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Article: Syphilitic hepatitis.

Supronowicz, Łukasz / Rogalska, Magdalena

2024 Volume 10, Issue 1, Page(s) 9–13

Abstract: Syphilis is a sexually transmitted multisystemic disease known as "the great imitator" due to its variable presentations. Despite being preventable and curable, it still constitutes a major health problem. Hepatic manifestation of syphilis is usually ... ...

Abstract	Syphilis is a sexually transmitted multisystemic disease known as "the great imitator" due to its variable presentations. Despite being preventable and curable, it still constitutes a major health problem. Hepatic manifestation of syphilis is usually mild cholestatic liver injury but in very rare cases can become fulminant. Moreover, syphilitic hepatitis, known for several decades, is considered rare but is probably under-diagnosed. Given the significant morbidity associated with a missed diagnosis, syphilitic hepatitis should be taken into account as an element of differential diagnosis in patients with unexplained elevation of liver enzymes.
Language	English
Publishing date	2024-03-12
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2937940-4
ISSN	2449-8238 ; 2392-1099
ISSN (online)	2449-8238
ISSN	2392-1099
DOI	10.5114/ceh.2024.136235
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Article ; Online: The Role of Th17 Response in COVID-19.

Martonik, Diana / Parfieniuk-Kowerda, Anna / Rogalska, Magdalena / Flisiak, Robert

Cells

2021 Volume 10, Issue 6

Abstract: COVID-19 is an acute infectious disease of the respiratory system caused by infection with the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission of SARS-CoV-2 infections occurs through droplets and contaminated objects. A ... ...

Abstract	COVID-19 is an acute infectious disease of the respiratory system caused by infection with the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission of SARS-CoV-2 infections occurs through droplets and contaminated objects. A rapid and well-coordinated immune system response is the first line of defense in a viral infection. However, a disturbed and over-activated immune response may be counterproductive, causing damage to the body. Severely ill patients hospitalised with COVID-19 exhibit increased levels of many cytokines, including Interleukin (IL)-1β, IL-2, IL-6, IL-7, IL-8, IL-10, IL-17, granulocyte colony stimulating factor (G-CSF), monocyte chemoattractant protein 1 (MCP-1) and tumor necrosis factor (TNF). Increasing evidence suggests that Th17 cells play an important role in the pathogenesis of COVID-19, not only by activating cytokine cascade but also by inducing Th2 responses, inhibiting Th1 differentiation and suppressing Treg cells. This review focuses on a Th17 pathway in the course of the immune response in COVID-19, and explores plausible targets for therapeutic intervention.
MeSH term(s)	COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Cytokines/metabolism ; Humans ; Immunity, Cellular/physiology ; Immunotherapy, Adoptive/methods ; SARS-CoV-2/immunology ; Th17 Cells/metabolism ; Th17 Cells/physiology
Chemical Substances	Cytokines
Language	English
Publishing date	2021-06-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10061550
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Article: Rotational Thromboelastometry (ROTEM

Rogalski, Pawel / Rogalska, Magdalena / Martonik, Diana / Rusak, Malgorzata / Pawlus, Joanna / Chociej-Stypulkowska, Joanna / Dabrowska, Milena / Flisiak, Robert

Journal of clinical medicine

2023 Volume 12, Issue 12

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12123919
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Article: Change in the Clinical Picture of Hospitalized Patients with COVID-19 between the Early and Late Period of Dominance of the Omicron SARS-CoV-2 Variant.

Flisiak, Robert / Zarębska-Michaluk, Dorota / Dobrowolska, Krystyna / Rorat, Marta / Rogalska, Magdalena / Kryńska, Justyna Anna / Moniuszko-Malinowska, Anna / Czupryna, Piotr / Kozielewicz, Dorota / Jaroszewicz, Jerzy / Sikorska, Katarzyna / Bednarska, Agnieszka / Piekarska, Anna / Rzymski, Piotr

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: This study aimed to compare the clinical picture of COVID-19 in the initial and later period of Omicron dominance and to identify populations still at risk. A retrospective comparison of the clinical data of 965 patients hospitalized during the early ... ...

