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  1. Article ; Online: The Effects of the Levosimendan Metabolites OR-1855 and OR-1896 on Endothelial Pro-Inflammatory Responses

    Hannah Kipka / Rebecca Schaflinger / Roland Tomasi / Kristin Pogoda / Hanna Mannell

    Biomedicines, Vol 11, Iss 918, p

    2023  Volume 918

    Abstract: The calcium sensitizer levosimendan is used for the treatment of acute decompensated heart failure. A small portion (4–7%) of levosimendan is metabolized to the pharmacologically active metabolite OR-1896 via the inactive intermediate OR-1855. In ... ...

    Abstract The calcium sensitizer levosimendan is used for the treatment of acute decompensated heart failure. A small portion (4–7%) of levosimendan is metabolized to the pharmacologically active metabolite OR-1896 via the inactive intermediate OR-1855. In addition, levosimendan has been shown to exert positive effects on the endothelium in vitro antagonizing vascular dysfunction and inflammation. However, the function of the levosimendan metabolites within this context is still unknown. In this study, we thus investigated the impact of the metabolites OR-1896 and OR-1855 on endothelial inflammatory processes in vitro. We observed a reduction of IL-1β-dependent endothelial adhesion molecule ICAM-1 and VCAM-1 as well as interleukin (IL) -6 expression upon levosimendan treatment but not after treatment with OR-1855 or OR-1896, as assessed by western blotting, flow cytometry, and qRT-PCR. Instead, the metabolites impaired IL-1β-induced ROS formation via inactivation of the MAPK p38, ERK1/2, and JNK. Our results suggest that the levosimendan metabolites OR-1896 and OR-1855 have certain anti-inflammatory properties, partly other than levosimendan. Importantly, they additionally show that the intermediate metabolite OR-1855 does, in fact, have pharmacological effects in the endothelium. This is interesting, as the metabolites are responsible for the long-term therapeutic effects of levosimendan, and heart failure is associated with vascular dysfunction and inflammation.
    Keywords levosimendan ; OR-1896 ; OR-1855 ; endothelial cells ; reactive oxygen species ; inflammation ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Early Use of Methylene Blue in Vasoplegic Syndrome

    Othmar Kofler / Maximilian Simbeck / Roland Tomasi / Ludwig Christian Hinske / Laura Valentina Klotz / Florian Uhle / Frank Born / Maximilian Pichlmaier / Christian Hagl / Markus Alexander Weigand / Bernhard Zwißler / Vera von Dossow

    Journal of Clinical Medicine, Vol 11, Iss 1121, p

    A 10-Year Propensity Score-Matched Cohort Study

    2022  Volume 1121

    Abstract: Background: Vasoplegic syndrome is associated with increased morbidity and mortality in patients undergoing cardiac surgery. This retrospective, single-center study aimed to evaluate the effect of early use of methylene blue (MB) on hemodynamics after an ...

    Abstract Background: Vasoplegic syndrome is associated with increased morbidity and mortality in patients undergoing cardiac surgery. This retrospective, single-center study aimed to evaluate the effect of early use of methylene blue (MB) on hemodynamics after an intraoperative diagnosis of vasoplegic syndrome (VS). Methods: Over a 10-year period, all patients diagnosed with intraoperative VS (hypotension despite treatment with norepinephrine ≥0.3 μg/kg/min and vasopressin ≥1 IE/h) while undergoing heart surgery and cardiopulmonary bypass were identified, and their data were examined. The intervention group received MB (2 mg/kg intravenous) within 15 min after the diagnosis of vasoplegia, while the control group received standard therapy. The two groups were matched using propensity scores. Results: Of the 1022 patients identified with VS, 221 received MB intraoperatively, and among them, 60 patients received MB within 15 min after the diagnosis of VS. After early MB application, mean arterial pressure was significantly higher, and vasopressor support was significantly lower within the first hour ( p = 0.015) after the diagnosis of vasoplegia, resulting in a lower cumulative amount of norepinephrine ( p = 0.018) and vasopressin ( p = 0.003). The intraoperative need of fresh frozen plasma in the intervention group was lower compared to the control group ( p = 0.015). Additionally, the intervention group had higher creatinine values in the first three postoperative days ( p = 0.036) without changes in dialysis incidence. The 90-day survival did not differ significantly ( p = 0.270). Conclusion: Our results indicate the additive effects of MB use during VS compared to standard vasopressor therapy only. Early MB administration for VS may significantly improve the patients’ hemodynamics with minor side effects.
    Keywords methylene blue ; vasoplegic syndrome ; vasoplegia ; shock ; cardiac anesthesia ; vasopressin ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Case report

