LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Endometrial cancer: predictors and oncological safety of tumor tissue manipulation.

    Quintana-Bertó, Raquel / Padilla-Iserte, Pablo / Lago, Víctor / Tauste, Carmen / Díaz-Feijoo, Berta / Cabrera, Silvia / Oliver-Pérez, Reyes / Coronado, Pluvio J / Martín-Salamanca, María Belén / Pantoja-Garrido, Manuel / Marcos-Sanmartin, Josefa / Cazorla, Eduardo / Lorenzo, Cristina / Rodríguez-Hernández, José Ramón / Roldán-Rivas, Fernando / Gilabert-Estellés, Juan / Muruzábal, Juan Carlos / Cañada, Antonio / Domingo, Santiago

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 26, Issue 5, Page(s) 1098–1105

    Abstract: Purpose: The main goal of this study is to assess the impact of tumor manipulation on the presence of lympho-vascular space invasion and its influence on oncological results.: Methods: We performed a retrospective multi-centric study amongst patients ...

    Abstract Purpose: The main goal of this study is to assess the impact of tumor manipulation on the presence of lympho-vascular space invasion and its influence on oncological results.
    Methods: We performed a retrospective multi-centric study amongst patients who had received primary surgical treatment for apparently early-stage endometrial cancer. A multivariate statistical analysis model was designed to assess the impact that tumor manipulation (with the use of uterine manipulator or preoperative hysteroscopy) has on lympho-vascular development (LVSI) in the final surgical specimen.
    Results: A total of 2852 women from 15 centers were included and divided into two groups based on the lympho-vascular status in the final surgical specimen: 2265 (79.4%) had no LVSI and 587 (20.6%) presented LVSI. The use of uterine manipulator was associated with higher chances of lympho-vascular involvement regardless of the type used: Balloon manipulator (HR: 95% CI 4.64 (2.99-7.33); p < 0.001) and No-Balloon manipulator ([HR]: 95% CI 2.54 (1.66-3.96); p < 0.001). There is no evidence of an association between the use of preoperative hysteroscopy and higher chances of lympho-vascular involvement (HR: 95% CI 0.90 (0.68-1.19); p = 0.479).
    Conclusion: Whilst performing common gynecological procedures, iatrogenic distention and manipulation of the uterine cavity are produced. Our study suggests that the use of uterine manipulator increases the rate of LVSI and, therefore, leads to poorer oncological results. Conversely, preoperative hysteroscopy does not show higher rates of LVSI involvement in the final surgical specimen and can be safely used.
    MeSH term(s) Female ; Humans ; Retrospective Studies ; Hysterectomy/methods ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology ; Neoplasm Staging
    Language English
    Publishing date 2023-09-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03310-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6644: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Oncological safety of hysteroscopy in endometrial cancer.

    Quintana-Bertó, Raquel / Padilla-Iserte, Pablo / Gil-Moreno, Antonio / Oliver-Pérez, Reyes / Coronado, Pluvio J / Martín-Salamanca, María Belén / Pantoja-Garrido, Manuel / Lorenzo, Cristina / Cazorla, Eduardo / Gilabert-Estellés, Juan / Sánchez, Lourdes / Roldán-Rivas, Fernando / Díaz-Feijoo, Berta / Rodríguez-Hernández, José Ramón / Marcos-Sanmartin, Josefina / Muruzábal, Juan Carlos / Cañada, Antonio / Domingo, Santiago

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2022  

    Abstract: Objective: It has been suggested that the manipulation of neoplastic tissue during hysteroscopy may lead to dissemination of tumor cells into the peritoneal cavity and worsen prognosis and overall survival. The goal of this study was to assess the ... ...