Abstract	This study aimed to compare the clinical picture of COVID-19 in the initial and later period of Omicron dominance and to identify populations still at risk. A retrospective comparison of the clinical data of 965 patients hospitalized during the early period of Omicron's dominance (EO, January-June 2022) with 897 patients from a later period (LO, July 2022-April 2023) from the SARSTer database was performed. Patients hospitalized during LO, compared to EO, were older, had a better clinical condition on admission, had a lower need for oxygen and mechanical ventilation, had less frequent lung involvement in imaging, and showed much faster clinical improvement. Moreover, the overall mortality during EO was 14%, higher than that in LO-9%. Despite the milder course of the disease, mortality exceeding 15% was similar in both groups among patients with lung involvement. The accumulation of risk factors such as an age of 60+, comorbidities, lung involvement, and oxygen saturation <90% resulted in a constant need for oxygen in 98% of patients, an 8% risk of mechanical ventilation, and a 30% mortality rate in the LO period. Multiple logistic regression revealed lower odds of death during the LO phase. Despite the milder course of infections caused by the currently dominant subvariants, COVID-19 prophylaxis is necessary in people over 60 years of age, especially those with comorbidities, and in the case of pneumonia and respiratory failure.
Language	English
Publishing date	2023-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175572
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Article ; Online: Variability in the Clinical Course of COVID-19 in a Retrospective Analysis of a Large Real-World Database.

Flisiak, Robert / Rzymski, Piotr / Zarębska-Michaluk, Dorota / Ciechanowski, Przemysław / Dobrowolska, Krystyna / Rogalska, Magdalena / Jaroszewicz, Jerzy / Szymanek-Pasternak, Anna / Rorat, Marta / Kozielewicz, Dorota / Kowalska, Justyna / Dutkiewicz, Ewa / Sikorska, Katarzyna / Moniuszko-Malinowska, Anna

Viruses

2023 Volume 15, Issue 1

Abstract: The COVID-19 pandemic proceeds in waves, with variable characteristics of the clinical picture resulting from the evolution of the SARS-CoV-2 virus. This study aimed to compare the epidemiological characteristics, symptomatology, and outcomes of the ... ...

Abstract	The COVID-19 pandemic proceeds in waves, with variable characteristics of the clinical picture resulting from the evolution of the SARS-CoV-2 virus. This study aimed to compare the epidemiological characteristics, symptomatology, and outcomes of the disease in patients hospitalized for COVID-19 during periods of different variants dominance. Comparing the periods of dominance of variants preceding the Delta variant, the Delta period was characterized by a higher share of hospitalized females, less frequent comorbidities among patients, and a different age distribution. The lowest need for oxygen therapy and mechanical ventilation was observed under Omicron dominance. The triad of classic COVID-19 symptoms, cough, fever, dyspnoea, and fatigue, were most prevalent during the Delta period, and significantly less common under the Omicron dominance. During the Omicron period, nearly twice as many patients as in the previous periods could be discharged from the hospital within 7 days; the overall 28-day mortality was significantly lower compared to that of the Delta period. It also did not differ between periods that were dominated by the BA.1 and BA.2 subvariants. The study indicates that the Omicron SARS-CoV-2 variant that dominated between January and June 2022 caused a disease which resembled the common cold, and was caused by seasonal alpha and beta-coronaviruses with a low pathogenicity for humans. However, one should note that this effect may not only have been related to biological features of the Omicron lineage, but may additionally have been driven by the increased levels of immunization through natural infections and vaccinations, for which we could not account for due to a lack of sufficient data.
MeSH term(s)	Female ; Humans ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Pandemics ; Retrospective Studies ; Disease Progression
Language	English
Publishing date	2023-01-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15010149
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Article: Retrospective Analysis of the Effectiveness of Remdesivir in COVID-19 Treatment during Periods Dominated by Delta and Omicron SARS-CoV-2 Variants in Clinical Settings.

