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Article ; Online: Hand eczema leaves systemic traces.

Roesner, Lennart M / Wittmann, Miriam

2023 Volume 189, Issue 3, Page(s) e56–e59

MeSH term(s)	Humans ; Dermatitis, Atopic ; Eczema/drug therapy ; Patient Acuity ; Employment ; Plant Leaves
Language	English
Publishing date	2023-05-24
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljad178
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Article ; Online: Barrier defect in atopic dermatitis - possibilities and limits of basic skin therapy.

Roesner, Lennart M / Heratizadeh, Annice

Allergologie select

2021 Volume 5, Page(s) 287–292

Abstract: The increased permeability of the skin barrier towards environmental factors such as allergens is considered a key factor in the pathogenesis of atopic dermatitis (AD). Strengthening the skin barrier through basic skin therapy represents the basis of any ...

Abstract	The increased permeability of the skin barrier towards environmental factors such as allergens is considered a key factor in the pathogenesis of atopic dermatitis (AD). Strengthening the skin barrier through basic skin therapy represents the basis of any therapy for AD. It is well known that genetic factors as well as the skin inflammation itself contribute to the weakening of the barrier; here, recent studies have led to a deeper understanding of the complex structures of the epidermis. The possibility of counteracting the disease preventively by the use of basic skin therapy from birth on has been studied intensively in recent years. This article summarizes recent findings on the effects of basic skin therapy as a primary and secondary preventive measure.
Language	English
Publishing date	2021-08-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2893503-2
ISSN	2512-8957 ; 2512-8957
ISSN (online)	2512-8957
ISSN	2512-8957
DOI	10.5414/ALX02268E
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Article ; Online: Autoimmunity (or Not) in Atopic Dermatitis.

Roesner, Lennart M / Werfel, Thomas

Frontiers in immunology

2019 Volume 10, Page(s) 2128

Abstract: Atopic dermatitis (AD), one of the most frequent inflammatory skin diseases worldwide, is believed to result from a disturbed skin barrier as well as aberrant immune reactions ... ...

Abstract	Atopic dermatitis (AD), one of the most frequent inflammatory skin diseases worldwide, is believed to result from a disturbed skin barrier as well as aberrant immune reactions against
MeSH term(s)	Allergens/immunology ; Autoantibodies/immunology ; Autoimmunity ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/pathology ; Humans ; Immunoglobulin E/immunology ; Skin/immunology ; Skin/pathology
Chemical Substances	Allergens ; Autoantibodies ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2019-09-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02128
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Article ; Online: Inhibition of IL-17 ameliorates keratinocyte-borne cytokine responses in an in vitro model for house-dust-mite triggered atopic dermatitis.

Haertlé, Juliane / Kienlin, Petra / Begemann, Gabriele / Werfel, Thomas / Roesner, Lennart M

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16628

Abstract: A subgroup of patients suffering from atopic dermatitis (AD) does not respond to biologics therapy targeting the key players of type-2 inflammation, and it is an ongoing discussion whether skin-infiltrating Th17 cells may underlie this phenomenon. This ... ...

Abstract	A subgroup of patients suffering from atopic dermatitis (AD) does not respond to biologics therapy targeting the key players of type-2 inflammation, and it is an ongoing discussion whether skin-infiltrating Th17 cells may underlie this phenomenon. This study aimed to investigate the potential of allergen-induced, immune-cell derived IL-17 on the induction of inflammatory processes in keratinocytes. Peripheral blood mononuclear cells derived from respectively sensitized AD patients were stimulated with house dust mite (HDM) extract and cell culture supernatants were applied subsequently in absence or presence of secukinumab to primary human keratinocytes. Hereby we confirm that the immune response of sensitized AD patients to HDM contains aside from type-2 cytokines significant amounts of IL-17. Blocking IL-17 efficiently reduced the stimulation-induced changes in keratinocyte gene expression. IL-17-dependent transcriptional changes included increased expression of the cytokines IL-20 and IL-24 as well as Suppressor of Cytokine Siganling 3 (SOCS3), a negative feedback-regulator of the STAT3/IL-17/IL-24 immune response. We conclude that the immune response to HDM can induce pro-inflammatory cytokines from keratinocytes in AD, which in part is mediated via IL-17. Targeting IL-17 may turn out to be a reasonable alternative therapy in a subgroup of patients with moderate to severe AD and HDM sensitization.
MeSH term(s)	Animals ; Humans ; Allergens ; Cytokines/metabolism ; Dermatitis, Atopic ; Dermatophagoides pteronyssinus ; Interleukin-17/metabolism ; Keratinocytes/metabolism ; Leukocytes, Mononuclear/metabolism ; Pyroglyphidae
Chemical Substances	Allergens ; Cytokines ; Interleukin-17
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42595-z
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Article ; Online: Dupilumab strengthens herpes simplex virus type 1-specific immune responses in atopic dermatitis.