    Sebastian G. Michel / Maja Hanuna / Joseph Pattathu / Jelena Pabst von Ohain / Christian Schneider / Theresa Kauke / Nikolaus Kneidinger / Juergen Behr / Katrin Milger / Juergen Barton / Tobias Veit / Christine Kamla / Christoph Mueller / Robert Dzieciol / Lauren Christen / Michael Irlbeck / Roland Tomasi / Jan Abicht / Patrick Scheiermann /
    Matthias Feuerecker / Robert Dalla-Pozza / Marcus Fischer / Andre Jakob / Matthias Hermann / Nikolaus Haas / Christian Hagl / Jürgen Hörer

    Frontiers in Transplantation, Vol

    Paracorporeal lung assist device for 215 days as a bridge-to-lung transplantation in a patient with bronchopulmonary dysplasia and severe pulmonary hypertension

    2023  Volume 2

    Abstract: Pulmonary hypertension (PH) is a known and life limiting complication of preterm born young adults with bronchopulmonary dysplasia (BPD), ultimately leading to progressive right ventricular (RV) failure. Prognosis remains poor, especially in patients ... ...

    Abstract Pulmonary hypertension (PH) is a known and life limiting complication of preterm born young adults with bronchopulmonary dysplasia (BPD), ultimately leading to progressive right ventricular (RV) failure. Prognosis remains poor, especially in patients unresponsive to modern vasoactive pharmacotherapy. Therefore, lung transplantation presents the treatment of choice to avert cardiac failure. With limited donor organ availability and long waiting times, the implantation of a paracorporeal lung assist device (PLAD) is a way to bridge the patient as an alternative to veno-arterial ECMO. Herein, we present the case of a prematurely born 23-year-old female, who developed severe PH due to BPD and consequently experienced therapy refractory RV failure. Urgent PLAD implantation was performed and the patient successfully underwent double-lung transplantation after 215 days of PLAD support. No major PLAD-associated complications occurred and full recovery of RV function could be observed after double-lung transplantation.
    Keywords lung assist device ; lung transplantation ; pulmonary hypertension ; bridge-to-lung transplant ; ECMOextracorporeal membrane oxygenation ; Specialties of internal medicine ; RC581-951
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

    Carola Fischer / Hendrik Milting / Evelyn Fein / Elisabeth Reiser / Kun Lu / Thomas Seidel / Camilla Schinner / Thomas Schwarzmayr / Rene Schramm / Roland Tomasi / Britta Husse / Xiaochun Cao-Ehlker / Ulrich Pohl / Andreas Dendorfer

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable for ... ...

    Abstract Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable for evaluation of drug safety, as exemplified for drugs interfering with cardiomyocyte repolarization.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Publisher Correction

    Carola Fischer / Hendrik Milting / Evelyn Fein / Elisabeth Reiser / Kun Lu / Thomas Seidel / Camilla Schinner / Thomas Schwarzmayr / Rene Schramm / Roland Tomasi / Britta Husse / Xiaochun Cao-Ehlker / Ulrich Pohl / Andreas Dendorfer

    Nature Communications, Vol 10, Iss 1, Pp 1-

    Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

    2019  Volume 1

    Abstract: The original version of this Article incorrectly acknowledged Elisabeth Reiser and Rene Schramm as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article. ...

    Abstract The original version of this Article incorrectly acknowledged Elisabeth Reiser and Rene Schramm as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  6. Article ; Online: Publisher Correction

    Carola Fischer / Hendrik Milting / Evelyn Fein / Elisabeth Reiser / Kun Lu / Thomas Seidel / Camilla Schinner / Thomas Schwarzmayr / Rene Schramm / Roland Tomasi / Britta Husse / Xiaochun Cao-Ehlker / Ulrich Pohl / Andreas Dendorfer

    Nature Communications, Vol 10, Iss 1, Pp 1-

    Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

    2019  Volume 1

    Abstract: The original version of this Article incorrectly acknowledged Elisabeth Reiser and Rene Schramm as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article. ...

    Abstract The original version of this Article incorrectly acknowledged Elisabeth Reiser and Rene Schramm as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

    Carola Fischer / Hendrik Milting / Evelyn Fein / Elisabeth Reiser / Kun Lu / Thomas Seidel / Camilla Schinner / Thomas Schwarzmayr / Rene Schramm / Roland Tomasi / Britta Husse / Xiaochun Cao-Ehlker / Ulrich Pohl / Andreas Dendorfer

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable for ... ...

    Abstract Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable for evaluation of drug safety, as exemplified for drugs interfering with cardiomyocyte repolarization.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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