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  1. Article ; Online: Cutaneous collagenous vasculopathy.

    Nelson, Garrett / Cameron, Michael C / Rodriguez-Waitkus, Paul M / Fenske, Neil Alan

    Cutis

    2020  Volume 105, Issue 2, Page(s) E23–E24

    MeSH term(s) Aged ; Collagen Type IV/metabolism ; Humans ; Male ; Skin Diseases, Vascular/diagnosis ; Skin Diseases, Vascular/pathology ; Telangiectasis/diagnosis ; Telangiectasis/pathology
    Chemical Substances Collagen Type IV
    Language English
    Publishing date 2020-03-10
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
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  2. Article ; Online: Metachromatic leukodystrophy and its effects on the gallbladder: a case report.

    Rodriguez-Waitkus, Paul M / Byrd, Robert / Hicks, John

    Ultrastructural pathology

    2011  Volume 35, Issue 6, Page(s) 271–276

    Abstract: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder caused by a deficiency of arylsulfatase A enzyme. This deficiency leads to accumulation of sulfatides in the central nervous system and other organs, such as the ... ...

    Abstract Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disorder caused by a deficiency of arylsulfatase A enzyme. This deficiency leads to accumulation of sulfatides in the central nervous system and other organs, such as the gallbladder. Here the authors discuss a 9-year-old Middle Eastern patient with late-infantile-type MLD who presented with symptoms of cholecystitis. Radiographic studies revealed an enlarged gallbladder with a thickened wall and a pericholecystic fluid collection with peripheral calcifications. Gross examination of the gallbladder showed multiple small to medium-sized papillary projections involving the entire mucosal surface. Sections through the gallbladder wall revealed multilocular dilated mucin-producing cystic spaces. Microscopically, the mucosa showed numerous papillary projections with complex folds lined by mucin-producing cuboidal to tall columnar cells. The cystic spaces were composed of numerous markedly distended Rokitansky-Aschoff sinuses filled with mucin. Ultrastructurally, the epithelial cells and macrophages showed frequent secondary lysosomes containing closely packed lamellar amorphous to prismatic material with alternating leaflets and tubules, imparting a "herringbone" or "tuffstone" pattern. This case illustrates the features of gallbladder involvement in MLD and the potential role of ultrastructural examination in diagnosis of MLD.
    MeSH term(s) Carcinoma in Situ/diagnosis ; Carcinoma in Situ/etiology ; Child ; Cholangiography/methods ; Cholecystitis/diagnosis ; Cholecystitis/etiology ; Epithelial Cells/pathology ; Gallbladder/pathology ; Gallbladder/ultrastructure ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/etiology ; Humans ; Leukodystrophy, Metachromatic/complications ; Leukodystrophy, Metachromatic/diagnosis ; Leukodystrophy, Metachromatic/pathology ; Lysosomes/pathology ; Macrophages/pathology ; Male ; Microscopy, Electron ; Mucous Membrane/pathology ; Staining and Labeling ; Tomography, X-Ray Computed
    Language English
    Publishing date 2011-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603269-2
    ISSN 1521-0758 ; 0191-3123
    ISSN (online) 1521-0758
    ISSN 0191-3123
    DOI 10.3109/01913123.2011.620730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Granuloma annulare mimicking multicentric reticulohistiocytosis.

    Wat, Margaret / Sun, Grace S / Rodriguez-Waitkus, Paul M / Hsu, Sylvia

    Dermatology online journal

    2013  Volume 19, Issue 11, Page(s) 20400

    Abstract: We describe a patient with granuloma annulare (GA) who presented with firm periungual papules mimicking "coral beads", a characteristic sign of multicentric reticulohistiocytosis (MRH). We highlight the importance of distinguishing between GA and MRH ... ...

    Abstract We describe a patient with granuloma annulare (GA) who presented with firm periungual papules mimicking "coral beads", a characteristic sign of multicentric reticulohistiocytosis (MRH). We highlight the importance of distinguishing between GA and MRH because the prognoses differ significantly.
    MeSH term(s) Aged ; Anti-Inflammatory Agents/therapeutic use ; Diagnosis, Differential ; Female ; Granuloma Annulare/drug therapy ; Granuloma Annulare/pathology ; Histiocytosis, Non-Langerhans-Cell/diagnosis ; Humans ; Recurrence ; Triamcinolone/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Triamcinolone (1ZK20VI6TY)
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1087-2108
    ISSN (online) 1087-2108
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  4. Article ; Online: Gastrointestinal histoplasmosis in a hepatitis C-infected individual.

    Rodriguez-Waitkus, Paul M / Bayat, Vafa / George, Elias / Sule, Norbert

    Mycopathologia

    2013  Volume 176, Issue 1-2, Page(s) 161–164

    Abstract: Gastrointestinal histoplasmosis is a rare manifestation of this fungal infection, typically identified in immunocompromised patients, such as those with HIV/AIDS. Here, we report a case of disseminated histoplasmosis with gastrointestinal involvement in ... ...