Dobrowolska, Krystyna / Zarębska-Michaluk, Dorota / Brzdęk, Michał / Rzymski, Piotr / Rogalska, Magdalena / Moniuszko-Malinowska, Anna / Kozielewicz, Dorota / Hawro, Marcin / Rorat, Marta / Sikorska, Katarzyna / Jaroszewicz, Jerzy / Kowalska, Justyna / Flisiak, Robert

Journal of clinical medicine

2023 Volume 12, Issue 6

Abstract: Continuous evaluation of real-world treatment effectiveness of COVID-19 medicines is required due to the ongoing evolution of SARS-CoV-2 and the possible emergence of resistance. Therefore, this study aimed to analyze, in a retrospective manner, the ... ...

Abstract	Continuous evaluation of real-world treatment effectiveness of COVID-19 medicines is required due to the ongoing evolution of SARS-CoV-2 and the possible emergence of resistance. Therefore, this study aimed to analyze, in a retrospective manner, the outcomes in patients hospitalized with COVID-19 during the pandemic waves dominated by Delta and Omicron variants and treated with remdesivir (RDV) (
Language	English
Publishing date	2023-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12062371
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Article ; Online: Differences between the course of SARS-CoV-2 infections in the periods of the Delta and Omicron variant dominance in Poland.

Dobrowolska, Krystyna / Brzdęk, Michał / Zarębska-Michaluk, Dorota / Rzymski, Piotr / Rogalska, Magdalena / Moniuszko-Malinowska, Anna / Szymanek-Pasternak, Anna / Jaroszewicz, Jerzy / Dutkiewicz, Ewa / Kowalska, Justyna / Sikorska, Katarzyna / Flisiak, Robert

Polish archives of internal medicine

2023 Volume 133, Issue 5

Abstract: Introduction: Up to now, COVID‑19 caused more than 6 million deaths worldwide. So far, 5 variants of concerns have been identified, with Delta and Omicron being the subject of our analysis.: Objectives: We aimed to compare baseline characteristics ... ...

Abstract	Introduction: Up to now, COVID‑19 caused more than 6 million deaths worldwide. So far, 5 variants of concerns have been identified, with Delta and Omicron being the subject of our analysis. Objectives: We aimed to compare baseline characteristics and outcomes of patients hospitalized during the Delta and Omicron predominance in Poland. Patients and methods: The study population consisted of 2225 patients divided into 2 groups depending on the variant with which they were infected during the corresponding period of the pandemic. Results: During the Delta wave, the median age of patients was significantly lower (65 vs 73 years; P <0.001), and the cohort was significantly less burdened with comorbidities than during the Omicron surge. The Omicron‑infected patients presented significantly less often in an unstable symptomatic state with SpO2 equal to or below 90% on admission (49.9% for Delta vs 29.9% for Omicron; P <0.001). Regardless of the pandemic period, the 2 most common early symptoms of COVID‑19 were fever and cough. In‑hospital treatment consisted of antiviral drugs, more frequently used in the Omicron wave, and immunomodulatory drugs, more frequently used during the Delta wave. The risk of mechanical ventilation was significantly lower in the patients infected with the Omicron variant (7.2% for Delta vs 3.1% for Omicron; P <0.001). For the age group above 80 years old, the risk of death was significantly higher during the Delta wave than during the Omicron wave. The risk of death was significantly lower in the patients treated with antiviral drugs regardless of the pandemic wave. Conclusions: The Delta variant is associated with a more severe clinical course of the disease and a higher risk of death than the Omicron variant.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; COVID-19 ; Poland ; SARS-CoV-2 ; Antiviral Agents
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-01-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16403
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Article ; Online: Short-term exposure to ambient air pollution and COVID-19 severity during SARS-CoV-2 Delta and Omicron waves: A multicenter study.