Traidl, Stephan / Harries, Leonard / Kienlin, Petra / Begemann, Gabriele / Roesner, Lennart M / Werfel, Thomas

The Journal of allergy and clinical immunology

2023 Volume 152, Issue 6, Page(s) 1460–1469.e5

Abstract: Background: Impaired virus clearance in a subgroup of atopic dermatitis (AD) patients can lead to severe herpes simplex virus (HSV) infections called eczema herpeticum (EH). We recently identified a type 2 skewed viral immune response in EH patients. ... ...

Abstract	Background: Impaired virus clearance in a subgroup of atopic dermatitis (AD) patients can lead to severe herpes simplex virus (HSV) infections called eczema herpeticum (EH). We recently identified a type 2 skewed viral immune response in EH patients. Clinical data suggest a reduced incidence of EH in AD patients treated with dupilumab, although immunologic investigations of this phenomenon are still lacking. Objective: We examined the impact of dupilumab on the HSV type 1 (HSV-1) specific immune response in AD, focusing on patients with (ADEH Methods: Sera and peripheral blood mononuclear cells were collected from ADEH Results: We confirmed that HSV-1-specific IgE is elevated in ADEH Conclusion: Dupilumab may improve the HSV-1-specific immune response in AD as a result of an increased type I immune response and a reduction of HSV-1-specific IgE.
MeSH term(s)	Humans ; Herpesvirus 1, Human ; Dermatitis, Atopic ; Leukocytes, Mononuclear ; CD8-Positive T-Lymphocytes ; Kaposi Varicelliform Eruption ; Cytokines ; Immunity ; Immunoglobulin E
Chemical Substances	dupilumab (420K487FSG) ; Cytokines ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2023.08.024
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Article ; Online: Eczema herpeticum in atopic dermatitis.

Traidl, Stephan / Roesner, Lennart / Zeitvogel, Jana / Werfel, Thomas

Allergy

2021 Volume 76, Issue 10, Page(s) 3017–3027

Abstract: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases leading to pruritic skin lesions. A subset of AD patients exhibits a disseminated severe HSV infection called eczema herpeticum (EH) that can cause life-threatening ... ...

Abstract	Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases leading to pruritic skin lesions. A subset of AD patients exhibits a disseminated severe HSV infection called eczema herpeticum (EH) that can cause life-threatening complications. This review gives an overview of the clinical picture, and characteristics of the patients as well as the diagnosis and therapy of EH. A special focus lies on the pathophysiological hallmarks identified so far that predispose for EH. This aspect covers genetic aberrations, immunological changes, and environmental influences displaying a complex multifactorial situation, which is not completely understood. Type 2 skewing of virus-specific T cells in ADEH
MeSH term(s)	Dermatitis, Atopic/epidemiology ; Eczema ; Humans ; Kaposi Varicelliform Eruption ; Microbiota ; Skin
Language	English
Publishing date	2021-05-03
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14853
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Article ; Online: The clinical impact of cross-reactions between allergens on allergic skin diseases.

Hoffmann-Sommergruber, Karin / Roesner, Lennart M

Current opinion in allergy and clinical immunology

2020 Volume 20, Issue 4, Page(s) 374–380

Abstract: Purpose of review: The route of allergen sensing via the skin appears to influence the immune system towards mounting a type 2 response, especially in genetically predisposed individuals. Allergens recognized this way may derive from microbial, animal, ... ...

