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  1. Article ; Online: Healthy aging, what does demography point out?

    Rodríguez Sánchez, Isabel / Rodríguez Mañas, Leocadio

    Medicina clinica

    2024  

    Title translation Envejecimiento saludable, ¿qué dice la demografía?
    Language Spanish
    Publishing date 2024-02-08
    Publishing country Spain
    Document type Editorial
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2024.01.001
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  2. Article ; Online: La fragilidad, una pers-pectiva a lo largo del tiempo.

    Rodríguez Mañas, Leocadio

    Revista espanola de salud publica

    2021  Volume 95

    Abstract: The demographic changes experienced throughout the 20th century have not only conditioned a series of modifications in the structure of the populations, but have also been accompanied by a change in the epidemiological profiles of the population, which ... ...

    Title translation Frailty, a perspective along the time.
    Abstract The demographic changes experienced throughout the 20th century have not only conditioned a series of modifications in the structure of the populations, but have also been accompanied by a change in the epidemiological profiles of the population, which have had as one of their main consequences the change in the main focus of the organizations responsible for health and of the citizens themselves. The main objective of delaying death has been added to avoid disability, the main factor related to health associated with a poor quality of life. In this endeavor, frailty, a nosological entity with less than 25 years of history, has been acquiring increasing relevance and prominence. Throughout this article, it is reviewed, from a historical perspective, how its conceptual frameworks have been defined and delimited, the problems posed by its detection, which have appeared as primary factors in diagnostic work once frailty is diagnosed, how to manage the entity from a point of view of prevention, individual treatment and adaptation of the organization of the health and social systems and the efforts that different national and supranational organizations are making to address the problem, ending with the description of the challenges care and research that frailty has come to pose.
    MeSH term(s) Frailty/diagnosis ; Frailty/epidemiology ; Humans ; Quality of Life ; Spain
    Language Spanish
    Publishing date 2021-10-08
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
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  3. Article: Urinary tract infections in the elderly: a review of disease characteristics and current treatment options.

    Rodriguez-Mañas, Leocadio

    Drugs in context

    2020  Volume 9

    Abstract: Urinary tract infections (UTIs) are common in the elderly, and cover a range of conditions from asymptomatic bacteriuria to urosepsis. Risk factors for developing symptomatic UTIs include immunosenescence, exposure to nosocomial pathogens, multiple ... ...

    Abstract Urinary tract infections (UTIs) are common in the elderly, and cover a range of conditions from asymptomatic bacteriuria to urosepsis. Risk factors for developing symptomatic UTIs include immunosenescence, exposure to nosocomial pathogens, multiple comorbidities, and a history of UTIs. European guidelines on urological infections recommend antimicrobial treatment only for symptomatic UTIs. Non-antimicrobial options to treat and prevent UTIs include among others cranberry products, OM-89
    Language English
    Publishing date 2020-07-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2719560-0
    ISSN 1740-4398 ; 1745-1981
    ISSN (online) 1740-4398
    ISSN 1745-1981
    DOI 10.7573/dic.2020-4-13
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  4. Article ; Online: Biomarkers of frailty.

    El Assar, Mariam / Rodríguez-Sánchez, Isabel / Álvarez-Bustos, Alejandro / Rodríguez-Mañas, Leocadio

    Molecular aspects of medicine

    2024  Volume 97, Page(s) 101271

    Abstract: Several biomarkers have been proposed to identify frailty, a multisystemic age-related syndrome. However, the complex pathophysiology and the absence of a consensus on a comprehensive and universal definition make it challenging to pinpoint a singular ... ...

    Abstract Several biomarkers have been proposed to identify frailty, a multisystemic age-related syndrome. However, the complex pathophysiology and the absence of a consensus on a comprehensive and universal definition make it challenging to pinpoint a singular biomarker or set of biomarkers that conclusively characterize frailty. This review delves into the main laboratory biomarkers, placing special emphasis on those associated with various pathways closely tied to the frailty condition, such as inflammation, oxidative stress, mitochondrial dysfunction, metabolic and endocrine alterations and microRNA. Additionally, we provide a summary of different clinical biomarkers encompassing different tools that have been proposed to assess frailty. We further address various imaging biomarkers such as Dual Energy X-ray Absorptiometry, Bioelectrical Impedance analysis, Computed Tomography and Magnetic Resonance Imaging, Ultrasound and D3 Creatine dilution. Intervention to treat frailty, including non-pharmacological ones, especially those involving physical exercise and nutrition, and pharmacological interventions, that include those targeting specific mechanisms such as myostatin inhibitors, insulin sensitizer metformin and with special relevance for hormonal treatments are mentioned. We further address the levels of different biomarkers in monitoring the potential positive effects of some of these interventions. Despite the availability of numerous biomarkers, their performance and usefulness in the clinical arena are far from being satisfactory. Considering the multicausality of frailty, there is an increasing need to assess the role of sets of biomarkers and the combination between laboratory, clinical and image biomarkers, in terms of sensitivity, specificity and predictive values for the diagnosis and prognosis of the different outcomes of frailty to improve detection and monitoring of older people with frailty or at risk of developing it, being this a need in the everyday clinical practice.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2024.101271
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  5. Article: Good nutrition across the lifespan is foundational for healthy aging and sustainable development.

