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  1. Article ; Online: Ambulant erworbene Pneumonie.

    Seeger, Alexander / Rohde, Gernot

    Deutsche medizinische Wochenschrift (1946)

    2023  Volume 148, Issue 6, Page(s) 335–341

    Abstract: Risk factors for severe courses: The CRB-65 score is recommended as a risk predictor, as well as consideration of unstable comorbidities and oxygenation.: Grouping of community-acquired pneumonia: Community-acquired pneumonia is divided into 3 groups: ...

    Title translation Community-acquired pneumonia.
    Abstract Risk factors for severe courses: The CRB-65 score is recommended as a risk predictor, as well as consideration of unstable comorbidities and oxygenation.
    Grouping of community-acquired pneumonia: Community-acquired pneumonia is divided into 3 groups: mild pneumonia, moderate pneumonia, severe pneumonia. Whether there is a curative vs palliative treatment goal should be determined early.
    Diagnostic recommendation: An X-ray chest radiograph is recommended to confirm the diagnosis, also in the outpatient setting if possible. Sonography of the thorax is an alternative, asking for additional imaging if negative. Streptococcus pneumoniae remains the most common bacterial pathogen.
    Therapy: Community-acquired pneumonia continues to be associated with high morbidity and lethality. Prompt diagnosis and prompt initiation of risk-adapted antimicrobial therapy are essential measures. However, in times of COVID-19, as well as the current influenza and RSV epidemic, purely viral pneumonias must also be expected. At least with COVID-19, antibiotics can often be avoided. Antiviral and anti-inflammatory drugs are used here.
    Post-acute course: Patients after community-acquired pneumonia have increased acute and long-term mortality due to cardiovascular events in particular. The focus of research is on improved pathogen identification, a better understanding of the host response with the potential of developing specific therapeutics, the role of comorbidities, and the long-term consequences of the acute illness.
    MeSH term(s) Humans ; COVID-19 ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/therapy ; Anti-Bacterial Agents/therapeutic use ; Antiviral Agents
    Chemical Substances Anti-Bacterial Agents ; Antiviral Agents
    Language German
    Publishing date 2023-03-06
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1940-8944
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  2. Article ; Online: Ambulant erworbene Pneumonie.

    Rohde, Gernot

    Deutsche medizinische Wochenschrift (1946)

    2019  Volume 144, Issue 20, Page(s) 1428–1431

    Abstract: Important new developments in the understanding of CAP encompass new insights into pathogens, risk stratification and antibiotic treatment. Respiratory viruses are increasingly described as relevant pathogens in CAP, such as influenza and rhinoviruses. ... ...

    Title translation Community-acquired pneumonia.
    Abstract Important new developments in the understanding of CAP encompass new insights into pathogens, risk stratification and antibiotic treatment. Respiratory viruses are increasingly described as relevant pathogens in CAP, such as influenza and rhinoviruses. Risk stratification is central in the management of CAP. In addition to the classical scores blood glucose levels add to the risk prediction. Risk adapted antibiotic treatment is increasingly refined and the use of macrolides in patients with bacteremia or marked inflammation is advocated. Recently developed new antibiotics add to the therapeutic options in CAP.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Community-Acquired Infections ; Humans ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language German
    Publishing date 2019-10-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-0883-7147
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  3. Article: Ambulant erworbene Pneumonie

    Seeger, Alexander / Rohde, Gernot

    DMW - Deutsche Medizinische Wochenschrift

    2023  Volume 148, Issue 06, Page(s) 335–341

    Abstract: Risikofaktoren für schwere Verläufe: Als Risikoprädiktor wird der CRB-65-Score empfohlen sowie die Berücksichtigung instabiler Komorbiditäten und der Oxygenierung.: Gruppeneinteilung der ambulant erworbenen Pneumonie : Die ambulant ... ...

    Abstract Risikofaktoren für schwere Verläufe: Als Risikoprädiktor wird der CRB-65-Score empfohlen sowie die Berücksichtigung instabiler Komorbiditäten und der Oxygenierung.
    Gruppeneinteilung der ambulant erworbenen Pneumonie : Die ambulant erworbene Pneumonie wird in 3 Gruppen eingeteilt: leichte Pneumonie, mittelschwere Pneumonie, schwere Pneumonie. Ob ein kuratives vs. palliatives Behandlungsziel besteht, sollte frühzeitig festgelegt werden.
    Diagnostikempfehlung: Zur Sicherung der Diagnose wird eine Röntgen-Thoraxaufnahme empfohlen, möglichst auch im ambulanten Bereich. Alternativ kann eine Sonografie des Thorax durchgeführt werden, wobei bei negativem Befund weitere Bildgebung empfohlen wird. Streptococcus pneumoniae ist weiterhin der häufigste bakterielle Erreger.
    Therapie: Die ambulant erworbene Pneumonie ist nach wie vor mit hoher Morbidität und Letalität assoziiert. Eine zügige Diagnosestellung und die umgehende Einleitung einer risikoadaptierten antimikrobiellen Therapie stellen wesentliche Maßnahmen dar. In Zeiten von COVID-19, aber auch der aktuellen Influenza- und RSV-Epidemie, muss aber auch mit rein viralen Pneumonien gerechnet werden. Zumindest bei COVID-19 kann häufig auf ein Antibiotikum verzichtet werden. Antivirale und entzündungshemmende Medikamente werden hier eingesetzt.
    Postakuter Verlauf: Patienten nach ambulant erworbener Pneumonie haben eine erhöhte Akut- und Langzeitletalität – aufgrund von insbesondere kardiovaskulären Ereignissen. Das Augenmerk der Forschung liegt auf verbesserter Erregererkennung, einem besseren Verständnis der Wirtsantwort, mit dem Potenzial der Entwicklung spezifischer Therapeutika, der Rolle von Komorbiditäten und den Langzeitfolgen der akuten Erkrankung.
    Keywords ambulant erworbene Pneumonie ; Risikofaktoren ; Leitlinie ; Diagnostik ; Therapie ; community-acquired pneumonia ; risk factors ; guideline ; diagnostics ; therapy
    Language German
    Publishing date 2023-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1940-8944
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  4. Article: Ambulant erworbene Pneumonie