Abstract	Purpose of review: The route of allergen sensing via the skin appears to influence the immune system towards mounting a type 2 response, especially in genetically predisposed individuals. Allergens recognized this way may derive from microbial, animal, food, or other plant sources and trigger atopic dermatitis. Allergens can be grouped into families depending on their structure and function, harboring significant structural and sequence similarities. Cross-reactivity between allergens is believed to arise as a consequence, and to underlie the development of further atopic diseases. Recent findings: Especially for the plant allergens of the families of PR10-related proteins and profilins, immune cross-reactions have been described. Actual studies support that food and pollen allergens can aggravate skin lesions in patients suffering from atopic dermatitis. Further on, allergens derived from air-borne or skin-borne fungi belong to common allergen families and bear cross-reactivity potential. Cross-reactivity to human homologous proteins, so-called autoallergens, is discussed to contribute to the chronification of atopic dermatitis. Summary: Due to high evolutionary conservation, allergic reactions can be triggered by highly homologous members of allergen families on the humoral as well as on the cellular level.
MeSH term(s)	Allergens/adverse effects ; Allergens/immunology ; Antigens, Fungal/immunology ; Antigens, Plant/adverse effects ; Antigens, Plant/immunology ; Aspergillus/immunology ; Chronic Disease ; Cross Reactions ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/microbiology ; Food Hypersensitivity/genetics ; Food Hypersensitivity/immunology ; Fungal Proteins/immunology ; Genetic Predisposition to Disease ; Humans ; Immunoglobulin E/immunology ; Malassezia/immunology ; Plant Proteins, Dietary/adverse effects ; Plant Proteins, Dietary/immunology ; Pollen/adverse effects ; Pollen/immunology ; Profilins/adverse effects ; Profilins/immunology ; Risk Factors ; Skin/immunology ; Skin/microbiology ; Skin/pathology
Chemical Substances	Allergens ; Antigens, Fungal ; Antigens, Plant ; Fungal Proteins ; Plant Proteins, Dietary ; Profilins ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000650
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Article ; Online: Dupilumab: An Opportunity to Unravel In Vivo Actions of IL-4 and IL-13 in Humans.

Roesner, Lennart M / Bridgewood, Charlie / McGonagle, Dennis / Wittmann, Miriam

The Journal of investigative dermatology

2021 Volume 141, Issue 8, Page(s) 1879–1881

Abstract: The application of biologics in clinical practice allows immunological observations under real-life conditions. In a new article in the Journal of Investigative Dermatology, Bakker et al. (2021) use deep immune cell phenotyping to demonstrate how ... ...

Abstract	The application of biologics in clinical practice allows immunological observations under real-life conditions. In a new article in the Journal of Investigative Dermatology, Bakker et al. (2021) use deep immune cell phenotyping to demonstrate how dupilumab acts in a targeted fashion on skin-homing T cells, the driver cells of atopic dermatitis.
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Humans ; Interleukin-13 ; Interleukin-4
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Interleukin-13 ; Interleukin-4 (207137-56-2) ; dupilumab (420K487FSG)
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2021.02.007
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Article ; Online: T-cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease.

Roesner, Lennart M / Farag, Ahmed K / Pospich, Rebecca / Traidl, Stephan / Werfel, Thomas

Allergy

2022 Volume 77, Issue 9, Page(s) 2737–2747

Abstract: Background: Atopic dermatitis (AD) and psoriasis represent two of the most common inflammatory skin diseases in developed countries. A hallmark of both diseases is T-cell infiltration into the skin. However, it is still not clarified to what extent ... ...

