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  1. Book ; Online: Chapter Adenovirus as Tools in Animal Health

    Rojas, José M. / Sevilla, Noemí / Martín, Verónica

    2019  

    Keywords Medical microbiology & virology ; adenovirus vectors, vaccines, animal health, immune response
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047397
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Ecology and Diversity of Weed Communities in the Northern Andes under Different Anthropogenic Pressures

    Duque, Yessica P. / Giraldo-Sánchez, Carlos E. / Quijano-Abril, Mario A. / Rojas, Jose M.

    Diversity. 2023 Aug. 17, v. 15, no. 8

    2023  

    Abstract: Weeds can have both positive and negative effects on agricultural environments. However, despite the growing interest in the ecology of weed communities in agricultural areas, a few studies have been carried out in the northern region of the Andes of ... ...

    Abstract Weeds can have both positive and negative effects on agricultural environments. However, despite the growing interest in the ecology of weed communities in agricultural areas, a few studies have been carried out in the northern region of the Andes of Colombia, where urban and agricultural expansion have generated highly disturbed scenarios. The aim of this study was to analyze the diversity of vegetation and weed seed banks in three agricultural production systems and a forest ecosystem in the northern Andes of Colombia. Hill numbers were used to compare diversity, Beta diversity to assess changes in composition, and range—abundance–dominance curves at different sites. Likewise, indicator species were analyzed to find species associations to each system. The results revealed differences in the composition of weeds between the forest ecosystem and the agricultural production systems, with higher equitability in the forest ecosystem and higher dominance in agricultural systems. Significant differentiation was observed among the dominant species within each agricultural system, particularly highlighting those species considered pests due to their unique life history traits. These traits confer them with a greater advantage in the face of various anthropogenic selection pressures. These findings highlight the impact of anthropogenic disturbances on the ecological dynamics of weed communities in different ecosystems, which should be considered when planning integrated weed management techniques.
    Keywords dominant species ; forest ecosystems ; indicator species ; integrated weed management ; life history ; species diversity ; vegetation ; weeds ; Andes region ; Colombia
    Language English
    Dates of publication 2023-0817
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2518137-3
    ISSN 1424-2818
    ISSN 1424-2818
    DOI 10.3390/d15080936
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission

    Rojas, José M. / Martín, Verónica / Sevilla, Noemí

    Pathogens. 2021 Nov. 22, v. 10, no. 11

    2021  

    Abstract: Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of Culicoides spp., however, some BTV strains can be transmitted vertically, and this is ... ...

    Abstract Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of Culicoides spp., however, some BTV strains can be transmitted vertically, and this is associated with fetus malformations and abortions. The viral factors associated with the virus potency to cross the placental barrier are not well defined. The potency of vertical transmission is retained and sometimes even increased in live attenuated BTV vaccine strains. Because BTV possesses a segmented genome, the possibility of reassortment of vaccination strains with wild-type virus could even favor the transmission of this phenotype. In the present review, we will describe the non-vector-based BTV infection routes and discuss the experimental vaccination strategies that offer advantages over this drawback of some live attenuated BTV vaccines.
    Keywords Bluetongue virus ; Culicoides ; fetus ; genome ; live vaccines ; phenotype ; vaccination ; viruses
    Language English
    Dates of publication 2021-1122
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10111528
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Vaccination as a Strategy to Prevent Bluetongue Virus Vertical Transmission.

    Rojas, José M / Martín, Verónica / Sevilla, Noemí

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite ... ...

    Abstract Bluetongue virus (BTV) produces an economically important disease in ruminants of compulsory notification to the OIE. BTV is typically transmitted by the bite of
    Language English
    Publishing date 2021-11-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10111528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A New Look at Vaccine Strategies Against PPRV Focused on Adenoviral Candidates.

    Rojas, José M / Sevilla, Noemí / Martín, Verónica

    Frontiers in veterinary science

    2021  Volume 8, Page(s) 729879

    Abstract: Peste des petits ruminants virus (PPRV) is a virus that mainly infects goats and sheep causing significant economic loss in Africa and Asia, but also posing a serious threat to Europe, as recent outbreaks in Georgia (2016) and Bulgaria (2018) have been ... ...

    Abstract Peste des petits ruminants virus (PPRV) is a virus that mainly infects goats and sheep causing significant economic loss in Africa and Asia, but also posing a serious threat to Europe, as recent outbreaks in Georgia (2016) and Bulgaria (2018) have been reported. In order to carry out the eradication of PPRV, an objective set for 2030 by the Office International des Epizooties (OIE) and the Food and Agriculture Organization of the United Nations (FAO), close collaboration between governments, pharmaceutical companies, farmers and researchers, among others, is needed. Today, more than ever, as seen in the response to the SARS-CoV2 pandemic that we are currently experiencing, these goals are feasible. We summarize in this review the current vaccination approaches against PPRV in the field, discussing their advantages and shortfalls, as well as the development and generation of new vaccination strategies, focusing on the potential use of adenovirus as vaccine platform against PPRV and more broadly against other ruminant pathogens.
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.729879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comprehensive immune profiling reveals that

    Louloudes-Lázaro, Andrés / Rojas, José M / García-García, Isabel / Rodríguez-Martín, Daniel / Morel, Esther / Martín, Verónica / Sevilla, Noemí

    Frontiers in immunology

    2023  Volume 14, Page(s) 1255803

    Abstract: Bluetongue virus (BTV) is an arbovirus transmitted by the bite of ... ...

    Abstract Bluetongue virus (BTV) is an arbovirus transmitted by the bite of infected
    MeSH term(s) Sheep ; Animals ; CD8-Positive T-Lymphocytes ; B7-H1 Antigen/metabolism ; CD4-Positive T-Lymphocytes ; Bluetongue virus ; Immunosuppression Therapy
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1255803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway.

