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Article: The subthalamic nucleus contributes causally to perceptual decision-making in monkeys.

Rogers, Kathryn / Gold, Joshua I / Ding, Long

bioRxiv : the preprint server for biology

2024

Abstract: The subthalamic nucleus (STN) plays critical roles in the motor and cognitive function of the basal ganglia (BG), but the exact nature of these roles is not fully understood, especially in the context of decision-making based on uncertain evidence. ... ...

Abstract	The subthalamic nucleus (STN) plays critical roles in the motor and cognitive function of the basal ganglia (BG), but the exact nature of these roles is not fully understood, especially in the context of decision-making based on uncertain evidence. Guided by theoretical predictions of specific STN contributions, we used single-unit recording and electrical microstimulation in the STN of healthy monkeys to assess its causal, computational roles in visual-saccadic decisions based on noisy evidence. The recordings identified subpopulations of STN neurons with distinct task-related activity patterns that related to different theoretically predicted functions. Microstimulation caused changes in behavioral choices and response times that reflected multiple contributions to an "accumulate-to-bound"-like decision process, including modulation of decision bounds and evidence accumulation, and to non-perceptual processes. These results provide new insights into the multiple ways that the STN can support higher brain function.
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.09.588715
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Article ; Online: Does non-implanted electrical stimulation reduce post-stroke urinary or fecal incontinence? A systematic review with meta-analysis.

Cruz, Enrique / Miller, Charne / Zhang, WenWen / Rogers, Kathryn / Lee, Hsiu-Ju / Wells, Yvonne / Cloud, Geoffrey C / Lannin, Natasha A

International journal of stroke : official journal of the International Stroke Society

2021 Volume 17, Issue 4, Page(s) 378–388

Abstract: Background: Urinary and fecal incontinence are disabling impairments after stroke that can be clinically managed with electrical stimulation.: Aim: The purpose of this systematic review was to determine the effectiveness of non-implanted electrical ... ...

Abstract	Background: Urinary and fecal incontinence are disabling impairments after stroke that can be clinically managed with electrical stimulation. Aim: The purpose of this systematic review was to determine the effectiveness of non-implanted electrical stimulation to reduce the severity of post-stroke incontinence. Summary of review: Clinical trials of non-implanted electrical stimulation applied for the purposes of treating post-stroke incontinence were searched in MEDLINE, EMBASE, CINAHL, PEDro, and CENTRAL. From a total of 5043 manuscripts, 10 trials met the eligibility criteria ( Conclusions: Published trials evaluating the effect of non-implanted electrical stimulation on post-stroke incontinence are few and heterogenous. Synthesized trials suggest that early and frequent treatment using electrical stimulation is probably more effective than sham or no treatment. Further trials measuring incontinence in an objective manner are required.
MeSH term(s)	Electric Stimulation ; Electric Stimulation Therapy ; Fecal Incontinence/etiology ; Fecal Incontinence/therapy ; Humans ; Stroke/complications ; Stroke/therapy
Language	English
Publishing date	2021-04-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2303728-3
ISSN	1747-4949 ; 1747-4930
ISSN (online)	1747-4949
ISSN	1747-4930
DOI	10.1177/17474930211006301
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Book ; Thesis: Beobachtungen zum klinischen Verlauf von bakteriellen Meningitiden unter Beruecksichtigung aetiologischer Kriterien

Eisermann-Rogers, Kathryn

1983

Language	German
Size	83 S.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Muenchen, Univ., Diss., 1983
HBZ-ID	HT002665005
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Article ; Online: Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain.

Schultz, Terry Wayne / Rogers, Kathryn / Aptula, Aynur Osman

Contact dermatitis

2009 Volume 60, Issue 1, Page(s) 21–31

Abstract: Background: Eliminating animal testing for skin sensitization is a significant challenge in consumer safety risk assessment. To be able to perform resilient risk assessments in the future, one will need alternative approaches to fill the data gaps.: ... ...

