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Article: Decadencia del arte clínico y auge de la medicina high-tech.

Rodríguez-Montes, J A

2009 Volume 209, Issue 8, Page(s) 361–363

Title translation	Decline of clinical art and growth of high-tech medicine.
MeSH term(s)	Clinical Medicine/standards ; Clinical Medicine/trends
Language	Spanish
Publishing date	2009-09-03
Publishing country	Spain
Document type	Editorial
ZDB-ID	123597-7
ISSN	0014-2565 ; 0014-2565
ISSN (online)	0014-2565
ISSN	0014-2565
DOI	10.1016/s0014-2565(09)72338-0
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Article: I + D + i: de la investigación a la gestión.

Rodríguez-Montes, J A

Nutricion hospitalaria

2007 Volume 22, Issue 3, Page(s) 283–286

Abstract: The project of the European Commission Towards a European Space of Research, presented in the year 2000, aims at increasing the impact on R+ D and defining the scientific policy for Europe. The materialization of this project implies commitment and ... ...

Title translation	I + D + i: from research to management.
Abstract	The project of the European Commission Towards a European Space of Research, presented in the year 2000, aims at increasing the impact on R+ D and defining the scientific policy for Europe. The materialization of this project implies commitment and support from member States, the coordination of research activities between each one of them, and the development of modern management systems and methods. In Spain, R+ D + i activities include (regional, national, and international) Programs, Plans, and Actions on R + D and the participation in relevant Contracts with enterprises, the Administration, or both. In this setting, several general aspects of the National Plan on R + D + i (2004-2007) and of the 7th European Framework Program of the EU are presented and some issues on biomedical research, the role of universities in scientific production, the relevance of knowledge as a significant resource, and the need of managing the latter as a source of competitive advantage are commented.
MeSH term(s)	Research/organization & administration ; Spain
Language	Spanish
Publishing date	2007-05
Publishing country	Spain
Document type	Editorial ; English Abstract
ZDB-ID	1481223-x
ISSN	0212-1611
ISSN	0212-1611
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Article: Development of Interpretable Predictive Models for BPH and Prostate Cancer.

Bermejo, Pablo / Vivo, Alicia / Tárraga, Pedro J / Rodríguez-Montes, J A

Clinical Medicine Insights. Oncology

2015 Volume 9, Page(s) 15–24

Abstract: Background: Traditional methods for deciding whether to recommend a patient for a prostate biopsy are based on cut-off levels of stand-alone markers such as prostate-specific antigen (PSA) or any of its derivatives. However, in the last decade we have ... ...

Abstract	Background: Traditional methods for deciding whether to recommend a patient for a prostate biopsy are based on cut-off levels of stand-alone markers such as prostate-specific antigen (PSA) or any of its derivatives. However, in the last decade we have seen the increasing use of predictive models that combine, in a non-linear manner, several predictives that are better able to predict prostate cancer (PC), but these fail to help the clinician to distinguish between PC and benign prostate hyperplasia (BPH) patients. We construct two new models that are capable of predicting both PC and BPH. Methods: An observational study was performed on 150 patients with PSA ≥3 ng/mL and age >50 years. We built a decision tree and a logistic regression model, validated with the leave-one-out methodology, in order to predict PC or BPH, or reject both. Results: Statistical dependence with PC and BPH was found for prostate volume (P-value < 0.001), PSA (P-value < 0.001), international prostate symptom score (IPSS; P-value < 0.001), digital rectal examination (DRE; P-value < 0.001), age (P-value < 0.002), antecedents (P-value < 0.006), and meat consumption (P-value < 0.08). The two predictive models that were constructed selected a subset of these, namely, volume, PSA, DRE, and IPSS, obtaining an area under the ROC curve (AUC) between 72% and 80% for both PC and BPH prediction. Conclusion: PSA and volume together help to build predictive models that accurately distinguish among PC, BPH, and patients without any of these pathologies. Our decision tree and logistic regression models outperform the AUC obtained in the compared studies. Using these models as decision support, the number of unnecessary biopsies might be significantly reduced.
Language	English
Publishing date	2015-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2577877-8
ISSN	1179-5549
ISSN	1179-5549
DOI	10.4137/CMO.S19739
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Article ; Online: Análisis comparativo: Efectividad del tratamiento antitabáquico en la población con comorbilidad psiquiátrica.