    Abstract Objective: It has been suggested that the manipulation of neoplastic tissue during hysteroscopy may lead to dissemination of tumor cells into the peritoneal cavity and worsen prognosis and overall survival. The goal of this study was to assess the oncological safety comparing hysteroscopy to Pipelle blind biopsy in the presurgical diagnosis of patients with endometrial cancer.
    Methods: We performed a retrospective multicentric study among patients who had received primary surgical treatment for endometrial cancer. A multivariate statistical analysis model was used to compare relapse and survival rates in patients who had been evaluated preoperatively either by hysteroscopy or Pipelle biopsy. The relapse rate, disease-free survival, and overall survival were assessed as the main outcomes. The histological type, tumor size, myometrial invasion, International Federation of Gynecology and Obstetrics (FIGO) stage, surgical approach, use of a uterine manipulator, and adjuvant treatment were also included in the analysis.
    Results: A total of 1731 women from 15 centers were included: 1044 in the hysteroscopy group and 687 in the Pipelle sampling group. 225 patients relapsed during the 10 year follow-up period: 139 (13.3%) in the hysteroscopy group and 86 (12.4%) in the Pipelle sampling group. There is no evidence of an association between the use of hysteroscopy as a diagnostic method and relapse rate (HR 1.24, 95% CI 0.92 to 1.66; p=0.16), lower disease-free survival (HR 1.23, 95% CI 0.92 to 1.66; p=0.15), or overall survival (HR 0.95, 95% CI 0.70 to 1.29; p=0.76).
    Conclusion: Hysteroscopy is a safe diagnostic method for patients with endometrial cancer with no impact on oncological outcomes when compared with sampling by Pipelle.
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2022-003586
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Preoperative sampling in endometrial cancer: evaluation of the histopathological agreement with definitive surgical specimen.

    Quintana-Bertó, Raquel / Padilla-Iserte, Pablo / Gil-Moreno, Antonio / Oliver-Pérez, Reyes / Coronado, Pluvio J / Martín-Salamanca, María Belén / Pantoja-Garrido, Manuel / Lorenzo, Cristina / Beric, Duska / Gilabert-Estellés, Juan / Sánchez, Lourdes / Roldán-Rivas, Fernando / Díaz-Feijoo, Berta / Rodríguez-Hernández, José Ramón / Marcos-Sanmartin, Josefina / Muruzábal, Juan Carlos / Cañada, Antonio / Domingo, Santiago

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2022  Volume 24, Issue 12, Page(s) 2388–2394

    Abstract: Purpose: The main goal of this study is to assess the diagnostic agreement between preoperative biopsy and definitive histology of the surgical specimen to determine which sampling method is most suitable for diagnosis of early-stage endometrial cancer.! ...

    Abstract Purpose: The main goal of this study is to assess the diagnostic agreement between preoperative biopsy and definitive histology of the surgical specimen to determine which sampling method is most suitable for diagnosis of early-stage endometrial cancer.
    Methods: We performed a retrospective multicentric study to assess the correlation between three endometrial sampling methods (hysteroscopy, pipelle and D&C) in patients who had undergone preoperative endometrial biopsy and received primary surgical treatment for endometrial cancer. The primary objective was the agreement rate between hysteroscopy (HSC), endometrial biopsy (pipelle) and dilatation and curettage (D&C).
    Results: A total of 1833 women who underwent preoperative sampling at 15 centers were included: 1042 biopsies were performed by HSC, 703 by pipelle and 88 by D&C. All three methods presented a moderate diagnostic concordance (κ = 0.40-0.61) with the definitive specimen's histology: HSC (κ = 0.47), pipelle sampling (κ = 0.48) and D&C (κ = 0.48). Likewise, a subgroup analysis was performed by histological subtype comparing HSC and endometrial biopsy, showing that neither is superior as a diagnostic method.
    Conclusions: According to this study, the use of pipelle sampling could become an adequate diagnostic method in endometrial cancer due to its similar agreement to HSC, ease of use and affordability.
    MeSH term(s) Biopsy/methods ; Dilatation and Curettage ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/surgery ; Endometrium/pathology ; Endometrium/surgery ; Female ; Humans ; Retrospective Studies
    Language English
    Publishing date 2022-08-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-022-02893-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6644: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group.

    Oliver-Perez, M Reyes / Padilla-Iserte, Pablo / Arencibia-Sanchez, Octavio / Martin-Arriscado, Cristina / Muruzabal, Juan Carlos / Diaz-Feijóo, Berta / Cabrera, Silvia / Coronado, Pluvio / Martín-Salamanca, M Belen / Pantoja-Garrido, Manuel / Marcos-Sanmartin, Josefa / Cabezas-López, Elena / Lorenzo, Cristina / Beric, Duska / Rodriguez-Hernandez, Jose Ramon / Roldan-Rivas, Fernando / Gilabert-Estelles, Juan / Sanchez, Lourdes / Laseca-Modrego, Maria /
    Tauste-Rubio, Carmen / Gil-Ibañez, Blanca / Tejerizo-Garcia, Alvaro / On Behalf Of The Spain-Gog Group

    Cancers

    2023  Volume 15, Issue 9

    Abstract: The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative ... ...