Abstract	Background: Eliminating animal testing for skin sensitization is a significant challenge in consumer safety risk assessment. To be able to perform resilient risk assessments in the future, one will need alternative approaches to fill the data gaps. Objectives: To this end, we propose a subcategory-based read-across approach to estimate and rank skin sensitization potential of chemicals. The example described here is for the mechanism of Michael-type nucleophilic addition with subcategories being limited to carbonyl-containing compounds. Patients/methods: In this approach, in silico tools based on structural alerts were used to determine both the mechanism of protein binding and the relative subcategories within that mechanism. Results: Fifty compounds previously evaluated in the in vivo mouse local lymph node assay (LLNA) were placed in 10 subcategories defined by their polarized alpha,beta-unsaturated substructure. To offset the limitations and skewness of the published in vivo data, in chemico glutathione (GSH) depletion data also were included. Conclusions: It was shown that the read-across approach can be successfully used to rank qualitatively skin sensitization potential of an untested carbonyl-containing Michael acceptor chemical by using subcategories. Moreover, the use of the more resilient in chemico GSH depletion data added further support to the read-across result.
MeSH term(s)	Animal Testing Alternatives/methods ; Animals ; Catalytic Domain ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/immunology ; Dermatitis, Irritant/diagnosis ; Dermatitis, Irritant/immunology ; Disease Models, Animal ; Glutathione/immunology ; Glutathione/toxicity ; Guinea Pigs ; Humans ; Immunization/methods ; Irritants/toxicity ; Local Lymph Node Assay ; Mice ; Models, Chemical ; Protein Binding/immunology ; Risk Factors ; Sensitivity and Specificity ; Severity of Illness Index ; Skin Irritancy Tests/methods ; Toxicity Tests/methods
Chemical Substances	Irritants ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2009-01
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/j.1600-0536.2008.01473.x
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Article ; Online: Violence and Its Impact on the Emergency Nurse.

Wolf, Lisa / Perhats, Cydne / Delao, Altair / Brim, Carla B / Gentry, Judith Carol / Leaver, Sue L / Papa, AnnMarie R / Proud, Matthew Edward / Riwitis, Cheryl Lynn / Rogers, Kathryn Starr / Stone, Elizabeth L / Uhlenbrock, Jennifer Schieferle / Winger, Justin / Zaleski, Mary Ellen / Lee Gillespie, Gordon / Kolbuk, Monica Escalante

Journal of emergency nursing

2020 Volume 46, Issue 3, Page(s) 354–358

MeSH term(s)	Emergency Nursing ; Emergency Service, Hospital ; Humans ; Occupational Health ; Societies, Nursing ; United States ; Workplace Violence
Language	English
Publishing date	2020-05-08
Publishing country	United States
Document type	Journal Article ; Practice Guideline
ZDB-ID	604632-0
ISSN	1527-2966 ; 0099-1767
ISSN (online)	1527-2966
ISSN	0099-1767
DOI	10.1016/j.jen.2020.01.005
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Article ; Online: Biochemical investigation is no substitute for clinical examination!

Rogers, Kathryn L A / Date, Ravindra S / Ward, Jeremy B

JOP : Journal of the pancreas

2008 Volume 9, Issue 2, Page(s) 209–211

Abstract: Context: Toxic shock syndrome has been shown previously to be associated with hyperamylasaemia. However, serum amylase levels do not usually exceed three times upper limit of normal in these cases.: Case report: We report a case of a young girl of 17 ...

Abstract	Context: Toxic shock syndrome has been shown previously to be associated with hyperamylasaemia. However, serum amylase levels do not usually exceed three times upper limit of normal in these cases. Case report: We report a case of a young girl of 17 years who presented with upper abdominal pain, severe shock and raised serum amylase level of 3,898 U/L, giving an impression of severe acute pancreatitis. It was only after finding a tampon in her vagina, and subsequently growing Staphylococcus aureus in her blood cultures, did the diagnosis of toxic shock syndrome become apparent. She recovered fully with supportive treatment and appropriate antibiotics. Conclusions: Toxic shock syndrome with such a high level of serum amylase has not been previously reported. This case exemplifies the importance of repeated clinical evaluation of patients in this era of multiple investigations, and not simply relying on biochemical values for diagnosis.
MeSH term(s)	Adolescent ; Amylases/blood ; Diagnostic Errors ; Female ; Humans ; Pancreatitis/blood ; Pancreatitis/diagnosis ; Shock, Septic/diagnosis ; Shock, Septic/enzymology ; Shock, Septic/microbiology ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/enzymology ; Staphylococcal Infections/microbiology
Chemical Substances	Amylases (EC 3.2.1.-)
Language	English
Publishing date	2008-03-08
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2039637-5
ISSN	1590-8577 ; 1590-8577
ISSN (online)	1590-8577
ISSN	1590-8577
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Article ; Online: Unique challenges of providing bioanalytical support for biological therapeutic pharmacokinetic programs.