Godoy, R / Callejas, F J / Cruz, J / Tornero, A I / Tárraga, P J / Rodríguez-Montes, J A

Semergen

2017 Volume 44, Issue 4, Page(s) 249–256

Abstract: Objective: To determine whether or not nicotine addiction treatment was less effective in psychiatric than in the healthy population.: Material and methods: A retrospective, descriptive and comparative cohort study was conducted in Albacete ... ...

Title translation	Comparative analysis: Effectiveness of nicotine addiction treatment in people with psychiatric comorbidity.
Abstract	Objective: To determine whether or not nicotine addiction treatment was less effective in psychiatric than in the healthy population. Material and methods: A retrospective, descriptive and comparative cohort study was conducted in Albacete University Hospital during years 2008-2012 on all patients that attended the Tobacco Cessation Unit. The statistical tests used were Chi-squared, likelihood ratio, and the Student t test. Statistical significance P≤.05. Results: The study included a total of 1,484 patients, of which 48.6% were female. The mean age was 46.8 years, and the mean age of starting smoking was 17.6 years. The mean number of previous attempts to quit was 1.48, and mean number of cigarettes smoked was 25.39. They had a mean Fagerström score of 6.04, a Richmond score of 8.13, and a mean carbon monoxide level of 16.65ppm. Most patients were referred from Primary Care (38.7%) and Chest Diseases department (33%), and the type of tobacco smoked was "light" in 75.8%. There was 15% with chronic obstructive pulmonary disease, 8% with asthma, and 9.4% with obstructive sleep apnoea syndrome. Furthermore, there was respiratory disease in 28.7%, cardiovascular disease in 4.6%, and both in 3.5%. Hiatus hernia was present in 7.2%, thyroid disease in 3.8%, hypertension in 19%, diabetes in 10.7%, and dyslipidaemia in 29.4%, Drugs were used by 7.1%, and 12.6% consumed alcohol. There was 39.3% psychiatric comorbidity (PC), and were comparable except in gender, age of onset, Fagerström, Richmond, source of referral, asthma, hiatus hernia, thyroid disease, hypertension, as well as drugs and treatment. Drug treatment was completed by 22.3% in the PC group, with no significant difference. There were differences in success (P=.008), but not in failure and relapse rates. Conclusion: Anti-smoking treatment in psychiatric patients is effective. An increase in the probability of treatment success is observed in patients without psychiatric comorbidity.
MeSH term(s)	Adult ; Carbon Monoxide/metabolism ; Cohort Studies ; Humans ; Male ; Mental Disorders/complications ; Mental Disorders/epidemiology ; Middle Aged ; Retrospective Studies ; Smoking/epidemiology ; Smoking Cessation/methods ; Smoking Prevention/methods ; Spain ; Tobacco Use Disorder/rehabilitation ; Treatment Outcome
Chemical Substances	Carbon Monoxide (7U1EE4V452)
Language	Spanish
Publishing date	2017-06-20
Publishing country	Spain
Document type	Comparative Study ; Journal Article
ISSN	1578-8865
ISSN (online)	1578-8865
DOI	10.1016/j.semerg.2017.03.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bases experimentales del trasplante de intestino.

Rodríguez Montes, J A

Anales de la Real Academia Nacional de Medicina

1993 Volume 110, Issue 1, Page(s) 129–144

Title translation	Experimental bases for the intestinal transplant.
MeSH term(s)	Animals ; Biopsy ; Gastrointestinal Motility ; Graft vs Host Reaction/immunology ; Intestine, Small/blood supply ; Intestine, Small/immunology ; Intestine, Small/pathology ; Intestine, Small/transplantation ; Replantation ; Therapeutic Irrigation ; Tissue Preservation ; Transplantation, Homologous
Language	Spanish
Publishing date	1993
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	732450-9
ISSN	0034-0634
ISSN	0034-0634
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Article: Hepatotoxicidad en el paciente crítico. El hígado bajo agresión aguda grave.

