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Article ; Online: Bempedoïnezuur, nieuwe lipidenverlagende medicatie.

Oostindjer, Andrew / Roeters van Lennep, Jeanine E

2023 Volume 167

Abstract: Statins have been de cornerstone for the treatment of hyperlipidaemia for decades now. More recently the introduction of the PCSK9 inhibitors, inclisiran and even more recently bempedoic acid have given us new options for the treatment of hyperlipidaemia. ...

Title translation	Bempedoic acid, a new cholesterol-lowering agent.
Abstract	Statins have been de cornerstone for the treatment of hyperlipidaemia for decades now. More recently the introduction of the PCSK9 inhibitors, inclisiran and even more recently bempedoic acid have given us new options for the treatment of hyperlipidaemia. Bempedoic acid is a prodrug which is metabolized in the liver and not in the peripheral tissues like muscles, this means that myalgia does not occur as a side effect. Its effect on the cholesterol synthesis occurs earlier in the chain of events than that of statins which work primarily via HMGcoA reductase. Other than that is has more or less the same effect as a statin. Next to cholesterol lowering effect it has a dampening effect on inflammation another important link in atherosclerosis. Bempedoic acid is cheap making it the drug of choice after statins and ezetimibe.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Proprotein Convertase 9 ; Cholesterol ; Hyperlipidemias
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid (1EJ6Z6Q368) ; Cholesterol (97C5T2UQ7J)
Language	Dutch
Publishing date	2023-11-23
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Lipid metabolism during pregnancy: consequences for mother and child.

Mulder, Janneke W C M / Kusters, D Meeike / Roeters van Lennep, Jeanine E / Hutten, Barbara A

Current opinion in lipidology

2024 Volume 35, Issue 3, Page(s) 133–140

Abstract: Purpose of review: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of gestational hyperlipidemia on ... ...

Abstract	Purpose of review: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of gestational hyperlipidemia on cardiovascular risk for mother and child. This review aims to provide a comprehensive overview of the current research on lipid profile alterations during pregnancy and its associated (cardiovascular) outcomes for mother and child from a clinical perspective. Recent findings: In a normal pregnancy, total and LDL-cholesterol levels increase by approximately 30-50%, HDL-cholesterol by 20-40%, and triglycerides by 50-100%. In some women, for example, with familial hypercholesterolemia (FH), a more atherogenic lipid profile is observed. Dyslipidemia during pregnancy is found to be associated with adverse (cardiovascular) outcomes for the mother (e.g. preeclampsia, gestational diabetes, metabolic syndrome, unfavorable lipid profile) and for the child (e.g. preterm birth, large for gestational age, preatherosclerotic lesions, unfavorable lipid profile). Summary: The lipid profile of women during pregnancy provides a unique window of opportunity into the potential future cardiovascular risk for mother and child. Better knowledge about adverse outcomes and specific risk groups could lead to better risk assessment and earlier cardiovascular prevention. Future research should investigate implementation of gestational screening possibilities.
MeSH term(s)	Humans ; Pregnancy ; Female ; Lipid Metabolism ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/blood ; Pregnancy Complications/metabolism ; Pregnancy Complications/blood ; Child ; Lipids/blood
Chemical Substances	Lipids
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1045394-5
ISSN	1473-6535 ; 0957-9672
ISSN (online)	1473-6535
ISSN	0957-9672
DOI	10.1097/MOL.0000000000000927
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Zs.A 3010: Show issues

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Article ; Online: Sex Differences in Familial Hypercholesterolemia.

Klevmoen, Marianne / Mulder, Janneke W C M / Roeters van Lennep, Jeanine E / Holven, Kirsten B

Current atherosclerosis reports

2023 Volume 25, Issue 11, Page(s) 861–868

Abstract: Purpose of review: This review aims to summarize the existing research on sex differences in familial hypercholesterolemia (FH) across the lifespan.: Recent findings: From childhood onward, total- and low-density lipoprotein cholesterol (LDL-C) ... ...

