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  1. Article ; Online: Afectación pulmonar tras la infección aguda por SARS-CoV-2.

    López Bauzá, Ángela / Rodríguez Portal, José Antonio

    Open respiratory archives

    2022  Volume 4, Issue 2, Page(s) 100167

    Title translation Lung Involvement Following Acute SARS-CoV-2 Infection.
    Language Spanish
    Publishing date 2022-02-08
    Publishing country Spain
    Document type Editorial
    ISSN 2659-6636
    ISSN (online) 2659-6636
    DOI 10.1016/j.opresp.2022.100167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Radiological Manifestations of a Rare and Unrecognized Disease: Primary Pulmonary Lymphoma.

    López Bauzá, Ángela / López Ramírez, Cecilia / Rodríguez Portal, José Antonio

    Archivos de bronconeumologia

    2022  Volume 58, Issue 5, Page(s) 429–430

    Title translation Manifestaciones radiológicas de una rara y olvidada enfermedad: el linfoma pulmonar primario.
    MeSH term(s) Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lymphoma/diagnostic imaging ; Radiography
    Language Spanish
    Publishing date 2022-04-27
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficacy and Safety of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis: An Update.

    Rodríguez-Portal, José Antonio

    Drugs in R&D

    2017  Volume 18, Issue 1, Page(s) 19–25

    Abstract: Idiopathic pulmonary fibrosis is a fatal form of progressive fibrosing interstitial pneumonia with limited treatment options. In recent years, its management has been transformed with the approval of two new antifibrotic drugs: nintedanib and pirfenidone. ...

    Abstract Idiopathic pulmonary fibrosis is a fatal form of progressive fibrosing interstitial pneumonia with limited treatment options. In recent years, its management has been transformed with the approval of two new antifibrotic drugs: nintedanib and pirfenidone. Nintedanib is a tyrosine kinase inhibitor that efficiently slows idiopathic pulmonary fibrosis progression and has an acceptable tolerability profile. This article reviews new available evidence on the long-term efficacy and safety of nintedanib in patients with idiopathic pulmonary fibrosis. Data from extension trials indicate that nintedanib continues to slow disease progression for up to 3 years and is similarly effective in patients with mild and severe impairment of lung function. Treatment with nintedanib reduces the risk of acute exacerbations, and a combined analysis of data from clinical trials of nintedanib shows a trend towards a reduction in mortality. Nintedanib is well tolerated and has been shown to be safe for up to 51 months. Gastrointestinal events, mainly diarrhoea, are the main adverse events caused by the treatment. Currently available data confirm its safety profile in real-life clinical settings, with no new safety concerns identified in patients with comorbidities.
    MeSH term(s) Disease Progression ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Indoles/adverse effects ; Indoles/therapeutic use ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Indoles ; Protein Kinase Inhibitors ; nintedanib (G6HRD2P839)
    Language English
    Publishing date 2017-12-02
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2020476-0
    ISSN 1179-6901 ; 1174-5886
    ISSN (online) 1179-6901
    ISSN 1174-5886
    DOI 10.1007/s40268-017-0221-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Search for Simplicity: Quantifying the Diagnostic Algorithm of Hypersensitivity Pneumonitis.

    Lopez-Campos, José Luis / Lopez-Ramírez, Cecilia / Lopez-Bauza, Angela / Rodriguez Portal, Jose Antonio

    Archivos de bronconeumologia

    2022  Volume 59, Issue 3, Page(s) 186–188

    MeSH term(s) Humans ; Alveolitis, Extrinsic Allergic ; Diagnosis, Differential ; Algorithms
    Language Spanish
    Publishing date 2022-09-24
    Publishing country Spain
    Document type Letter
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment of Adult Primary Alveolar Proteinosis.

    Rodríguez Portal, José Antonio

    Archivos de bronconeumologia

    2015  Volume 51, Issue 7, Page(s) 344–349

    Abstract: Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of surfactant-like lipoproteinaceous material in the distal air spaces and terminal bronchi, which may lead to impaired gas exchange. This accumulation of surfactant ...