García de Lorenzo y Mateos, A / Rodríguez Montes, J A

Nutricion hospitalaria

2008 Volume 23 Suppl 2, Page(s) 19–24

Abstract: The liver plays an essential role in the metabolism of most of the nutrients since it is a mainly metabolic organ carrying out a series of physiological and metabolic processes related with protein and energy metabolism. The intestinal tract is ... ...

Title translation	Hepatotoxicity in the critically ill patient. The liver under an acute severe insult.
Abstract	The liver plays an essential role in the metabolism of most of the nutrients since it is a mainly metabolic organ carrying out a series of physiological and metabolic processes related with protein and energy metabolism. The intestinal tract is considered a key element in the development of Multiorgan Dysfunction (MOD) or failure by loosing its barrier function (impaired permeability) against toxins, bio-products and occasionally intraluminal bacteria secondary to hypoxia, one of the main pathophysiogenic mechanisms being the insufficient blood flow to splacnic organs. Liver dysfunction and/or impairment of liver function test are a common event in critically ill patients. They may be due to previous liver cirrhosis or to more immediate causes of liver failure such as sepsis, drugs, liver transplant or any of the multiple etiologies for hepatitis.
MeSH term(s)	Critical Illness ; Energy Metabolism ; Humans ; Liver/metabolism ; Liver/physiology ; Liver Circulation ; Liver Failure/etiology ; Liver Failure/therapy ; Liver Function Tests ; Multiple Organ Failure/etiology ; Multiple Organ Failure/physiopathology ; Nutritional Support ; Systemic Inflammatory Response Syndrome/etiology
Language	Spanish
Publishing date	2008-05
Publishing country	Spain
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	1481223-x
ISSN	0212-1611
ISSN	0212-1611
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Article: Sustitución de la vía biliar extrahepática.

Rodríguez Montes, J A

Anales de la Real Academia Nacional de Medicina

1991 Volume 108, Issue 3, Page(s) 541–552

Title translation	The replacement of the extrahepatic biliary tract.
MeSH term(s)	Biliary Tract/abnormalities ; Biliary Tract/injuries ; Biliary Tract Diseases/surgery ; Biliary Tract Neoplasms/surgery ; Biliary Tract Surgical Procedures/methods ; Humans
Language	Spanish
Publishing date	1991
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	732450-9
ISSN	0034-0634
ISSN	0034-0634
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Article: Utilidad de la determinación sérica de microRNA-21 en la enfermedad inflamatoria del colon.

Menéndez, P / Villarejo, P / Padilla, D / Palomino, T / Nieto, P / Menéndez, J M / Rodríguez-Montes, J A

Revista de gastroenterologia de Mexico

2013 Volume 78, Issue 2, Page(s) 70–74

Abstract: Background: MicroRNAs are 20-22 nucleotide molecular structures with post-transcriptional activity that are involved in the immune response, as well as in the inflammatory pathways of different cells and tissues.: Aims: We present herein a ... ...