    Abstract Gastrointestinal histoplasmosis is a rare manifestation of this fungal infection, typically identified in immunocompromised patients, such as those with HIV/AIDS. Here, we report a case of disseminated histoplasmosis with gastrointestinal involvement in a Hepatitis C-infected patient. The fungal agent was confirmed to be Histoplasma capsulatum by a DNA probe assay performed on a bone marrow sample. We propose that this fungal disease should be kept on the differential of patients infected with the Hepatitis C virus, as it has been reported to have numerous damaging effects on the adaptive immune system.
    MeSH term(s) Bone Marrow/microbiology ; Bone Marrow/pathology ; Female ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/microbiology ; Gastrointestinal Diseases/pathology ; Hepatitis C, Chronic/complications ; Histocytochemistry/methods ; Histoplasma/genetics ; Histoplasma/isolation & purification ; Histoplasmosis/diagnosis ; Histoplasmosis/microbiology ; Histoplasmosis/pathology ; Humans ; Lung/pathology ; Microbiological Techniques ; Middle Aged ; Molecular Diagnostic Techniques
    Language English
    Publishing date 2013-06-13
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391081-7
    ISSN 1573-0832 ; 0369-299X ; 0301-486X ; 0027-5530
    ISSN (online) 1573-0832
    ISSN 0369-299X ; 0301-486X ; 0027-5530
    DOI 10.1007/s11046-013-9669-5
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  5. Article ; Online: Sporotrichoid pattern of Mycobacterium chelonae-abscessus infection.

    Boulavsky, Jessica L / Wright, Holly M / Rodriguez-Waitkus, Paul M / DiNardo, Andrew R / Woc-Colburn, Laila E / Dao, Harry

    Cutis

    2017  Volume 100, Issue 3, Page(s) E4–E5

    MeSH term(s) Adult ; Anti-Bacterial Agents/administration & dosage ; Biopsy/methods ; Humans ; Immunocompromised Host ; Male ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/immunology ; Mycobacterium Infections, Nontuberculous/microbiology ; Mycobacterium chelonae/drug effects ; Mycobacterium chelonae/isolation & purification ; Skin/microbiology ; Skin/pathology ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2017-09-28
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
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  6. Article ; Online: A Rare Case of Gastric Fundic Gland Adenocarcinoma (Chief Cell Predominant Type).

    Chen, Wei-Chung / Rodriguez-Waitkus, Paul M / Barroso, Alberto / Balsaver, Ashok / McKechnie, John C

    Journal of gastrointestinal cancer

    2012  Volume 43 Suppl 1, Page(s) S262–5

    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Chief Cells, Gastric/pathology ; Gastric Fundus/pathology ; Gastric Fundus/surgery ; Humans ; Male ; Prognosis ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2012-07-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-012-9416-z
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    Zs.A 2184: Show issues Location:
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  7. Article ; Online: Rhinoscleroma in an urban nonendemic setting.

    Suchanova, Pavlina P / Mohyuddin, Nadia G / Rodriguez-Waitkus, Paul M / Eicher, Susan A

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2012  Volume 147, Issue 1, Page(s) 173–174

    MeSH term(s) Adult ; Endemic Diseases ; Female ; Humans ; Male ; Middle Aged ; Rhinoscleroma/diagnosis ; Rhinoscleroma/therapy ; Urban Health
    Language English
    Publishing date 2012-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599811431663
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  8. Article ; Online: Eccrine hidrocystomas presenting as multiple papules on the cheeks.

    Jabbar, Ahmad S / Matinpour, Keyan / Orengo, Ida / Rodriguez-Waitkus, Paul M / Diwan, Abdul H / Motaparthi, Kiran

    Dermatology online journal

    2013  Volume 19, Issue 8, Page(s) 19269

    Abstract: Hidrocystomas are common, benign adnexal neoplasms most frequently found on the eyelids, canthi, or periocular areas. Herein, we report a case of multiple hidrocystomas distributed over less common facial areas: cheeks and cutaneous lips. ...

    Abstract Hidrocystomas are common, benign adnexal neoplasms most frequently found on the eyelids, canthi, or periocular areas. Herein, we report a case of multiple hidrocystomas distributed over less common facial areas: cheeks and cutaneous lips.
    MeSH term(s) Cheek/pathology ; Facial Neoplasms/pathology ; Female ; Hidrocystoma/pathology ; Humans ; Middle Aged ; Sweat Gland Neoplasms/pathology
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1087-2108
    ISSN (online) 1087-2108
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  9. Article: Steroid hormone signaling between Schwann cells and neurons regulates the rate of myelin synthesis.

    Rodriguez-Waitkus, Paul M / Lafollette, Andrew J / Ng, Benjamin K / Zhu, Thant S / Conrad, H Edward / Glaser, Michael

    Annals of the New York Academy of Sciences

    2003  Volume 1007, Page(s) 340–348

    Abstract: Fluorescence digital imaging microscopy was used to develop a method that allows the continuous monitoring and quantitative measurement of a single myelin internode throughout its development. Using this technique, steroid hormones such as progesterone ... ...

    Abstract Fluorescence digital imaging microscopy was used to develop a method that allows the continuous monitoring and quantitative measurement of a single myelin internode throughout its development. Using this technique, steroid hormones such as progesterone and dexamethasone were shown to reduce the time required for the initiation and to regulate the rate of myelin synthesis. Progesterone was capable of increasing the rate of myelin synthesis in Schwann cell/neuronal co-cultures in a dose-dependent manner. RT-PCR and in situ hydridization studies revealed that the mRNAs for P450scc and 3beta-hydroxysteroid dehydrogenase, the enzymes involved in progesterone biosynthesis, were induced at the onset of myelin synthesis. The progesterone receptor protein translocated into the nucleus of the neurons during myelin synthesis, suggesting that progesterone could also be affecting neuronal gene expression. Changes in gene expression caused by progesterone are being examined to identify additional factors that may control myelin formation.
    MeSH term(s) Animals ; Coculture Techniques ; Dose-Response Relationship, Drug ; Gonadal Steroid Hormones/pharmacology ; Gonadal Steroid Hormones/physiology ; Myelin Sheath/drug effects ; Myelin Sheath/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Rats ; Schwann Cells/drug effects ; Schwann Cells/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2003-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1196/annals.1286.033
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