Poniedziałek, Barbara / Rzymski, Piotr / Zarębska-Michaluk, Dorota / Rogalska, Magdalena / Rorat, Marta / Czupryna, Piotr / Kozielewicz, Dorota / Hawro, Marcin / Kowalska, Justyna / Jaroszewicz, Jerzy / Sikorska, Katarzyna / Flisiak, Robert

Journal of medical virology

2023 Volume 95, Issue 7, Page(s) e28962

Abstract: Air pollution may affect the clinical course of respiratory diseases, including COVID-19. This study aimed to evaluate the relationship between exposure of adult patients to mean 24 h levels of particulate matter sized <10 μm ( ... ...

Abstract	Air pollution may affect the clinical course of respiratory diseases, including COVID-19. This study aimed to evaluate the relationship between exposure of adult patients to mean 24 h levels of particulate matter sized <10 μm (PM
MeSH term(s)	Adult ; Humans ; SARS-CoV-2 ; COVID-19 ; Environmental Exposure ; Air Pollution/adverse effects ; Air Pollution/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Disease Progression
Chemical Substances	Particulate Matter
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28962
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Article: Chronic hepatitis B virus infection is associated with decreased serum 25(OH)D concentration in non-cirrhotic patients.

Parfieniuk-Kowerda, Anna / Świderska, Magdalena / Rogalska, Magdalena / Maciaszek, Magdalena / Jaroszewicz, Jerzy / Flisiak, Robert

Clinical and experimental hepatology

2019 Volume 5, Issue 1, Page(s) 75–80

Abstract: Aim of the study: Recent reports provide evidence for the immunomodulatory properties of vitamin D. Decreased vitamin D levels may contribute to the progression of liver disease in hepatitis B virus (HBV) infection. This study aims to assess serum 25(OH) ...

Abstract	Aim of the study: Recent reports provide evidence for the immunomodulatory properties of vitamin D. Decreased vitamin D levels may contribute to the progression of liver disease in hepatitis B virus (HBV) infection. This study aims to assess serum 25(OH)D in patients with chronic HBeAg-negative HBV (CHB) infection at different phases of disease. Material and methods: Fifty-eighty patients with CHB, 10 with a history of HBsAg/anti-HBs seroconversion, were enrolled. The control group consisted of 9 healthy volunteers. Serum 25(OH)D concentration was assessed by ELISA. Results: Serum 25(OH)D concentration was significantly lower in the CHB group in comparison to the HC group. It did not differ across the consecutive phases of the HBeAg-negative HBV infection. Negative correlations between serum 25(OH)D and alanine aminotransferase (ALT) as well as frequency of peripheral blood monocytes were observed. Serum 25(OH)D in samples collected in winter was significantly lower in comparison to the pool of samples collected in the summer. Serum 25(OH)D concentration was not associated with the phases of HBV-infection, HBV viral load, APRI or liver histology. Conclusions: Serum 25(OH)D is significantly decreased in HBV infection irrespectively of the phase of the infection and negatively correlates with serum ALT level, which may reflect the deterioration of liver function. Based on our results, we can conclude that the role of vitamin D in the immune control of HBV infection is probably irrelevant.
Language	English
Publishing date	2019-02-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2937940-4
ISSN	2449-8238 ; 2392-1099
ISSN (online)	2449-8238
ISSN	2392-1099
DOI	10.5114/ceh.2019.83160
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Article ; Online: Correction: Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance.

Flisiak, Robert / Zarębska-Michaluk, Dorota / Rogalska, Magdalena / Kryńska, Justyna Anna / Kowalska, Justyna / Dutkiewicz, Ewa / Dobrowolska, Krystyna / Jaroszewicz, Jerzy / Moniuszko-Malinowska, Anna / Rorat, Marta / Podlasin, Regina / Tronina, Olga / Rzymski, Piotr

Pharmacological reports : PR

2022 Volume 74, Issue 6, Page(s) 1328

Language	English
Publishing date	2022-10-03
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2186248-5
ISSN	2299-5684 ; 1734-1140
ISSN (online)	2299-5684
ISSN	1734-1140
DOI	10.1007/s43440-022-00419-3
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