Abstract	Background: Atopic dermatitis (AD) and psoriasis represent two of the most common inflammatory skin diseases in developed countries. A hallmark of both diseases is T-cell infiltration into the skin. However, it is still not clarified to what extent these infiltrating T cells are antigen-specific skin-homing T cells or unspecific heterogeneous bystander cells. Methods: To elucidate this, T cells from lesional skin and from blood of 9 AD and 10 psoriasis patients were compared by receptor (TCR) sequencing. Therefore, peripheral blood mononuclear cells (PBMC) were cell-sorted according to expression of the cutaneous leukocyte antigen (CLA) into skin-homing (CLA Results: Intra-individual comparison of TCRB CDR3 regions revealed that clonally expanded T cells in skin lesions of both AD and psoriasis patients corresponded to skin-homing circulating T cells. However, in psoriasis patients, these T-cell clones were also detectable to a larger extent among CLA Conclusions: Our data show that in line with the systemic nature of psoriasis, T-cell clones that infiltrate psoriatic skin lesions do not exclusively possess skin-homing ability and are therefore most probably specific to antigens that are not exclusively expressed or located in the skin. T cells driving AD skin inflammation appear to home nearly exclusively to the skin and are, to a certain extent, specific to aeroallergens.
MeSH term(s)	Allergens ; Antigens, Differentiation, T-Lymphocyte ; Antigens, Neoplasm ; Dermatitis, Atopic ; Humans ; Leukocytes, Mononuclear/metabolism ; Membrane Glycoproteins ; Psoriasis ; Receptors, Antigen, T-Cell/genetics ; Receptors, Lymphocyte Homing
Chemical Substances	Allergens ; Antigens, Differentiation, T-Lymphocyte ; Antigens, Neoplasm ; Membrane Glycoproteins ; Receptors, Antigen, T-Cell ; Receptors, Lymphocyte Homing
Language	English
Publishing date	2022-03-14
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15272
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Article ; Online: Specific IgE against the house dust mite allergens Der p 5, 20 and 21 influences the phenotype and severity of atopic diseases

Walsemann, Theresa / Böttger, Marisa / Traidl, Stephan / Schwager, Christian / Gülsen, Askin / Freimooser, Sina / Roesner, Lennart Matthias / Werfel, Thomas / Jappe, Uta

Allergy. 2023 Mar., v. 78, no. 3, p. 731-742

2023 , Page(s) 731–742

Abstract: BACKGROUND: House dust mites (HDM) are among the most important sources for airborne allergens with high relevance for atopic diseases. Routine tests contain only 4 of 32 registered allergens of Dermatophagoides pteronyssinus. Clinical relevance and ... ...

Abstract	BACKGROUND: House dust mites (HDM) are among the most important sources for airborne allergens with high relevance for atopic diseases. Routine tests contain only 4 of 32 registered allergens of Dermatophagoides pteronyssinus. Clinical relevance and pathomechanistic properties of many allergens are not well understood. OBJECTIVE: The association of several HDM allergens with allergic rhinitis, allergic asthma, and atopic dermatitis was investigated to identify allergens with biomarker potential and to transfer them into diagnostics. METHODS: Eight out of nine D. pteronyssinus allergens (nDer p 1, rDer p 2, rDer p 5, rDer p 7, rDer p 10, rDer p 13, rDer p 20, rDer p 21, rDer p 23) were recombinantly expressed and purified. Sensitization patterns of 384 HDM‐allergic individuals exhibiting different clinical phenotypes were analyzed with a serum‐saving multiplex array. RESULTS: Sensitization to more than three mite allergens (sensitization count) was associated with allergic asthma and/or atopic dermatitis. Reactions to Der p 5 and Der p 21 were more frequent in allergic asthma compared to allergic rhinitis. Atopic dermatitis patients were more often sensitized to Der p 5, Der p 20, and Der p 21 among others. Der p 20‐IgE > 80 kU/L was associated with severe atopic dermatitis in 75% of patients. CONCLUSION: This study demonstrates the clinical importance of the sensitization count and of certain allergens (Der p 5, Der p 20, and Der p 21) not available for routine diagnostics yet. Implementing them as well as the sensitization count in diagnostic measures will improve diagnosis and risk assessment of HDM‐allergic patients.
Keywords	Dermatophagoides pteronyssinus ; allergic rhinitis ; asthma ; atopic dermatitis ; biomarkers ; diagnostic techniques ; dust ; dust mites ; phenotype ; risk assessment
Language	English
Dates of publication	2023-03
Size	p. 731-742.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15553
Database	NAL-Catalogue (AGRICOLA)

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