    Abstract The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%,
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092612
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Accuracy and Survival Outcomes after National Implementation of Sentinel Lymph Node Biopsy in Early Stage Endometrial Cancer.

    Cabrera, Silvia / Gómez-Hidalgo, Natalia R / García-Pineda, Virginia / Bebia, Vicente / Fernández-González, Sergi / Alonso, Paula / Rodríguez-Gómez, Tomás / Fusté, Pere / Gracia-Segovia, Myriam / Lorenzo, Cristina / Chacon, Enrique / Roldan Rivas, Fernando / Arencibia, Octavio / Martí Edo, Marina / Fidalgo, Soledad / Sanchis, Josep / Padilla-Iserte, Pablo / Pantoja-Garrido, Manuel / Martínez, Sergio /
    Peiró, Ricard / Escayola, Cecilia / Oliver-Pérez, M Reyes / Aghababyan, Cristina / Tauste, Carmen / Morales, Sara / Torrent, Anna / Utrilla-Layna, Jesus / Fargas, Francesc / Calvo, Ana / Aller de Pace, Laura / Gil-Moreno, Antonio

    Annals of surgical oncology

    2023  Volume 30, Issue 12, Page(s) 7653–7662

    Abstract: Background: Sentinel lymph node (SLN) biopsy has recently been accepted to evaluate nodal status in endometrial cancer at early stage, which is key to tailoring adjuvant treatments. Our aim was to evaluate the national implementation of SLN biopsy in ... ...

    Abstract Background: Sentinel lymph node (SLN) biopsy has recently been accepted to evaluate nodal status in endometrial cancer at early stage, which is key to tailoring adjuvant treatments. Our aim was to evaluate the national implementation of SLN biopsy in terms of accuracy to detect nodal disease in a clinical setting and oncologic outcomes according to the volume of nodal disease.
    Patients and methods: A total of 29 Spanish centers participated in this retrospective, multicenter registry including patients with endometrial adenocarcinoma at preoperative early stage who had undergone SLN biopsy between 2015 and 2021. Each center collected data regarding demographic, clinical, histologic, therapeutic, and survival characteristics.
    Results: A total of 892 patients were enrolled. After the surgery, 12.9% were suprastaged to FIGO 2009 stages III-IV and 108 patients (12.1%) had nodal involvement: 54.6% macrometastasis, 22.2% micrometastases, and 23.1% isolated tumor cells (ITC). Sensitivity of SLN biopsy was 93.7% and false negative rate was 6.2%. After a median follow up of 1.81 years, overall surivial and disease-free survival were significantly lower in patients who had macrometastases when compared with patients with negative nodes, micrometastases or ITC.
    Conclusions: In our nationwide cohort we obtained high sensitivity of SLN biopsy to detect nodal disease. The oncologic outcomes of patients with negative nodes and low-volume disease were similar after tailoring adjuvant treatments. In total, 22% of patients with macrometastasis and 50% of patients with micrometastasis were at low risk of nodal metastasis according to their preoperative risk factors, revealing the importance of SLN biopsy in the surgical management of patients with early stage EC.
    MeSH term(s) Female ; Humans ; Sentinel Lymph Node Biopsy ; Lymph Nodes/pathology ; Neoplasm Micrometastasis/pathology ; Retrospective Studies ; Neoplasm Staging ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node/pathology ; Lymph Node Excision
    Language English
    Publishing date 2023-08-26
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-14065-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Urinothorax: An unusual complication of an oncologic gynecological surgery.