    Rohde, Gernot

    DMW - Deutsche Medizinische Wochenschrift

    2019  Volume 144, Issue 20, Page(s) 1428–1431

    Abstract: Pathogene: Die Bedeutung von Atemwegsviren bei der CAP wird zunehmend beschrieben. Influenza und Rhinoviren stehen aktuell im Fokus, aber auch andere Atemwegsviren werden genannt.: Risikostratifizierung: Zusätzlich zu den etablierten Parametern ... ...

    Abstract Pathogene: Die Bedeutung von Atemwegsviren bei der CAP wird zunehmend beschrieben. Influenza und Rhinoviren stehen aktuell im Fokus, aber auch andere Atemwegsviren werden genannt.
    Risikostratifizierung: Zusätzlich zu den etablierten Parametern stellt der Blutglukosespiegel bei Aufnahme einen zusätzlichen Risikofaktor dar.
    Antibiotika: Der Stellenwert der zusätzlichen Makrolid-Gabe im Rahmen einer Kombination mit einem Betalaktam-Antibiotikum wird zunehmend differenziert. Patienten mit Bakteriämie und/oder ausgeprägter Entzündungsreaktion profitieren besonders. Bei Patienten mit schwerer Pneumonie sollte immer eine Kombinationstherapie durchgeführt werden. Omadacycline und Solithromycin stellen neue interessante Antibiotika mit erweitertem Spektrum dar.
    Keywords Pathogene ; Atemwegsviren ; Management ; Antibiotika ; Risikostratifizierung ; pathogens ; respiratory viruses ; management ; antibiotics ; risk stratification
    Language German
    Publishing date 2019-10-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-0883-7147
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  5. Article ; Online: Characteristics, clinical course and outcome of ventilated patients at a non-surgical intensive care unit in Germany: a single-centre, retrospective observational cohort analysis.

    Grünewaldt, Achim / Peiffer, Kai-Henrik / Bojunga, Jörg / Rohde, Gernot G U

    BMJ open

    2023  Volume 13, Issue 7, Page(s) e069834

    Abstract: Objectives: The objective of this study was to evaluate epidemiological characteristics, clinical course and outcome of mechanically ventilated non-surgical intensive care unit (ICU) patients, with the aim of improving the strategic planning of ICU ... ...

    Abstract Objectives: The objective of this study was to evaluate epidemiological characteristics, clinical course and outcome of mechanically ventilated non-surgical intensive care unit (ICU) patients, with the aim of improving the strategic planning of ICU capacities.
    Design: We conducted a retrospective observational cohort analysis. Data from mechanically ventilated intensive care patients were obtained by investigating electronic health records. The association between clinical parameters and ordinal scale data of clinical course was evaluated using Spearman correlation and Mann-Whitney U test. Relations between clinical parameters and in-hospital mortality rates were examined using binary logistic regression analysis.
    Setting: A single-centre study at the non-surgical ICU of the University Hospital of Frankfurt, Germany (tertiary care-level centre).
    Participants: All cases of critically ill adult patients in need of mechanical ventilation during the years 2013-2015 were included. In total, 932 cases were analysed.
    Results: From a total of 932 cases, 260 patients (27.9%) were transferred from peripheral ward, 224 patients (24.1%) were hospitalised via emergency rescue services, 211 patients (22.7%) were admitted via emergency room and 236 patients (25.3%) via various transfers. In 266 cases (28.5%), respiratory failure was the reason for ICU admission. The length of stay was higher in non-geriatric patients, patients with immunosuppression and haemato-oncological disease or those in need of renal replacement therapy. 431 patients died, which corresponds to an all-cause in-hospital mortality rate of 46.2%. 92 of 172 patients with presence of immunosuppression (53.5%), 111 of 186 patients (59.7%) with pre-existing haemato-oncological disease, 27 of 36 patients (75.0%) under extracorporeal membrane oxygenation (ECMO) therapy, and 182 of 246 patients (74.0%) undergoing renal replacement therapy died. In logistic regression analysis, these subgroups and older age were significantly associated with higher mortality rates.
    Conclusions: Respiratory failure was the main reason for ventilatory support at this non-surgical ICU. Immunosuppression, haemato-oncological diseases, the need for ECMO or renal replacement therapy and older age were associated with higher mortality.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Respiration, Artificial ; Intensive Care Units ; Respiratory Insufficiency ; Disease Progression ; Hospital Mortality
    Language English
    Publishing date 2023-07-09
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069834
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  6. Book ; Thesis: Increase in non-specific bronchial hyperresponsiveness in the absence of a specific response to isocyanates in isocyanate induced asthma