Nowatzke, William L / Rogers, Kathryn / Wells, Edward / Bowsher, Ronald R / Ray, Chad / Unger, Steve

Bioanalysis

2011 Volume 3, Issue 5, Page(s) 509–521

Abstract: Regulatory recommendations for providing bioanalytical support for biological therapeutics have co-evolved with the increasing success of these unique pharmaceuticals. Immunoassays have been used to quantify biological macromolecules for more than 50 ... ...

Abstract	Regulatory recommendations for providing bioanalytical support for biological therapeutics have co-evolved with the increasing success of these unique pharmaceuticals. Immunoassays have been used to quantify biological macromolecules for more than 50 years. These assays rely on the use of antigen-specific antibodies. More recently, LC-MS methods have being adapted to quantitate biologics. LC-MS has attributes that complement the limitations encountered by immunoassays. Whether employing immunoassay or LC-MS methods, compared with traditional chemical-based therapeutics, biological therapeutics present unique analytical challenges to analysts. In this article, we review bioanalytical strategies for supporting biologics and discuss the regulatory and analytical challenges that must be met.
MeSH term(s)	Chromatography, Liquid ; Humans ; Immunoassay ; Macromolecular Substances/analysis ; Macromolecular Substances/pharmacokinetics ; Macromolecular Substances/therapeutic use ; Peptides/analysis ; Peptides/pharmacokinetics ; Peptides/therapeutic use ; Proteins/analysis ; Proteins/pharmacokinetics ; Proteins/therapeutic use ; Tandem Mass Spectrometry
Chemical Substances	Macromolecular Substances ; Peptides ; Proteins
Language	English
Publishing date	2011-03
Publishing country	England
Document type	Journal Article ; Review
ISSN	1757-6199
ISSN (online)	1757-6199
DOI	10.4155/bio.11.2
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Article ; Online: The impact of decreased bead count to determine concentrations of amyloid beta1-42, total-tau, and phosphorylated-tau181 in human cerebrospinal fluid using xMAP technology.

Bjornstal, Olaf / Rogers, Kathryn / Zhang, Wei / Delhaye, Richard / Malone, Michele / Unger, Steve / Nowatzke, William

Journal of pharmaceutical sciences

2011 Volume 100, Issue 11, Page(s) 4655–4663

Abstract: Alzheimer's disease is the leading cause of human dementia. The lack of diagnostic tests and limited therapeutic options has driven the search for endogenous biomarkers. The INNO-BIA AlzBio3 assay is a multiplex flow-based immunoassay measuring Aβ42, tau, ...

Abstract	Alzheimer's disease is the leading cause of human dementia. The lack of diagnostic tests and limited therapeutic options has driven the search for endogenous biomarkers. The INNO-BIA AlzBio3 assay is a multiplex flow-based immunoassay measuring Aβ42, tau, and p-tau in cerebrospinal fluid (CSF). This study assesses assays performance under varying bead count (BC) parameters. Original method validation parameters at 100 BC were acceptable. Reanalyses performed at 3, 10, 25, and 50 BCs were compared to 100 BC data by ANOVA, Bland-Altman analysis, evaluation of concordance correlation coefficients, and frequency distribution of coefficient of variation (CV) ranges. Method validation characteristics were acceptable with 100 BCs. Equivalency for 25 and 50 versus 100 BCs was demonstrated, but not for 3 and 10 BCs. A general trend of decreasing agreement between decreasing BCs and the 100 BC reference resulted in decreases in concordance coefficients ρ(c) . The frequency of CV values greater than 20% increased with decreasing BCs, and CV values of 5% or less decreased with decreased BCs. Statistical analyses demonstrate that BCs of 3 and 10 are not equivalent with the reference and should not be used as a basis for determination of Aβ42, tau, and p-tau concentration in human CSF.
MeSH term(s)	Alzheimer Disease/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Humans ; Immunoassay ; Peptide Fragments/cerebrospinal fluid ; Phosphorylation ; Reproducibility of Results ; tau Proteins/cerebrospinal fluid
Chemical Substances	Amyloid beta-Peptides ; Peptide Fragments ; amyloid beta-protein (1-42) ; tau Proteins
Language	English
Publishing date	2011-11
Publishing country	United States
Document type	Journal Article ; Validation Studies
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1002/jps.22700
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Article: Steroid-associated side effects in patients with multiple myeloma: consensus statement of the IMF Nurse Leadership Board.

