Issue 6

    Abstract: Objectives: Despite the success of coronary artery bypass graft (CABG) surgery using autologous saphenous vein grafts (SVGs), nearly 50% of patients experience vein graft disease within 10 years of surgery. One contributing factor to early vein graft ... ...

    Abstract Objectives: Despite the success of coronary artery bypass graft (CABG) surgery using autologous saphenous vein grafts (SVGs), nearly 50% of patients experience vein graft disease within 10 years of surgery. One contributing factor to early vein graft disease is endothelial damage during short-term storage of SVGs in inappropriate solutions. Our aim was to evaluate the effects of a novel endothelial damage inhibitor (EDI) on SVGs from patients undergoing elective CABG surgery and on venous endothelial cells (VECs) derived from these SVGs.
    Methods: SVGs from 11 patients participating in an ongoing clinical registry (NCT02922088) were included in this study, and incubated with both full electrolyte solution (FES) or EDI for 1 h and then examined histologically. In 8 of 11 patients, VECs were isolated from untreated grafts, incubated with both FES and EDI for 2 h under hypothermic stress conditions and then analysed for activation of an inflammatory phenotype, cell damage and cytotoxicity, as well as endothelial integrity and barrier function.
    Results: The EDI was superior to FES in protecting the endothelium in SVGs (74 ± 8% versus 56 ± 8%, P < 0.001). Besides confirming that the EDI prevents apoptosis in SVG-derived VECs, we also showed that the EDI temporarily reduces adherens junctions in VECs while protecting focal adhesions compared to FES.
    Conclusions: The EDI protects the connectivity and function of the SVG endothelium. Our data suggest that the EDI can preserve focal adhesions in VECs during short-term storage after graft harvesting. This might explain the superiority of the EDI in maintaining most of the endothelium in venous CABG surgery conduits.
    MeSH term(s) Humans ; Endothelial Cells ; Saphenous Vein/transplantation ; Vascular Patency/physiology ; Coronary Artery Bypass/adverse effects ; Endothelium, Vascular ; Vascular Diseases
    Language English
    Publishing date 2023-09-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad327
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
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  10. Article ; Online: Impact of Metabolism on Immune Responses.

    Elkhal, Abdallah / Rodriguez Cetina Biefer, Hector / de la Fuente, Miguel A

    Journal of immunology research

    2018  Volume 2018, Page(s) 5069316

    MeSH term(s) Animals ; Asthma/immunology ; Cellular Reprogramming ; Dendritic Cells/immunology ; Estrogens/metabolism ; Humans ; Immune System/metabolism ; Immunity ; Lipid Metabolism ; Obesity/immunology ; Th1 Cells/immunology ; Toll-Like Receptors/metabolism
    Chemical Substances Estrogens ; Toll-Like Receptors
    Language English
    Publishing date 2018-07-26
    Publishing country Egypt
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2018/5069316
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