LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: m

    Olazagoitia-Garmendia, Ane / Rojas-Márquez, Henar / Sebastian-delaCruz, Maialen / Agirre-Lizaso, Aloña / Ochoa, Anne / Mendoza-Gomez, Luis Manuel / Perugorria, Maria J / Bujanda, Luis / Madrigal, Alain Huerta / Santin, Izortze / Castellanos-Rubio, Ainara

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 13, Page(s) e2307928

    Abstract: Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs (lncRNAs) play key roles in the ... ...

    Abstract Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs (lncRNAs) play key roles in the pathogenesis of inflammatory disorders, while inflammation associated variants are described to affect their function or essential RNA modifications as N
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Cytokines ; Intestines ; Inflammatory Bowel Diseases
    Chemical Substances RNA, Long Noncoding ; Cytokines
    Language English
    Publishing date 2024-01-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202307928
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats.

    Casquero-Veiga, Marta / Lamanna-Rama, Nicolás / Romero-Miguel, Diego / Rojas-Marquez, Henar / Alcaide, Julia / Beltran, Marc / Nacher, Juan / Desco, Manuel / Soto-Montenegro, Maria Luisa

    Frontiers in behavioral neuroscience

    2023  Volume 16, Page(s) 1022622

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2022.1022622
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Inhibition of YTHDF1 by salvianolic acid overcomes gluten-induced intestinal inflammation.

    Olazagoitia-Garmendia, Ane / Rojas-Márquez, Henar / Romero, Maria Del Mar / Ruiz, Pamela / Agirre-Lizaso, Aloña / Chen, Yantao / Perugorria, Maria Jesus / Herrero, Laura / Serra, Dolors / Luo, Cheng / Bujanda, Luis / He, Chuan / Castellanos-Rubio, Ainara

    Gut

    2023  

    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330459
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Preparation of pepsin trypsin digested gliadin for stimulation experiments.

    Mendoza-Gomez, Luis Manuel / Sebastian-delaCruz, Maialen / Olazagoitia-Garmendia, Ane / González-Moro, Itziar / Rojas-Márquez, Henar / Mentxaka, Jon / Santin, Izortze / Castellanos-Rubio, Ainara

    Methods in cell biology

    2022  Volume 179, Page(s) 195–201

    Abstract: Celiac disease (CD) is a complex immune disorder of the intestine that developes in genetically susceptible individuals. CD develops as an intolerance to ingested gluten proteins (gliadins, secalins, hordeins and avenins), being gliadin one of the most ... ...

    Abstract Celiac disease (CD) is a complex immune disorder of the intestine that developes in genetically susceptible individuals. CD develops as an intolerance to ingested gluten proteins (gliadins, secalins, hordeins and avenins), being gliadin one of the most immunogenic. Here we present a protocol for the preparation of digested gliadin for laboratory use, a fundamental axis for in vitro and in vivo stimulation studies related to celiac disease research. The importance of a scrupulous handling of materials, products and laboratory instruments to achieve a lipopolysaccharide free gliadin is explained and emphasized. Therefore, in the present chapter, a step-by-step set-up of the protocol for pepsin trypsin gliadin digestion is explained.
    MeSH term(s) Humans ; Gliadin ; Pepsin A ; Trypsin ; Celiac Disease ; Laboratories
    Chemical Substances Gliadin (9007-90-3) ; Pepsin A (EC 3.4.23.1) ; Trypsin (EC 3.4.21.4)
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2022.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of

    González-Moro, Itziar / Rojas-Márquez, Henar / Sebastian-delaCruz, Maialen / Mentxaka-Salgado, Jon / Olazagoitia-Garmendia, Ane / Mendoza, Luis Manuel / Lluch, Aina / Fantuzzi, Federica / Lambert, Carmen / Ares Blanco, Jessica / Marselli, Lorella / Marchetti, Piero / Cnop, Miriam / Delgado, Elías / Fernández-Real, José Manuel / Ortega, Francisco José / Castellanos-Rubio, Ainara / Santin, Izortze

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1101934

    Abstract: Introduction: Most of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long non-coding RNAs (lncRNA), but ... ...

    Abstract Introduction: Most of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long non-coding RNAs (lncRNA), but the contribution of these molecules to the development of complex diseases remains to be clarified.
    Methods: Here, we performed a genetic association study between a SNP located in a lncRNA known as LncTGM2 and the risk of developing type 2 diabetes (T2D), and analyzed its implication in disease pathogenesis at pancreatic beta cell level. Genetic association study was performed on human samples linking the rs2076380 polymorphism with T2D and glycemic traits. The pancreatic beta cell line EndoC-bH1 was employed for functional studies based on LncTGM2 silencing and overexpression experiments. Human pancreatic islets were used for eQTL analysis.
    Results: We have identified a genetic association between LncTGM2 and T2D risk. Functional characterization of the LncTGM2 revealed its implication in the transcriptional regulation of TGM2, coding for a transglutaminase. The T2Dassociated risk allele in LncTGM2 disrupts the secondary structure of this lncRNA, affecting its stability and the expression of TGM2 in pancreatic beta cells. Diminished LncTGM2 in human beta cells impairs glucose-stimulated insulin release.
    Conclusions: These findings provide novel information on the molecular mechanisms by which T2D-associated SNPs in lncRNAs may contribute to disease, paving the way for the development of new therapies based on the modulation of lncRNAs.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances RNA, Long Noncoding ; TGM2 protein, human
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1101934
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top