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  1. Article ; Online: Catching a shark while looking for flounders.

    Orlandi, Riccardo / Leuzzi, Giovanni / Lorenzini, Daniele / Rolli, Luigi / Ferrari, Michele / Conca, Elena / Pastorino, Ugo

    JTCVS techniques

    2023  Volume 21, Page(s) 215–220

    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2023.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Post-operative lung ultrasonography in daily routine thoracic surgery: can we trust its results?

    Scanagatta, Paolo / Rolli, Luigi

    Journal of thoracic disease

    2019  Volume 11, Issue 1, Page(s) 42–44

    Language English
    Publishing date 2019-03-07
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.12.96
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Long-Term Survival Analysis of Pleural Mesothelioma Patients Undergoing Surgery: Brief Report From a Tertiary Referral Centre.

    Orlandi, Riccardo / Leuzzi, Giovanni / Rolli, Luigi / Ferrari, Michele / Stanzi, Alessia / Valsecchi, Camilla / Pastorino, Ugo

    Clinical lung cancer

    2023  Volume 25, Issue 1, Page(s) e5–e10

    Abstract: Objectives: to date, no consensus has been reached on the surgical gold-standard in pleural mesothelioma (PM). We retrospectively reviewed our experience as a tertiary referral centre, to compare short- and long-term survival of PM patients undergoing ... ...

    Abstract Objectives: to date, no consensus has been reached on the surgical gold-standard in pleural mesothelioma (PM). We retrospectively reviewed our experience as a tertiary referral centre, to compare short- and long-term survival of PM patients undergoing different types of surgery.
    Methods: in retrospective, observational, single-centre study, we analysed all the patients histologically diagnosed with PM undergoing surgical procedures with palliative or curative intent at IRCCS Istituto Nazionale dei Tumori of Milan, Italy, from January 2003 to December 2020. The primary study endpoint was 10-year overall survival (OS) in three different types of resections: extra-pleural-pneumonectomy (EPP), pleurectomy/decortication (P/D), partial-pleurectomy/pleural-biopsy (PP/B). Secondary endpoints were postoperative hospital stay and postoperative 30-day and 90-day mortality rates. The survival function was estimated using Kaplan-Meier, and the Log-rank test was used for testing differences. Univariable and Multivariable Cox regression models were implemented to estimate Hazard Ratio (HR) for all variables of interest.
    Results: 243 consecutive patients were enrolled, EPP was performed in 49 (20.2%), P/D in 58 (23.8%), PP/B in 136 (56.0%) patients. The median follow-up time was 19.8 months. 10-year OS was significantly better for P/D group (16%, Log-Rank test p<0.0001) compared to PP/B (1.8%) and EPP (0%). No statistically significant differences were found among the 3 surgical groups in 30- and 90-day mortality rates. At multivariable analysis, gender (male, HR=1.58), type of resection (P/D, HR=0.55) and surgery date (recent years, HR=0.61) were found to be independent prognostic factors for OS.
    Conclusions: in PM, lung-sparing curative approach (e.g. P/D) should be preferred in highly selected patients and in highly experienced centres, whenever appropriate. Anyway, when P/D is not indicated, adopting palliative/conservative management (e.g. PP/B) could ensure comparable results as extremely aggressive surgeries (e.g. EPP). The aim of surgery in PM should not be reaching complete resection, but rather accomplishing significant resection allowing to complete the multimodality treatment in highly selected patients in experienced centers.
    MeSH term(s) Humans ; Male ; Retrospective Studies ; Tertiary Care Centers ; Lung Neoplasms/pathology ; Treatment Outcome ; Mesothelioma, Malignant/surgery ; Mesothelioma ; Pleural Neoplasms/pathology ; Pneumonectomy/methods ; Proportional Hazards Models
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145146-1
    ISSN 1938-0690 ; 1525-7304
    ISSN (online) 1938-0690
    ISSN 1525-7304
    DOI 10.1016/j.cllc.2023.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Routine perioperative blood tests predict survival of resectable lung cancer.

    Morelli, Daniele / Cantarutti, Anna / Valsecchi, Camilla / Sabia, Federica / Rolli, Luigi / Leuzzi, Giovanni / Bogani, Giorgio / Pastorino, Ugo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17072

    Abstract: There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm to predict lung cancer outcome. Perioperative routine blood tests (RBT) of a cohort of patients ... ...