Abstract	Purpose of review: This review aims to summarize the existing research on sex differences in familial hypercholesterolemia (FH) across the lifespan. Recent findings: From childhood onward, total- and low-density lipoprotein cholesterol (LDL-C) levels in girls are higher than those in boys with FH. By the age of 30 years, women with FH have a higher LDL-C burden than men. In adulthood, women are diagnosed later than men, receive less lipid-lowering treatment, and consequently have higher LDL-C levels. An excessive atherosclerotic cardiovascular disease risk is reported in young female compared to male FH patients. The periods of pregnancy and breastfeeding contribute to treatment loss and increased cholesterol burden. Earlier initiation of treatment, especially in girls with FH, and lifelong treatment during all life stages are important. Future research should aim to recruit both women and men, report sex-specific data, and investigate the impact of the female life course on cardiovascular outcomes. Future guidelines should include sex-specific aspects.
MeSH term(s)	Female ; Humans ; Male ; Child ; Adult ; Cholesterol, LDL ; Sex Characteristics ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/epidemiology ; Hyperlipoproteinemia Type II/genetics ; Atherosclerosis/epidemiology ; Atherosclerosis/etiology
Chemical Substances	Cholesterol, LDL
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2057369-8
ISSN	1534-6242 ; 1523-3804
ISSN (online)	1534-6242
ISSN	1523-3804
DOI	10.1007/s11883-023-01155-6
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Zs.A 5534: Show issues

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Article ; Online: Sex differences in efficacy and safety of PCSK9 monoclonal antibodies: A real-world registry.

Galema-Boers, Annette M H / Mulder, Janneke W C M / Steward, Kim / Roeters van Lennep, Jeanine E

Atherosclerosis

2023 Volume 384, Page(s) 117108

Abstract: Background and aims: Proprotein convertase subtilisin/kexin 9 monoclonal antibodies (PCSK9 mAbs) reduce low-density lipoprotein (LDL-c) with a favourable safety profile. Available data from PCSK9 antibody trials suggest LDL-c reduction is lower in women ...

Abstract	Background and aims: Proprotein convertase subtilisin/kexin 9 monoclonal antibodies (PCSK9 mAbs) reduce low-density lipoprotein (LDL-c) with a favourable safety profile. Available data from PCSK9 antibody trials suggest LDL-c reduction is lower in women compared to men. Data in real-world setting is scarce. The aim of this study was to assess sex differences in efficacy and safety of PCSK9 antibodies in clinical care. Methods: All patients starting with evolocumab or alirocumab in our lipid clinic were included in a prospective registry. We collected clinical information, including baseline and follow-up mean LDL-C levels after initiation of PCSK9 mAbs treatment. In addition, side effects and PCSK9 mAbs discontinuation were recorded. Results: We analysed 436 patients (209 women), mean age 58 ± 11 years. Women had higher baseline LDL-c levels compared to men (4.7 ± 1.6 mmol/L vs 4.1 ± 1.4 mmol/L, p < 0.01). PCSK9 mAbs resulted in less relative LDL-c reduction in women compared to men (50% vs 61% p<0.01), but equal absolute LDL-c reduction (respectively 2.3 ± 1.3 mmol/L vs 2.5 ± 1.1 mmol/L, p = 0.087). Women less often reached LDL-c target levels than men (50% vs 72%). No sex differences were observed in reporting of side effects (women 32% vs men 27% p = 0.26) or PCSK9 mAbs discontinuation (women 13% vs men 10%, p = 0.46). Conclusions: In clinical practice, PCSK9 mAbs are less effective in reducing LDL-c levels in women compared to men and equally safe, implying the importance of sex differences in PCSK9 metabolism.
MeSH term(s)	Humans ; Female ; Male ; Middle Aged ; Aged ; Antibodies, Monoclonal/adverse effects ; Proprotein Convertase 9/metabolism ; Cholesterol, LDL ; Sex Characteristics ; PCSK9 Inhibitors ; Subtilisins ; Registries ; Anticholesteremic Agents/adverse effects
Chemical Substances	Antibodies, Monoclonal ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Cholesterol, LDL ; PCSK9 Inhibitors ; Subtilisins (EC 3.4.21.-) ; Anticholesteremic Agents
Language	English
Publishing date	2023-03-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2023.03.013
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Zs.A 226: Show issues

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Article ; Online: Influence of sex and gender on the biology of atherosclerotic cardiovascular disease: Special issue.

Osto, Elena / Roeters van Lennep, Jeanine E / Tokgözoğlu, Lale / Öörni, Katariina

Atherosclerosis

2023 Volume 384, Page(s) 117297

MeSH term(s)	Male ; Female ; Humans ; Cardiovascular Diseases/epidemiology ; Atherosclerosis/epidemiology ; Risk Factors ; Biology ; Sex Factors
Language	English
Publishing date	2023-10-07
Publishing country	Ireland
Document type	Editorial
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2023.117297
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Zs.A 226: Show issues

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Article: First clinical experiences with inclisiran in a real-world setting.

Mulder, Janneke W C M / Galema-Boers, Annette M H / Roeters van Lennep, Jeanine E

Journal of clinical lipidology

2023 Volume 17, Issue 6, Page(s) 818–827

Abstract: Background and objective: Inclisiran is the first-in-class small interfering RNA (siRNA) proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor. In clinical trials inclisiran showed effective and sustained low-density lipoprotein cholesterol ( ... ...

