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  1. Article ; Online: How COVID-19 and the Dutch ‘intelligent lockdown’ change activities, work and travel behaviour

    Mathijs de Haas / Roel Faber / Marije Hamersma

    Transportation Research Interdisciplinary Perspectives, Vol 6, Iss , Pp 100150- (2020)

    Evidence from longitudinal data in the Netherlands

    2020  

    Abstract: COVID-19 has massively affected the lives of people all over the world. This paper presents first insights in current and potential future effects of the virus and the Dutch government's ‘intelligent lockdown’ on people's activities and travel behaviour. ...

    Abstract COVID-19 has massively affected the lives of people all over the world. This paper presents first insights in current and potential future effects of the virus and the Dutch government's ‘intelligent lockdown’ on people's activities and travel behaviour. Findings are based on a representative sample of about 2500 respondents from the Netherlands Mobility Panel (MPN). We show that approximately 80% of people reduced their activities outdoors, with a stronger decrease for older people. 44% of workers started or increased the amount of hours working from home and 30% have more remote meetings. Most of these workers report positive experiences. Students and school pupils, however, are mostly not happy with following education from home. Furthermore, the amount of trips and distance travelled dropped by 55% and 68% respectively when compared to the fall of 2019. So-called ‘roundtrips’ (e.g. a walking or cycling tour) gained in popularity. People are currently more positive towards the car and far more negative towards public transport. Changes in outdoor activities seem to be temporal, with over 90% of people who currently reduced their outdoor activities not expecting to continue this behaviour in the future after corona. However, 27% of home-workers expect to work from home more often in the future. In addition, 20% of people expect to cycle and walk more and 20% expect to fly less in the future. These findings show that the coronavirus crisis might result in structural behavioural changes, although future longitudinal analyses are needed to observe these possible structural effects.
    Keywords Travel behaviour ; COVID-19 ; Coronavirus ; Longitudinal travel data ; Netherlands Mobility Panel (MPN) ; Panel data ; Transportation and communications ; HE1-9990 ; covid19
    Subject code 300
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Application of new host biomarker profiles in quantitative point-of-care tests facilitates leprosy diagnosis in the fieldResearch in context

    Anouk van Hooij / Susan van den Eeden / Renate Richardus / Elisa Tjon Kon Fat / Louis Wilson / Kees L.M.C. Franken / Roel Faber / Merufa Khatun / Khorshed Alam / Abu Sufian Chowdhury / Jan Hendrik Richardus / Paul Corstjens / Annemieke Geluk

    EBioMedicine, Vol 47, Iss , Pp 301-

    2019  Volume 308

    Abstract: Background: Transmission of Mycobacterium leprae, the pathogen causing leprosy, is still persistent. To facilitate timely (prophylactic) treatment and reduce transmission it is vital to both early diagnose leprosy, and identify infected individuals ... ...

    Abstract Background: Transmission of Mycobacterium leprae, the pathogen causing leprosy, is still persistent. To facilitate timely (prophylactic) treatment and reduce transmission it is vital to both early diagnose leprosy, and identify infected individuals lacking clinical symptoms. However, leprosy-specific biomarkers are limited, particularly for paucibacillary disease. Therefore, our objective was to identify new biomarkers for leprosy and assess their applicability in point-of-care (POC) tests. Methods: Using multiplex-bead-arrays, 60 host-proteins were measured in a cross-sectional approach in 24-h whole blood assays (WBAs) collected in Bangladesh (79 patients; 54 contacts; 51 endemic controls (EC)). Next, 17 promising biomarkers were validated in WBAs of a separate cohort (55 patients; 27 EC). Finally, in a third cohort (36 patients; 20 EC), five candidate markers detectable in plasma were assessed for application in POC tests. Findings: This study identified three new biomarkers for leprosy (ApoA1, IL-1Ra, S100A12), and confirmed five previously described biomarkers (CCL4, CRP, IL-10, IP-10, αPGL-I IgM). Overnight stimulation in WBAs provided increased specificity for leprosy and was required for IL-10, IL-1Ra and CCL4. The remaining five biomarkers were directly detectable in plasma, hence suitable for rapid POC tests. Indeed, lateral flow assays (LFAs) utilizing this five-marker profile detected both multi- and paucibacillary leprosy patients with variable immune responses. Interpretation: Application of novel host-biomarker profiles to rapid, quantitative LFAs improves leprosy diagnosis and allows POC testing in low-resource settings. This platform can thus aid diagnosis and classification of leprosy and also provides a tool to detect M.leprae infection in large-scale contact screening in the field. Keywords: Biomarkers, Early diagnosis, Immune profiling, Lateral flow (LF), M.leprae, Upconverting reporter particles (UCP), User-friendly rapid test
    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610 ; 310
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Longitudinal assessment of anti-PGL-I serology in contacts of leprosy patients in Bangladesh.

    Renate A Richardus / Konrad van der Zwet / Anouk van Hooij / Louis Wilson / Linda Oskam / Roel Faber / Susan J F van den Eeden / David Pahan / Khorshed Alam / Jan Hendrik Richardus / Annemieke Geluk

    PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e

    2017  Volume 0006083

    Abstract: Despite elimination efforts, the number of Mycobacterium leprae (M. leprae) infected individuals who develop leprosy, is still substantial. Solid evidence exists that individuals living in close proximity to patients are at increased risk to develop ... ...

    Abstract Despite elimination efforts, the number of Mycobacterium leprae (M. leprae) infected individuals who develop leprosy, is still substantial. Solid evidence exists that individuals living in close proximity to patients are at increased risk to develop leprosy. Early diagnosis of leprosy in endemic areas requires field-friendly tests that identify individuals at risk of developing the disease before clinical manifestation. Such assays will simultaneously contribute to reduction of current diagnostic delay as well as transmission. Antibody (Ab) levels directed against the M.leprae-specific phenolic glycolipid I (PGL-I) represents a surrogate marker for bacterial load. However, it is insufficiently defined whether anti-PGL-I antibodies can be utilized as prognostic biomarkers for disease in contacts. Particularly, in Bangladesh, where paucibacillary (PB) patients form the majority of leprosy cases, anti-PGL-I serology is an inadequate method for leprosy screening in contacts as a directive for prophylactic treatment.Between 2002 and 2009, fingerstick blood from leprosy patients' contacts without clinical signs of disease from a field-trial in Bangladesh was collected on filter paper at three time points covering six years of follow-up per person. Analysis of anti-PGL-I Ab levels for 25 contacts who developed leprosy during follow-up and 199 contacts who were not diagnosed with leprosy, was performed by ELISA after elution of bloodspots from filter paper.Anti-PGL-I Ab levels at intake did not significantly differ between contacts who developed leprosy during the study and those who remained free of disease. Moreover, anti-PGL-I serology was not prognostic in this population as no significant correlation was identified between anti-PGL-I Ab levels at intake and the onset of leprosy.In this highly endemic population in Bangladesh, no association was observed between anti-PGL-I Ab levels and onset of disease, urging the need for an extended, more specific biomarker signature for early detection of leprosy in this ...
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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