    Abstract There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm to predict lung cancer outcome. Perioperative routine blood tests (RBT) of a cohort of patients with resectable primary lung cancer (LC) were analysed. Inflammatory, immunologic, and metabolic profiles were used to create a single algorithm (RBT index) predicting LC survival. A concurrent cohort of patients with resectable lung metastases (LM) was used to validate the RBT index. Charts of 2088 consecutive LC and 1129 LM patients undergoing lung resection were evaluated. Among RBT parameters, C-reactive protein (CRP), lymphocytes, neutrophils, hemoglobin, albumin and glycemia independently correlated with survival, and were used to build the RBT index. Patients with a high RBT index had a higher 5-year mortality than low RBT patients (adjusted HR 1.93, 95% CI 1.62-2.31). High RBT patients also showed a fourfold higher risk of 30-day postoperative mortality (2.3% vs. 0.5%, p 0.0019). The LM analysis validated the results of the LC cohort. We developed a simple and easily available multifunctional tool predicting short-term and long-term survival of curatively resected LC and LM. Prospective external validation of RBT index is warranted.
    MeSH term(s) Humans ; Prospective Studies ; Lung Neoplasms/surgery ; Hematologic Tests ; C-Reactive Protein/metabolism ; Lymphocytes/metabolism ; Retrospective Studies ; Prognosis
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44308-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Treatment of anaemia in the "ERAS" era: how far can we go?

    Rolli, Luigi / Duranti, Leonardo / Leuzzi, Giovanni

    Journal of thoracic disease

    2019  Volume 11, Issue 9, Page(s) 3692–3695

    Language English
    Publishing date 2019-10-11
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.09.21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Post-surgical Regression of Thoracic Metastases After Salvage Lobectomy for Recurrent Renal Cell Carcinoma.

    Stanzi, Alessia / Verzoni, Elena / Ruggirello, Margherita / Rolli, Luigi / Pastorino, Ugo

    Clinical genitourinary cancer

    2019  Volume 18, Issue 3, Page(s) e284–e288

    MeSH term(s) Aged ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Metastasectomy/adverse effects ; Neoplasm Recurrence, Local/surgery ; Postoperative Complications/etiology ; Postoperative Complications/pathology ; Prognosis ; Salvage Therapy ; Thoracic Neoplasms/etiology ; Thoracic Neoplasms/secondary
    Language English
    Publishing date 2019-12-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2019.11.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparison of clinical and oncologic effectiveness between flexible 3-dimensional and bidimensional video-thoracoscopic surgery for lung cancer.

    Pardolesi, Alessandro / Rolli, Luigi / Scanagatta, Paolo / Duranti, Leonardo / Tavecchio, Luca / Pastorino, Ugo

    Tumori

    2020  Volume 107, Issue 3, Page(s) 261–266

    Abstract: Background: Three-dimensional (3D) vision systems are available for video-assisted thoracic surgery (VATS). It is unclear whether 3D-VATS is superior to bidimensional (2D) VATS systems.: Methods: We analyzed patients who received 3D-VATS (: Results! ...

    Abstract Background: Three-dimensional (3D) vision systems are available for video-assisted thoracic surgery (VATS). It is unclear whether 3D-VATS is superior to bidimensional (2D) VATS systems.
    Methods: We analyzed patients who received 3D-VATS (
    Results: Operative time, length of hospital stay, number of dissected lymph nodes, and rate of postoperative complications were similar in both groups. In the 3D group, there was no conversion to thoracotomy for intraoperative major vascular injuries, while conversion to an open procedure for uncontrolled bleeding was recorded in 4 (1.7%) patients in the 2D group. Reoperation for hemostasis and/or aerostasis occurred in 6 (2.6%) patients of the 2D group (
    Conclusion: Nonrandomized comparison of different surgical approaches is challenging. In our experience, 3D-VATS was safe and effective and offered excellent operative perception and sensitivity, enabling safer dissection of hilar structures. The 3D-VATS system helped skilled surgeons beyond the boundaries of more oncologically aggressive surgery.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Length of Stay ; Lung Neoplasms/diagnosis ; Lymph Node Excision/methods ; Male ; Middle Aged ; Operative Time ; Pneumonectomy/methods ; Postoperative Complications/diagnosis ; Reoperation/methods ; Retrospective Studies ; Thoracic Surgery, Video-Assisted/methods ; Thoracotomy/methods ; Treatment Outcome
    Language English
    Publishing date 2020-05-27
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    DOI 10.1177/0300891620925901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Extra-pleural pneumonectomy.