    Rodríguez-Mañas, Leocadio / Murray, Robert / Glencorse, Carole / Sulo, Suela

    Frontiers in nutrition

    2023  Volume 9, Page(s) 1113060

    Abstract: Ensuring healthy lives and promoting wellbeing across the age spectrum are essential to sustainable development. Nutrition is at the heart of the World Health Organization (WHO) Sustainable Development Goals, particularly for Sustainable Development Goal ...

    Abstract Ensuring healthy lives and promoting wellbeing across the age spectrum are essential to sustainable development. Nutrition is at the heart of the World Health Organization (WHO) Sustainable Development Goals, particularly for Sustainable Development Goal 2/Subgoal 2, which is to
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.1113060
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  6. Article ; Online: Long COVID-19: The Need for an Interdisciplinary Approach.

    Rodriguez-Sanchez, Isabel / Rodriguez-Mañas, Leocadio / Laosa, Olga

    Clinics in geriatric medicine

    2022  Volume 38, Issue 3, Page(s) 533–544

    Abstract: Long coronavirus disease 2019 (COVID-19) is characterized by persistent COVID-19 symptoms that last for at least 2 months. In the elderly population, apart from the typical symptoms (fatigue, cough, or dyspnea), unspecific symptoms coexist (functional ... ...

    Abstract Long coronavirus disease 2019 (COVID-19) is characterized by persistent COVID-19 symptoms that last for at least 2 months. In the elderly population, apart from the typical symptoms (fatigue, cough, or dyspnea), unspecific symptoms coexist (functional deterioration, cognitive impairment, or delirium) that can mitigate the prevalence of this syndrome in this age group. Its main consequence is the functional decline, leading to sarcopenia, frailty, and disability, in addition to the nutritional and cognitive disorders. Thus, a multicomponent and individualized program (exercise, diet, cognitive stimulation) should be designed for older people with persistent COVID, where new technologies could be useful.
    MeSH term(s) Aged ; COVID-19/complications ; Frail Elderly ; Frailty ; Humans ; Sarcopenia/etiology ; Sarcopenia/prevention & control ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1064151-8
    ISSN 1879-8853 ; 0749-0690
    ISSN (online) 1879-8853
    ISSN 0749-0690
    DOI 10.1016/j.cger.2022.03.005
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  7. Article ; Online: COVID-19 en las personas mayores: lecciones por aprender.

    Rodríguez-Mañas, Leocadio / Rodríguez-Sánchez, Isabel

    Revista espanola de geriatria y gerontologia

    2022  Volume 57, Issue 6, Page(s) 289–290

    Title translation COVID-19 in older people: Lessons to learn.
    MeSH term(s) Humans ; Aged ; COVID-19 ; SARS-CoV-2
    Language Spanish
    Publishing date 2022-10-21
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 605609-x
    ISSN 1578-1747 ; 0211-139X
    ISSN (online) 1578-1747
    ISSN 0211-139X
    DOI 10.1016/j.regg.2022.10.002
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    Zs.B 2677: Show issues Location:
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  8. Article ; Online: Eficacia y eficiencia de las unidades geriátricas de agudos: un tópico clásico revisitado.

    Baztán Cortés, Juan José / Rodríguez-Mañas, Leocadio

    Revista espanola de geriatria y gerontologia

    2022  Volume 57, Issue 4, Page(s) 230–235

    Abstract: Previous meta-analyses have shown that the hospital admission of older patients in acute geriatric units (AGU) compared to admission to other conventional units, significantly reduced the risk of functional deterioration during hospitalization, ... ...

    Title translation Effectiveness and efficiency of acute geriatric units: A classic topic revisited.
    Abstract Previous meta-analyses have shown that the hospital admission of older patients in acute geriatric units (AGU) compared to admission to other conventional units, significantly reduced the risk of functional deterioration during hospitalization, increasing the possibility of returning home, with an added reduction in cost of hospitalization. A new meta-analysis on the subject has recently been published in Age and Aging, which adds six new studies to the five clinical trials analyzed in previous meta-analyses. This article analyzes the results of this new meta-analysis, delving into the characteristics of the new studies included and making some considerations on the implications for care in the future development of AGU.
    MeSH term(s) Aged ; Aging ; Geriatric Assessment/methods ; Hospitalization ; Humans
    Language Spanish
    Publishing date 2022-07-12
    Publishing country Spain
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 605609-x
    ISSN 1578-1747 ; 0211-139X
    ISSN (online) 1578-1747
    ISSN 0211-139X
    DOI 10.1016/j.regg.2022.06.005
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  9. Article ; Online: Response rates and associated factors after a multicomponent intervention in frail older adults with diabetes.