    Rojas, José M / Alejo, Alí / Martín, Verónica / Sevilla, Noemí

    Cellular and molecular life sciences : CMLS

    2020  Volume 78, Issue 4, Page(s) 1423–1444

    Abstract: Antiviral responses of interferons (IFNs) are crucial in the host immune response, playing a relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN-γ) and III (IFN-λ), are classified according to their ... ...

    Abstract Antiviral responses of interferons (IFNs) are crucial in the host immune response, playing a relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN-γ) and III (IFN-λ), are classified according to their receptor usage, mode of induction, biological activity and amino acid sequence. Here, we provide a comprehensive review of type I IFN responses and different mechanisms that viruses employ to circumvent this response. In the first part, we will give an overview of the different induction and signaling cascades induced in the cell by IFN-I after virus encounter. Next, highlights of some of the mechanisms used by viruses to counteract the IFN induction will be described. And finally, we will address different mechanism used by viruses to interference with the IFN signaling cascade and the blockade of IFN induced antiviral activities.
    MeSH term(s) Host-Pathogen Interactions/genetics ; Humans ; Immune Evasion/genetics ; Immunity, Innate/genetics ; Interferon-alpha/genetics ; Interferon-alpha/immunology ; Interferons/classification ; Interferons/genetics ; Interferons/immunology ; Signal Transduction ; Virus Diseases/genetics ; Virus Diseases/immunology
    Chemical Substances Interferon-alpha ; Interferons (9008-11-1)
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-020-03671-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Interplay between Bluetongue Virus Infections and Adaptive Immunity

    Rodríguez-Martín, Daniel / Louloudes-Lázaro, Andrés / Avia, Miguel / Martín, Verónica / Rojas, José M. / Sevilla, Noemí

    Viruses. 2021 July 31, v. 13, no. 8

    2021  

    Abstract: Viral infections have long provided a platform to understand the workings of immunity. For instance, great strides towards defining basic immunology concepts, such as MHC restriction of antigen presentation or T-cell memory development and maintenance, ... ...

    Abstract Viral infections have long provided a platform to understand the workings of immunity. For instance, great strides towards defining basic immunology concepts, such as MHC restriction of antigen presentation or T-cell memory development and maintenance, have been achieved thanks to the study of lymphocytic choriomeningitis virus (LCMV) infections. These studies have also shaped our understanding of antiviral immunity, and in particular T-cell responses. In the present review, we discuss how bluetongue virus (BTV), an economically important arbovirus from the Reoviridae family that affects ruminants, affects adaptive immunity in the natural hosts. During the initial stages of infection, BTV triggers leucopenia in the hosts. The host then mounts an adaptive immune response that controls the disease. In this work, we discuss how BTV triggers CD8⁺ T-cell expansion and neutralizing antibody responses, yet in some individuals viremia remains detectable after these adaptive immune mechanisms are active. We present some unpublished data showing that BTV infection also affects other T cell populations such as CD4⁺ T-cells or γδ T-cells, as well as B-cell numbers in the periphery. This review also discusses how BTV evades these adaptive immune mechanisms so that it can be transmitted back to the arthropod host. Understanding the interaction of BTV with immunity could ultimately define the correlates of protection with immune mechanisms that would improve our knowledge of ruminant immunology.
    Keywords B-lymphocytes ; Bluetongue virus ; Lymphocytic choriomeningitis mammarenavirus ; antigen presentation ; arboviruses ; arthropods ; memory ; ruminants ; viremia
    Language English
    Dates of publication 2021-0731
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13081511
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Adenoviral delivery of soluble ovine OX40L or CD70 costimulatory molecules improves adaptive immune responses to a model antigen in sheep.

    Rojas, José M / Mancho, Carolina / Louloudes-Lázaro, Andrés / Rodríguez-Martín, Daniel / Avia, Miguel / Moreno, Santiago / Sevilla, Noemí / Martín, Verónica

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 1010873

    Abstract: The tumour necrosis factor superfamily OX40L and CD70 and their receptors are costimulatory signalling axes critical for adequate T and B cell activation in humans and mice. In this work we inoculated groups of sheep with human recombinant adenovirus ... ...

    Abstract The tumour necrosis factor superfamily OX40L and CD70 and their receptors are costimulatory signalling axes critical for adequate T and B cell activation in humans and mice. In this work we inoculated groups of sheep with human recombinant adenovirus type 5 (Ad) expressing
    MeSH term(s) Adenoviridae/genetics ; Animals ; CD27 Ligand ; CD8-Positive T-Lymphocytes ; Humans ; Immunoglobulin G ; Interleukin-4 ; Leukocytes, Mononuclear ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Sheep ; Tumor Necrosis Factor-alpha
    Chemical Substances CD27 Ligand ; CD70 protein, human ; Immunoglobulin G ; Tumor Necrosis Factor-alpha ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.1010873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diagnosing bluetongue virus in domestic ruminants: current perspectives.

    Rojas, José M / Rodríguez-Martín, Daniel / Martín, Verónica / Sevilla, Noemí

    Veterinary medicine (Auckland, N.Z.)

    2019  Volume 10, Page(s) 17–27

    Abstract: This review provides an overview of current and potential new diagnostic techniques against bluetongue virus (BTV), ... ...

    Abstract This review provides an overview of current and potential new diagnostic techniques against bluetongue virus (BTV), an
    Language English
    Publishing date 2019-02-14
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 2230-2034
    ISSN (online) 2230-2034
    DOI 10.2147/VMRR.S163804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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