Title translation	Serum microRNA-21 usefulness in inflammatory pathology of the colon.
Abstract	Background: MicroRNAs are 20-22 nucleotide molecular structures with post-transcriptional activity that are involved in the immune response, as well as in the inflammatory pathways of different cells and tissues. Aims: We present herein a prospective study in which serum microRNA-21 expression was determined in patients diagnosed with acute appendicitis as a model of bowel inflammation. Material and methods: A prospective cohort study of patients diagnosed with acute appendicitis was conducted. Serum microRNA-21 was analyzed through the PCR of blood samples taken from the patients prior to surgery. MicroRNA-21 values were compared with the analytic variables (leukocytes, hemoglobin, hematocrit, platelets, prothrombin activity, glucose, urea, and creatinine) and the anatomopathologic variables (normal appendix, phlegmonous, gangrenous, and perforated acute appendicitis). Results: A total of 60 patients with acute appendicitis diagnosis were consecutively included in the study from June to October 2009. Sixty-six percent of the patients were men (40 men and 20 women), with a mean age of 26.2±14.8 years. The mean absolute level of microRNA-21 was 24.8±0.93, whereas the mean microRNA-21 gene expression was 1.04±0.28. No correlation between the analytic and anatomopathologic parameters evaluated was observed (P=.47). Conclusions: It is necessary to continue to search for the most appropriate microRNAs, so that their determination in serum can lead to greater precision in establishing the diagnosis and outcome of inflammatory disorders of the bowel.
MeSH term(s)	Acute Disease ; Adult ; Appendicitis/blood ; Colitis/blood ; Female ; Humans ; Male ; MicroRNAs/blood ; Prospective Studies
Chemical Substances	MIRN21 microRNA, human ; MicroRNAs
Language	Spanish
Publishing date	2013-04
Publishing country	Mexico
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	732082-6
ISSN	0375-0906
ISSN	0375-0906
DOI	10.1016/j.rgmx.2013.02.004
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Article: Tratamiento del intestino corto.

Rodríguez Montes, J A

Anales de la Real Academia Nacional de Medicina

1990 Volume 107, Issue 1, Page(s) 91–113

Title translation	Treatment of short bowel syndrome.
MeSH term(s)	Diet ; Humans ; Intestinal Absorption ; Intestine, Small/surgery ; Nutritional Requirements ; Obesity, Morbid/surgery ; Parenteral Nutrition ; Short Bowel Syndrome/etiology ; Short Bowel Syndrome/metabolism ; Short Bowel Syndrome/therapy
Language	Spanish
Publishing date	1990
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	732450-9
ISSN	0034-0634
ISSN	0034-0634
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Article: Fisiopatología de las alteraciones neuromusculares en el paciente crítico.

García de Lorenzo, A / Vilas, E / Rodríguez Montes, J A

Nutricion hospitalaria

2006 Volume 21 Suppl 3, Page(s) 96–103

Abstract: Objective: to analyze the causes and manifestations of muscle weakness that critically ill patients develop during their staying at the ICU, and literature review.: Development: in the early 1980s, a mixed axonal polyneuropathy was described in ... ...

Title translation	Pathophysiology of neuromuscular impairments in the critically ill patient.
Abstract	Objective: to analyze the causes and manifestations of muscle weakness that critically ill patients develop during their staying at the ICU, and literature review. Development: in the early 1980s, a mixed axonal polyneuropathy was described in septic critically ill patients, which clinically manifested by muscle weakness of variable severity, leading to quadriplegia and/or ventilator dependency in its most severe presentation. Almost at the same time, an acute intensive care myopathy was described in asthmatic patients admitted to the ICU for asthma exacerbation. Later on, this myopathy was also observed in transplanted, septic, or burnt patients. Several authors consider acute intensive care myopathy as the main cause of muscle weakness in the ICU. Conclusions: in this article, we describe the clinical presentation, etiopathogenesis, diagnosis, and treatment of polyneuropathy of the critically ill patient and of acute intensive care myopathy. Both clinical pictures may be differentiated, with neurophysiological studies and eventually muscle biopsy being of great help. Although some authors rather include these conditions under the name of polyneuromyopathy, we propose the general denomination of Acute Neuromuscular Syndrome of the Critically Ill Patient, a more descriptive term no presupposing a single mechanism or etiology.
MeSH term(s)	Critical Illness ; Humans ; Intensive Care Units ; Muscle Weakness/physiopathology ; Muscular Diseases/physiopathology ; Polyneuropathies/physiopathology ; Syndrome
Language	Spanish
Publishing date	2006-05
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1481223-x
ISSN	0212-1611
ISSN	0212-1611
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