    Abstract Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of surfactant-like lipoproteinaceous material in the distal air spaces and terminal bronchi, which may lead to impaired gas exchange. This accumulation of surfactant is due to decreased clearance by the alveolar macrophages. Its primary, most common form, is currently considered an autoimmune disease. Better knowledge of the causes of PAP have led to the emergence of alternatives to whole lung lavage, although this is still considered the treatment of choice. Most studies are case series, often with limited patient numbers, so the level of evidence is low. Since the severity of presentation and clinical course are variable, not all patients will require treatment. Due to the low level of evidence, some objective criteria based on expert opinion have been arbitrarily proposed in an attempt to define in which patients it is best to initiate treatment.
    MeSH term(s) Adult ; Allografts ; Animals ; Antibiotic Prophylaxis ; Antibodies, Neutralizing/analysis ; Antibodies, Neutralizing/immunology ; Autoantibodies/analysis ; Autoantibodies/immunology ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Bronchoalveolar Lavage Fluid/immunology ; Clinical Trials as Topic ; Combined Modality Therapy ; Disease Management ; Disease Models, Animal ; Granulocyte-Macrophage Colony-Stimulating Factor/deficiency ; Granulocyte-Macrophage Colony-Stimulating Factor/physiology ; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin G/immunology ; Lung Transplantation ; Macrophages/pathology ; Mice ; Mice, Knockout ; Oxygen Inhalation Therapy ; Plasmapheresis ; Prospective Studies ; Pulmonary Alveolar Proteinosis/epidemiology ; Pulmonary Alveolar Proteinosis/genetics ; Pulmonary Alveolar Proteinosis/immunology ; Pulmonary Alveolar Proteinosis/therapy ; Pulmonary Gas Exchange ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/deficiency ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/physiology ; Rituximab/therapeutic use ; Therapeutic Irrigation
    Chemical Substances Antibodies, Neutralizing ; Autoantibodies ; Immunoglobulin G ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; Rituximab (4F4X42SYQ6) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language Spanish
    Publishing date 2015-07
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2015.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rheumatoid Arthritis and Tobacco.

    Rodríguez Portal, José Antonio / López Ramírez, Cecilia / Aguilera Cros, Clara

    Archivos de bronconeumologia

    2020  Volume 57, Issue 5, Page(s) 315–316

    Title translation Artritis reumatoide y tabaco.
    MeSH term(s) Arthritis, Rheumatoid/drug therapy ; Humans ; Rheumatoid Factor ; Nicotiana ; Tobacco Products ; Tobacco Use
    Chemical Substances Rheumatoid Factor (9009-79-4)
    Language Spanish
    Publishing date 2020-06-18
    Publishing country Spain
    Document type Editorial
    ZDB-ID 2591346-3
    ISSN 2173-5751 ; 2173-5751
    ISSN (online) 2173-5751
    ISSN 2173-5751
    DOI 10.1016/j.arbres.2020.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Granulomatous lung disease associated with the use of intravesical mytomycin.

    López Ramírez, Cecilia / Gómez Izquierdo, Lourdes / Rodríguez Portal, José Antonio

    Medicina clinica

    2020  Volume 157, Issue 4, Page(s) 206–207

    Title translation Enfermedad granulomatosa pulmonar asociada al uso de mitomicina intravesical.
    MeSH term(s) Administration, Intravesical ; BCG Vaccine/adverse effects ; Carcinoma, Transitional Cell ; Humans ; Lung Diseases ; Urinary Bladder Neoplasms
    Chemical Substances BCG Vaccine
    Language Spanish
    Publishing date 2020-08-18
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.05.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Intersticial pneumonia as the first manifestation of lupus in a pregnant woman in the early stages of the disease.