Abstract	Background and objective: Inclisiran is the first-in-class small interfering RNA (siRNA) proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor. In clinical trials inclisiran showed effective and sustained low-density lipoprotein cholesterol (LDL-C) reduction of ± 50 %. As data in clinical setting are scarce, we aim to investigate the efficacy and safety in clinical practice. Methods: We describe a registry of consecutive patients who started with inclisiran at a lipid clinic of a university hospital. Patients were eligible if they fulfilled the reimbursement criteria in the Netherlands. Patients were included if they started with inclisiran as first line (group 1) or switched from PCSK9 monoclonal antibody (mAbs) to inclisiran (group 2). LDL-C levels were measured at 3 and 9 months after initiation of inclisiran. Median change of LDL-C levels was calculated on an individual and group level. Results: We analysed 65 patients (36 women), median [25 Conclusion: Our initial experience of inclisiran in a clinical setting showed less reduction in LDL-C levels compared to clinical trials but a similar safety profile. Moreover, patients who switched from PCSK9 mAbs to inclisiran generally showed an increase in LDL-C levels implying that inclisiran is less potent in LDL-C reduction compared to PCSK9 mAbs.
MeSH term(s)	Humans ; Female ; Cholesterol, LDL ; Proprotein Convertase 9 ; RNA, Small Interfering/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Anticholesteremic Agents/therapeutic use
Chemical Substances	Cholesterol, LDL ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; ALN-PCS ; RNA, Small Interfering ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Anticholesteremic Agents
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2023.09.005
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Article ; Online: Advancing Sex and Gender Considerations in Perioperative Cardiovascular-Risk Assessment.

Nerenberg, Kara A / Roeters van Lennep, Jeanine E

The Canadian journal of cardiology

2021 Volume 37, Issue 12, Page(s) 1912–1914

MeSH term(s)	Cardiovascular System ; Humans ; Perioperative Care ; Risk Assessment
Language	English
Publishing date	2021-08-28
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2021.08.011
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Zs.A 2150: Show issues

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Article ; Online: Why women are not small men.

Roeters van Lennep, Jeanine E

Maturitas

2018 Volume 107, Page(s) A3–A4

Language	English
Publishing date	2018-01
Publishing country	Ireland
Document type	Editorial
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2017.09.008
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Zs.A 1432: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Spotlight on Cardiovascular Risk Assessment in Patients with Inflammatory Bowel Disease.

Sleutjes, Jasmijn A M / Roeters van Lennep, Jeanine E / de Vries, Annemarie C

Digestive diseases and sciences

2022 Volume 67, Issue 9, Page(s) 4326–4329

MeSH term(s)	Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Heart Disease Risk Factors ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-022-07449-0
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Ui V Zs.35: Show issues

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Article ; Online: Effects of menstruation on the onset of acute coronary syndrome in premenopausal women: A case series.

van der Bijl, Marte F / Sunamura, Madoka / Ter Hoeve, Nienke / Schreuder, Michelle M / Lenzen, Mattie J / Roeters van Lennep, Jeanine E

Case reports in women's health

2023 Volume 37, Page(s) e00486

Abstract: Background: The incidence of cardiovascular disease (CVD) among women is lower before the menopause, which may be due to the atheroprotective effects of female sex hormones, including estrogens. This study explored whether women experienced acute ... ...

Abstract	Background: The incidence of cardiovascular disease (CVD) among women is lower before the menopause, which may be due to the atheroprotective effects of female sex hormones, including estrogens. This study explored whether women experienced acute coronary syndrome (ACS) more often during menstruation, when the levels of female sex hormones are low. Methods: All premenopausal women referred to the local cardiac rehabilitation program after ACS between August 2010 and September 2018 were contacted by telephone to gather information about their menstrual cycle, contraceptive use and whether ACS occurred during menstruation. Information on cardiovascular risk factors was collected using the clinical electronic health record. Results: Of the 22 women fulfilling the inclusion criteria and having a regular menstrual cycle, 22.7% reported that they were diagnosed with ACS at the time of menstruation. Conclusions: The percentage of women who were menstruating whilst having their cardiovascular event is higher than the percentage expected if the event was unrelated to the menstrual cycle. To gain more insight into the effect of female sex hormones on ACS, it is suggested that information on the menstrual cycle is routinely collected from women admitted to hospital with the condition.
Language	English
Publishing date	2023-02-13
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2800286-6
ISSN	2214-9112 ; 2214-9112
ISSN (online)	2214-9112
ISSN	2214-9112
DOI	10.1016/j.crwh.2023.e00486
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