    Álvarez-Bustos, Alejandro / Laosa, Olga / Marzetti, Emanuele / Carnicero, Jose Antonio / Castro-Rodriguez, Marta / Landi, Francesco / Sinclair, Alan J / Rodriguez-Mañas, Leocadio

    Age and ageing

    2024  Volume 53, Issue 1

    Abstract: Background: Type 2 diabetes mellitus (T2DM) and frailty are associated with functional decline in older population.: Objective: To explore the individual response to a multimodal intervention on functional performance.: Design: A cluster- ... ...

    Abstract Background: Type 2 diabetes mellitus (T2DM) and frailty are associated with functional decline in older population.
    Objective: To explore the individual response to a multimodal intervention on functional performance.
    Design: A cluster-randomised multicentre clinical trial.
    Setting: Outpatients in hospital or primary care.
    Subjects: 843 (77.83 years, 50.65% men) prefrail and frail individuals ≥70 years with T2DM.
    Methods: Participants were allocated to usual care group (UCG) or a multicomponent intervention group (IG): 16-week progressive resistance training, seven nutritional and diabetological educational sessions and achievement of glycated haemoglobin (7-8%) and blood pressure (<150 mmHg) targets. Functional performance was assessed with the Short Physical Performance Battery (SPPB) at 1 year. We used multivariate binomial and multinomial logistic regression models to explore the effect of the IG, and adherence on the outcomes studied, in several adjusted models.
    Results: 53.7% in the IG versus 38.0% in the UCG improved by at least 1 point in their SPPB score [OR (95% CI): 2.07 (1.43, 2.98), P value <0.001]. Age, SPPB score and number of frailty criteria met decreased the probability of improving the SPPB score. Factors associated with worsening were pertaining to IG (decreased), age, SPPB score and the number of frailty criteria (increased). An adherence ≥84% was needed to achieve benefits, reaching the peak in the probability of improving SPPB when this was ≥85% [OR(95%CI): 2.38 (1.29, 4.79), P value 0.014].
    Conclusions: Factors predicting the likelihood of improvement in a multimodal programme in pre-frail and frail older adults with diabetes are age, basal SPPB score, the number of frailty criteria and adherence.
    MeSH term(s) Male ; Aged ; Humans ; Female ; Frail Elderly ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/therapy ; Frailty/diagnosis ; Frailty/therapy ; Blood Pressure ; Educational Status
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afad253
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  10. Article ; Online: La experiencia europea ADVANTAGE para el manejo de la fragilidad: claves sobre su aplicabilidad en América Latina.

    Alonso Bouzón, Cristina / Rodríguez Mañas, Leocadio

    Revista panamericana de salud publica = Pan American journal of public health

    2021  Volume 45, Page(s) e107

    Abstract: The European Commission and 22 of its Member States cofinanced, in 2017-2019, the first joint action to address frailty in older persons, known as ADVANTAGE Joint Action. The initiative developed a common strategy, based on the best scientific evidence, ... ...

    Title translation The European ADVANTAGE experience for management of frailty: keys to its applicability in Latin AmericaA experiência europeia ADVANTAGE para manejo da fragilidade: apontamentos para sua aplicabilidade na América Latina.
    Abstract The European Commission and 22 of its Member States cofinanced, in 2017-2019, the first joint action to address frailty in older persons, known as ADVANTAGE Joint Action. The initiative developed a common strategy, based on the best scientific evidence, to position healthy aging and frailty as priority public health issues in the participating countries and thus contribute to uniformly addressing frailty across Europe. This article details the methodology and main achievements of ADVANTAGE and includes an analysis of the key factors contributing to its success. In the Action's three years, powerful multisectoral networks were formed and developed, both nationally and internationally. ADVANTAGE succeeded in mapping out practical routes for comprehensively addressing frailty and dependency prevention in 22 countries with very heterogeneous political, economic, social, and organizational realities. ADVANTAGE has demonstrated that actions of this type are feasible and effective, and that if the key points of success that have been identified are considered and applied, duly adjusted to each reality, this action can be replicable in any country resolved to promoting the healthy aging of its population, including those of Latin America and the Caribbean.
    Language Spanish
    Publishing date 2021-09-13
    Publishing country United States
    Document type English Abstract ; Journal Article
    ZDB-ID 1376934-0
    ISSN 1680-5348 ; 1020-4989
    ISSN (online) 1680-5348
    ISSN 1020-4989
    DOI 10.26633/RPSP.2021.107
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