    López-Bauzá, Ángela / Rodríguez Suárez, Santiago / Rodríguez Portal, Jose Antonio

    Medicina clinica

    2020  Volume 157, Issue 7, Page(s) 350–352

    Title translation Neumonía intersticial como primera manifestación de un lupus en una gestante en etapas tempranas de la enfermedad.
    MeSH term(s) Female ; Humans ; Lung Diseases, Interstitial ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Pneumonia ; Pregnancy ; Pregnant Women
    Language Spanish
    Publishing date 2020-08-27
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.07.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Management of progressive pulmonary fibrosis associated with connective tissue disease.

    Molina-Molina, María / Castellví, Iván / Valenzuela, Claudia / Ramirez, José / Rodríguez Portal, José Antonio / Franquet, Tomás / Narváez, Javier

    Expert review of respiratory medicine

    2022  Volume 16, Issue 7, Page(s) 765–774

    Abstract: Introduction: Fibrotic interstitial lung disease (ILD) is a frequent and severe complication of connective tissue disease (CTD).: Areas covered: In this narrative review, we update the most relevant differential characteristics of fibrotic ILD ... ...

    Abstract Introduction: Fibrotic interstitial lung disease (ILD) is a frequent and severe complication of connective tissue disease (CTD).
    Areas covered: In this narrative review, we update the most relevant differential characteristics of fibrotic ILD associated with CTD (CTD-ILD) and propose a diagnostic and therapeutic approach based on a review of the articles published between 2002 and 2022 through PubMed.
    Expert opinion: The subset of ILD, mainly the radiological/histological pattern and the degree of fibrotic component, usually determines the prognosis and therapeutic strategy for these patients. Some patients with CTD-ILD can develop progressive pulmonary fibrosis (PPF) with severe deterioration of lung function, rapid progression to chronic respiratory failure, and high mortality. PPF has been described in many CTDs, mainly in systemic sclerosis and rheumatoid arthritis, and requires a multidisciplinary diagnostic and therapeutic approach to improve patient outcomes.
    MeSH term(s) Connective Tissue Diseases ; Humans ; Lung Diseases, Interstitial ; Prognosis ; Pulmonary Fibrosis ; Scleroderma, Systemic
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2022.2107508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Asbestos-related disease: screening and diagnosis.

    Rodríguez Portal, José Antonio

    Advances in clinical chemistry

    2012  Volume 57, Page(s) 163–185

    Abstract: Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of ... ...

    Abstract Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face a poor prognosis. Therefore, it is highly important to develop an early diagnostic method with the greatest challenge on screening techniques to detect the disease at a subclinical stage. Early detection is critical for the development of more effective therapies in these patients. Unfortunately, radiologic studies have not proven effective. Biomarkers might be a useful adjunct tool among populations previously exposed to asbestos. This review will provide an update of recent progress in serum biomarkers (osteopontin (OPN), soluble mesothelin (SM), and megakaryocyte potentiating factor (MPF)) to diagnose, detect, and monitor MPM. Of these, SM has demonstrated the greatest diagnostic potential although MPF may serve as an equal alternative. Despite recent studies, it is apparent that long-term large-cohort research is required to conclusively demonstrate the usefulness of these markers in this disease.
    MeSH term(s) Animals ; Asbestosis/diagnosis ; Asbestosis/diagnostic imaging ; Biomarkers ; Biomarkers, Tumor/analysis ; GPI-Linked Proteins/analysis ; GPI-Linked Proteins/genetics ; Humans ; Mass Screening ; Mesothelioma/diagnosis ; Mesothelioma/diagnostic imaging ; Mesothelioma/etiology ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/diagnostic imaging ; Pleural Neoplasms/etiology ; Prognosis ; Radiography, Thoracic
    Chemical Substances Biomarkers ; Biomarkers, Tumor ; GPI-Linked Proteins ; mesothelin
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 210505-6
    ISSN 0065-2423
    ISSN 0065-2423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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