Faiman, Beth / Bilotti, Elizabeth / Mangan, Patricia A / Rogers, Kathryn

Clinical journal of oncology nursing

2008 Volume 12, Issue 3 Suppl, Page(s) 53–63

Abstract: Steroids have been the foundation of multiple myeloma therapy for more than 30 years and continue to be prescribed as single agents and in combination with other antimyeloma drugs, including novel therapies. Steroids cause a wide range of side effects ... ...

Abstract	Steroids have been the foundation of multiple myeloma therapy for more than 30 years and continue to be prescribed as single agents and in combination with other antimyeloma drugs, including novel therapies. Steroids cause a wide range of side effects that affect almost every system of the body. Identification and prompt management of the toxicities contribute to the success of steroid-containing antimyeloma regimens. By following patients carefully and educating them and their caregivers, nurses can promote adherence to therapy and improve quality of life. The International Myeloma Foundation's Nurse Leadership Board developed this consensus statement for the management of steroid-associated side effects to be used by healthcare providers in any medical setting.
MeSH term(s)	Humans ; Leadership ; Multiple Myeloma/drug therapy ; Societies, Nursing ; Steroids/adverse effects ; Steroids/therapeutic use
Chemical Substances	Steroids
Language	English
Publishing date	2008-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2014665-6
ISSN	1538-067X ; 1092-1095
ISSN (online)	1538-067X
ISSN	1092-1095
DOI	10.1188/08.CJON.S1.53-62
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Article: Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain.

Leventhal, Liza / Smith, Valerie / Hornby, Geoffrey / Andree, Terrance H / Brandt, Michael R / Rogers, Kathryn E

The Journal of pharmacology and experimental therapeutics

2007 Volume 320, Issue 3, Page(s) 1178–1185

Abstract: There is increasing recognition that norepinephrine (NE) and serotonin (5-HT) reuptake inhibitors (NRIs and SRIs) are efficacious in treating some types of pain. To date, studies have not systematically evaluated the relative activity at the NE and/or 5- ... ...

Abstract	There is increasing recognition that norepinephrine (NE) and serotonin (5-HT) reuptake inhibitors (NRIs and SRIs) are efficacious in treating some types of pain. To date, studies have not systematically evaluated the relative activity at the NE and/or 5-HT transporter required for maximal efficacy in rodent pain models. Known selective NE and 5-HT reuptake inhibitors reboxetine, desipramine, fluoxetine, and paroxetine were evaluated in both in vitro and in vivo assays. Using the spinal nerve ligation model of neuropathic pain, the compounds differentially reversed tactile allodynia. Evaluation of a broader spectrum of reuptake inhibitors in the para-phenylquinone (PPQ)-induced abdominal constriction model, a model of acute visceral pain, demonstrated that both the SRIs and the NRIs significantly blocked abdominal constrictions. However, the magnitude of this effect was greater following treatment with compounds having greater affinity for NRI compared with SRI affinity. In addition, isobolographic analyses indicated significant synergistic effects for all combinations of desipramine and fluoxetine in the PPQ model of visceral pain. Collectively, the present results support the hypothesis that compounds with greater NRI activity should be more effective for the treatment of pain than compounds having only SRI activity, and this hypothesis is also supported by clinical data. These studies also suggest that the potency and effectiveness of NRIs might be enhanced by the presence of 5-HT activity.
MeSH term(s)	Analgesics, Non-Narcotic/administration & dosage ; Analgesics, Non-Narcotic/pharmacology ; Analgesics, Non-Narcotic/therapeutic use ; Animals ; Cell Line, Tumor ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Synergism ; Drug Therapy, Combination ; Humans ; Male ; Mice ; Mice, Inbred Strains ; Norepinephrine/administration & dosage ; Norepinephrine/pharmacology ; Norepinephrine/therapeutic use ; Pain/drug therapy ; Pain/metabolism ; Pain Threshold/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic/metabolism ; Receptors, Serotonin/metabolism ; Serotonin Uptake Inhibitors/administration & dosage ; Serotonin Uptake Inhibitors/pharmacology ; Serotonin Uptake Inhibitors/therapeutic use ; Time Factors
Chemical Substances	Analgesics, Non-Narcotic ; Receptors, Adrenergic ; Receptors, Serotonin ; Serotonin Uptake Inhibitors ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2007-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.106.109728
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