    Rohde, Gernot Gerhard Ulrich

    1997  

    Author's details vorgelegt von Gernot G. U. Rohde
    Language English
    Size 60 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bochum, Univ., Diss., 1999
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x ; Zsfassung in dt. Sprache
    HBZ-ID HT011211652
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Die Situation der Ärztinnen und Ärzte in Akutkrankenhäusern während der zweiten Welle der SARS-CoV-2-Pandemie: eine Onlinebefragung.

    Mai, Tobias / Franke, Vanessa / Todisco, Laura / Schilder, Michael / Rohde, Gernot

    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

    2022  Volume 174, Page(s) 52–58

    Abstract: Background: The SARS-CoV-2 pandemic has an impact on the wellbeing of health care workers. The influence of a work-related sense of coherence as well as perceived organizational support on the level of burnout and the intention to leave the job is ... ...

    Title translation The situation of physicians in acute hospitals during the second wave of the SARS-CoV-2 pandemic: An online survey.
    Abstract Background: The SARS-CoV-2 pandemic has an impact on the wellbeing of health care workers. The influence of a work-related sense of coherence as well as perceived organizational support on the level of burnout and the intention to leave the job is largely unknown, especially for physicians in German hospitals.
    Method: In December 2020 and January 2021, physicians of 81 hospitals in Hessian (Germany) participated in an online survey using the BAT (Burnout Assessment Tool), Work-SoC (Work-related Sense of Coherence), the POS-s (Perceived Organizational SUPPORT - short version) and literature-based items based.
    Results: Of 181 physicians, 34% showed a moderate or high burnout level, 21% would leave the job after the pandemic. The higher the work-SoC (β = -0.560; p < 0.001) and the higher the POS-s (β = -0.125; p < 0.05), the lower the burnout level. Not being able to care sufficiently for their patients has a negative impact on the sense of coherence. 46.4% reported that they did not feel sufficiently prepared by their employer during the pandemic. They wished to have support in the form of the mindfulness and resilience trainings (45%), emergency childcare (41%) and a crisis counselor in their team (32%).
    Conclusion: Regardless of the pandemic, health-promoting work conditions have to be developed that facilitate coherent work and prevent "moral injuries" or enable physicians to deal with them.
    MeSH term(s) Humans ; SARS-CoV-2 ; Germany ; COVID-19/epidemiology ; Pandemics ; Burnout, Professional/epidemiology ; Surveys and Questionnaires ; Hospitals
    Language German
    Publishing date 2022-10-05
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 2412512-X
    ISSN 2212-0289 ; 1865-9217
    ISSN (online) 2212-0289
    ISSN 1865-9217
    DOI 10.1016/j.zefq.2022.08.005
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  8. Article ; Online: Letalität der ambulant erworbenen Pneumonie nicht unterschätzen!

    Grünewaldt, Achim / Hügel, Christian / Bellinghausen, Carla / Rohde, Gernot

    MMW Fortschritte der Medizin

    2020  Volume 162, Issue 4, Page(s) 39–42

    Title translation State of the art in diagnosis and therapy of community aquired pneumonia.
    MeSH term(s) Community-Acquired Infections/diagnosis ; Community-Acquired Infections/therapy ; Humans ; Pneumonia/diagnosis ; Pneumonia/therapy
    Language German
    Publishing date 2020-03-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-020-0216-2
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  9. Article: Ambulant erworbene Pneumonie bei älteren Menschen

    Schöll, Niklas / Rohde, Gernot G. U.

    Geriatrie up2date

    2020  Volume 2, Issue 01, Page(s) 15–26

    Keywords Pneumonie ; Ältere ; Risikostratifizierung ; Ätiologie ; Dysphagie
    Language German
    Publishing date 2020-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2627-0897 ; 2627-0889
    ISSN (online) 2627-0897
    ISSN 2627-0889
    DOI 10.1055/a-1001-0016
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  10. Article ; Online: Pneumonia in the third year of the pandemic: one eye on the pathogens, the other on the host.

    Julius, Christina / Pletz, Matthias W / Rupp, Jan / Witzenrath, Martin / Barten-Neiner, Grit / Rohde, Gernot

    American journal of physiology. Lung cellular and molecular physiology

    2022  Volume 323, Issue 5, Page(s) L611–L614

    MeSH term(s) Female ; Infant, Newborn ; Humans ; Anti-Bacterial Agents/therapeutic use ; Pandemics ; Global Health ; Premature Birth ; Drug Resistance, Bacterial ; Pneumonia/drug therapy ; Community-Acquired Infections ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00330.2022
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