    Garcia-Simon, Raquel / Hergueta Herrera, Jesus / Cañizares Oliver, Silvia / Roldan Rivas, Fernando / Fabre González, Ernesto

    Taiwanese journal of obstetrics & gynecology

    2015  Volume 54, Issue 3, Page(s) 336–338

    MeSH term(s) Adenocarcinoma/surgery ; Endometrial Neoplasms/surgery ; Female ; Humans ; Hysterectomy/adverse effects ; Middle Aged ; Ovariectomy/adverse effects ; Pleural Effusion/etiology ; Radiography ; Ureteral Obstruction/diagnostic imaging ; Ureteral Obstruction/etiology ; Urine ; Urinoma/diagnostic imaging ; Urinoma/etiology
    Language English
    Publishing date 2015-06
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Journal Article
    ISSN 1875-6263
    ISSN (online) 1875-6263
    DOI 10.1016/j.tjog.2014.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Impact of uterine manipulator on oncological outcome in endometrial cancer surgery.

    Padilla-Iserte, Pablo / Lago, Víctor / Tauste, Carmen / Díaz-Feijoo, Berta / Gil-Moreno, Antonio / Oliver, Reyes / Coronado, Pluvio / Martín-Salamanca, María Belén / Pantoja-Garrido, Manuel / Marcos-Sanmartin, Josefina / Gilabert-Estellés, Juan / Lorenzo, Cristina / Cazorla, Eduardo / Roldán-Rivas, Fernando / Rodríguez-Hernández, José Ramón / Sánchez, Lourdes / Muruzábal, Juan Carlos / Hervas, David / Domingo, Santiago

    American journal of obstetrics and gynecology

    2020  Volume 224, Issue 1, Page(s) 65.e1–65.e11

    Abstract: Background: There are limited data available to indicate whether oncological outcomes might be influenced by the uterine manipulator, which is used at the time of hysterectomy for minimally invasive surgery in patients with endometrial cancer. The ... ...

    Abstract Background: There are limited data available to indicate whether oncological outcomes might be influenced by the uterine manipulator, which is used at the time of hysterectomy for minimally invasive surgery in patients with endometrial cancer. The current evidence derives from retrospective studies with limited sample sizes. Without substantial evidence to support its use, surgeons are required to make decisions about its use based only on their personal choice and surgical experience.
    Objective: To evaluate the use of the uterine manipulator on oncological outcomes after minimally invasive surgery, for apparent early-stage endometrial cancer.
    Study design: We performed a retrospective multicentric study to assess the oncological safety of uterine manipulator use in patients with apparent early-stage endometrial cancer, treated with minimally invasive surgery. The type of manipulator, surgical staging, histology, lymphovascular space invasion, International Federation of Gynecology and Obstetrics stage, adjuvant treatment, recurrence, and pattern of recurrence were evaluated. The primary objective was to determine the relapse rate. The secondary objective was to determine recurrence-free survival, overall survival, and the pattern of recurrence.
    Results: A total of 2661 women from 15 centers were included; 1756 patients underwent hysterectomy with a uterine manipulator and 905 without it. Both groups were balanced with respect to histology, tumor grade, myometrial invasion, International Federation of Gynecology and Obstetrics stage, and adjuvant therapy. The rate of recurrence was 11.69% in the uterine manipulator group and 7.4% in the no-manipulator group (P<.001). The use of the uterine manipulator was associated with a higher risk of recurrence (hazard ratio, 2.31; 95% confidence interval, 1.27-4.20; P=.006). The use of uterine manipulator in uterus-confined endometrial cancer (International Federation of Gynecology and Obstetrics [FIGO] I-II) was associated with lower disease-free survival (hazard ratio, 1.74; 95% confidence interval, 0.57-0.97; P=.027) and higher risk of death (hazard ratio, 1.74; 95% confidence interval, 1.07-2.83; P=.026). No differences were found regarding the pattern of recurrence between both groups (chi-square statistic, 1.74; P=.63).
    Conclusion: In this study, the use of a uterine manipulator was associated with a worse oncological outcome in patients with uterus-confined endometrial cancer (International Federation of Gynecology and Obstetrics I-II) who underwent minimally invasive surgery. Prospective trials are essential to confirm these results.
    MeSH term(s) Aged ; Carcinoma, Endometrioid/mortality ; Carcinoma, Endometrioid/surgery ; Disease-Free Survival ; Endometrial Neoplasms/mortality ; Endometrial Neoplasms/surgery ; Female ; Humans ; Hysterectomy/instrumentation ; Middle Aged ; Minimally Invasive Surgical Procedures/instrumentation ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies ; Spain ; Treatment Outcome
    Language English
    Publishing date 2020-07-18
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2020.07.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um I Zs.152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top