    Duranti, Leonardo / Pardolesi, Alessandro / Bertolaccini, Luca / Tavecchio, Luca / Scanagatta, Paolo / Rolli, Luigi / Pastorino, Ugo

    Journal of thoracic disease

    2019  Volume 11, Issue 3, Page(s) 1022–1030

    Abstract: The extra-pleural pneumonectomy (EPP) is a standardised surgical procedure born for pleural tuberculosis and later used in pleural cancer treatment, especially in malignant pleural mesothelioma (MPM). This systematic review aimed to focus on the actual ... ...

    Abstract The extra-pleural pneumonectomy (EPP) is a standardised surgical procedure born for pleural tuberculosis and later used in pleural cancer treatment, especially in malignant pleural mesothelioma (MPM). This systematic review aimed to focus on the actual overall EPP role in surgical oncology. The literature search was performed from January 1985 to January 2018 In PubMed, Embase, and Cochrane according to PRISMA protocol. The search was restricted to publications in English with the research words "extrapleural pneumonectomy", "malignant pleural mesothelioma", "pleural malignancies". The results were then filtered focusing only on papers with series of patients treated with EPP, for mesothelioma and non-mesothelioma malignancies. The search was restricted to publications in English. We found a 5-year overall survival (OS) ranging from 0 to 78%. The peri-operative mortality and morbidity ranged from 0 to 11.8% and 0 to 82.6%, respectively. The most represented and described post-operative complications reported were ARDS, pericardial tamponade, cardiac herniation, pulmonary embolism, respiratory infections, respiratory failure, atrial arrhythmia, myocardial infarction. In referral centres and selected patients, EPP is a cytoreductive or radical surgical treatment in extended pleural malignancies. Prospective studies are needed to standardise the timing of the procedure in a multimodality treatment program, according to the oncological and functional indications, to keep an acceptable complications rate and post-operative quality of life status.
    Language English
    Publishing date 2019-04-18
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.02.61
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Worsening Hemoptysis in a Rare Intrapulmonary Triton Tumor Mimicking Lung Cancer.

    Scanagatta, Paolo / Furia, Simone / Pardolesi, Alessandro / Rolli, Luigi / Fabbri, Alessandra / Stacchiotti, Silvia / Pastorino, Ugo

    The Annals of thoracic surgery

    2019  Volume 109, Issue 3, Page(s) e199–e201

    Abstract: A 71-year-old male former smoker was referred for worsening hemoptysis from a hilar left tumor without radiologic or bronchoscopic identification of the bleeding source. He underwent an urgent upper lobectomy extended to the pericardium and left phrenic ... ...

    Abstract A 71-year-old male former smoker was referred for worsening hemoptysis from a hilar left tumor without radiologic or bronchoscopic identification of the bleeding source. He underwent an urgent upper lobectomy extended to the pericardium and left phrenic nerve to control active bleeding. Histologic analysis revealed a malignant triton tumor, a rare aggressive subtype of malignant peripheral nerve sheath tumors. This is a case report of unusual pulmonary involvement associated with hemoptysis. Despite radical surgery and multimodal treatment with adjuvant chemotherapy the patient died of systemic dissemination 10 months after surgery, with a disease-free survival of 3 months.
    MeSH term(s) Aged ; Diagnosis, Differential ; Fatal Outcome ; Hemoptysis/etiology ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/pathology ; Male ; Neurofibrosarcoma/complications ; Neurofibrosarcoma/pathology ; Symptom Flare Up
    Language English
    Publishing date 2019-08-07
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2019.06.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Permeable Nonabsorbable Mesh for Total Diaphragmatic Replacement in Extended Pneumonectomy.

    Rolli, Luigi / Leuzzi, Giovanni / Girotti, Paolo / Duranti, Leonardo / Pastorino, Ugo

    The Annals of thoracic surgery

    2017  Volume 104, Issue 1, Page(s) e105–e107

    Abstract: After complex thoracic exenterations, total diaphragmatic resection and reconstruction is challenging. We describe our novel technique for total diaphragmatic replacement with permeable nonabsorbable mesh after extended pneumonectomy. ...

    Abstract After complex thoracic exenterations, total diaphragmatic resection and reconstruction is challenging. We describe our novel technique for total diaphragmatic replacement with permeable nonabsorbable mesh after extended pneumonectomy.
    MeSH term(s) Adult ; Female ; Hernia, Diaphragmatic/diagnosis ; Hernia, Diaphragmatic/etiology ; Hernia, Diaphragmatic/surgery ; Herniorrhaphy/methods ; Humans ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Pneumonectomy/adverse effects ; Postoperative Complications ; Retrospective Studies ; Surgical Mesh ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2017-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2017.02.077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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